An Internet-based program for depressive symptoms using human and automated support: a randomized controlled trial
Open accessAbstract
PURPOSE: The purpose of this study was to analyze the efficacy of an Internet-based program for depressive symptoms using automated support by information and communication technologies (ICTs) and human support. PATIENTS AND METHODS: An Internet-based program was used to teach adaptive ways to cope with depressive symptoms and daily problems. A total of 124 participants who were experiencing at least one stressful event that caused interference in their lives, many of whom had clinically significant depressive symptoms, were randomly assigned into either an intervention group with ICT support (automated mobile phone messages, automated emails, and continued feedback through the program); an intervention group with ICT support plus human support (brief weekly support phone call without clinical content); or a waiting-list control. At pre-, post-, and 12-month follow-up, they completed depression, anxiety, positive and negative effect, and perceived stress measures. Results were analyzed using both intention-to-treat and completers data. The majority were women (67.7%), with a mean age of 35.6 years (standard deviation =9.7). RESULTS: The analysis showed that the two intervention groups improved significantly pre- to posttreatment, compared with the control group. Furthermore, improvements were maintained at the 12-month follow-up. Adherence and satisfaction with the program was high in both conditions. CONCLUSION: The Internet-based program was effective and well accepted, with and without human support, showing that ICT-based automated support may be useful. It is essential to continue to study other ICT strategies for providing support.
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This intervention has shown its efficacy in different RCTs.
“It has shown its efficacy in different RCTs [51–53].”
The results coincide with literature indicating that people treated with Internet-based programs report high levels of acceptability and high satisfaction.
“Our results coincide with the literature indicating that people treated with Internet-based programs report high levels of acceptability and high satisfaction (58, 73–78).”
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BackgroundMethodInfluentialDíaz-García, A., González-Robles, A., Mor, S., Mira, A., Quero, S., García-Palacios, A., Baños, R. M., & Botella, C. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-2472-1 · Cited by 207 · see citing works
Self-citationEngagement and retention in digital mental health interventions: a narrative review
Boucher, E. M., & Raiker, J. S. (2024) · BMC Digital Health · doi:10.1186/s44247-024-00105-9 · Cited by 200 · see citing works
Karyotaki, E., Kemmeren, L., Riper, H., Twisk, J., Hoogendoorn, A., Kleiboer, A., Mira, A., Mackinnon, A., Meyer, B., Botella, C., et al. (2018) · Psychological Medicine · doi:10.1017/s0033291718000648 · Cited by 167 · see citing works
“…(Christensen et al. 2004; de Graaf et al. 2009; Berger et al. 2011; Farrer et al. 2011; Gilbody et al. 2015; Karyotaki et al. 2017 accepted, Spek et al. 2007; Meyer et al. 2009; Moritz et al. 2012; Phillips et al. 2014; Kleiboer et al. 2015; Meyer et al. 2015; Klein et al. 2016; Mira et al. 2017).”
BackgroundMethodSelf-citationHornstein, S., Zantvoort, K., Lueken, U., Funk, B., & Hilbert, K. (2023) · Frontiers in Digital Health · doi:10.3389/fdgth.2023.1170002 · Cited by 134 · see citing works
Rigabert, A., Motrico, E., Moreno-Peral, P., Resurrección, D. M., Conejo-Cerón, S., Cuijpers, P., Martín-Gómez, C., López-Del-Hoyo, Y., & Bellón, J. Á. (2020) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101931 · Cited by 92 · see citing works
Beintner, I., Vollert, B., Zarski, A.-C., Bolinski, F., Musiat, P., Görlich, D., Ebert, D. D., & Jacobi, C. (2019) · Journal of Medical Internet Research · doi:10.2196/14181 · Cited by 89 · see citing works
A systematic review on automated clinical depression diagnosis
Mao, K., Wu, Y., & Chen, J. (2023) · npj Mental Health Research · doi:10.1038/s44184-023-00040-z · Cited by 91 · see citing works
“In addition, these tools can be designed to customize treatment based on an individual ’ s speci fi c symptoms, improving treatment ef fi cacy 36,37 .”
