Administration of Non-Absorbable Antibiotics to Pregnant Mice to Perturb the Maternal Gut Microbiota Is Associated with Alterations in Offspring Behavior
Open accessAbstract
There is increasing evidence that the gut microbiota plays a major role in host health and disease. In this study, we examined whether perturbation of the maternal gut microbiota during pregnancy, induced by administration of non-absorbable antibiotics to pregnant dams, influences the behavior of offspring. Terminal restriction fragment length polymorphism analyses of fecal bacterial composition showed that the relative abundance of the bacterial order Lactobacillales was lower in offspring born from antibiotic-treated dams (20.7 ± 3.4%) than in control offspring (42.1 ± 6.2%) at P24, while the relative abundance of the bacterial family Clostridium subcluster XIVa was higher in offspring born from antibiotic-treated dams (34.2 ± 5.0%) than in control offspring (16.4 ± 3.3%). Offspring born from antibiotic-treated dams exhibited low locomotor activity in both familiar and novel environments, and preferred to explore in the peripheral area of an unfamiliar field at postnatal week 4. At postnatal weeks 7-8, no difference was observed in the level of locomotor activity between control offspring and offspring from antibiotic-treated dams, while the tendency for the offspring from antibiotic-treated dams to be less engaged in exploring the inside area was still observed. The behavioral phenotypes of the offspring from antibiotic-treated dams at postnatal week 4 could be rescued to a considerable extent through fostering of these offspring by normal dams from postnatal day 1. Although the detailed underlying mechanisms are not fully elucidated, the present results suggest that administration of non-absorbable antibiotics to pregnant dams to perturb the maternal gut microbiota during pregnancy leads to alterations in the behavior of their offspring.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Non-absorbable antibiotics such as vancomycin, neomycin, and bacitracin knockdown the microbiota in the gut while not entering systemic circulation, thereby avoiding potential systemic and CNS effects.
“Non-absorbable antibiotics (i.e.vancomycin, neomycin, and bacitracin (Tochitani et al., 2016)) offer the advantage that they knockdown the microbiota in the gut while not entering systemic circulation, thereby avoiding any potential systemic and even central nervous system (CNS) effects”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Tochitani et al., 2016
Materials and Methods (Animals and non-absorbable AB treatment; page unavailable) says non-absorbable antibiotics concentrate in the gastrointestinal tract, perturb gut microbiota, and have limited serum concentrations. Its treatment contains neomycin and bacitracin, but not vancomycin. The passage suggests minimal collateral effects; it does not establish that the drugs never enter systemic circulation or avoid all potential systemic and CNS effects. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Metagenomic biomarker discovery and explanation
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192 · see citing works
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572 · see citing works
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251 · see citing works
Gut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182 · see citing works
The impact of the gut microbiota on human health: an integrative view
Clemente, J. C., Ursell, L. K., Parfrey, L. W., & Knight, R. (2012) · Cell · doi:10.1016/j.cell.2012.01.035 · Cited by 3,710 · see citing works
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283 · see citing works
Normal gut microbiota modulates brain development and behavior
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228 · see citing works
Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., & Meaney, M. J. (1997) · Science · doi:10.1126/science.277.5332.1659 · Cited by 3,170 · see citing works
Human Genetics Shape the Gut Microbiome
Goodrich, J. K., Waters, J. L., Poole, A. C., Sutter, J. L., Koren, O., Blekhman, R., Beaumont, M., Van Treuren, W., Knight, R., Bell, J. T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.053 · Cited by 3,164 · see citing works
Waste Not, Want Not: Why Rarefying Microbiome Data Is Inadmissible
