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Antibiotic Pollution in the Environment: From Microbial Ecology to Public Policy

Kraemer, Susanne A., Ramachandran, Arthi, Perron, Gabriel G.·2019·Microorganisms
DOI 10.3390/microorganisms7060180
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Abstract

The ability to fight bacterial infections with antibiotics has been a longstanding cornerstone of modern medicine. However, wide-spread overuse and misuse of antibiotics has led to unintended consequences, which in turn require large-scale changes of policy for mitigation. In this review, we address two broad classes of corollaries of antibiotics overuse and misuse. Firstly, we discuss the spread of antibiotic resistance from hotspots of resistance evolution to the environment, with special concerns given to potential vectors of resistance transmission. Secondly, we outline the effects of antibiotic pollution independent of resistance evolution on natural microbial populations, as well as invertebrates and vertebrates. We close with an overview of current regional policies tasked with curbing the effects of antibiotics pollution and outline areas in which such policies are still under development.

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  1. Levy, S.B., and Bergman, M.M. (2003). The Antibiotic Paradox: How the Misuse of Antibiotics Destroys Their Curative Powers. Clinical Infectious Diseases, Perseus Publishing. [2nd ed.]. · doi:10.1086/344466
  2. Barber, 1961, Hospital infection yeaterday and today, J. Clin. Pathol., 14, 2, 10.1136/jcp.14.1.2 · doi:10.1136/jcp.14.1.2
  3. Davies, 2006, Where have all the antibiotics gone?, Can. J. Infect. Dis. Med. Microbiol., 17, 287, 10.1155/2006/707296 · DOI · Paper page
  4. Abraham, 1940, An enzyme from bacteria able to destroy penicillin, Nature, 146, 837, 10.1038/146837a0 · DOI · Paper page
  5. Barber, 1948, Infection by penicillin-resistant staphylococci, Lancet, 2, 641, 10.1016/S0140-6736(48)92166-7 · DOI · Paper page
  6. Barber, 1947, Staphylococcal Infection due to Penicillin-resistant Strains, BMJ, 2, 863, 10.1136/bmj.2.4534.863 · DOI
  7. Smith, 2000, Population structure and evolutionary dynamics of pathogenic bacteria, BioEssays, 22, 1115, 10.1002/1521-1878(200012)22:12<1115::AID-BIES9>3.0.CO;2-R · DOI
  8. Bush, 2011, Tackling antibiotic resistance, Nat. Rev. Microbiol., 9, 894, 10.1038/nrmicro2693 · DOI · Paper page
  9. Davies, 2013, Annual Report of the Chief Medical Officer: Infection and the Rise of Antimicrobial esistance, Lancet, 381, 1606, 10.1016/S0140-6736(13)60604-2 · DOI · Paper page
  10. Livermore, 2011, Discovery research: The scientific challenge of finding new antibiotics, J. Antimicrob. Chemother., 66, 1941, 10.1093/jac/dkr262 · DOI · Paper page
  11. Cohen, 1992, Epidemiology of drug resistance: Implications for a post-antimicrobial era, Science, 257, 1050, 10.1126/science.257.5073.1050 · DOI · Paper page
  12. Brower, 2015, Global trends in antimicrobial use in food animals, Proc. Natl. Acad. Sci. USA, 112, 5649, 10.1073/pnas.1503141112 · DOI · Paper page
  13. Henriksson, 2018, Unpacking factors influencing antimicrobial use in global aquaculture and their implication for management: A review from a systems perspective, Sustain. Sci., 13, 1105, 10.1007/s11625-017-0511-8 · DOI · Paper page
  14. Petrovic, 2018, Towards the understanding of antibiotic occurrence and transport in groundwater: Findings from the Baix Fluvià alluvial aquifer (NE Catalonia, Spain), Sci. Total Environ., 612, 1387, 10.1016/j.scitotenv.2017.09.012 · DOI
  15. Andersson, 2012, Evolution of antibiotic resistance at non-lethal drug concentrations, Drug Resist. Updates, 15, 162, 10.1016/j.drup.2012.03.005 · DOI · Paper page
  16. 2009, Antibiotics in the aquatic environment—A review—Part II, Chemosphere, 75, 435, 10.1016/j.chemosphere.2008.12.006 · DOI · Paper page
  17. Finland, 1979, Emergence of antibiotic resistance in hospitals, 1935–1975, Rev. Infect. Dis., 1, 4, 10.1093/clinids/1.1.4 · DOI · Paper page
  18. Spellberg, 2008, Antibiotic resistance and antibiotic development, Lancet Infect. Dis., 8, 211, 10.1016/S1473-3099(08)70048-3 · DOI
  19. Shoemaker, 2001, Evidence for extensive resistance gene transfer among Bacteroides spp. and among Bacteroides and other genera in the human colon, Appl. Environ. Microbiol., 67, 561, 10.1128/AEM.67.2.561-568.2001 · DOI · Paper page
  20. Knapp, 2010, Evidence of increasing antibiotic resistance gene abundances in archived soils since 1940, Environ. Sci. Technol., 44, 580, 10.1021/es901221x · DOI · Paper page
  21. Walsh, 2000, Molecular mechanisms that confer antibacterial drug resistance, Nature, 406, 775, 10.1038/35021219 · DOI · Paper page
  22. Wright, 2011, Molecular mechanisms of antibiotic resistance, Chem. Commun., 47, 4055, 10.1039/c0cc05111j · DOI · Paper page
