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The Role of miR-128 in Neurodegenerative Diseases

Lanza, Marika, Cuzzocrea, Salvatore, Oddo, Salvatore, Esposito, Emanuela, Casili, Giovanna·2023·International Journal of Molecular Sciences
DOI 10.3390/ijms24076024PMC PMC10093830
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Abstract

Several neurodegenerative disorders are characterized by the accumulation of misfolded proteins and are collectively known as proteinopathies. Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD) represent some of the most common neurodegenerative disorders whose steady increase in prevalence is having a major socio-economic impact on our society. Multiple laboratories have reported hundreds of changes in gene expression in selective brain regions of AD, PD, and HD brains. While the mechanisms underlying these changes remain an active area of investigation, alterations in the expression of noncoding RNAs, which are common in AD, PD, and HD, may account for some of the changes in gene expression in proteinopathies. In this review, we discuss the role of miR-128, which is highly expressed in mammalian brains, in AD, PD, and HD. We highlight how alterations in miR-128 may account, at least in part, for the gene expression changes associated with proteinopathies. Indeed, miR-128 is involved, among other things, in the regulation of neuronal plasticity, cytoskeletal organization, and neuronal death, events linked to various proteinopathies. For example, reducing the expression of miR-128 in a mouse model of AD ameliorates cognitive deficits and reduces neuropathology. Overall, the data in the literature suggest that targeting miR-128 might be beneficial to mitigate the behavioral phenotype associated with these diseases.

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Figure 1 The role of miR-128 in AD. Figure created with BioRender.com accessed on 1 March 2023.
Figure 1 The role of miR-128 in AD. Figure created with BioRender.com accessed on 1 March 2023.CC BY · PubMed Central
Figure 2 The role of miR-128 in PD. Figure created with BioRender.com accessed on 1 March 2023.
Figure 2 The role of miR-128 in PD. Figure created with BioRender.com accessed on 1 March 2023.CC BY · PubMed Central

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Research works printed but not linked: 82

  1. Palazzo, 2015, Non-coding RNA: What is functional and what is junk?, Front. Genet., 6, 2, 10.3389/fgene.2015.00002 · DOI
  2. Fire, 1998, Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans, Nature, 391, 806, 10.1038/35888 · DOI · Paper page
  3. Eidem, 2016, Noncoding RNAs: Regulators of the Mammalian Transcription Machinery, J. Mol. Biol., 428, 2652, 10.1016/j.jmb.2016.02.019 · DOI
  4. Quan, 2020, Identification and characterization of long noncoding RNAs provide insight into the regulation of gene expression in response to heat stress in rainbow trout (Oncorhynchus mykiss), Comp. Biochem. Physiol. Part D Genom. Proteom., 36, 100707
  5. Xue, 2017, MicroRNAs, Long Noncoding RNAs, and Their Functions in Human Disease, Methods Mol. Biol., 1617, 1, 10.1007/978-1-4939-7046-9_1 · DOI
  6. Ying, 2008, The MicroRNA (miRNA): Overview of the RNA Genes that Modulate Gene Function, Mol. Biotechnol., 38, 257, 10.1007/s12033-007-9013-8 · DOI