McMurdie, P. J., & Holmes, S. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003531 · Cited by 2,894 · see citing works
Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735 · see citing works
The gut microbiota influences blood-brain barrier permeability in mice
Braniste, V., Al-Asmakh, M., Kowal, C., Anuar, F., Abbaspour, A., Tóth, M., Korecka, A., Bakocevic, N., Ng, L. G., Kundu, P., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009759 · Cited by 2,530 · see citing works
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
Yoshimoto, S., Loo, T. M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., et al. (2013) · Nature · doi:10.1038/nature12347 · Cited by 2,219 · see citing works
The cell biology of neurogenesis
Götz, M., & Huttner, W. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1739 · Cited by 2,130 · see citing works
Epidemiology of Pervasive Developmental Disorders
Fombonne, E. (2009) · Pediatric Research · doi:10.1203/pdr.0b013e31819e7203 · Cited by 1,971 · see citing works
Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.052 · Cited by 1,748 · see citing works
Bacteria as vitamin suppliers to their host: A gut microbiota perspective
LeBlanc, J. G., Milani, C., de Giori, G. S., Sesma, F., van Sinderen, D., & Ventura, M. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2012.08.005 · Cited by 1,613 · see citing works
Takahashi, S., Tomita, J., Nishioka, K., Hisada, T., & Nishijima, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105592 · Cited by 1,514 · see citing works
Control of brain development, function, and behavior by the microbiome
Sampson, T. R., & Mazmanian, S. K. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.011 · Cited by 1,093 · see citing works
Microbiota and neurodevelopmental windows: implications for brain disorders
Borre, Y. E., O’Keeffe, G. W., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.05.002 · Cited by 1,089 · see citing works
Nutrition and brain development in early life
Prado, E. L., & Dewey, K. G. (2014) · Nutrition Reviews · doi:10.1111/nure.12102 · Cited by 1,036 · see citing works
Microbiota is essential for social development in the mouse
Desbonnet, L., Clarke, G., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.65 · Cited by 866 · see citing works
Cicchetti, D., & Toth, S. L. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.144029 · Cited by 861 · see citing works
Gut microbiota depletion from early adolescence in mice: implications for brain and behaviour
Desbonnet, L., Clarke, G., Traplin, A., O’Sullivan, O., Crispie, F., Moloney, R. D., Cotter, P. D., Dinan, T. G., & Cryan, J. F. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.04.004 · Cited by 760 · see citing works
The environment and susceptibility to schizophrenia
Brown, A. S. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.09.003 · Cited by 664 · see citing works
Jacquemont, S., Coe, B. P., Hersch, M., Duyzend, M. H., Krumm, N., Bergmann, S., Beckmann, J. S., Rosenfeld, J. A., & Eichler, E. E. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.02.001 · Cited by 605 · see citing works
Specialized metabolites from the microbiome in health and disease
Sharon, G., Garg, N., Debelius, J., Knight, R., Dorrestein, P. C., & Mazmanian, S. K. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.10.016 · Cited by 544 · see citing works
Microbiota and host determinants of behavioural phenotype in maternally separated mice
De Palma, G., Blennerhassett, P., Lu, J., Deng, Y., Park, A. J., Green, W., Denou, E., Silva, M. A., Santacruz, A., Sanz, Y., et al. (2015) · Nature Communications · doi:10.1038/ncomms8735 · Cited by 517 · see citing works
Diet and the development of the human intestinal microbiome
Voreades, N., Kozil, A., & Weir, T. L. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00494 · Cited by 495 · see citing works
Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice
Verdú, E. F., Bercik, P., Verma-Gandhu, M., Huang, X.-X., Blennerhassett, P., Jackson, W., Mao, Y., Wang, L., Rochat, F., & Collins, S. M. (2006) · Gut · doi:10.1136/gut.2005.066100 · Cited by 448 · see citing works
Behavioral phenotyping strategies for mutant mice
Crawley, J. N. (2008) · Neuron · doi:10.1016/j.neuron.2008.03.001 · Cited by 439 · see citing works
Ivy, A. S., Rex, C. S., Chen, Y., Dubé, C., Maras, P. M., Grigoriadis, D. E., Gall, C. M., Lynch, G., & Baram, T. Z. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1784-10.2010 · Cited by 402 · see citing works