  23. Gullberg, E., Cao, S., Berg, O.G., Ilbäck, C., Sandegren, L., Hughes, D., and Andersson, D.I. (2011). Selection of resistant bacteria at very low antibiotic concentrations. PLoS Pathog., 7. · DOI · Paper page
  24. Kim, 2014, Alternating antibiotic treatments constrain evolutionary paths to multidrug resistance, Proc. Natl. Acad. Sci. USA, 111, 14494, 10.1073/pnas.1409800111 · DOI · Paper page
  25. Haas, 2003, Regulation of antibiotic production in root-colonizing Peudomonas spp. and relevance for biological control of plant disease, Ann. Rev. Phytopathol., 41, 117, 10.1146/annurev.phyto.41.052002.095656 · DOI · Paper page
  26. Long, 2001, Antagonistic Interactions among Marine Pelagic Bacteria, Appl. Environ. Microbiol., 67, 4975, 10.1128/AEM.67.11.4975-4983.2001 · DOI · Paper page
  27. Davies, 2006, Are antibiotics naturally antibiotics?, J. Ind. Microbiol. Biotechnol., 33, 496, 10.1007/s10295-006-0112-5 · DOI · Paper page
  28. Goh, 2002, Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics, Proc. Natl. Acad. Sci. USA, 99, 17025, 10.1073/pnas.252607699 · DOI · Paper page
  29. Skindersoe, 2008, Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa, Antimicrob. Agents Chemother., 52, 3648, 10.1128/AAC.01230-07 · DOI · Paper page
  30. Aminov, 2009, The role of antibiotics and antibiotic resistance in nature, Environ. Microbiol., 11, 2970, 10.1111/j.1462-2920.2009.01972.x · DOI · Paper page
  31. Evans, 1988, Characterization of the Conjugation System Associated with the Staphylococcus aureus Plasmid pJE1, Microbiology, 134, 1, 10.1099/00221287-134-1-1 · DOI
  32. Zhang, 2013, Combined treatment with the antibiotics kanamycin and streptomycin promotes the conjugation of Escherichia coli, FEMS Microbiol. Lett., 348, 149, 10.1111/1574-6968.12282 · DOI
  33. Perron, G.G., Whyte, L., Turnbaugh, P.J., Goordial, J., Hanage, W.P., Dantas, G., and Desai, M.M. (2015). Functional characterization of bacteria isolated from ancient arctic soil exposes diverse resistance mechanisms to modern antibiotics. PLoS ONE, 10. · DOI
  34. Lee, S.H., and Lee, J.H. (2011). Molecular Characterization of TEM-Type beta-Lactamases Identified in Cold-Seep Sediments of Edison Seamount (South of Lihir Island, Papua New Guinea). Handbook of Molecular Microbial Ecology II: Metagenomics in Different Habitats, Wiley-Blackwell. · DOI
  35. 2008, Antibiotics and antibiotic resistance genes in natural environments, Science, 321, 365, 10.1126/science.1159483 · DOI · Paper page
  36. Norman, 2009, Conjugative plasmids: Vessels of the communal gene pool, Philos. Trans. R. Soc. B Boil. Sci., 364, 2275, 10.1098/rstb.2009.0037 · DOI · Paper page
  37. Palmer, 2011, Horizontal Gene Transfer and the Genomics of Enterococcal Antibiotic Resistance, Curr. Opin. Microbiol., 13, 632, 10.1016/j.mib.2010.08.004 · DOI · Paper page
  38. Springman, 2009, Selection, recombination, and virulence gene diversity among group B streptococcal genotypes, J. Bacteriol., 191, 5419, 10.1128/JB.00369-09 · DOI
  39. Fournier, P.E., Vallenet, D., Barbe, V., Audic, S., Ogata, H., Poirel, L., Richet, H., Robert, C., Mangenot, S., and Abergel, C. (2006). Comparative genomics of multidrug resistance in Acinetobacter baumannii. PLoS Genet., 2. · DOI · Paper page
  40. Barton, 2011, Bacteriophage-mediated transduction of antibiotic resistance in enterococci, Lett. Appl. Microbiol., 52, 559, 10.1111/j.1472-765X.2011.03043.x · DOI
  41. Colomer-Lluch, M., Jofre, J., and Muniesa, M. (2011). Antibiotic resistance genes in the bacteriophage DNA fraction of environmental samples. PLoS ONE, 6. · DOI · Paper page
  42. Xu, 2011, Resistance class 1 integron in clinical methicillin-resistant Staphylococcus aureus strains in southern China, 2001–2006, Clin. Microbiol. Infect., 17, 714, 10.1111/j.1469-0691.2010.03379.x · doi:10.1111/j.1469-0691.2010.03379.x
  43. Machado, 2008, Antibiotic resistance integrons and extended-spectrum β-lactamases among Enterobacteriaceae isolates recovered from chickens and swine in Portugal, J. Antimicrob. Chemother., 62, 296, 10.1093/jac/dkn179 · doi:10.1093/jac/dkn179
  44. Mazel, 2002, The role of integrons in antibiotic resistance gene capture, Int. J. Med. Microbiol., 292, 115, 10.1078/1438-4221-00197 · DOI · Paper page
  45. Gillings, 2015, Using the class 1 integron-integrase gene as a proxy for anthropogenic pollution, ISME J., 9, 1269, 10.1038/ismej.2014.226 · DOI · Paper page
  46. Box, 2002, Evidence of Extensive Interspecies Transfer of Integron-Mediated Antimicrobial Resistance Genes among Multidrug-Resistant Enterobacteriaceae in a Clinical Setting, J. Infect. Dis., 186, 49, 10.1086/341078 · DOI
  47. Summers, 1993, Mercury released from dental ‘silver’ fillings provokes an increase in mercury- and antibiotic-resistant bacteria in oral and intestinal floras of primates, Antimicrob. Agents Chemother., 37, 825, 10.1128/AAC.37.4.825 · DOI