  7. Shivdasani, 2006, MicroRNAs: Regulators of gene expression and cell differentiation, Blood, 108, 3646, 10.1182/blood-2006-01-030015 · DOI
  8. Hayder, 2018, Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation, Front. Endocrinol., 9, 402, 10.3389/fendo.2018.00402 · DOI · Paper page
  9. Carmel, 2012, Does base-pairing strength play a role in microRNA repression?, RNA, 18, 1947, 10.1261/rna.032185.111 · DOI
  10. Salta, 2017, Noncoding RNAs in neurodegeneration, Nat. Rev. Neurosci., 18, 627, 10.1038/nrn.2017.90 · DOI · Paper page
  11. Zhang, H., Yao, L., Zheng, Z., Koc, S., and Lu, G. (2022). The Role of Non-Coding RNAs in the Pathogenesis of Parkinson’s Disease: Recent Advancement. Pharmaceuticals, 15. · DOI
  12. Denham, A.N., Drake, J., Gavrilov, M., Taylor, Z.N., Bacanu, S.-A., and Vladimirov, V.I. (2022). Long Non-Coding RNAs: The New Frontier into Understanding the Etiology of Alcohol Use Disorder. Non-Coding RNA, 8. · DOI
  13. Wang, 2022, Non-coding RNAs and Alzheimer’s disease: Perspectives from omics studies, Hum. Mol. Genet., 31, R54, 10.1093/hmg/ddac202 · DOI
  14. Salta, 2012, Non-coding RNAs with essential roles in neurodegenerative disorders, Lancet Neurol., 11, 189, 10.1016/S1474-4422(11)70286-1 · DOI
  15. Holoch, 2015, RNA-mediated epigenetic regulation of gene expression, Nat. Rev. Genet., 16, 71, 10.1038/nrg3863 · DOI
  16. Burenina, 2017, Non-Coding RNAs as Transcriptional Regulators In Eukaryotes, Acta Nat., 9, 13, 10.32607/20758251-2017-9-4-13-25 · DOI
  17. Denis, 2011, Regulation of mammalian DNA methyltransferases: A route to new mechanisms, EMBO Rep., 12, 647, 10.1038/embor.2011.110 · DOI
  18. Williams, 2009, MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice, Science, 326, 1549, 10.1126/science.1181046 · DOI · Paper page
  19. Kim, 2008, MicroRNA-directed transcriptional gene silencing in mammalian cells, Proc. Natl. Acad. Sci. USA, 105, 16230, 10.1073/pnas.0808830105 · DOI
  20. Johnson, 2012, Long non-coding RNAs in Huntington’s disease neurodegeneration, Neurobiol. Dis., 46, 245, 10.1016/j.nbd.2011.12.006 · DOI
  21. Ha, 2014, Regulation of microRNA biogenesis, Nat. Rev. Mol. Cell Biol., 15, 509, 10.1038/nrm3838 · DOI · Paper page
  22. Bartel, 2004, MicroRNAs: Genomics, Biogenesis, Mechanism, and Function, Cell, 116, 281, 10.1016/S0092-8674(04)00045-5 · DOI
  23. 2007, Therapeutic RNA interference for neurodegenerative diseases: From promise to progress, Pharmacol. Ther., 114, 34, 10.1016/j.pharmthera.2007.01.003 · DOI
  24. Mathis, S., and Le Masson, G. (2018). RNA-Targeted Therapies and Amyotrophic Lateral Sclerosis. Biomedicines, 6. · DOI
  25. Garofalo, M., Pandini, C., Sproviero, D., Pansarasa, O., Cereda, C., and Gagliardi, S. (2021). Advances with Long Non-Coding RNAs in Alzheimer’s Disease as Peripheral Biomarker. Genes, 12. · DOI
  26. Muddashetty, 2002, Poly(A)-binding Protein is Associated with Neuronal BC1 and BC200 Ribonucleoprotein Particles, J. Mol. Biol., 321, 433, 10.1016/S0022-2836(02)00655-1 · DOI
  27. Mus, 2007, Dendritic BC200 RNA in aging and in Alzheimer’s disease, Proc. Natl. Acad. Sci. USA, 104, 10679, 10.1073/pnas.0701532104 · DOI
  28. Takemata, 2016, Role of non-coding RNA transcription around gene regulatory elements in transcription factor recruitment, RNA Biol., 14, 1, 10.1080/15476286.2016.1248020 · DOI