The Impact of Microbiota on Brain and Behavior: Mechanisms & Therapeutic Potential
Borre, Y. E., Moloney, R. D., Clarke, G., Dinan, T. G., & Cryan, J. F. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_17 · Cited by 329 · see citing works
Fujimoto, T., Imaeda, H., Takahashi, K., Kasumi, E., Bamba, S., Fujiyama, Y., & Andoh, A. (2013) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12073 · Cited by 304 · see citing works
Development of the preterm infant gut microbiome: a research priority
Groer, M. W., Luciano, A. A., Dishaw, L. J., Ashmeade, T. L., Miller, E. M., & Gilbert, J. A. (2014) · Microbiome · doi:10.1186/2049-2618-2-38 · Cited by 285 · see citing works
Jacka, F. N., Ystrøm, E., Brantsæter, A. L., Karevold, E., Roth, C., Haugen, M. A., Meltzer, H. M., Schjølberg, S., & Berk, M. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.07.002 · Cited by 284 · see citing works
Delahaye, F., Breton, C., Risold, P., Enache, M., Dutriez-Casteloot, I., Laborie, C., Lésage, J., & Vieau, D. (2007) · Endocrinology · doi:10.1210/en.2007-1263 · Cited by 266 · see citing works
Wang, T., Hu, X., Liang, S., Li, W., Wu, X., Wang, L., & Jin, F. (2015) · Beneficial Microbes · doi:10.3920/bm2014.0177 · Cited by 233 · see citing works
Nagashima, K., Hisada, T., Sato, M., & Mochizuki, J. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.2.1251-1262.2003 · Cited by 233 · see citing works
Collins, S. M., Kassam, Z., & Berčík, P. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.06.004 · Cited by 206 · see citing works
Genetic dissection of mouse exploratory behaviour
Crusio, W. E. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00280-7 · Cited by 201 · see citing works
Bhatia, H. S., Agrawal, R., Sharma, S., Huo, Y., Ying, Z., & Gómez‐Pinilla, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028451 · Cited by 170 · see citing works
Ghosh, S. S., Bie, J., Wang, J., & Ghosh, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108577 · Cited by 162 · see citing works
Léonhardt, M., Lésage, J., Croix, D., Dutriez-Casteloot, I., Beauvillain, J. C., & Dupouy, J. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.102.003269 · Cited by 150 · see citing works
Jašarević, E., Rodgers, A. B., & Bale, T. L. (2014) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.10.005 · Cited by 147 · see citing works
Zhu, Q., Zou, L., Jagavelu, K., Simonetto, D. A., Huebert, R. C., Jiang, Z.-D., DuPont, H. L., & Shah, V. H. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.11.013 · Cited by 144 · see citing works
Relational interventions for child maltreatment: Past, present and future perspectives
Toth, S. L., Gravener-Davis, J. A., Guild, D. J., & Cicchetti, D. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000795 · Cited by 124 · see citing works
Blaze, J., Scheuing, L., & Roth, T. L. (2013) · Developmental Neuroscience · doi:10.1159/000350716 · Cited by 123 · see citing works
HPA axis programming by maternal undernutrition in the male rat offspring
Vieau, D., Sebaai, N., Léonhardt, M., Dutriez-Casteloot, I., Molendi‐Coste, O., Laborie, C., Breton, C., DELOOF, S., & Lésage, J. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.03.014 · Cited by 117 · see citing works
AMPAKINE enhancement of social interaction in the BTBR mouse model of autism
Silverman, J. L., Oliver, C. F., Karras, M. N., Gastrell, P. T., & Crawley, J. N. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.07.013 · Cited by 112 · see citing works
Lopatina, O. L., Yoshihara, T., Nishimura, T., Zhong, J., Akther, S., Fakhrul, A. A. K. M., Liang, M., Higashida, C., Sumi, K., Furuhara, K., et al. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00133 · Cited by 106 · see citing works
Nagashima, K., Mochizuki, J., Hisada, T., Suzuki, S., & Shimomura, K. (2006) · Bioscience and Microflora · doi:10.12938/bifidus.25.99 · Cited by 104 · see citing works
Shiozaki, A., Yoneda, S., Yoneda, N., Yonezawa, R., Matsubayashi, T., Seo, G., & Saito, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111374 · Cited by 97 · see citing works
Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation
Tochitani, S., & Hayashizaki, Y. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.05.127 · Cited by 86 · see citing works
Self-citationIshikawa, H., Takaki, A., Tsuzaki, R., Yasunaka, T., KOIKE, K. A., Shimomura, Y., Seki, H., Matsushita, H., Miyake, Y., Ikeda, F., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100627 · Cited by 83 · see citing works