  48. Hayashi, 2000, The DsbA-DsbB disulfide bond formation system of Burkholderia cepacia is involved in the production of protease and alkaline phosphatase, motility, metal resistance, and multi-drug resistance, Microbiol. Immunol., 44, 41, 10.1111/j.1348-0421.2000.tb01244.x · DOI
  49. Wright, 2006, Co-selection of antibiotic and metal resistance, Trends Microbiol., 14, 176, 10.1016/j.tim.2006.02.006 · DOI · Paper page
  50. Chen, 2013, Differentiating anthropogenic impacts on ARGs in the Pearl River Estuary by using suitable gene indicators, Water Res., 47, 2811, 10.1016/j.watres.2013.02.042 · DOI · Paper page
  51. Ju, 2019, Wastewater treatment plant resistomes are shaped by bacterial composition, genetic exchange, and upregulated expression in the effluent microbiomes, ISME J., 13, 346, 10.1038/s41396-018-0277-8 · DOI · Paper page
  52. Graham, 2016, Appearance of β-lactam Resistance Genes in Agricultural Soils and Clinical Isolates over the 20 th Century, Sci. Rep., 6, 21550, 10.1038/srep21550 · DOI
  53. Pruden, 2012, Correlation between upstream human activities and riverine antibiotic resistance genes, Environ. Sci. Technol., 46, 11541, 10.1021/es302657r · DOI · Paper page
  54. Baquero, 2008, Antibiotics and antibiotic resistance in water environments, Curr. Opin. Biotechnol., 19, 260, 10.1016/j.copbio.2008.05.006 · DOI · Paper page
  55. Berendonk, 2015, Tackling antibiotic resistance: The environmental framework, Nat. Rev. Microbiol., 13, 310, 10.1038/nrmicro3439 · DOI · Paper page
  56. Pitout, 2005, Emergence of Enterobacteriaceae producing extended-spectrum β-lactamases (ESBLs) in the community, J. Antimicrob. Chemother., 56, 52, 10.1093/jac/dki166 · DOI · Paper page
  57. Breathnach, 2012, Multidrug-resistant Pseudomonas aeruginosa outbreaks in two hospitals: Association with contaminated hospital waste-water systems, J. Hosp. Infect., 82, 19, 10.1016/j.jhin.2012.06.007 · doi:10.1016/j.jhin.2012.06.007
  58. Wang, 2003, Healthcare-associated outbreak due to pan-drug resistant Acinetobacter baumannii in a surgical intensive care unit, J. Hosp. Infect., 53, 97, 10.1053/jhin.2002.1348 · DOI
  59. Mathers, 2017, The Hospital Water Environment as a Reservoir for Carbapenem-Resistant Organisms Causing Hospital-Acquired Infections—A Systematic Review of the Literature, Clin. Infect. Dis., 64, 1435, 10.1093/cid/cix132 · DOI · Paper page
  60. Folkesson, 2012, Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: An evolutionary perspective, Nat. Rev. Microbiol., 10, 841, 10.1038/nrmicro2907 · DOI · Paper page
  61. López-Causapé, C., Rojo-Molinero, E., Mulet, X., Cabot, G., Moyà, B., Figuerola, J., Togores, B., Pérez, J.L., and Oliver, A. (2013). Clonal Dissemination, Emergence of Mutator Lineages and Antibiotic Resistance Evolution in Pseudomonas aeruginosa Cystic Fibrosis Chronic Lung Infection. PLoS ONE, 8. · DOI
  62. Hocquet, 2016, What happens in hospitals does not stay in hospitals: Antibiotic-resistant bacteria in hospital wastewater systems, J. Hosp. Infect., 93, 395, 10.1016/j.jhin.2016.01.010 · DOI · Paper page
  63. Reinthaler, 2003, Antibiotic resistance of E. Coli in sewage and sludge, Water Res., 37, 1685, 10.1016/S0043-1354(02)00569-9 · DOI · Paper page
  64. Szczepanowski, 2009, Detection of 140 clinically relevant antibiotic-resistance genes in the plasmid metagenome of wastewater treatment plant bacteria showing reduced susceptibility to selected antibiotics, Microbiology, 155, 2306, 10.1099/mic.0.028233-0 · DOI · Paper page
  65. Frigon, 2018, Water and sanitation: An essential battlefront in the war on antimicrobial resistance, FEMS Microbiol. Ecol., 94, fiy101
  66. Yang, 2014, Fate of antibiotic resistance genes in sewage treatment plant revealed by metagenomic approach, Water Res., 62, 97, 10.1016/j.watres.2014.05.019 · DOI · Paper page
  67. Chen, 2013, Occurrence and removal of antibiotic resistance genes in municipal wastewater and rural domestic sewage treatment systems in eastern China, Environ. Int., 55, 9, 10.1016/j.envint.2013.01.019 · DOI · Paper page
  68. Munir, 2011, Release of antibiotic resistant bacteria and genes in the effluent and biosolids of five wastewater utilities in Michigan, Water Res., 45, 681, 10.1016/j.watres.2010.08.033 · DOI · Paper page
  69. Eamens, 2008, Salmonella uptake in sheep exposed to pastuRes. after biosolids application to agricultural land, Soil Res., 46, 302, 10.1071/SR07152 · DOI
  70. Diehl, 2010, Effect of temperature on the fate of genes encoding tetracycline resistance and the integrase of class 1 integrons within anaerobic and aerobic digesters treating municipal wastewater solids, Environ. Sci. Technol., 44, 9128, 10.1021/es102765a · DOI · Paper page
  71. Mackie, 2009, Fate and Transport of Antibiotic Residues and Antibiotic Resistance Genes following Land Application of Manure Waste, J. Environ. Q., 38, 1086, 10.2134/jeq2008.0128 · DOI · Paper page
  72. Ventola, 2015, The antibiotic resistance crisis: Part 1: Causes and threats, Pharm. Ther. J., 40, 277
