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The Role of miR-128 in Neurodegenerative Diseases

Lanza, Marika, Cuzzocrea, Salvatore, Oddo, Salvatore, Esposito, Emanuela, Casili, Giovanna·2023·International Journal of Molecular Sciences
DOI 10.3390/ijms24076024PMC PMC10093830
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Abstract

Several neurodegenerative disorders are characterized by the accumulation of misfolded proteins and are collectively known as proteinopathies. Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD) represent some of the most common neurodegenerative disorders whose steady increase in prevalence is having a major socio-economic impact on our society. Multiple laboratories have reported hundreds of changes in gene expression in selective brain regions of AD, PD, and HD brains. While the mechanisms underlying these changes remain an active area of investigation, alterations in the expression of noncoding RNAs, which are common in AD, PD, and HD, may account for some of the changes in gene expression in proteinopathies. In this review, we discuss the role of miR-128, which is highly expressed in mammalian brains, in AD, PD, and HD. We highlight how alterations in miR-128 may account, at least in part, for the gene expression changes associated with proteinopathies. Indeed, miR-128 is involved, among other things, in the regulation of neuronal plasticity, cytoskeletal organization, and neuronal death, events linked to various proteinopathies. For example, reducing the expression of miR-128 in a mouse model of AD ameliorates cognitive deficits and reduces neuropathology. Overall, the data in the literature suggest that targeting miR-128 might be beneficial to mitigate the behavioral phenotype associated with these diseases.

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Figure 1 The role of miR-128 in AD. Figure created with BioRender.com accessed on 1 March 2023.
Figure 1 The role of miR-128 in AD. Figure created with BioRender.com accessed on 1 March 2023.CC BY · PubMed Central
Figure 2 The role of miR-128 in PD. Figure created with BioRender.com accessed on 1 March 2023.
Figure 2 The role of miR-128 in PD. Figure created with BioRender.com accessed on 1 March 2023.CC BY · PubMed Central

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Metadata

Authors
Lanza, M., Cuzzocrea, S., Oddo, S., Esposito, E., & Casili, G.
Affiliations
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, 31-98166 Messina, Italy
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2023-03-23
Volume
24
Issue
7
Pages
6024
ISSN
1422-0067
DOI
10.3390/ijms24076024
PMC
PMC10093830
Cited by
27
References
4
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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