Unno, T., Hisada, T., & Takahashi, S. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b02649 · Cited by 74 · see citing works
Tanigawa, T., Watanabe, T., Otani, K., Nadatani, Y., Ohkawa, F., Sogawa, M., Yamagami, H., Shiba, M., Watanabe, K., Tominaga, K., et al. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.02.010 · Cited by 54 · see citing works
Hinde, K., & Lewis, Z. T. (2015) · Science · doi:10.1126/science.aac7436 · Cited by 52 · see citing works
Milk bioactives may manipulate microbes to mediate parent-offspring conflict
Allen‐Blevins, C. R., Sela, D. A., & Hinde, K. (2015) · Evolution Medicine and Public Health · doi:10.1093/emph/eov007 · Cited by 52 · see citing works
Tousen, Y., Abe, F., Ishida, T., Uehara, M., & Ishimi, Y. (2011) · Metabolism · doi:10.1016/j.metabol.2011.02.009 · Cited by 52 · see citing works
Influence of Maternal Bifidobacteria on the Development of Gut Bifidobacteria in Infants
Mikami, K., Kimura, M., & Takahashi, H. (2012) · Pharmaceuticals · doi:10.3390/ph5060629 · Cited by 42 · see citing works
Wattez, J.-S., Delahaye, F., Barella, L. F., Dickès-Coopman, A., Montel, V., Breton, C., Mathias, P. C. D. F., Foligné, B., Lésage, J., & Vieau, D. (2014) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174413000548 · Cited by 33 · see citing works
Yoda, K., He, F., Miyazawa, K., Kawase, M., Kubota, A., & Hiramatsu, M. (2012) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2012.05316.x · Cited by 33 · see citing works
Aomatsu, T., Imaeda, H., Fujimoto, T., Takahashi, K., Yoden, A., Tamai, H., Fujiyama, Y., & Andoh, A. (2012) · Digestion · doi:10.1159/000339777 · Cited by 28 · see citing works
Trujillo, V., Durando, P. E., & Suárez, M. M. (2015) · Stress · doi:10.3109/10253890.2015.1105958 · Cited by 26 · see citing works
Imaeda, H., Fujimoto, T., Takahashi, K., Kasumi, E., Fujiyama, Y., & Andoh, A. (2012) · Digestion · doi:10.1159/000341508 · Cited by 20 · see citing works
Oda, Y., Ueda, F., Kamei, A., Kakinuma, C., & Abe, K. (2010) · BioFactors · doi:10.1002/biof.132 · Cited by 17 · see citing works
Kohata, Y., Nakahara, K., Tanigawa, T., Yamagami, H., Shiba, M., Watanabe, T., Tominaga, K., Fujiwara, Y., & Arakawa, T. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3662-4 · Cited by 16 · see citing works
Tochitani, S., Sakata‐Haga, H., & Fukui, Y. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.01.071 · Cited by 15 · see citing works
Self-citationMiyazawa, K., Yoda, K., Kawase, M., Harata, G., & He, F. (2015) · Microbiology and Immunology · doi:10.1111/1348-0421.12226 · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [32]Desbonnet L, Clarke G, Traplin A, O'Sullivan O, Crispie F, Moloney RD, et al Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour. Brain, behavior, and immunity. 2015; 48: 165– 73. Epub 2015/04/14. 10.1016/j.bbi.2015.04.004. 25866195 · DOI · Paper page
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
Silva, Y. P., Bernardi, A., & Frozza, R. L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00025 · Cited by 3,043 · see citing works
“In a similar way, growing evidence has shown that alterations in maternal microbiome during pregnancy, such as use of antibiotics or probiotics (41, 42), variations in diet (43), immune activation (44, 45), and exposure to stress (46) can modulate the microbiome, neurodevelopment, and behavior of offspring in both rod…”
BackgroundThe central nervous system and the gut microbiome
Sharon, G., Sampson, T. R., Geschwind, D. H., & Mazmanian, S. K. (2016) · Cell · doi:10.1016/j.cell.2016.10.027 · Cited by 1,513 · see citing works
Microbial Changes during Pregnancy, Birth, and Infancy
Nuriel‐Ohayon, M., Neuman, H., & Koren, O. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01031 · Cited by 624 · see citing works
Zhu, F., Guo, R., Wang, W., Ju, Y., Wang, Q., Ma, Q., Sun, Q., Fan, Y., Xie, Y., Yang, Z., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0475-4 · Cited by 323 · see citing works
The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective
Cussotto, S., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.04.002 · Cited by 326 · see citing works
“31 anxiety-like behaviour thus suggesting that disruption of maternal gut microbiota during pregnancy may lead to alterations in the behaviour of their offspring (Tochitani et al., 2016).”