  73. Woolhouse, 2015, Antimicrobial resistance in humans, livestock and the wider environment, Philos. Trans. R. Soc. B Boil. Sci., 370, 20140083, 10.1098/rstb.2014.0083 · DOI · Paper page
  74. Pruden, 2006, Antibiotic resistance genes as emerging contaminants: Studies in northern Colorado, Environ. Sci. Technol., 40, 7445, 10.1021/es060413l · DOI · Paper page
  75. Peak, 2007, Abundance of six tetracycline resistance genes in wastewater lagoons at cattle feedlots with different antibiotic use strategies, Environ. Microbiol., 9, 143, 10.1111/j.1462-2920.2006.01123.x · DOI · Paper page
  76. Cabello, 2016, Aquaculture as yet another environmental gateway to the development and globalisation of antimicrobial resistance, Lancet Infect. Dis., 16, 127, 10.1016/S1473-3099(16)00100-6 · DOI · Paper page
  77. Shah, 2014, Antimicrobial resistance and antimicrobial resistance genes in marine bacteria from salmon aquaculture and non-aquaculture sites, Environ. Microbiol., 16, 1310, 10.1111/1462-2920.12421 · DOI · Paper page
  78. Buschmann, A.H., Tomova, A., López, A., Maldonado, M.A., Henríquez, L.A., Ivanova, L., Moy, F., Godfrey, H.P., and Cabello, F.C. (2012). Salmon aquaculture and antimicrobial resistance in the marine environment. PLoS ONE, 7. · DOI
  79. Watts, J.E.M., Schreier, H.J., Lanska, L., and Hale, M.S. (2017). The rising tide of antimicrobial resistance in aquaculture: Sources, sinks and solutions. Mar. Drugs, 15. · DOI · Paper page
  80. Larsson, 2014, Pollution from drug manufacturing: Review and perspectives, Philos. Trans. R. Soc. B Boil. Sci., 369, 20130571, 10.1098/rstb.2013.0571 · DOI · Paper page
  81. Larsson, 2007, Effluent from drug manufactuRes. contains extremely high levels of pharmaceuticals, J. Hazard. Mater., 148, 751, 10.1016/j.jhazmat.2007.07.008 · DOI · Paper page
  82. Li, 2009, Antibiotic-resistance profile in environmental bacteria isolated from penicillin production wastewater treatment plant and the receiving river, Environ. Microbiol., 11, 1506, 10.1111/j.1462-2920.2009.01878.x · DOI · Paper page
  83. Johnning, 2013, Acquired genetic mechanisms of a multiresistant bacterium isolated from a treatment plant receiving wastewater from antibiotic production, Appl. Environ. Microbiol., 79, 7256, 10.1128/AEM.02141-13 · DOI
  84. Storteboom, 2010, Identification of antibiotic-resistance-gene molecular signatuRes. suitable as tracers of pristine River, urban, and agricultural sources, Environ. Sci. Technol., 44, 1947, 10.1021/es902893f · DOI
  85. Graham, 2011, Antibiotic resistance gene abundances associated with waste discharges to the AlmendaRes. river near Havana, Cuba, Environ. Sci. Technol., 45, 418, 10.1021/es102473z · DOI · Paper page
  86. Pei, 2006, Effect of River Landscape on the sediment concentrations of antibiotics and corresponding antibiotic resistance genes (ARG), Water Res., 40, 2427, 10.1016/j.watres.2006.04.017 · DOI · Paper page
  87. Kristiansson, E., Fick, J., Janzon, A., Grabic, R., Rutgersson, C., Weijdegård, B., Söderström, H., and Joakim Larsson, D.G. (2011). Pyrosequencing of antibiotic-contaminated river sediments reveals high levels of resistance and gene transfer elements. PLoS ONE, 6. · DOI · Paper page
  88. Li, 2018, Global Survey of Antibiotic Resistance Genes in Air, Environ. Sci. Technol., 52, 10975, 10.1021/acs.est.8b02204 · DOI · Paper page
  89. Hu, 2018, Metagenomic profiling of ARGs in airborne particulate matters during a severe smog event, Sci. Total Environ., 615, 1332, 10.1016/j.scitotenv.2017.09.222 · DOI
  90. Dueker, M.E., O’Mullan, G.D., Martínez, J.M., Juhl, A.R., and Weathers, K.C. (2017). Onshore wind speed modulates microbial aerosols along an urban waterfront. Atmosphere, 8. · DOI
  91. Pirnay, J.P., Bilocq, F., Pot, B., Cornelis, P., Zizi, M., Van Eldere, J., Deschaght, P., Vaneechoutte, M., Jennes, S., and Pitt, T. (2009). Pseudomonas aeruginosa population structure revisited. PLoS ONE, 4. · DOI · Paper page
  92. Hwang, 2005, Phylogenetic characterization of virulence and resistance phenotypes of Pseudomonas syringae, Appl. Environ. Microbiol., 71, 5182, 10.1128/AEM.71.9.5182-5191.2005 · DOI · Paper page
  93. Christner, 2008, Ubiquity of biological ice nucleators in snowfall, Science, 319, 1214, 10.1126/science.1149757 · DOI · Paper page
  94. Li, 2016, Bioaerosol emissions and detection of airborne antibiotic resistance genes from a wastewater treatment plant, Atmos. Environ., 124, 404, 10.1016/j.atmosenv.2015.06.030 · DOI · Paper page
  95. Gao, 2017, Size-related bacterial diversity and tetracycline resistance gene abundance in the air of concentrated poultry feeding operations, Environ. Pollut., 220, 1342, 10.1016/j.envpol.2016.10.101 · DOI
  96. McEachran, 2015, Antibiotics, bacteria, and antibiotic resistance genes: Aerial transport from cattle feed yards via particulate matter, Environ. Health Perspect., 123, 337, 10.1289/ehp.1408555 · DOI · Paper page