  29. Thomson, 2016, Endogenous microRNA sponges: Evidence and controversy, Nat. Rev. Genet., 17, 272, 10.1038/nrg.2016.20 · DOI · Paper page
  30. Han, 2017, The Multifaceted Role of SNARE Proteins in Membrane Fusion, Front. Physiol., 8, 5, 10.3389/fphys.2017.00005 · DOI
  31. Tan, 2012, Non-coding RNAs in Alzheimer’s Disease, Mol. Neurobiol., 47, 382, 10.1007/s12035-012-8359-5 · DOI
  32. Faghihi, 2008, Expression of a noncoding RNA is elevated in Alzheimer’s disease and drives rapid feed-forward regulation of β-secretase, Nat. Med., 14, 723, 10.1038/nm1784 · DOI · Paper page
  33. Koelsch, G. (2017). BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer’s Disease Pathology. Molecules, 22. · DOI
  34. Liu, 2014, Attenuated ability of BACE1 to cleave the amyloid precursor protein via silencing long noncoding RNA BACE1-AS expression, Mol. Med. Rep., 10, 1275, 10.3892/mmr.2014.2351 · DOI
  35. Tan, 2013, MicroRNA-128 Governs Neuronal Excitability and Motor Behavior in Mice, Science, 342, 1254, 10.1126/science.1244193 · DOI · Paper page
  36. Li, 2013, miR-128 and its target genes in tumorigenesis and metastasis, Exp. Cell Res., 319, 3059, 10.1016/j.yexcr.2013.07.031 · DOI
  37. Sucharov, 2017, Myocardial microRNAs associated with reverse remodeling in human heart failure, J. Clin. Investig., 2, e89169
  38. Zhang, 2016, MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex, eLife, 5, e11324, 10.7554/eLife.11324 · DOI · Paper page
  39. Guidi, M., Muiños-Gimeno, M., Kagerbauer, B., Martí, E., Estivill, X., and Espinosa-Parrilla, Y. (2010). Overexpression of miR-128 specifically inhibits the truncated isoform of NTRK3 and upregulates BCL2 in SH-SY5Y neuroblastoma cells. BMC Mol. Biol., 11. · DOI
  40. Godlewski, 2008, Targeting of the Bmi-1 Oncogene/Stem Cell Renewal Factor by MicroRNA-128 Inhibits Glioma Proliferation and Self-Renewal, Cancer Res., 68, 9125, 10.1158/0008-5472.CAN-08-2629 · DOI · Paper page
  41. Shang, 2015, miR-128 regulates the apoptosis and proliferation of glioma cells by targeting RhoE, Oncol. Lett., 11, 904, 10.3892/ol.2015.3927 · DOI
  42. Evangelisti, 2009, MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness, FASEB J., 23, 4276, 10.1096/fj.09-134965 · DOI · Paper page
  43. Khan, 2010, Quantitative Proteomic Profiling of Prostate Cancer Reveals a Role for miR-128 in Prostate Cancer, Mol. Cell. Proteom., 9, 298, 10.1074/mcp.M900159-MCP200 · DOI
  44. Hu, 2014, microRNA-128 plays a critical role in human non-small cell lung cancer tumourigenesis, angiogenesis and lymphangiogenesis by directly targeting vascular endothelial growth factor-C, Eur. J. Cancer, 50, 2336, 10.1016/j.ejca.2014.06.005 · DOI
  45. Mets, 2014, MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia, Haematologica, 99, 1326, 10.3324/haematol.2013.099515 · DOI
  46. Zhuang, L., Xu, L., Wang, P., and Meng, Z. (2015). Serum miR-128-2 Serves as a Prognostic Marker for Patients with Hepatocellular Carcinoma. PLoS ONE, 10. · DOI
  47. Li, 2019, miR-128 Functions as an OncomiR for the Downregulation of HIC1 in Breast Cancer, Front. Pharmacol., 10, 1202, 10.3389/fphar.2019.01202 · DOI