BackgroundSherwin, E., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2016) · CNS Drugs · doi:10.1007/s40263-016-0370-3 · Cited by 297 · see citing works
Nogacka, A. M., Salazar, N., Suárez, M., Milani, C., Arboleya, S., Sánchez, G. S., Fernández, N., Alaez, L., Hernández‐Barranco, A. M., Reyes‐Gavilán, C. G. D. L., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0313-3 · Cited by 233 · see citing works
The Gut-Brain Axis, BDNF, NMDA and CNS Disorders
Maqsood, R., & Stone, T. W. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2039-1 · Cited by 223 · see citing works
You’ve got male: Sex and the microbiota-gut-brain axis across the lifespan
Jaggar, M., Rea, K., Spichak, S., Dinan, T. G., & Cryan, J. F. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100815 · Cited by 200 · see citing works
Programming Bugs: Microbiota and the Developmental Origins of Brain Health and Disease
Codagnone, M. G., Spichak, S., O’Mahony, S. M., O’Leary, O. F., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.06.014 · Cited by 198 · see citing works
Heijtz, R. D. (2016) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2016.04.012 · Cited by 193 · see citing works
Dahiya, D., & Nigam, P. S. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043074 · Cited by 193 · see citing works
The contribution of the gut microbiome to neurodevelopment and neuropsychiatric disorders
Warner, B. B. (2018) · Pediatric Research · doi:10.1038/s41390-018-0191-9 · Cited by 168 · see citing works
Gut microbiota: a potential regulator of neurodevelopment
Tognini, P. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00025 · Cited by 163 · see citing works
A gut feeling: Microbiome-brain-immune interactions modulate social and affective behaviors
Sylvia, K. E., & Demas, G. E. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.02.001 · Cited by 151 · see citing works
Gut-Brain-Microbiota Axis: Antibiotics and Functional Gastrointestinal Disorders
Karakan, T., Özkul, C., Akkol, E. K., Bilici, S., Sobarzo‐Sánchez, E., & Capasso, R. (2021) · Nutrients · doi:10.3390/nu13020389 · Cited by 155 · see citing works
Structural diversity, functional aspects and future therapeutic applications of human gut microbiome
Ghosh, S., & Pramanik, S. (2021) · Archives of Microbiology · doi:10.1007/s00203-021-02516-y · Cited by 151 · see citing works
Paternal microbiome perturbations impact offspring fitness
Argaw-Denboba, A., Schmidt, T., Giacomo, M. D., Ranjan, B., Devendran, S., Mastrorilli, E., Lloyd, C. T., Pugliese, D., Paribeni, V., Dabin, J., et al. (2024) · Nature · doi:10.1038/s41586-024-07336-w · Cited by 151 · see citing works
Microbiota–neuroepithelial signalling across the gut–brain axis
Ohara, T. E., & Hsiao, E. Y. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01136-9 · Cited by 147 · see citing works
Microbiota‐gut‐brain axis as a regulator of reward processes
García‐Cabrerizo, R., Carbia, C., O’Riordan, K. J., Schellekens, H., & Cryan, J. F. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15284 · Cited by 147 · see citing works
Intestinal Dysbiosis Secondary to Proton-Pump Inhibitor Use
Naito, Y., Kashiwagi, K., Takagi, T., Andoh, A., & Inoüe, R. (2018) · Digestion · doi:10.1159/000481813 · Cited by 109 · see citing works
Degroote, S., Hunting, D. J., Baccarelli, A. A., & Takser, L. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.06.010 · Cited by 106 · see citing works
Early microbiota, antibiotics and health
Nogacka, A. M., Salazar, N., Arboleya, S., Suárez, M., Fernández, N., Sánchez, G. S., Reyes‐Gavilán, C. G. D. L., & Gueimonde, M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2670-2 · Cited by 99 · see citing works
Gut microbiota and Autism Spectrum Disorder: From pathogenesis to potential therapeutic perspectives
Mehra, A., Arora, G., Sahni, G., Kaur, M., Singh, H. B., Singh, B., & Kaur, S. (2022) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2022.03.001 · Cited by 106 · see citing works
Targeting the gut microbiota to influence brain development and function in early life
Wang, S., Harvey, L., Martı́n, R., van der Beek, E. M., Knol, J., Cryan, J. F., & Renes, I. B. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.002 · Cited by 92 · see citing works
Vaudin, P., Augé‐Gouillou, C., Just, N., Mhaouty‐Kodja, S., Mortaud, S., & Pillon, D. (2021) · Environmental Research · doi:10.1016/j.envres.2021.112495 · Cited by 95 · see citing works
Lydholm, C. N., Köhler‐Forsberg, O., Nordentoft, M., Yolken, R. H., Mortensen, P. B., Petersen, L. V., & Benros, M. E. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.09.013 · Cited by 80 · see citing works
Karmon, G., Sragovich, S., Hacohen-Kleiman, G., Ben-Horin-Hazak, I., Kašpárek, P., Schuster, B., Sedláček, R., Pasmanik‐Chor, M., Theotokis, P., Touloumi, O., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.09.018 · Cited by 75 · see citing works
Establishment of the early-life microbiome: a DOHaD perspective
Stinson, L. F. (2019) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174419000588 · Cited by 77 · see citing works
Staude, B., Oehmke, F., Lauer, T., Behnke, J., Göpel, W., Schloter, M., Schulz, H., Krauss‐Etschmann, S., & Ehrhardt, H. (2018) · BioMed Research International · doi:10.1155/2018/7218187 · Cited by 75 · see citing works
Microbiota and Neurodevelopmental Trajectories: Role of Maternal and Early-Life Nutrition
Codagnone, M. G., Stanton, C., O’Mahony, S. M., Dinan, T. G., & Cryan, J. F. (2019) · Annals of Nutrition and Metabolism · doi:10.1159/000499144 · Cited by 73 · see citing works
Antibiotics and the nervous system: More than just the microbes?
