Cited by 409Digital Mental Health InterventionsAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMental Health Treatment and Access

Predictors of treatment dropout in self-guided web-based interventions for depression: an ‘individual patient data’ meta-analysis

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Karyotaki, E., Kleiboer, A., Smit, F., Turner, D. T., Pastor, A. M., Andersson, G., Berger, T., Botella, C. +16 more·2015·Psychological Medicine

Abstract

Background: It is well known that web-based interventions can be effective treatments for depression. However, dropout rates in web-based interventions are typically high, especially in self-guided web-based interventions. Rigorous empirical evidence regarding factors influencing dropout in self-guided web-based interventions is lacking due to small study sample sizes. In this paper we examined predictors of dropout in an individual patient data meta-analysis to gain a better understanding of who may benefit from these interventions. Method: A comprehensive literature search for all randomized controlled trials (RCTs) of psychotherapy for adults with depression from 2006 to January 2013 was conducted. Next, we approached authors to collect the primary data of the selected studies. Predictors of dropout, such as socio-demographic, clinical, and intervention characteristics were examined. Results: Data from 2705 participants across ten RCTs of self-guided web-based interventions for depression were analysed. The multivariate analysis indicated that male gender [relative risk (RR) 1.08], lower educational level (primary education, RR 1.26) and co-morbid anxiety symptoms (RR 1.18) significantly increased the risk of dropping out, while for every additional 4 years of age, the risk of dropping out significantly decreased (RR 0.94). Conclusions: Dropout can be predicted by several variables and is not randomly distributed. This knowledge may inform tailoring of online self-help interventions to prevent dropout in identified groups at risk.

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  • The study found no evidence for many previously identified predictive factors for adherence including baseline symptom levels, gender, age, or education.

    “In contrast to previous studies on adherence in depression and anxiety interventions, we found no evidence for many of the previously identified predictive factors for adherence including baseline symptom levels, gender, age, or education (Christensen et al., 2009; Farrer et al., 2014; Karyotaki et al., 2015; Beatty et al., 2017).”

    From Predictors of acceptability and engagement in a self-guided online program for depression and anxiety (2021) · cites this paper as Karyotaki et al., 2015

    The citation supports the citing authors’ reference to previously identified predictors: the Main findings section reports that gender, age, and education predicted dropout. But the Wider context section says baseline depression severity did not significantly predict dropout overall, although a separate CES-D analysis found a small association. The citing authors’ statement that they themselves found no evidence is not a finding attributed to this source. (LLM, conf=0.87)

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  • The results coincide with literature indicating that people treated with Internet-based programs report high levels of acceptability and high satisfaction.

    “Our results coincide with the literature indicating that people treated with Internet-based programs report high levels of acceptability and high satisfaction (58, 73–78).”

    From Exploring the relationship between the acceptability of an internet-based intervention for depression in primary care and clinical outcomes: Secondary analysis of a randomized controlled trial (2019) · cites this paper as [78]

    The Introduction (page not provided) says self-guided web-based treatments can preserve anonymity and reduce concerns about stigma, making them more acceptable to many people. It does not report high acceptability ratings from treated participants or high satisfaction; a search for satisfaction found no such finding. (LLM, conf=0.82)

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  • Available research shows that the effect of eHealth interventions does not depend on age and that older adults are even more adherent than younger adults.

    “Although available research shows that the effect of eHealth interventions does not depend on age and that older adults are even more adherent than younger adults [58], several precautions will be taken to reduce dropout and heighten compliance throughout this study.”

    From An Internet-based Acceptance and Commitment Therapy intervention for older adults with anxiety complaints: study protocol for a cluster randomized controlled trial. (2018) · cites this paper as [58]

    The Abstract and ‘Predictors of dropout’ section report that dropout decreased with increasing age among participants in self-guided web-based interventions for depression, supporting the adherence comparison. The paper does not establish that intervention effectiveness is independent of age; it examines dropout rather than age-related differences in treatment effects. Page numbers were not available in our copy. (LLM, conf=0.90)

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  • Previous efforts to identify nontechnological factors influencing attrition in online interventions have yielded inconclusive results.

    “although previous efforts to identify nontechnological factors influencing attrition in online interventions have yielded inconclusive results [71-75].”

    From Short-term effectiveness of web-based guided self-help for phobic outpatients: randomized controlled trial. (2014) · cites this paper as [74]

    The Introduction says earlier studies of dropout predictors often lacked the power to find reliable effects, supporting the characterization of previous results as inconclusive. The paper addresses self-guided web-based interventions for depression, however, rather than online interventions generally. (LLM, conf=0.82)

    Experimental — accuracy not yet measured
  • Nearly 40% of participants withdrew before completing at least 25% of all treatment modules in self-guided W-MHIs.

    “Nearly 40% of participants withdrew before completing at least 25% of all treatment modules in self-guided W-MHIs”

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Authors
Karyotaki, E., Kleiboer, A., Smit, F., Turner, D. T., Pastor, A. M., Andersson, G., Berger, T., Botella, C., Breton, J. M., Carlbring, P., Christensen, H., de Graaf, E., Griffiths, K., Donker, T., Farrer, L., Huibers, M. J. H., Lenndin, J., Mackinnon, A., Meyer, B., Moritz, S., Riper, H., Spek, V., Vernmark, K., & Cuijpers, P.
Affiliations
  • Amsterdam Public Health (NL)
  • Trimbos Institute (NL)
  • Universitat Jaume I (ES)
  • Linköping University (SE)
  • University of Bern (CH)
  • Stockholm University (SE)
  • Black Dog Institute (AU)
  • Australian National University (AU)
  • The University of Melbourne (AU)
  • City, University of London (GB)
  • University Medical Center Hamburg-Eppendorf (DE)
  • Avans University of Applied Sciences (NL)
Corresponding author
Karyotaki, E.
Venue
Psychological Medicine
Published
2015-04-17
Volume
45
Issue
13
Pages
2717-2726
ISSN
  • 0033-2917 (ISSN-L)
  • 1469-8978
OpenAlex
W2133074847
Cited by
408
References
37
Citations by year
2026: 38 · 2025: 47 · 2024: 57 · 2023: 46 · 2022: 39 · 2021: 44 · 2020: 33 · 2019: 32 · 2018: 29 · 2017: 23 · 2016: 14 · 2015: 4 · 2014: 1
FWCI
3.25
Type
journal article
Language
en
Open access
Locations
  • Psychological Medicine (publishedVersion)
  • Research portal (Tilburg University) (publishedVersion)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
  • VU Research Portal (publishedVersion, other-oa)
  • Repositori UJI (Universitat Jaume I) (acceptedVersion)
  • reroDoc Digital Library (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • BORIS (University Library Bern) (submittedVersion, other-oa)
  • Research Publications (Maastricht University) (submittedVersion, other-oa)
  • ANU Open Research (Australian National University) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion, other-oa)
  • Research Publications (Maastricht University) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
  • Open Access CRIS of the University of Bern
Topics
  • Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords
treatment discontinuation, depression, predictors of dropout, online self-help, individual patient data, gender differences, educational attainment, anxiety comorbidity, age, intervention tailoring
MeSH terms
Anxiety, Depression, Humans, Patient Dropouts, Prognosis, Psychotherapy, Randomized Controlled Trials as Topic, Internet

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