  97. Gilbert, 2010, Airborne bacteria and antibiotic resistance genes in hospital rooms, Aerobiologia, 26, 185, 10.1007/s10453-010-9155-1 · DOI
  98. Angelin, 2015, The human gut microbiome as a transporter of antibiotic resistance genes between continents, Antimicrob. Agents Chemother., 59, 6551, 10.1128/AAC.00933-15 · DOI
  99. Langelier, 2018, Microbiome and Antimicrobial Resistance Gene Dynamics in International Travelers, Emerg. Infect. Dis., 2018, 506394
  100. Hanselman, 2006, Methicillin-resistant Staphylococcus aureus colonization in veterinary personnel, Emerg. Infect. Dis., 12, 1933, 10.3201/eid1212.060231 · DOI
  101. Price, 2007, Elevated risk of carrying gentamicin-resistant Escherichia coli among U.S. poultry workers, Environ. Health Perspect., 115, 1738, 10.1289/ehp.10191 · DOI
  102. Levy, 1978, Emergence of antibiotic-resistant bacteria in the intestinal flora of farm inhabitants, J. Infect. Dis., 137, 688, 10.1093/infdis/137.5.688 · DOI
  103. Chang, 2015, Antibiotics in agriculture and the risk to human health: How worried should we be?, Evol. Appl., 8, 240, 10.1111/eva.12185 · DOI · Paper page
  104. Lis, 2009, Methicillin resistance of airborne coagulase-negative staphylococci in homes of persons having contact with a hospital environment, Am, J. Infect. Control, 37, 177, 10.1016/j.ajic.2008.09.013 · doi:10.1016/j.ajic.2008.09.013
  105. Baran, 2002, Stool Colonization With Vancomycin-Resistant Enterococci in Healthcare Workers and Their Households, Infect. Control Hosp. Epidemiol., 23, 23, 10.1086/501963 · DOI
  106. Eveillard, 2004, Carriage of Methicillin-Resistant Staphylococcus aureus Among Hospital Employees: Prevalence, Duration, and Transmission to Households, Infect. Control Hosp. Epidemiol., 25, 114, 10.1086/502360 · DOI · Paper page
  107. Zurek, 2014, Insects represent a link between food animal farms and the urban environment for antibiotic resistance traits, Appl. Environ. Microbiol., 80, 3562, 10.1128/AEM.00600-14 · DOI · Paper page
  108. Doud, 2014, Role of House Flies in the Ecology of Enterococcus faecalis from Wastewater Treatment Facilities, Microb. Ecol., 67, 380, 10.1007/s00248-013-0337-6 · DOI
  109. Donkor, 2013, Microbial Carriage of Cockroaches at a Tertiary Care Hospital in Ghana, Environ. Health Insights, 7, 59
  110. Tilahun, 2012, High load of multi-drug resistant nosocomial neonatal pathogens carried by cockroaches in a neonatal intensive care unit at Tikur Anbessa specialized hospital, AdDis. Ababa, Ethiopia, Antimicrob. Resist. Infect. Control, 1, 12, 10.1186/2047-2994-1-12 · doi:10.1186/2047-2994-1-12
  111. Joyner, C., Mills, M.K., and Nayduch, D. (2013). Pseudomonas aeruginosa in Musca domestica L.: Temporospatial examination of bacteria population dynamics and house fly antimicrobial responses. PLoS ONE, 8. · doi:10.1371/journal.pone.0079224
  112. Petridis, 2006, Horizontal transfer of Shiga toxin and antibiotic resistance genes among Escherichia coli strains in house fly (Diptera: Muscidae) gut, J. Med. Entomol., 43, 288, 10.1093/jmedent/43.2.288 · doi:10.1093/jmedent/43.2.288
  113. Vittecoq, 2016, Antimicrobial resistance in wildlife, J. Appl. Ecol., 53, 519, 10.1111/1365-2664.12596 · DOI · Paper page
  114. Allen, 2011, Antimicrobial resistance in generic Escherichia coli isolates from wild small mammals living in swine farm, residential, landfill, and natural environments in Southern Ontario, Canada, Appl. Environ. Microbiol., 77, 882, 10.1128/AEM.01111-10 · doi:10.1128/aem.01111-10
  115. Kozak, 2009, Antimicrobial resistance in Escherichia coli isolates from Swine and wild small mammals in the proximity of swine farms and in natural environments in Ontario, Canada, Appl. Environ. Microbiol., 75, 559, 10.1128/AEM.01821-08 · DOI · Paper page
  116. Marcelino, 2018, High levels of antibiotic resistance gene expression among birds living in a wastewater treatment plant, BioRxiv, 2018, 462366
  117. Radhouani, 2011, Molecular characterization of antibiotic resistance in enterococci recovered from seagulls (Larus cachinnans) representing an environmental health problem, J. Environ. Monit., 13, 2227, 10.1039/c0em00682c · DOI
  118. Poeta, 2008, Seagulls of the Berlengas natural reserve of Portugal as carriers of fecal Escherichia coli harboring CTX-M and TEM extended-spectrum beta-lactamases, Appl. Environ. Microbiol., 74, 7439, 10.1128/AEM.00949-08 · DOI
  119. Andrews, 2004, Survival of enterococci and Tn 916 -like conjugative transposons in soil, Can. J. Microbiol., 50, 957, 10.1139/w04-090 · doi:10.1139/w04-090
  120. Jamieson, 2002, Movement and persistence of fecal bacteria in agricultural soils and subsurface drainage water: A review, Can. Biosyst. Eng., 44, 1
  121. Avery, 2008, Survival of Escherichia coli O157:H7 in waters from lakes, rivers, puddles and animal-drinking troughs, Sci. Total Environ., 389, 378, 10.1016/j.scitotenv.2007.08.049 · doi:10.1016/j.scitotenv.2007.08.049