Champagne-Jorgensen, K., Kunze, W. A., Forsythe, P., Bienenstock, J., & McVey Neufeld, K.-A. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.12.014 · Cited by 92 · see citing works
Prescott, S., & Logan, A. (2016) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph13111075 · Cited by 63 · see citing works
Factors Affecting the Immunity to Respiratory Syncytial Virus: From Epigenetics to Microbiome
Fonseca, W., Lukacs, N. W., & Ptaschinski, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00226 · Cited by 63 · see citing works
Needham, B. D., Tang, W., & Wu, W. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22581 · Cited by 59 · see citing works
Wang, H., Ji, Y., Yin, C., Deng, M., Tang, T., Deng, B., Ren, W., Deng, J., Yin, Y., & Tan, C. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01665 · Cited by 59 · see citing works
A Revolutionizing Approach to Autism Spectrum Disorder Using the Microbiome
Johnson, D., Letchumanan, V., Thurairajasingam, S., & Lee, L. (2020) · Nutrients · doi:10.3390/nu12071983 · Cited by 64 · see citing works
Qiu, W., Fang, M., Magnuson, J. T., Greer, J. B., Chen, Q., Zheng, Y., Xiong, Y., Luo, S., Zheng, C., & Schlenk, D. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.123009 · Cited by 52 · see citing works
Eshraghi, R. S., Davies, C., Iyengar, R., Perez, L., Mittal, R., & Eshraghi, A. A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm10010027 · Cited by 57 · see citing works
Lebovitz, Y., Kowalski, E., Wang, X., Kelly, C., Lee, M., McDonald, V., Ward, R., Creasey, M., Mills, W. A., Basso, E. K. G., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.07.025 · Cited by 53 · see citing works
O’Connor, R., Moloney, G. M., Fülling, C., O’Riordan, K. J., Fitzgerald, P., Bastiaanssen, T. F. S., Schellekens, H., Dinan, T. G., & Cryan, J. F. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113156 · Cited by 50 · see citing works
Morel, C., Sánchez, I. M., Cherifi, Y., Chartrel, N., & Heijtz, R. D. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109479 · Cited by 42 · see citing works
Gestational Insulin Resistance Is Mediated by the Gut Microbiome–Indoleamine 2,3-Dioxygenase Axis
Priyadarshini, M., Navarro, G., Reiman, D. J., Sharma, A., Xu, K., Lednovich, K., Manzella, C. R., Khan, M. W., Garcia, M. S., Allard, S. M., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.01.008 · Cited by 42 · see citing works
Wu, J.-T., Sun, C.-L., Lai, T.-T., Liou, C.-W., Lin, Y.-Y., Xue, J.-Y., Wang, H.-W., Chai, L. M. X., Lee, Y.-J., Chen, S., et al. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109140 · Cited by 42 · see citing works
Inflammation in Mental Disorders: Is the Microbiota the Missing Link?
