Fecal Microbiota Composition and Frailty

Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics

Gibson, G. R., & Roberfroid, M. B. (1995) · Journal of Nutrition · doi:10.1093/jn/125.6.1401 · Cited by 7,659 · see citing works

Combination of 16S rRNA-targeted oligonucleotide probes with flow cytometry for analyzing mixed microbial populations

Amann, R., Binder, B. J., Olson, R. J., Chisholm, S. W., Devereux, R., & Stahl, D. A. (1990) · Applied and Environmental Microbiology · doi:10.1128/aem.56.6.1919-1925.1990 · Cited by 3,998 · see citing works

Gut flora in health and disease

Guarner, F., & Malagelada, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12489-0 · Cited by 3,395 · see citing works

Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut

Suau, A., Bonnet, R., Sutren, M., Godon, J.-J., Gibson, G. R., Collins, M. D., & Doré, J. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.11.4799-4807.1999 · Cited by 1,490 · see citing works

Temperature Gradient Gel Electrophoresis Analysis of 16S rRNA from Human Fecal Samples Reveals Stable and Host-Specific Communities of Active Bacteria

Zoetendal, E. G., Akkermans, A. D. L., & de Vos, W. M. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.10.3854-3859.1998 · Cited by 1,360 · see citing works

Analysis of Intestinal Flora Development in Breast-Fed and Formula-Fed Infants by Using Molecular Identification and Detection Methods

Harmsen, H. J. M., Wildeboer-Veloo, A. C. M., Raangs, G. C., Wagendorp, A. A., Klijn, N., BINDELS, J. G., & Welling, G. W. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200001000-00019 · Cited by 1,326 · see citing works

Application of a suite of 16S rRNA-specific oligonucleotide probes designed to investigate bacteria of the phylum cytophaga-flavobacter-bacteroides in the natural environment

Manz, W., Amann, R., Ludwig, W., Vancanneyt, M., & SCHLEIFER, K. H. (1996) · Microbiology · doi:10.1099/13500872-142-5-1097 · Cited by 1,176 · see citing works

Variations of Bacterial Populations in Human Feces Measured by Fluorescent In Situ Hybridization with Group-Specific 16S rRNA-Targeted Oligonucleotide Probes

Franks, A. H., Harmsen, H. J. M., Raangs, G. C., Jansen, G. J., Schut, F., & Welling, G. W. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.9.3336-3345.1998 · Cited by 1,055 · see citing works

Quantitative fluorescence in situ hybridization of Bifidobacterium spp. with genus-specific 16S rRNA-targeted probes and its application in fecal samples

Langendijk-Genevaux, P. S., Schut, F., Jansen, G. J., Raangs, G. C., Kamphuis, G. R., Wilkinson, M. H. F., & Welling, G. W. (1995) · Applied and Environmental Microbiology · doi:10.1128/aem.61.8.3069-3075.1995 · Cited by 974 · see citing works

Characterization of Bacterial Communities in Feces from Healthy Elderly Volunteers and Hospitalized Elderly Patients by Using Real-Time PCR and Effects of Antibiotic Treatment on the Fecal Microbiota

Bartosch, S., Fite, A., Macfarlane, G. T., & McMurdo, M. E. T. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.6.3575-3581.2004 · Cited by 762 · cited 3× · see citing works

Growth requirements and fermentation products of Fusobacterium prausnitzii, and a proposal to reclassify it as Faecalibacterium prausnitzii gen. nov., comb. nov

Duncan, S. H., Hold, G. L., Harmsen, H. J. M., Stewart, C. S., & Flint, H. J. (2002) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-52-6-2141 · Cited by 735 · see citing works

Psychoneuroimmunology: psychological influences on immune function and health

Kiecolt-Glaser, J. K., McGuire, L., Robles, T. F., & Glaser, R. (2002) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.70.3.537 · Cited by 686 · see citing works

Normal Indigenous Intestinal Flora

Finegold, S. M., Sutter, V. L., & Mathisen, G. E. (1983) · Elsevier eBooks · doi:10.1016/b978-0-12-341280-5.50007-0 · Cited by 618 · see citing works

Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons

Kleessen, B., Sykura, B., Zunft, H. ‐., & Blaut, M. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.5.1397 · Cited by 586 · see citing works

Age and disease related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance, and community cellular fatty acid profiles

Hopkins, M. J., Sharp, R., & Macfarlane, G. T. (2001) · Gut · doi:10.1136/gut.48.2.198 · Cited by 577 · see citing works

Human colonic biota studied by ribosomal DNA sequence analysis

Wilson, K. H., & Blitchington, R. B. (1996) · Applied and Environmental Microbiology · doi:10.1128/aem.62.7.2273-2278.1996 · Cited by 526 · see citing works

Quantification of Bacterial Groups within Human Fecal Flora by Oligonucleotide Probe Hybridization

Sghir, A., Gramet, G., Suau, A., Rochet, V., Pochart, P., & Dore, J. M. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.5.2263-2266.2000 · Cited by 521 · see citing works

Human fecal flora: variation in bacterial composition within individuals and a possible effect of emotional stress

Holdeman, L. V., Good, I. J., & Moore, W. E. (1976) · Applied and Environmental Microbiology · doi:10.1128/aem.31.3.359-375.1976 · Cited by 498 · see citing works

Old or frail: what tells us more?