Gan, D. Z. Q., McGillivray, L., Larsen, M. E., Christensen, H. M., & Torok, M. H. (2022) · Digital Health · doi:10.1177/20552076221098268 · Cited by 80 · see citing works
“42 Coaching.”
BackgroundWhat Is the Current and Future Status of Digital Mental Health Interventions?
Baños, R. M., Herrero, R., & Vara, M. D. (2022) · The Spanish Journal of Psychology · doi:10.1017/sjp.2022.2 · Cited by 82 · see citing works
New Technologies for the Understanding, Assessment, and Intervention of Emotion Regulation
Colombo, D., Fernández-Álvarez, J., García Palacios, A., Cipresso, P., Botella, C., & Riva, G. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.01261 · Cited by 75 · see citing works
Self-citationWeisel, K. K., Zarski, A.-C., Berger, T., Krieger, T., Schaub, M. P., Moser, C. T., Berking, M., Dey, M., Botella, C., Baños, R., et al. (2019) · Internet Interventions · doi:10.1016/j.invent.2018.04.002 · Cited by 57 · see citing works
Self-citationSchure, M. B., Lindow, J. C., Greist, J. H., Nakonezny, P. A., Bailey, S. J., Bryan, W. L., & Byerly, M. (2019) · Journal of Medical Internet Research · doi:10.2196/14754 · Cited by 50 · see citing works
“%) unweighted mean completion rate [24-30,52,55,58-64] for short-term (6-16 weeks) follow-up assessments of all studies in Karyotaki et al [21].”
InfluentialGonzález-Robles, A., Mira, A., Miguel, C., Molinari, G., Díaz-García, A., García-Palacios, A., Bretón-López, J. M., Quero, S., Baños, R. M., & Botella, C. (2018) · PLOS ONE · doi:10.1371/journal.pone.0206516 · Cited by 51 · see citing works
Self-citationSander, L., Gerhardinger, K., Bailey, E., Robinson, J., Lin, J., Cuijpers, P. J., & Mühlmann, C. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.11.045 · Cited by 44 · see citing works
McCall, H. C., Hadjistavropoulos, H. D., & Sundström, C. (2021) · Journal of Medical Internet Research · doi:10.2196/26939 · Cited by 39 · see citing works
“5 Web browser 10 modules CBT and other approaches Depression Sonreír es Divertidoh Mira et al, 2017 [62] and Montero-Marin et al, 2016 [64]”
BackgroundGlover, A. C., Schueller, S. M., Winiarski, D. A., Smith, D. L., Karnik, N. S., & Zalta, A. K. (2019) · JMIR Mental Health · doi:10.2196/15144 · Cited by 40 · see citing works
“Although some recent research studies have demonstrated that automated interventions without a human component can yield high levels of engagement and do not necessarily increase the risk of attrition [24,26], many studies have found that human support leads to higher rates of engagement [50].”
Díaz-García, A., González-Robles, A., García-Palacios, A., Fernández-Álvarez, J., Castilla, D., Bretón, J. M., Baños, R. M., Quero, S., & Botella, C. (2021) · Journal of Medical Internet Research · doi:10.2196/21335 · Cited by 36 · see citing works
“Indeed, this aspect has great relevance in the literature on internet-based interventions [95,96].”
BackgroundSelf-citationGonzález-Robles, A., Díaz-García, A., García-Palacios, A., Roca, P., Ramos-Quiroga, J. A., & Botella, C. (2020) · Journal of Medical Internet Research · doi:10.2196/18220 · Cited by 40 · see citing works
“Finally, in Spain, several RCTs have been conducted using the internet to provide evidence-based treatments, showing that they are effective for the treatment of ED and, in particular, depression, in community samples [94] and primary care [115,116], and others are underway [117].”