Marin, S., Hé, Y., Butler, K., & Tsuang, M. T. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00535-1 · Cited by 41 · see citing works
Wilczyńska, P., Skarżyńska, E., & Lisowska‐Myjak, B. (2017) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2017.1387888 · Cited by 40 · see citing works
Antibiotics Treatment Modulates Microglia–Synapses Interaction
Cordella, F., Sanchini, C., Rosito, M., Ferrucci, L., Pediconi, N., Cortese, B., Guerrieri, F., Pascucci, G. R., Antonangeli, F., Peruzzi, G., et al. (2021) · Cells · doi:10.3390/cells10102648 · Cited by 38 · see citing works
van Wattum, J. J., Leferink, T. M., Wilffert, B., & ter Horst, P. G. J. (2018) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13098 · Cited by 39 · see citing works
The role of microbiota in autism spectrum disorders
Campion, D., Ponzo, P., Alessandria, C., Saracco, G. M., & Balzola, F. A. (2018) · Minerva Gastroenterologica e Dietologica · doi:10.23736/s1121-421x.18.02493-5 · Cited by 40 · see citing works
Hebert, J. C., Radford‐Smith, D. E., Probert, F., Ilott, N. E., Chan, K. W., Anthony, D. C., & Burnet, P. W. J. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.09.034 · Cited by 37 · see citing works
Chen, Y., Fang, H., Li, C., Wu, G. G., Xu, T., Yang, X., Zhao, L., Ke, X., & Zhang, C. (2020) · mSphere · doi:10.1128/msphere.01044-20 · Cited by 38 · see citing works
Hayer, S. S., Hwang, S., & Clayton, J. B. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1237177 · Cited by 36 · see citing works
Forssten, S. D., Ouwehand, A. C., Griffin, S. M., & Patterson, E. (2022) · Nutrients · doi:10.3390/nu14030568 · Cited by 39 · see citing works
The call of the wild: using non-model systems to investigate microbiome–behaviour relationships
Cusick, J. A., Wellman, C. L., & Demas, G. E. (2021) · Journal of Experimental Biology · doi:10.1242/jeb.224485 · Cited by 34 · see citing works
Taurine: A Maternally Derived Nutrient Linking Mother and Offspring
Tochitani, S. (2022) · Metabolites · doi:10.3390/metabo12030228 · Cited by 36 · see citing works
Self-citationAntibiotic Driven Changes in Gut Motility Suggest Direct Modulation of Enteric Nervous System
Delungahawatta, T., Amin, J. Y., Stanisz, A. M., Bienenstock, J., Forsythe, P., & Kunze, W. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00588 · Cited by 32 · see citing works
Impact of the Age of Cecal Material Transfer Donors on Alzheimer’s Disease Pathology in 5xFAD Mice
Valeri, F., Guilherme, M. D. S., He, F., Stoye, N. M., Schwiertz, A., & Endres, K. (2021) · Microorganisms · doi:10.3390/microorganisms9122548 · Cited by 32 · see citing works
Hassib, L., de Oliveira, C. L., Rouvier, G. A., Kanashiro, A., Guimarães, F. S., & Ferreira, F. R. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2226282 · Cited by 33 · see citing works
Hamad, A. F., Alessi‐Severini, S., Mahmud, S. M., Brownell, M. D., & Kuo, I. F. (2019) · American Journal of Epidemiology · doi:10.1093/aje/kwz178 · Cited by 31 · see citing works
Hamad, A. F., Alessi‐Severini, S., Mahmud, S. M., Brownell, M. D., & Kuo, I. F. (2020) · Canadian Medical Association Journal · doi:10.1503/cmaj.190883 · Cited by 30 · see citing works
Tochitani, S. (2020) · Neuroscience Research · doi:10.1016/j.neures.2020.11.006 · Cited by 30 · see citing works
Self-citationLucerne, K. E., Osman, A., Meckel, K. R., & Kiraly, D. D. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108598 · Cited by 26 · see citing works
Pochakom, A., Mu, C., Rho, J. M., Tompkins, T. A., Mayengbam, S., & Shearer, J. (2022) · Brain Sciences · doi:10.3390/brainsci12060781 · Cited by 30 · see citing works
Infections, antibiotic treatment and the Microbiome in relation to schizophrenia
Klein‐Petersen, A. W., Köhler‐Forsberg, O., & Benros, M. E. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.11.033 · Cited by 26 · see citing works
Diamanti, T., Prete, R., Battista, N., Corsetti, A., & Jaco, A. D. (2022) · Antibiotics · doi:10.3390/antibiotics11121767 · Cited by 27 · see citing works
Characterization of Early Life Stress-Affected Gut Microbiota
Usui, N., Matsuzaki, H., & Shimada, S. (2021) · Brain Sciences · doi:10.3390/brainsci11070913 · Cited by 24 · see citing works
Self-citationExposure to antibiotics during pregnancy alters offspring outcomes
Qu, W., Liu, L., & Miao, L. (2021) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2021.1974000 · Cited by 24 · see citing works
Lebovitz, Y., Ringel-Scaia, V. M., Allen, I. C., & Theus, M. H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01993 · Cited by 24 · see citing works