Schuurmans, H., Steverink, N., Lindenberg, S., Frieswijk, N., & Slaets, J. P. J. (2004) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/59.9.m962 · Cited by 491 · see citing works

Colonization resistance

Vollaard, E. J., & Clasener, H. A. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.3.409 · Cited by 478 · see citing works

Changes in predominant bacterial populations in human faeces with age and with Clostridium difficile infection

Hopkins, M. J., & Macfarlane, G. T. (2002) · Journal of Medical Microbiology · doi:10.1099/0022-1317-51-5-448 · Cited by 473 · see citing works

Extensive Set of 16S rRNA-Based Probes for Detection of Bacteria in Human Feces

Harmsen, H. J. M., Raangs, G. C., He, T., Degener, J. E., & Welling, G. W. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.6.2982-2990.2002 · Cited by 401 · see citing works

A 16S rRNA-targeted Probe for Detection of Lactobacilli and Enterococci in Faecal Samples by FluorescentIn SituHybridization

Harmsen, P. E. H. J. M. (1999) · Microbial Ecology in Health and Disease · doi:10.1080/089106099435862 · Cited by 372 · see citing works

Measuring frailty: Developing and testing the GFI (Groningen frailty indicator).

Steverink, N., Slaets, J., Schuurmans, H., & Lis, M. (2001) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 327 · see citing works

Development of 16S rRNA-Based Probes for the Coriobacterium Group and the Atopobium Cluster and Their Application for Enumeration of Coriobacteriaceae in Human Feces from Volunteers of Different Age Groups

Harmsen, H. J. M., Wildeboer-Veloo, A. C. M., Grijpstra, J., Knol, J., Degener, J. E., & Welling, G. W. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.10.4523-4527.2000 · Cited by 309 · see citing works

BACTEROIDES OF THE HUMAN LOWER INTESTINAL TRACT

Salyers, A. A. (1984) · Annual Review of Microbiology · doi:10.1146/annurev.mi.38.100184.001453 · Cited by 309 · see citing works

Intestinal Flora and Aging

MITSUOKA, T. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1992.tb02499.x · Cited by 301 · see citing works

Conceptualisation and Measurement of Frailty in Elderly People

Rockwood, K. J., Hogan, D. B., & MacKnight, C. (2000) · Drugs & Aging · doi:10.2165/00002512-200017040-00005 · Cited by 299 · see citing works

Physiological state of Escherichia coli BJ4 growing in the large intestines of streptomycin-treated mice

Poulsen, L. K., Licht, T. R., Rang, C. U., Krogfelt, K. A., & Molin, S. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.20.5840-5845.1995 · Cited by 202 · see citing works

Fusobacterium prausnitzii and Related Species Represent a Dominant Group Within the Human Fecal Flora

Suau, A., Rochet, V., Sghir, A., Gramet, G., Brewaeys, S., Sutren, M., Rigottier‐Gois, L., & Dore, J. M. (2001) · Systematic and Applied Microbiology · doi:10.1078/0723-2020-00015 · Cited by 195 · see citing works

Development and validation of an automated, microscopy-based method for enumeration of groups of intestinal bacteria

Jansen, G. J., Wildeboer-Veloo, A. C. M., Tonk, R. H. J., Franks, A. H., & Welling, G. W. (1999) · Journal of Microbiological Methods · doi:10.1016/s0167-7012(99)00049-4 · Cited by 170 · see citing works

Quantification of Uncultured Ruminococcus obeum -Like Bacteria in Human Fecal Samples by Fluorescent In Situ Hybridization and Flow Cytometry Using 16S rRNA-Targeted Probes

Zoetendal, E. G., Amor, K. B., Harmsen, H. J. M., Schut, F., Akkermans, A. D. L., & de Vos, W. M. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.9.4225-4232.2002 · Cited by 129 · see citing works

Gut changes attributed to ageing: effects on intestinal microflora

Hébuterne, X. (2003) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200301000-00008 · Cited by 119 · see citing works

Gastrointestinal tract and the elderly: functional foods, gut microflora and healthy ageing

Saunier, K., & Dore, J. M. (2002) · Digestive and Liver Disease · doi:10.1016/s1590-8658(02)80158-x · Cited by 74 · see citing works