  122. Xi, 2009, Prevalence of antibiotic resistance in drinking water treatment and distribution systems, Appl. Environ. Microbiol., 75, 5714, 10.1128/AEM.00382-09 · DOI · Paper page
  123. Andersson, 1999, The biological cost of antibiotic resistance, Curr. Opin. Microbiol., 2, 489, 10.1016/S1369-5274(99)00005-3 · DOI · Paper page
  124. Andersson, 2010, Antibiotic resistance and its cost: Is it possible to reverse resistance?, Nat. Rev. Microbiol., 8, 260, 10.1038/nrmicro2319 · DOI · Paper page
  125. Schmitt, 2006, Tetracyclines and tetracycline resistance in agricultural soils: Microcosm and field studies, Microb. Ecol., 51, 267, 10.1007/s00248-006-9035-y · DOI · Paper page
  126. Munir, 2011, Levels of Antibiotic Resistance Genes in Manure, Biosolids, and Fertilized Soil, J. Environ. Q., 40, 248, 10.2134/jeq2010.0209 · DOI · Paper page
  127. Nielsen, 2000, Natural transformation of Acinetobacter sp. strain BD413 with cell lysates of Acinetobacter sp., Pseudomonas fluorescens, and Burkholderia cepacia in soil microcosms, Appl. Environ. Microbiol., 66, 206, 10.1128/AEM.66.1.206-212.2000 · doi:10.1128/aem.66.1.206-212.2000
  128. Smalla, 1997, Manure enhances plasmid mobilization and survival of Pseudomonas putida introduced into field soil, Appl. Environ. Microbiol., 63, 1980, 10.1128/aem.63.5.1980-1986.1997 · DOI
  129. Martin, 2003, Organization and Expression of Genes Involved in the Biosynthesis of Antibiotics and other Secondary Metabolites, Ann. Rev. Microbiol., 43, 173, 10.1146/annurev.mi.43.100189.001133 · DOI · Paper page
  130. Barlow, 2003, Experimental prediction of the natural evolution of antibiotic resistance, Genetics, 163, 1237, 10.1093/genetics/163.4.1237 · DOI
  131. Davies, 2010, Origins and evolution of antibiotic resistance, Microbiologia, 74, 417
  132. Yim, 2007, Antibiotics as signalling molecules, Philos. Trans. R. Soc. B Boil. Sci., 362, 1195, 10.1098/rstb.2007.2044 · DOI · Paper page
  133. Hall, 2004, Evolution of the serine β-lactamases: Past, present and future, Drug Resist. Updates, 7, 111, 10.1016/j.drup.2004.02.003 · DOI · Paper page
  134. Aminov, 2007, Evolution and ecology of antibiotic resistance genes, FEMS Microbiol. Lett., 271, 147, 10.1111/j.1574-6968.2007.00757.x · DOI · Paper page
  135. 2017, Effect of antibiotics on bacterial populations: A multi-hierarchical selection process, F1000Research, 6, 51, 10.12688/f1000research.9685.1 · DOI
  136. Casadesus, 2013, Contribution of phenotypic heterogeneity to adaptive antibiotic resistance, Proc. Natl. Acad. Sci. USA, 111, 355
  137. Dunlop, 2018, Heterogeneity in efflux pump expression predisposes antibiotic-resistant cells to mutation, Science, 362, 686, 10.1126/science.aar7981 · DOI
  138. Lee, 2018, Intermediate Levels of Antibiotics May Increase Diversity of Colony Size Phenotype in Bacteria, Comput. Struct. Biotechnol. J., 16, 307, 10.1016/j.csbj.2018.08.004 · DOI
  139. Saxer, G., Doebeli, M., and Travisano, M. (2010). The repeatability of adaptive radiation during long-term experimental evolution of Escherichia coli in a multiple nutrient environment. PLoS ONE, 5. · DOI
  140. Justice, 2008, Morphological plasticity as a bacterial survival strategy, Nat. Rev. Microbiol., 6, 162, 10.1038/nrmicro1820 · DOI · Paper page
  141. Foster, 2007, Stress-induced mutagenesis in bacteria, Crit. Rev. Biochem. Mol. Biol., 42, 373, 10.1080/10409230701648494 · DOI · Paper page
  142. Andersson, 2014, Microbiological effects of sublethal levels of antibiotics, Nat. Rev. Microbiol., 12, 465, 10.1038/nrmicro3270 · DOI · Paper page
  143. Maiques, 2006, β-lactam antibiotics induce the SOS response and horizontal transfer of virulence factors in Staphylococcus aureus, J. Bacteriol., 188, 2726, 10.1128/JB.188.7.2726-2729.2006 · DOI · Paper page
  144. Slager, 2014, Antibiotic-induced replication stress triggers bacterial competence by increasing gene dosage near the origin, Cell, 157, 395, 10.1016/j.cell.2014.01.068 · DOI · Paper page
  145. Davies, 2006, The world of subinhibitory antibiotic concentrations, Curr. Opin. Microbiol., 9, 445, 10.1016/j.mib.2006.08.006 · DOI · Paper page
  146. Blount, 2006, Riboswitches as antibacterial drug targets, Nat. Biotechnol., 24, 1558, 10.1038/nbt1268 · DOI · Paper page
  147. Mion, 2018, Interference in bacterial quorum sensing: A biopharmaceutical perspective, Front. Pharmacol., 9, 203, 10.3389/fphar.2018.00203 · DOI · Paper page
  148. Lozupone, 2007, Global patterns in bacterial diversity, Proc. Natl. Acad. Sci. USA, 104, 11436, 10.1073/pnas.0611525104 · DOI · Paper page
  149. Caporaso, 2011, Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample, Proc. Natl. Acad. Sci. USA, 108, 4516, 10.1073/pnas.1000080107 · DOI · Paper page
  150. Torsvik, 2002, Microbial Diversity and Function in Soil: From Genes to Ecosystems, Curr. Opin. Microbiol., 5, 240, 10.1016/S1369-5274(02)00324-7 · DOI · Paper page