BackgroundMethodResultSelf-citationLin, A., & Espay, A. J. (2021) · Epilepsy & Behavior Reports · doi:10.1016/j.ebr.2021.100469 · Cited by 38 · see citing works
“They found that both intervention groups improved significantly compared to the control, with no significant difference between the group that received automated messages and the group that received human support [31].”
BackgroundTokgöz, P., Hrynyschyn, R., Hafner, J., Schönfeld, S., & Dockweiler, C. (2021) · JMIR Mental Health · doi:10.2196/26268 · Cited by 36 · see citing works
“Most of the studies (39/52, 75%) used a web-based system in which an application was used online [21-23,28,33-46,48,49,52-55,57-67,69-72].”
BackgroundMethodInfluentialJonathan, G., Dopke, C. A., Michaels, T., Bank, A., Martin, C. R., Adhikari, K., Krakauer, R. L., Ryan, C., McBride, A., Babington, P., et al. (2021) · JMIR Mental Health · doi:10.2196/20424 · Cited by 36 · see citing works
“Research suggests that human support for app use reduces attrition and improves adherence; however, increased engagement does not always translate into improved outcomes [29,38,66,95-97].”
BackgroundCampos, D., Bretón-López, J., Botella, C., Mira, A., Castilla, D., Mor, S., Baños, R., & Quero, S. (2019) · BMC Psychiatry · doi:10.1186/s12888-019-2060-4 · Cited by 32 · see citing works
Self-citationCampos, D., Mira, A., Bretón-López, J., Castilla, D., Botella, C., Baños, R. M., & Quero, S. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s153041 · Cited by 30 · see citing works
“55,56 Therefore, it is interesting to continue to investigate whether there are differences in acceptability, depending on the support provided.”
Self-citationLeong, Q. Y., Sridhar, S., Blasiak, A., Tadeo, X., Yeo, G., Remus, A., & Ho, D. (2021) · Journal of Medical Internet Research · doi:10.2196/27388 · Cited by 34 · see citing works
“7% (145/8362) of articles (Multimedia Appendix 2 [22-166]).”
Renfrew, M. E., Morton, D. P., Morton, J. K., & Przybylko, G. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.716106 · Cited by 32 · see citing works
Heterogeneity of Treatment Effects in Internet- and Mobile-Based Interventions for Depression
Terhorst, Y., Kaiser, T., Brakemeier, E., Moshe, I., Philippi, P., Cuijpers, P. J., Baumeister, H., & Sander, L. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.23241 · Cited by 32 · see citing works
Enrique, Á., Mooney, O., Salamanca-Sanabria, A., Lee, C. T., Farrell, S., & Richards, D. (2020) · JMIR Formative Research · doi:10.2196/20167 · Cited by 29 · see citing works
“This may have been due to a greater sense of agency in the automated support group as participants were not dependent on a therapist and the quality of automated support [27,29].”
InfluentialMira, A., Soler, C., Alda, M., Baños, R., Castilla, D., Castro, A., García-Campayo, J., García-Palacios, A., Gili, M., Hurtado, M., et al. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00325 · Cited by 29 · see citing works
Self-citationCheung, E. O., Addington, E. L., Bassett, S. M., Schuette, S., Shiu, E. W., Cohn, M., Leykin, Y., Saslow, L. R., & Moskowitz, J. T. (2018) · JMIR Research Protocols · doi:10.2196/10494 · Cited by 25 · see citing works
“Even when interventions are entirely computerized, contact with a person associated with the intervention has been found to increase adherence to the study [43,85-89].”
BackgroundEnrique, Á., Mooney, O., Salamanca-Sanabria, A., Lee, C. T., Farrell, S., & Richards, D. (2019) · Internet Interventions · doi:10.1016/j.invent.2019.100254 · Cited by 23 · see citing works
“, automated reminders or emails) may represent a more cost- and timeefficient alternative to human support and different studies have shown positive results (Baumeister et al., 2014; Campos et al., 2019; Mira et al., 2017; Titov et al., 2013), but more research is needed to support Fig.”