Gut reaction

Abbott, A. (2004) · Nature · doi:10.1038/427284a · Cited by 42 · see citing works

Composition of faecal microbiota of elderly people

He, T., Harmsen, H. J. M., Raangs, G. C., & Welling, G. W. (2003) · Microbial Ecology in Health and Disease · doi:10.1080/08910600310020505 · Cited by 38 · see citing works

Influence ofLactobacillusF19 on Intestinal Microflora in Children and Elderly Persons and Impact onHelicobacter pyloriInfections

Sullivan, Å., Bennet, R., Viitanen, M. H., Palmgren, A., & Nord, C. E. (2002) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v14i1.8205 · Cited by 17 · see citing works

The Microbiota-Gut-Brain Axis

Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works

Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

Ferrucci, L., & Fabbri, E. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0064-2 · Cited by 3,690 · see citing works

Gut microbiota composition correlates with diet and health in the elderly

Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314 · see citing works

The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age

Mariat, D., Firmesse, O., Levenez, F., Guimarăes, V., Sokol, H., Doré, J., Corthier, G., & Furet, J.-P. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-123 · Cited by 1,755 · see citing works

The central nervous system and the gut microbiome

Sharon, G., Sampson, T. R., Geschwind, D. H., & Mazmanian, S. K. (2016) · Cell · doi:10.1016/j.cell.2016.10.027 · Cited by 1,513 · see citing works

Colonic bacterial composition in Parkinson's disease

Keshavarzian, A., Green, S. J., Engen, P. A., Voigt, R. M., Naqib, A., Forsyth, C. B., Mutlu, E., & Shannon, K. M. (2015) · Movement Disorders · doi:10.1002/mds.26307 · Cited by 1,281 · see citing works

Intestinal microbiota in human health and disease: the impact of probiotics

Gerritsen, J., Smidt, H., Rijkers, G. T., & de Vos, W. M. (2011) · Genes & Nutrition · doi:10.1007/s12263-011-0229-7 · Cited by 724 · see citing works

Gut Bifidobacteria Populations in Human Health and Aging

Arboleya, S., Watkins, C., Stanton, C., & Ross, R. P. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01204 · Cited by 683 · see citing works

Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality

Clark, R. I., Salazar, A., Yamada, R., Fitz-Gibbon, S., Morselli, M., Alcaraz, J., Rana, A., Rera, M., Pellegrini, M., Ja, W. W., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.004 · Cited by 510 · see citing works

Role of the gut microbiota in human nutrition and metabolism

Ramakrishna, B. (2013) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12294 · Cited by 505 · see citing works

Diet and the development of the human intestinal microbiome

Voreades, N., Kozil, A., & Weir, T. L. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00494 · Cited by 495 · see citing works

Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition

Calder, P. C., Bosco, N., Bourdet‐Sicard, R., Capuron, L., Delzenne, N. M., Dore, J. M., Franceschi, C., Lehtinen, M. J., Recker, T., Salvioli, S., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.09.001 · Cited by 498 · see citing works

Microbial shifts in the aging mouse gut

Langille, M. G., Meehan, C. J., Koenig, J. E., Dhanani, A. S., Rose, R. A., Howlett, S. E., & Beiko, R. G. (2014) · Microbiome · doi:10.1186/s40168-014-0050-9 · Cited by 437 · see citing works

Role of the intestinal microbiome in health and disease: from correlation to causation

de Vos, W. M., & de Vos, E. A. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00505.x · Cited by 440 · see citing works

Signatures of early frailty in the gut microbiota

Jackson, M. A., Jeffery, I. B., Beaumont, M., Bell, J. T., Clark, A. G., Ley, R. E., O’Toole, P. W., Spector, T. D., & Steves, C. J. (2016) · Genome Medicine · doi:10.1186/s13073-016-0262-7 · Cited by 436 · see citing works

Cultured Representatives of Two Major Phylogroups of Human Colonic Faecalibacterium prausnitzii Can Utilize Pectin, Uronic Acids, and Host-Derived Substrates for Growth

Lopez-Siles, M., Khan, T. M., Duncan, S. H., Harmsen, H. J. M., Garcia-Gil, L. J., & Flint, H. J. (2012) · Applied and Environmental Microbiology · doi:10.1128/aem.06858-11 · Cited by 433 · see citing works

Composition and temporal stability of the gut microbiota in older persons

Jeffery, I. B., Lynch, D. B., & O’Toole, P. W. (2016) · The ISME Journal · doi:10.1038/ismej.2015.88 · Cited by 421 · see citing works

The gut microbiota and healthy aging: A mini-review

Kim, S., & Jazwinski, S. M. (2018) · Gerontology · doi:10.1159/000490615 · Cited by 427 · see citing works