  48. Mayeux, 2012, Epidemiology of Alzheimer Disease, Cold Spring Harb. Perspect. Med., 2, a006239, 10.1101/cshperspect.a006239 · DOI
  49. Pennanen, 2004, Hippocampus and entorhinal cortex in mild cognitive impairment and early AD, Neurobiol. Aging, 25, 303, 10.1016/S0197-4580(03)00084-8 · DOI
  50. Shankar, 2009, Alzheimer’s disease: Synaptic dysfunction and Aβ, Mol. Neurodegener., 4, 48, 10.1186/1750-1326-4-48 · DOI · Paper page
  51. Trinchese, 2004, Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice, Ann. Neurol., 55, 801, 10.1002/ana.20101 · DOI
  52. Improta-Caria, A.C., Nonaka, C.K.V., Cavalcante, B.R.R., De Sousa, R.A.L., Júnior, R.A., and Souza, B.S.D.F. (2020). Modulation of MicroRNAs as a Potential Molecular Mechanism Involved in the Beneficial Actions of Physical Exercise in Alzheimer Disease. Int. J. Mol. Sci., 21. · DOI
  53. Vergallo, 2021, MiRNA-15b and miRNA-125b are associated with regional Aβ-PET and FDG-PET uptake in cognitively normal individuals with subjective memory complaints, Transl. Psychiatry, 11, 78, 10.1038/s41398-020-01184-8 · DOI
  54. Liu, 2018, MicroRNA-128 knockout inhibits the development of Alzheimer’s disease by targeting PPARγ in mouse models, Eur. J. Pharmacol., 843, 134, 10.1016/j.ejphar.2018.11.004 · DOI · Paper page
  55. Siedlecki-Wullich, D., Miñano-Molina, A., and Rodríguez-Álvarez, J. (2021). microRNAs as Early Biomarkers of Alzheimer’s Disease: A Synaptic Perspective. Cells, 10. · DOI · Paper page
  56. Shao, N.-Y., Hu, H.Y., Yan, Z., Xu, Y., Hu, H., Menzel, C., Li, N., Chen, W., and Khaitovich, P. (2010). Comprehensive survey of human brain microRNA by deep sequencing. BMC Genom., 11. · DOI · Paper page
  57. Miners, 2009, Angiotensin-converting enzyme levels and activity in Alzheimer’s disease: Differences in brain and CSF ACE and association with ACE1 genotypes, Am. J. Transl. Res., 1, 163
  58. Zhang, 2021, Serum miR-128 Serves as a Potential Diagnostic Biomarker for Alzheimer’s Disease, Neuropsychiatr. Dis. Treat., 17, 269, 10.2147/NDT.S290925 · DOI
  59. Kou, 2020, The Regulation of microRNAs in Alzheimer’s Disease, Front. Neurol., 11, 288, 10.3389/fneur.2020.00288 · DOI · Paper page
  60. Sheinin, 2021, miR-128 as a Regulator of Synaptic Properties in 5xFAD Mice Hippocampal Neurons, J. Mol. Neurosci., 71, 2593, 10.1007/s12031-021-01862-2 · DOI
  61. McSweeney, 2016, Inhibition of microRNA 128 promotes excitability of cultured cortical neuronal networks, Genome Res., 26, 1411, 10.1101/gr.199828.115 · DOI
  62. Lin, 2011, The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory, Nat. Neurosci., 14, 1115, 10.1038/nn.2891 · DOI · Paper page
  63. Angelopoulou, E., Paudel, Y.N., Papageorgiou, S.G., and Piperi, C. (2022). Environmental Impact on the Epigenetic Mechanisms Underlying Parkinson’s Disease Pathogenesis: A Narrative Review. Brain Sci., 12. · DOI
  64. Stoker, T.B., and Greenland, J.C. (2018). Parkinson’s Disease: Pathogenesis and Clinical Aspects, Codon Publications. · DOI
  65. Kalia, 2015, Parkinson’s disease, Lancet, 386, 896, 10.1016/S0140-6736(14)61393-3 · DOI · Paper page
  66. Armstrong, 2020, Diagnosis and Treatment of Parkinson Disease: A Review, JAMA, 323, 548, 10.1001/jama.2019.22360 · DOI · Paper page
  67. Decressac, 2013, TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity, Proc. Natl. Acad. Sci. USA, 110, E1817, 10.1073/pnas.1305623110 · DOI · Paper page