ResultMira, A., Bretón-López, J., Enrique, Á., Castilla, D., García-Palacios, A., Baños, R., & Botella, C. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.02360 · Cited by 21 · see citing works
“…intervention were included, that is, participants from both intervention groups, with and without human support (no differences were found between them on any measure; Mira et al., 2017), and participants from the waiting list control group who completed the program after the wait time.”
BackgroundMethodResultInfluentialSelf-citationSchure, M. B., McCrory, B., Franklin, K. T., Greist, J. H., & Weissman, R. S. (2020) · Journal of Medical Internet Research · doi:10.2196/21336 · Cited by 21 · see citing works
“In Mira and colleagues’ trial [19], 12-month effect sizes for depression symptoms demonstrated a moderate within-group effect size ( d = 0.67).”
InfluentialGhosh, A., Cherian, R. J., Wagle, S., Sharma, P., Kannan, K. R., Bajpai, A., & Gupta, N. (2023) · Journal of Medical Internet Research · doi:10.2196/41005 · Cited by 23 · see citing works
Tong, A. C. Y., Ho, F. S., Chu, O. H., & Mak, W. W. S. (2023) · Journal of Medical Internet Research · doi:10.2196/39029 · Cited by 19 · see citing works
Yan, K., Yusufi, M. H., & Nazari, N. (2022) · World Journal of Clinical Cases · doi:10.12998/wjcc.v10.i24.8599 · Cited by 16 · see citing works
Dopke, C. A., McBride, A., Babington, P., Jonathan, G., Michaels, T., Ryan, C., Duffecy, J. L., Mohr, D. C., & Goulding, E. H. (2021) · JMIR Formative Research · doi:10.2196/25810 · Cited by 14 · see citing works
González-Robles, A., Suso‐Ribera, C., Díaz‐García, A., García‐Palacios, A., Castilla, D., & Botella, C. (2021) · Internet Interventions · doi:10.1016/j.invent.2021.100420 · Cited by 14 · see citing works
Self-citationA scoping review of therapist behaviors in guided digital mental health interventions
González-Robles, A., Miguel, C., Richards, D., Duffy, D., & Enrique, Á. (2024) · Internet Interventions · doi:10.1016/j.invent.2024.100751 · Cited by 12 · see citing works
“…of guidance seems to be out of question, most of the research on internet-delivered treatments have focused on aspects such as how intensely and frequently the guidance is delivered (e.g., number of emails, number and duration of phone calls) (Gonz ´ alez-Ro-bles et al., 2020; Mira et al., 2017).”
BackgroundGonzález‐Robles, A., García‐Palacios, A., Baños, R., Quero, S., & Botella, C. (2017) · Behavior Modification · doi:10.1177/0145445517735631 · Cited by 11 · see citing works
“This component has already been empirically tested in a randomized controlled trial (RCT) exploring the efficacy of a web-based intervention for depression (Mira et al., 2017).”
Self-citationla Rosa-Gómez, A. D., Flores-Plata, L. A., Esquivel-Santoveña, E. E., Torija, C. S. T., Flores, R. G., Rodríguez, A. D., Arenas-Landgrave, P., Castellanos-Vargas, R. O., Ruiz, E. B., Silvestre-Ramírez, R., et al. (2022) · BMC Psychiatry · doi:10.1186/s12888-022-04132-6 · Cited by 12 · see citing works
Guided Internet-Delivered Treatment for Depression: Scoping Review
Børtveit, L., Dechsling, A., Sütterlin, S., Nordgreen, T., & Nordahl‐Hansen, A. (2022) · JMIR Mental Health · doi:10.2196/37342 · Cited by 11 · see citing works
“In Multimedia Appendix 5 [17,73-182], the data charted from and the characteristics of the different sources of evidence are presented.”