Gut Microbiome

Cresci, G., & Bawden, E. (2015) · Nutrition in Clinical Practice · doi:10.1177/0884533615609899 · Cited by 424 · see citing works

(Dis)Trust your gut: the gut microbiome in age-related inflammation, health, and disease

Buford, T. W. (2017) · Microbiome · doi:10.1186/s40168-017-0296-0 · Cited by 409 · see citing works

Gut microbiota as the key controllers of “healthy” aging of elderly people

Ragonnaud, E., & Biragyn, A. (2021) · Immunity & Ageing · doi:10.1186/s12979-020-00213-w · Cited by 417 · see citing works

Gut microbiota and cardiovascular disease: opportunities and challenges

Kazemian, N., Mahmoudi, M., Halperin, F. A., Wu, J. C., & Pakpour, S. (2020) · Microbiome · doi:10.1186/s40168-020-00821-0 · Cited by 392 · see citing works

Gut Microbiota Contribute to Age-Related Changes in Skeletal Muscle Size, Composition, and Function: Biological Basis for a Gut-Muscle Axis

Grosicki, G. J., Fielding, R. A., & Lustgarten, M. S. (2018) · Calcified Tissue International · doi:10.1007/s00223-017-0345-5 · Cited by 388 · see citing works

Metagenomic and metabolomic analyses unveil dysbiosis of gut microbiota in chronic heart failure patients

Cui, X., Ye, L., Li, J., Jin, L., Wang, W., Li, S., Bao, M., Wu, S., Li, L., Geng, B., et al. (2018) · Scientific Reports · doi:10.1038/s41598-017-18756-2 · Cited by 373 · see citing works

The Gut Microbiota and Unhealthy Aging: Disentangling Cause from Consequence

DeJong, E. N., Surette, M. G., & Bowdish, D. M. E. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.07.013 · Cited by 370 · see citing works

Functional Characterization of Novel Faecalibacterium prausnitzii Strains Isolated from Healthy Volunteers: A Step Forward in the Use of F. prausnitzii as a Next-Generation Probiotic

Martín, R., Miquel, S., Benevides, L., Bridonneau, C., Robert, V., Hudault, S., Chain, F., Berteau, O., Azevedo, V., Chatel, J. M., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01226 · Cited by 398 · see citing works

Ageing of the human metaorganism: the microbial counterpart

Biagi, E., Candela, M., Fairweather‐Tait, S. J., Franceschi, C., & Brigidi, P. (2011) · AGE · doi:10.1007/s11357-011-9217-5 · Cited by 365 · see citing works

Understanding the gut microbiota and sarcopenia: a systematic review

Liu, C., Cheung, W., Li, J., Chow, S. K., Yu, J., Wong, S. H., Ip, M., Sung, J. J. Y., & Wong, R. M. Y. (2021) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12784 · Cited by 363 · see citing works

Gut microbiota and aging

Ling, Z., Liu, X., Cheng, Y., Yan, X., & Wu, S. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1867054 · Cited by 366 · see citing works

Butyrate and Dietary Soluble Fiber Improve Neuroinflammation Associated With Aging in Mice

Matt, S. M., Allen, J. M., Lawson, M. A., Mailing, L. J., Woods, J. A., & Johnson, R. W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01832 · Cited by 330 · see citing works

Exploring the Diversity of the Bifidobacterial Population in the Human Intestinal Tract

Turroni, F., Foroni, E., Pizzetti, P., Giubellini, V., Ribbera, A., Merusi, P., Cagnasso, P., Bizzarri, B., de'Angelis, G. L., Shanahan, F., et al. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.02216-08 · Cited by 311 · see citing works

Nonalcoholic fatty liver disease and aging: Epidemiology to management

Bertolotti, M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i39.14185 · Cited by 309 · see citing works

The gut microbiome composition associates with bipolar disorder and illness severity

Evans, S. J., Bassis, C. M., Hein, R., Assari, S., Flowers, S. A., Kelly, M., Young, V. B., Ellingrod, V. E., & McInnis, M. G. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.12.007 · Cited by 308 · see citing works

Ageing and gut microbes: Perspectives for health maintenance and longevity

Biagi, E., Candela, M., Turroni, S., Garagnani, P., Franceschi, C., & Brigidi, P. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.005 · Cited by 276 · see citing works

The role of nutrition in inflammaging

Giosia, P. D., Stamerra, C. A., Giorgini, P., Jamialahamdi, T., Butler, A. E., & Sahebkar, A. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101596 · Cited by 250 · see citing works

Structural and Functional Dysbiosis of Fecal Microbiota in Chinese Patients With Alzheimer's Disease

Ling, Z., Zhu, M., Yan, X., Cheng, Y., Shao, L., Liu, X., Jiang, R., & Wu, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.634069 · Cited by 245 · see citing works

The human gut microbiome in health: Establishment and resilience of microbiota over a lifetime