  151. Gibbons, 2015, Microbial diversity-exploration of natural ecosystems and microbiomes, Curr. Opin. Genet. Dev., 35, 66, 10.1016/j.gde.2015.10.003 · DOI
  152. Goss, 2019, One Health—Cycling of diverse microbial communities as a connecting force for soil, plant, animal, human and ecosystem health, Sci. Total Environ., 664, 927, 10.1016/j.scitotenv.2019.02.091 · DOI
  153. Delcour, 2009, Outer membrane permeability and antibiotic resistance, Biochim. Biophys. Acta Proteins Proteom., 1794, 808, 10.1016/j.bbapap.2008.11.005 · DOI · Paper page
  154. Ding, 2010, Effect of antibiotics in the environment on microbial populations, Appl. Microbiol. Biotechnol., 87, 925, 10.1007/s00253-010-2649-5 · DOI · Paper page
  155. Eckert, 2019, Antibiotic disturbance affects aquatic microbial community composition and food web interactions but not community resilience, Mol. Ecol., 28, 1170, 10.1111/mec.15033 · DOI
  156. Grenni, 2018, Ecological effects of antibiotics on natural ecosystems: A review, Microchem. J., 136, 25, 10.1016/j.microc.2017.02.006 · DOI · Paper page
  157. Westergaard, 2001, Effects of tylosin as a disturbance on the soil microbial community, Soil Biol. Biochem., 33, 2061, 10.1016/S0038-0717(01)00134-1 · DOI · Paper page
  158. Beck, 2005, Effects of sulfonamide and tetracycline antibiotics on soil microbial activity and microbial biomass, Chemosphere, 59, 457, 10.1016/j.chemosphere.2005.01.023 · DOI · Paper page
  159. Mrozik, 2019, Antibiotics in the Soil Environment—Degradation and Their Impact on Microbial Activity and Diversity, Front. Microbiol., 10, 338, 10.3389/fmicb.2019.00338 · DOI · Paper page
  160. Drury, 2013, Triclosan exposure increases triclosan resistance and influences taxonomic composition of benthic bacterial communities, Environ. Sci. Technol., 47, 8923, 10.1021/es401919k · DOI
  161. Cunha, 2001, Antibiotic side effects, Med. Clin. N. Am., 85, 149, 10.1016/S0025-7125(05)70309-6 · DOI · Paper page
  162. Mojica, E.-R.E., and Aga, D.S. (2011). Antibiotics Pollution in Soil and Water: Potential Ecological and Human Health Issues. Encyclopedia of Environmental Health, Elsevier. · DOI
  163. Ye, 2007, Trace analysis of trimethoprim and sulfonamide, macrolide, quinolone, and tetracycline antibiotics in chlorinated drinking water using liquid chromatography electrospray tandem mass spectrometry, Anal. Chem., 79, 1135, 10.1021/ac060972a · DOI · Paper page
  164. Halden, 2005, Co-occurrence of triclocarban and triclosan in U.S. water resources, Environ. Sci. Technol., 39, 1420, 10.1021/es049071e · DOI · Paper page
  165. Bever, 2018, Effects of triclosan in breast milk on the infant fecal microbiome, Chemosphere, 203, 467, 10.1016/j.chemosphere.2018.03.186 · doi:10.1016/j.chemosphere.2018.03.186
  166. Weatherly, 2017, Triclosan exposure, transformation, and human health effects, J. Toxicol. Environ. Health Part B Crit. Rev., 20, 447, 10.1080/10937404.2017.1399306 · DOI · Paper page
  167. Calafat, 2008, Urinary concentrations of triclosan in the U.S. population: 2003–2004, Environ. Health Perspect., 116, 303, 10.1289/ehp.10768 · DOI · Paper page
  168. Snow, 2015, A review of ecological effects and environmental fate of illicit drugs in aquatic ecosystems, J. Hazard. Mater., 282, 18, 10.1016/j.jhazmat.2014.06.062 · DOI
  169. Kelly, 2015, Antibiotic stewardship should consider environmental fate of antibiotics, Environ. Sci. Technol., 49, 5257, 10.1021/acs.est.5b01519 · DOI
  170. Flaherty, 2005, Effects of pharmaceuticals on Daphnia survival, growth, and reproduction, Chemosphere, 61, 200, 10.1016/j.chemosphere.2005.02.016 · DOI · Paper page
  171. Migliore, 1997, Toxicity of several important agricultural antibiotics to Artemia, Water Res., 31, 1801, 10.1016/S0043-1354(96)00412-5 · DOI
  172. Jung, 2008, Environmental levels of ultraviolet light potentiate the toxicity of sulfonamide antibiotics in Daphnia magna, Ecotoxicology, 17, 37, 10.1007/s10646-007-0174-9 · doi:10.1007/s10646-007-0174-9
  173. Liu, 2018, Progress of research on the toxicology of antibiotic pollution in aquatic organisms, Acta Ecol. Sin., 38, 36, 10.1016/j.chnaes.2018.01.006 · DOI · Paper page
  174. Wang, 2014, Toxicity evaluation of β-diketone antibiotics on the development of embryo-larval zebrafish (Danio rerio), Environ. Toxicol., 29, 1134, 10.1002/tox.21843 · DOI
  175. Lin, 2014, Integrated biomarker responses in zebrafish exposed to sulfonamides, Environ. Toxicol. Pharmacol., 38, 444, 10.1016/j.etap.2014.07.020 · DOI
  176. Wang, 2009, Adverse effects of enrofloxacin when associated with environmental stress in Tra catfish (Pangasianodon hypophthalmus), Chemosphere, 77, 1577, 10.1016/j.chemosphere.2009.09.038 · doi:10.1016/j.chemosphere.2009.09.038
  177. Zhang, 2015, Effects of tetracycline on developmental toxicity and molecular responses in zebrafish (Danio rerio) embryos, Ecotoxicology, 24, 707, 10.1007/s10646-015-1417-9 · DOI