BackgroundMira, A., Díaz-García, A., Castilla, D., Campos, D., Romero, S., Bretón-López, J., García-Palacios, A., Baños, R., & Botella, C. (2019) · BMC Psychiatry · doi:10.1186/s12888-019-2099-2 · Cited by 9 · see citing works
Self-citationQuiñonez-Freire, C., Vara, M. D., Herrero, R., Mira, A., García‐Palacios, A., Botella, C., & Baños, R. (2020) · Internet Interventions · doi:10.1016/j.invent.2020.100352 · Cited by 8 · see citing works
Self-citationBlended transdiagnostic group CBT for emotional disorders: A feasibility trial protocol
Díaz‐García, A., González‐Robles, A., García‐Palacios, A., Fernández‐Felipe, I., Tur, C., Castilla, D., & Botella, C. (2021) · Internet Interventions · doi:10.1016/j.invent.2021.100363 · Cited by 8 · see citing works
Self-citationApplication of the Supportive Accountability Model in Digital Health Interventions: Scoping Review
Kwok, G., Cheung, S., Duffecy, J. L., & Devine, K. A. (2025) · Journal of Medical Internet Research · doi:10.2196/72639 · Cited by 8 · see citing works
“Health professionals included nurses and nurse interns [54,55]; a behavioral weight loss interventionist [56]; dietitians [57]; mental health providers, such as clinical psychologists [57,58]; therapists [59-61]; and clinic staff [49,50].”
Pugh, D., Saunders, R., Jones, A., Dunn, B. D., & Buckman, J. E. J. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120165 · Cited by 5 · see citing works
Hadjistavropoulos, H. D., Reiser, S. J., Beahm, J. D., McCall, H. C., Dena, I., Phillips, A. R., Scheltgen, M., Sekhar, S., Cox, M., Cramm, H. A., et al. (2023) · JMIR Formative Research · doi:10.2196/51088 · Cited by 4 · see citing works
“Research has shown that clients of both therapist-guided [17] and self-guided ICBT [25-27] maintain treatment gains at 1 year or longer after treatment.”
BackgroundQuality of Life Outcomes in Internet-Delivered (Space from Depression) Treatment for Depression
Enrique, Á., Burke, J., Richards, D., & Timulák, L. (2018) · Applied Research in Quality of Life · doi:10.1007/s11482-018-9654-8 · Cited by 4 · see citing works
Arango, F. E., Torres, A. M. F., Jiménez, M. J. E., & Valencia, A. A. (2022) · Revista Virtual Universidad Católica del Norte · doi:10.35575/rvucn.n67a9 · Cited by 4 · see citing works
Lorente-Català, R., Gili, M., del Hoyo, Y. L., Mayoral, F., Pérez‐Aranda, A., Castro, A., Moreno, E. V., Baños, R., Roca, M., Monreal‐Bartolomé, A., et al. (2022) · Internet Interventions · doi:10.1016/j.invent.2022.100581 · Cited by 4 · see citing works
Self-citationA Telemedicine Application for Remote Diagnosis and Assessment of Mood Disorders
Κωνσταντοπούλου, Γ., Panagiotakopoulos, T., Mandellos, G. J., Asimakopoulos, K., & Lymberopoulos, D. K. (2018) · Lecture notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering · doi:10.1007/978-3-030-05195-2_12 · Cited by 2 · see citing works
Romero, S., Mira, A., Bretón-López, J. M., Díaz‐García, A., Díaz-Sanahuja, L., García‐Palacios, A., & Botella, C. (2019) · Lecture notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering · doi:10.1007/978-3-030-25872-6_10 · Cited by 2 · see citing works
Self-citationSchure, M. B., McCrory, B., Greist, J. H., & Weissman, R. S. (2022) · Discover Psychology · doi:10.1007/s44202-022-00030-w · Cited by 2 · see citing works
Eicher, S., Heinrich, M., Zagorscak, P., Brose, A., & Knaevelsrud, C. (2025) · Internet Interventions · doi:10.1016/j.invent.2025.100818 · Cited by 1 · see citing works
“Besides, several studies examined the effect of additional phone support in un-guided interventions (e.g. Andersson et al., 2003; Gilbody et al., 2017; Kenwright et al., 2005; Mira et al., 2017).”