Greenhalgh, K., Meyer, K. M., Aagaard, K. M., & Wilmes, P. (2016) · Environmental Microbiology · doi:10.1111/1462-2920.13318 · Cited by 218 · see citing works

The inflammatory status of old age can be nurtured from the intestinal environment

Guigoz, Y., Dore, J. M., & Schiffrin, E. J. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3282f2bfdf · Cited by 224 · see citing works

Faecalibacterium prausnitzii (ATCC 27766) has preventive and therapeutic effects on chronic unpredictable mild stress-induced depression-like and anxiety-like behavior in rats

Hao, Z., Wang, W., Guo, R., & Liu, H. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.02.025 · Cited by 242 · see citing works

Age-dependent changes in GI physiology and microbiota: time to reconsider?

An, R., Wilms, E., Masclee, A. A. M., Smidt, H., Zoetendal, E. G., & Jonkers, D. (2018) · Gut · doi:10.1136/gutjnl-2017-315542 · Cited by 209 · see citing works

Quantitative differences in intestinal Faecalibacterium prausnitzii in obese Indian children

Ramadass, B., George, G., Kabeerdoss, J., Hepsiba, J., Chandragunasekaran, A. M. S., & Ramakrishna, B. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509992182 · Cited by 209 · see citing works

The links between the gut microbiome, aging, modern lifestyle and Alzheimer's disease

Askarova, S., Umbayev, B., Masoud, A.-R., Kaiyrlykyzy, A., Safarova, Y., Tsoy, A., Olzhayev, F., & Kushugulova, A. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00104 · Cited by 208 · see citing works

The intestinal microbiota in aged mice is modulated by dietary resistant starch and correlated with improvements in host responses

Tachon, S., Zhou, J., Keenan, M. J., Martin, R. J., & Marco, M. L. (2012) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2012.01475.x · Cited by 207 · see citing works

You’ve got male: Sex and the microbiota-gut-brain axis across the lifespan

Jaggar, M., Rea, K., Spichak, S., Dinan, T. G., & Cryan, J. F. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100815 · Cited by 200 · see citing works

Inflammatory Bowel Disease and the Elderly: A Review

Taleban, S., Colombel, J., Mohler, M. J., & Fain, M. J. (2015) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjv059 · Cited by 202 · see citing works

Occurrence and Dynamism of Lactic Acid Bacteria in Distinct Ecological Niches: A Multifaceted Functional Health Perspective

George, F., Daniel, C., Thomas, M., Singer, E., Guilbaud, A., Tessier, F. J., Revol-Junelles, A.-M., Borges, F., & Foligné, B. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02899 · Cited by 198 · see citing works

Probiotics and prebiotics and health in ageing populations

Duncan, S. H., & Flint, H. J. (2013) · Maturitas · doi:10.1016/j.maturitas.2013.02.004 · Cited by 187 · see citing works

Alterations in intestinal microbiota diversity, composition, and function in patients with sarcopenia

Kang, L., Li, P., Wang, D., Wang, T., Dong, H., & Qu, X. (2021) · Scientific Reports · doi:10.1038/s41598-021-84031-0 · Cited by 190 · see citing works

Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia

Picca, A., Fanelli, F., Calvani, R., Mulè, G., Pesce, V., Sisto, A., Pantanelli, C., Bernabei, R., Landi, F., & Marzetti, E. (2018) · Mediators of Inflammation · doi:10.1155/2018/7026198 · Cited by 181 · see citing works

The gut microbiota as a novel regulator of cardiovascular function and disease

Battson, M. L., Lee, D. M., Weir, T. L., & Gentile, C. L. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.12.010 · Cited by 185 · see citing works

Exopolysaccharides produced by Bifidobacterium longum IPLA E44 and Bifidobacterium animalis subsp. lactis IPLA R1 modify the composition and metabolic activity of human faecal microbiota in pH-controlled batch cultures

Salazar, N., Ruas-Madiedo, P., Kolida, S., Collins, M., Rastall, R., Gibson, G., & de los Reyes-Gavilán, C. G. (2009) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2009.08.017 · Cited by 168 · see citing works

Parkinson’s Disease and the Gastrointestinal Microbiome

Lubomski, M., Tan, A. H., Lim, S.-Y., Holmes, A. J., Davis, R. L., & Sue, C. M. (2020) · Journal of Neurology · doi:10.1007/s00415-019-09320-1 · Cited by 172 · see citing works

Ecology and metabolism of the beneficial intestinal commensal bacteriumFaecalibacterium prausnitzii

Miquel, S., Martín, R., Bridonneau, C., Robert, V., Sokol, H., Bermúdez‐Humarán, L. G., Thomas, M., & Langella, P. (2014) · Gut Microbes · doi:10.4161/gmic.27651 · Cited by 171 · see citing works