  178. Xu, 2006, Residues of enrofloxacin, furazolidone and their metabolites in Nile tilapia (Oreochromis niloticus), Aquaculture, 254, 1, 10.1016/j.aquaculture.2005.10.030 · doi:10.1016/j.aquaculture.2005.10.030
  179. Zhang, 2016, Toxicity assessment of combined fluoroquinolone and tetracycline exposure in zebrafish (Danio rerio), Environ. Toxicol., 31, 736, 10.1002/tox.22087 · DOI
  180. Kim, 2017, Multigenerational Effects of the Antibiotic Tetracycline on Transcriptional Responses of Daphnia magna and Its Relationship to Higher Levels of Biological Organizations, Environ. Sci. Technol., 51, 12898, 10.1021/acs.est.7b05050 · DOI
  181. Raymann, 2018, The role of the gut microbiome in health and disease of adult honey bee workers, Curr. Opin. Insect Sci., 26, 97, 10.1016/j.cois.2018.02.012 · DOI · Paper page
  182. Turnbaugh, 2011, Human Health and Disease in a Microbial World, Front. Microbiol., 2, 190, 10.3389/fmicb.2011.00190 · DOI
  183. Langdon, 2016, The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation, Genome Med., 8, 39, 10.1186/s13073-016-0294-z · DOI · Paper page
  184. Ianiro, 2016, Antibiotics as deep modulators of gut microbiota: Between good and evil, Gut, 65, 1906, 10.1136/gutjnl-2016-312297 · DOI · Paper page
  185. Schmidt, 2016, Influence of Fishmeal-Free Diets on Microbial Communities in Atlantic Salmon (Salmo salar) Recirculation Aquaculture Systems, Appl. Environ. Microbiol., 82, 4470, 10.1128/AEM.00902-16 · DOI
  186. Schmidt, 2015, Community assembly of a euryhaline fish microbiome during salinity acclimation, Mol. Ecol., 24, 2537, 10.1111/mec.13177 · DOI
  187. Navarrete, 2008, Oxytetracycline treatment reduces bacterial diversity of intestinal microbiota of Atlantic salmon, J. Aquat. Anim. Health, 20, 177, 10.1577/H07-043.1 · DOI · Paper page
  188. Schmidt, 2017, Subtle Microbiome Manipulation Using Probiotics Reduces Antibiotic-Associated Mortality in Fish, MSystems, 2, e00133-17, 10.1128/mSystems.00133-17 · DOI
  189. Bielen, 2017, Negative environmental impacts of antibiotic-contaminated effluents from pharmaceutical industries, Water Res., 126, 79, 10.1016/j.watres.2017.09.019 · DOI · Paper page
  190. Carlson, 2017, Microbiome disruption and recovery in the fish Gambusia affinis following exposure to broad-spectrum antibiotic, Infect. Drug Resist., 10, 143, 10.2147/IDR.S129055 · DOI
  191. Pindling, 2018, Dysbiosis and early mortality in zebrafish larvae exposed to subclinical concentrations of streptomycin, FEMS Microbiol. Lett., 365, fny188, 10.1093/femsle/fny188 · DOI
  192. Yan, 2016, Long-term effects of antibiotics, norfloxacin, and sulfamethoxazole, in a partial life-cycle study with zebrafish (Danio rerio): Effects on growth, development, and reproduction, Environ. Sci. Pollut. Res., 23, 18222, 10.1007/s11356-016-7018-1 · DOI
  193. Adlard, 2015, The butterfly effect: Parasite diversity, environment, and emerging disease in aquatic wildlife, Trends Parasitol., 31, 160, 10.1016/j.pt.2014.11.001 · DOI
  194. Holloway, 2017, Antibiotic use in South East Asia and policies to promote appropriate use: Reports from country situational analyses, BMJ, 358, j2291, 10.1136/bmj.j2291 · DOI
  195. Ghafur, 2013, Chennai Declaration: A solution to the antibiotic resistance in developing countries, Indian J. Cancer, 50, 71, 10.4103/0019-509X.104065 · DOI
  196. Leonard, 2015, Human recreational exposure to antibiotic resistant bacteria in coastal bathing waters, Environ. Int., 82, 92, 10.1016/j.envint.2015.02.013 · DOI · Paper page
  197. Ashbolt, 2013, Human health risk assessment (HHRA) for environmental development and transfer of antibiotic resistance, Environ. Health Perspect., 121, 993, 10.1289/ehp.1206316 · DOI · Paper page

Cited by

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Metadata

Authors
Kraemer, S. A., Ramachandran, A., & Perron, G. G.
Affiliations
  • Department of Biology, Concordia University, 7141 Sherbrooke Street W, Montreal, QC H4B1R6, Canada
  • Department of Biology, Reem-Kayden Center for Sciences and Computation, Bard College, 31 Campus Road, Annandale-On-Hudson, NY 12504, USA
ORCID
Perron, Gabriel G.
Venue
Microorganisms
Publisher
MDPI AG
Published
2019-06-22
Volume
7
Issue
6
Pages
180
ISSN
2076-2607
DOI
10.3390/microorganisms7060180
Cited by
932
References
14
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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CoChat. (2026). Citation check: Antibiotic Pollution in the Environment: From Microbial Ecology to Public Policy. https://app.cochat.ai/papers/10.3390/microorganisms7060180
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Kraemer, S. A., Ramachandran, A., & Perron, G. G. (2019). Antibiotic Pollution in the Environment: From Microbial Ecology to Public Policy. Microorganisms. https://doi.org/10.3390/microorganisms7060180

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