InfluentialSaar, C. R., Brandes, O., & Baumel, A. (2025) · Frontiers in Digital Health · doi:10.3389/fdgth.2025.1586668 · Cited by 1 · see citing works
Hybrid effectiveness-implementation studies in mental health: three practical examples
Lorente-Català, R., & García‐Palacios, A. (2026) · International Journal of Evidence-Based Healthcare · doi:10.1097/xeb.0000000000000592 · Cited by 1 · see citing works
Self-citationPreliminary Criteria For Ict in Assisting Students With Psychological Problems
Jakovljevic, M., Karačić, M. J., & Pjano, O. (2024) · Journal Human Research in Rehabilitation · doi:10.21554/hrr.042403 · Cited by 1 · see citing works
Ghosh, A., Cherian, R. J., Wagle, S., Sharma, P., Kannan, K. R., Bajpai, A., & Gupta, N. (2021) · medRxiv · doi:10.1101/2021.11.24.21266799 · Cited by 1 · see citing works
Beintner, I., Vollert, B., Zarski, A., Bolinski, F., Musiat, P., Görlich, D., Ebert, D. D., & Jacobi, C. (2019) · doi:10.2196/preprints.14181 · Cited by 1 · see citing works
Schure, M. B., McCrory, B., Greist, J. H., & Weissman, R. S. (2021) · Research Square · doi:10.21203/rs.3.rs-965880/v1
Lorente-Català, R., Font-Furnieles, P., Escriva-Sanchis, R., Bertó-García, C., Vera-Albero, P., & García‐Palacios, A. (2024) · Internet Interventions · doi:10.1016/j.invent.2024.100742
“Based on previous studies (Mira et al., 2017, 2019) a loss-to-follow-up rate of 30 % was anticipated on post-treatment assessment.”
BackgroundMethodSelf-citationAdvanced robot interfaces are unnecessary for effective psychological health interventions
Huang, I. S., & Hoorn, J. F. (2026) · Computers in Human Behavior Reports · doi:10.1016/j.chbr.2026.100955
Degani, M., Natale, A. F. D., Cremaschi, G., & Villani, D. (2026) · Behavioral Sciences · doi:10.3390/bs16081332
“Meta-analytic evidence suggests that guided interventions generally outperform self-guided approaches (Baumeister et al., 2014; Richards & Richardson, 2012), with their effectiveness depending not only on the presence of human guidance but also on its quality and implementation (Mira et al., 2017).”
- Authors
- Mira, A., Bretón-López, J., García-Palacios, A., Quero, S., Baños, R. M., & Botella, C.
- Affiliations
- Universitat Jaume I (ES)
- Universitat de València (ES)
- Corresponding author
- Mira, Adriana
- Venue
- Neuropsychiatric Disease and Treatment
- Publisher
- Informa UK Limited
- Published
- 2017-03
- Volume
- Volume 13
- Pages
- 987-1006
- ISSN
- 1176-6328 (ISSN-L)
- 1178-2021
- PMC
- PMC5384701
- OpenAlex
- W2602064865
- Cited by
- 71
- References
- 72
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 15 · 2020: 8 · 2019: 12 · 2018: 9 · 2017: 2
- FWCI
- 9.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Neuropsychiatric Disease and Treatment (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Repositori UJI (Universitat Jaume I) (acceptedVersion, cc-by-nc)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Funders
- Ministerio de Economía y Competitividad
- Instituto de Salud Carlos III
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- depressive symptoms, online intervention, automated support, human support, mobile phone messages, email feedback, coping, life events, perceived stress, anxiety, depression, program adherence, user satisfaction, maintenance of treatment effects
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