Diabetic gut microbiota dysbiosis as an inflammaging and immunosenescence condition that fosters progression of retinopathy and nephropathy

Fernandes, R., Viana, S., Nunes, S., & Reis, F. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.09.032 · Cited by 172 · see citing works

Age-Related Inflammation: the Contribution of Different Organs, Tissues and Systems. How to Face it for Therapeutic Approaches

Cevenini, E., Caruso, C., Candore, G., Capri, M., Nuzzo, D., Duro, G., Rizzo, C., Colonna‐Romano, G., Lio, D., Carlo, D., et al. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790883840 · Cited by 166 · see citing works

The gut microbiota of centenarians: Signatures of longevity in the gut microbiota profile

Biagi, E., Rampelli, S., Turroni, S., Quercia, S., Candela, M., & Brigidi, P. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.12.013 · Cited by 166 · see citing works

The Commensal Microbiology of the Gastrointestinal Tract

Manson, J. M., Rauch, M., & Gilmore, M. S. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-09550-9_2 · Cited by 161 · see citing works

Muscle strength is increased in mice that are colonized with microbiota from high-functioning older adults

Fielding, R. A., Reeves, A. R., Jasuja, R., Liu, C. K., Barrett, B. B., & Lustgarten, M. S. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110722 · Cited by 163 · see citing works

Aging and the human gut microbiota—from correlation to causality

Saraswati, S., & Sitaraman, R. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00764 · Cited by 153 · see citing works

Comparative Metagenomic Study of Alterations to the Intestinal Microbiota and Risk of NosocomialClostridum difficile–Associated Disease

Manges, A. R., Labbe, A., Loo, V. G., Atherton, J., Behr, M. A., Masson, L., Tellis, P. A., & Brousseau, R. (2010) · The Journal of Infectious Diseases · doi:10.1086/657319 · Cited by 151 · see citing works

The microbiome: An emerging key player in aging and longevity

Kim, M., & Benayoun, B. A. (2020) · Translational Medicine of Aging · doi:10.1016/j.tma.2020.07.004 · Cited by 142 · see citing works

Roles and Mechanisms of Gut Microbiota in Patients With Alzheimer’s Disease

Wu, S., Liu, X., Jiang, R., Yan, X., & Ling, Z. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.650047 · Cited by 146 · see citing works

Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective

Vemuri, R., Gundamaraju, R., Shastri, M. D., Shukla, S. D., Kalpurath, K., Ball, M. A. Z., Tristram, S. G., Shankar, E. M., Ahuja, K., & Eri, R. D. (2018) · BioMed Research International · doi:10.1155/2018/4178607 · Cited by 141 · see citing works

Dietary Protein and Muscle in Aging People: The Potential Role of the Gut Microbiome

Lochlainn, M. N., Bowyer, R. C. E., & Steves, C. J. (2018) · Nutrients · doi:10.3390/nu10070929 · Cited by 138 · see citing works

The pleiotropic effects of prebiotic galacto-oligosaccharides on the aging gut

Arnold, J. W., Roach, J. M., Fabela, S., Moorfield, E., Ding, S., Blue, E., Dagher, S. F., Magness, S. T., Tamayo, R., Bruno-Bárcena, J. M., et al. (2021) · Microbiome · doi:10.1186/s40168-020-00980-0 · Cited by 134 · see citing works

Bacterial Composition of the Human Upper Gastrointestinal Tract Microbiome Is Dynamic and Associated with Genomic Instability in a Barrett’s Esophagus Cohort

Gall, A., Fero, J., McCoy, C. O., Claywell, B. C., Sanchez, C. A., Blount, P. L., Li, X., Vaughan, T. L., Matsen, F. A., IV, Reid, B. J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129055 · Cited by 126 · see citing works

The Microbiome and Musculoskeletal Conditions of Aging: A Review of Evidence for Impact and Potential Therapeutics

Steves, C. J., Bird, S., Williams, F. M. K., & Spector, T. D. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2765 · Cited by 119 · see citing works

Gut microbiota and old age: Modulating factors and interventions for healthy longevity

Coman, V., & Vodnar, D. C. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111095 · Cited by 124 · see citing works

Microbiome-health interactions in older people

O’Toole, P. W., & Jeffery, I. B. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2673-z · Cited by 117 · see citing works

The aging gut microbiota: New perspectives

Biagi, E., Candela, M., Franceschi, C., & Brigidi, P. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.03.004 · Cited by 116 · see citing works

Review on microbiota and effectiveness of probiotics use in older

Rondanelli, M. (2015) · World Journal of Clinical Cases · doi:10.12998/wjcc.v3.i2.156 · Cited by 116 · see citing works

Gut Microbiota as a Target in the Pathogenesis of Metabolic Disorders: A New Approach to Novel Therapeutic Agents