  68. Zhou, 2018, MicroRNA-128 Protects Dopamine Neurons from Apoptosis and Upregulates the Expression of Excitatory Amino Acid Transporter 4 in Parkinson’s Disease by Binding to AXIN1, Cell. Physiol. Biochem., 51, 2275, 10.1159/000495872 · DOI · Paper page
  69. Zhang, 2020, HIF-1α/microRNA-128-3p axis protects hippocampal neurons from apoptosis via the Axin1-mediated Wnt/β-catenin signaling pathway in Parkinson’s disease models, Aging, 12, 4067, 10.18632/aging.102636 · DOI · Paper page
  70. 2021, Molecular Strategies to Target Protein Aggregation in Huntington’s Disease, Front. Mol. Biosci., 8, 769184, 10.3389/fmolb.2021.769184 · DOI
  71. Keum, 2016, The HTT CAG-Expansion Mutation Determines Age at Death but Not Disease Duration in Huntington Disease, Am. J. Hum. Genet., 98, 287, 10.1016/j.ajhg.2015.12.018 · DOI
  72. Konovalova, J., Gerasymchuk, D., Parkkinen, I., Chmielarz, P., and Domanskyi, A. (2019). Interplay between MicroRNAs and Oxidative Stress in Neurodegenerative Diseases. Int. J. Mol. Sci., 20. · DOI
  73. Aronin, 2014, Huntingtin-lowering strategies in Huntington’s disease: Antisense oligonucleotides, small RNAs, and gene editing, Mov. Disord., 29, 1455, 10.1002/mds.26020 · DOI
  74. Kocerha, 2014, microRNA-128a dysregulation in transgenic Huntington’s disease monkeys, Mol. Brain, 7, 46, 10.1186/1756-6606-7-46 · DOI · Paper page
  75. Pantano, 2010, A myriad of miRNA variants in control and Huntington’s disease brain regions detected by massively parallel sequencing, Nucleic Acids Res., 38, 7219, 10.1093/nar/gkq575 · DOI · Paper page
  76. Lee, 2011, Altered microRNA regulation in Huntington’s disease models, Exp. Neurol., 227, 172, 10.1016/j.expneurol.2010.10.012 · DOI · Paper page
  77. Langfelder, P., Gao, F., Wang, N., Howland, D., Kwak, S., Vogt, T.F., Aaronson, J.S., Rosinski, J., Coppola, G., and Horvath, S. (2018). MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice. PLoS ONE, 13. · DOI
  78. Cloud, 2012, Seizures in juvenile Huntington’s disease: Frequency and characterization in a multicenter cohort, Mov. Disord., 27, 1797, 10.1002/mds.25237 · DOI
  79. Gantois, 2007, Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior, Proc. Natl. Acad. Sci. USA, 104, 4182, 10.1073/pnas.0611625104 · DOI
  80. Pewinska, 2021, Artificial miRNAs as therapeutic tools: Challenges and opportunities, Wiley Interdiscip. Rev. RNA, 12, e1640, 10.1002/wrna.1640 · DOI
  81. Xu, 2012, MicroRNAs in autophagy and their emerging roles in crosstalk with apoptosis, Autophagy, 8, 873, 10.4161/auto.19629 · DOI
  82. Zhang, 2019, Protocols for the Analysis of microRNA Expression, Biogenesis, and Function in Immune Cells, Curr. Protoc. Immunol., 126, e78, 10.1002/cpim.78 · DOI

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Metadata

Authors
Lanza, M., Cuzzocrea, S., Oddo, S., Esposito, E., & Casili, G.
Affiliations
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres, 31-98166 Messina, Italy
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2023-03-23
Volume
24
Issue
7
Pages
6024
ISSN
1422-0067
DOI
10.3390/ijms24076024
PMC
PMC10093830
Cited by
27
References
4
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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