Ejtahed, H., Soroush, A. R., Angoorani, P., Larijani, B. A., & Hasani‐Ranjbar, S. (2016) · Hormone and Metabolic Research · doi:10.1055/s-0042-107792 · Cited by 113 · see citing works

Role of gut microbiota in aging-related health decline: insights from invertebrate models

Clark, R. I., & Walker, D. W. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2671-1 · Cited by 111 · see citing works

Host and Microbiome Genome-Wide Association Studies: Current State and Challenges

Awany, D., Allali, I., Dalvie, S., Hemmings, S. M. J., Mwaikono, K. S., Thomford, N. E., Gomez, A. M., Mulder, N., & Chimusa, E. R. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2018.00637 · Cited by 108 · see citing works

A Multi-Strain Probiotic Formulation Improves Intestinal Barrier Function by the Modulation of Tight and Adherent Junction Proteins

di Vito, R., Conte, C., & Traina, G. (2022) · Cells · doi:10.3390/cells11162617 · Cited by 110 · see citing works

Concentrations of host-specific and generic fecal markers measured by quantitative PCR in raw sewage and fresh animal feces

Silkie, S. S., & Nelson, K. L. (2009) · Water Research · doi:10.1016/j.watres.2009.08.017 · Cited by 106 · see citing works

Microbiota and Aging. A Review and Commentary

García‐Peña, C., Álvarez‐Cisneros, T., Quiroz‐Baez, R., & Friedland, R. P. (2017) · Archives of Medical Research · doi:10.1016/j.arcmed.2017.11.005 · Cited by 105 · see citing works

Searching for the Bacterial Effector: The Example of the Multi-Skilled Commensal Bacterium Faecalibacterium prausnitzii

Martín, R., Bermúdez‐Humarán, L. G., & Langella, P. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00346 · Cited by 105 · see citing works

Depletion of gut microbiota induces skeletal muscle atrophy by FXR-FGF15/19 signalling

Qiu, Y., Yu, J., Li, Y., Yang, F., Yu, H., Xue, M., Zhang, F., Jiang, X., Ji, X., & Bao, Z. (2021) · Annals of Medicine · doi:10.1080/07853890.2021.1900593 · Cited by 105 · see citing works

Gut Microbiota Interaction with the Central Nervous System throughout Life

Ojeda, J., Ávila, A., & Vidal, P. M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10061299 · Cited by 107 · see citing works

Mechanisms Linking the Gut-Muscle Axis With Muscle Protein Metabolism and Anabolic Resistance: Implications for Older Adults at Risk of Sarcopenia

Prokopidis, K., Chambers, E. S., Lochlainn, M. N., & Witard, O. C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.770455 · Cited by 109 · see citing works

Biomarkers of Physical Frailty and Sarcopenia: Coming up to the Place?

Picca, A., Calvani, R., Cesari, M., Landi, F., Bernabei, R., Coelho‐Júnior, H. J., & Marzetti, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165635 · Cited by 101 · see citing works

Age-mediated changes in the gastrointestinal tract

Merchant, H. A., Liu, F., Orlu, M., & Basit, A. W. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.04.024 · Cited by 96 · see citing works

Differential gut microbiota and intestinal permeability between frail and healthy older adults: A systematic review

Rashidah, N. H., Lim, S. M., Neoh, C. F., Majeed, A. B. A., Tan, M. P., Khor, H. M., Tan, A. H., Rehiman, S. H., & Ramasamy, K. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101744 · Cited by 96 · see citing works

Optimising Bacterial DNA Extraction from Faecal Samples: Comparison of Three Methods

Smith, B., Li, N., Andersen, A. S., Slotved, H., & Krogfelt, K. A. (2011) · The Open Microbiology Journal · doi:10.2174/1874285801105010014 · Cited by 91 · see citing works

Viability of Bifidobacteria Strains in Yogurt with Added Oat Beta‐Glucan and Corn Starch during Cold Storage

Rosburg, V. A., Boylston, T. D., & White, P. J. (2010) · Journal of Food Science · doi:10.1111/j.1750-3841.2010.01620.x · Cited by 90 · see citing works

Compositional dynamics of the human intestinal microbiota with aging: Implications for health

Lakshminarayanan, B., Stanton, C., O’Toole, P. W., & Ross, R. P. (2014) · The journal of nutrition health & aging · doi:10.1007/s12603-014-0549-6 · Cited by 91 · see citing works

The microbiota-gut-brain axis: Focus on the fundamental communication pathways

Bistoletti, M., Bosi, A., Banfi, D., Giaroni, C., & Baj, A. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.08.012 · Cited by 88 · see citing works

Characterization of the gut‐liver‐muscle axis in cirrhotic patients with sarcopenia

Ponziani, F. R., Picca, A., Marzetti, E., Calvani, R., Conta, G., CHIERICO, F. D., Capuani, G., Faccia, M., Fianchi, F., Funaro, B., et al. (2021) · Liver International · doi:10.1111/liv.14876 · Cited by 89 · see citing works

The effect of ageing with and without non-steroidal anti-inflammatory drugs on gastrointestinal microbiology and immunology

Tiihonen, K., Tynkkynen, S., Ouwehand, A. C., Ahlroos, T., & Rautonen, N. (2008) · British Journal Of Nutrition · doi:10.1017/s000711450888871x · Cited by 86 · see citing works

Plant-Derived Bioactive Compounds and Potential Health Benefits: Involvement of the Gut Microbiota and Its Metabolic Activity

Chen, X., Pan, S., Li, F., Xu, X., & Hua, X. (2022) · Biomolecules · doi:10.3390/biom12121871 · Cited by 86 · see citing works

Review article: emerging role of the gut microbiome in the progression of nonalcoholic fatty liver disease and potential therapeutic implications

Jayakumar, S., & Loomba, R. S. (2019) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15314 · Cited by 88 · see citing works

Maintenance of a healthy trajectory of the intestinal microbiome during aging: A dietary approach

Candela, M., Biagi, E., Brigidi, P., O’Toole, P. W., & de Vos, W. M. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.12.004 · Cited by 85 · see citing works

An investigation into physical frailty as a link between the gut microbiome and cognitive health

Verdi, S., Jackson, M. A., Beaumont, M., Bowyer, R. C. E., Bell, J. T., Spector, T. D., & Steves, C. J. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00398 · Cited by 82 · see citing works

Contribution of the Intestinal Microbiota to Human Health: From Birth to 100 Years of Age

Cheng, J., Palva, A., de Vos, W. M., & Satokari, R. M. (2011) · Current topics in microbiology and immunology · doi:10.1007/82_2011_189 · Cited by 84 · see citing works

Gut-muscle crosstalk. A perspective on influence of microbes on muscle function

Chew, W., Lim, Y. P., Lim, W. S., Chambers, E. S., Frost, G. S., Wong, S. H., & Ali, Y. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2022.1065365 · Cited by 82 · see citing works

Complexity of Anti‐immunosenescence Strategies in Humans

Capri, M., Monti, D., Salvioli, S., Lescai, F., Pierini, M., Altilia, S., Sevini, F., Valensin, S., Ostan, R., Bucci, L., et al. (2006) · Artificial Organs · doi:10.1111/j.1525-1594.2006.00295.x · Cited by 81 · see citing works

Lactobacillus plantarum TWK10 Improves Muscle Mass and Functional Performance in Frail Older Adults: A Randomized, Double-Blind Clinical Trial

Lee, M., Tu, Y.-T., Lee, C., Tsai, S.-C., Hsu, H., Tsai, T., Liu, T., Young, S.-L., Lin, J., & Huang, C. (2021) · Microorganisms · doi:10.3390/microorganisms9071466 · Cited by 79 · see citing works

Gut microbiota and microbial metabolites for osteoporosis

Zheng, X.-Q., Wang, D.-B., Jiang, Y., & Song, C. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2437247 · Cited by 89 · see citing works

Pharmacokinetic and pharmacodynamic alterations in older people with dementia

Reeve, E., Trenaman, S. C., Rockwood, K. J., & Hilmer, S. N. (2017) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2017.1325873 · Cited by 80 · see citing works

Comparison of gut microbiota profiles between patients suffering from elderly frailty syndrome and non-frail elderly individuals

Mirfakhraee, H., Sabaei, M., Niksolat, M., Faraji, F., Larijani, S. S., Fard, S. R., Zandieh, Z., & Minaeian, S. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09271-5 · Cited by 3 · see citing works

Altered Fecal Microbiota Composition in Older Adults With Frailty

Xu, Y., Wang, Y., Li, H., Dai, Y., Chen, D., Wang, M., Jiang, X., Huang, Z., Yu, H., Huang, J., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.696186 · Cited by 81 · see citing works

Analysis of alterations in the composition of the intestinal microbiota in frail older individuals

Zhang, C., Gong, L., Luo, S., Yang, L., & Yan, X. (2025) · PLoS ONE · doi:10.1371/journal.pone.0320918 · Cited by 2 · see citing works

Gut microbiota changes associated with frailty in older adults: A systematic review of observational studies

Wen, N.-N., Sun, L., Qian, G., & Zheng, G.-H. (2024) · World Journal of Clinical Cases · doi:10.12998/wjcc.v12.i35.6815 · Cited by 31 · see citing works

Association Between Gut Microbiome and Frailty in the Older Adult Population in Korea

Lim, M. Y., Hong, S. P., Kim, J., & Nam, Y. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa319 · Cited by 63 · see citing works