Radford‐Smith, D. E., & Anthony, D. C. (2023) · Metabolites · doi:10.3390/metabo13030455 · Cited by 22 · see citing works
The microbiome as a modulator of neurological health across the maternal-offspring interface
Orchanian, S. B., & Hsiao, E. Y. (2025) · Journal of Clinical Investigation · doi:10.1172/jci184314 · Cited by 22 · see citing works
Kitano, T., Takagi, K., Arai, I., Yasuhara, H., Ebisu, R., Ohgitani, A., Kitagawa, D., Oka, M., Masuo, K., & Minowa, H. (2019) · Journal of Infection and Chemotherapy · doi:10.1016/j.jiac.2019.04.012 · Cited by 21 · see citing works
Tochitani, S., Maehara, Y., Kawase, T., Tsukahara, T., Shimizu, R., Watanabe, T., Maehara, K., Asaoka, K., & Matsuzaki, H. (2021) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.21-96 · Cited by 19 · see citing works
Self-citationRoles of the gut microbiota in human neurodevelopment and adult brain disorders
Mallick, R., Basak, S., Das, R. K., Banerjee, A., Paul, S., Pathak, S., & Duttaroy, A. K. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1446700 · Cited by 51 · see citing works
Early-Life Microbiota Perturbations and Behavioral Effects
Oladipo, A. F., & Domínguez-Bello, M. G. (2019) · Trends in Microbiology · doi:10.1016/j.tim.2019.04.004 · Cited by 18 · see citing works
Otten, K., Keller, L., Puiu, A. A., Herpertz‐Dahlmann, B., Seitz, J., Kohn, N., Edgar, J. C., Wagels, L., & Konrad, K. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104776 · Cited by 17 · see citing works
Hua, H., Huang, L., Yang, B., Jiang, S., Zhang, Y., Liu, J., Yan, C., & Xu, J. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114798 · Cited by 17 · see citing works
Hunter, S., Flaten, E., Petersen, C., Gervain, J., Werker, J. F., Trainor, L. J., & Finlay, B. B. (2023) · PLoS ONE · doi:10.1371/journal.pone.0288689 · Cited by 19 · see citing works
Yan, C., Liu, Z., Xie, W., Zhang, T., Zhang, J., Li, G., Xu, X., Ye, L., & Gong, J. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114672 · Cited by 18 · see citing works
More than just a number: the gut microbiota and brain function across the extremes of life
Nuzum, N. D., Deady, C., Kittel‐Schneider, S., Cryan, J. F., O’Mahony, S. M., & Clarke, G. A. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2418988 · Cited by 20 · see citing works
Intrauterine antibiotic exposure affected neonatal gut bacteria and infant growth speed
Zhou, Y., Ma, W., Zeng, Y., Yan, C., Zhao, Y., Wang, P., Shi, H., Lu, W., & Zhang, Y. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.117901 · Cited by 18 · see citing works
The Role of Gut Microbiota in the High-Risk Construct of Severe Mental Disorders: A Mini Review
Sani, G., Manchia, M., Simonetti, A., Janiri, D., Paribello, P., Pinna, F., & Carpiniello, B. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.585769 · Cited by 18 · see citing works
Mahalakshmi, A. M., Ray, B., Tuladhar, S., Hediyal, T. A., Raj, P., Rathipriya, A. G., Qoronfleh, M. W., Essa, M. M., & Chidambaram, S. B. (2021) · Cells · doi:10.3390/cells10123405 · Cited by 16 · see citing works
Cusick, J. A., Wellman, C. L., & Demas, G. E. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2022.105146 · Cited by 16 · see citing works
LaGamma, E. F., Hu, F., Cruz, F. P., Bouchev, P., & Nankova, B. B. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100376 · Cited by 16 · see citing works
Xie, M.-J., Iwata, K., Ishikawa, Y., Nomura, Y., Tani, T., Murata, K., Fukazawa, Y., & Matsuzaki, H. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.748627 · Cited by 16 · see citing works
Self-citationWei, J., Liu, C., Qin, D., Ren, F., Duan, J., Chen, T., & Wu, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102544 · Cited by 15 · see citing works
Ji, C., Luo, Y., Yang, J., Dai, Y., Miao, J., Yue, S., & Zhao, M. (2022) · Journal of Environmental Sciences · doi:10.1016/j.jes.2022.06.028 · Cited by 15 · see citing works
Greenberg, J. M., Romero, R. J., Winters, A. D., Galaz, J., Garcia‐Flores, V., Arenas‐Hernandez, M., Panzer, J. J., Shaffer, Z., Kracht, D. J., Gomez‐Lopez, N., et al. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.01286-22 · Cited by 16 · see citing works
Faas, M. M., Liu, Y., Wekema, L., Weiss, G. A., Bouwman, C. A., & Silva, L. (2023) · Nutrients · doi:10.3390/nu15122723 · Cited by 15 · see citing works
Intestinal dysbiosis during pregnancy and microbiota-associated impairments in offspring
Abu, Y. F., & Roy, S. (2025) · Frontiers in Microbiomes · doi:10.3389/frmbi.2025.1548650 · Cited by 18 · see citing works
Oral antibiotics reduce voluntary exercise behavior in athletic mice
McNamara, M. P., Cadney, M. D., Castro, A. A., Hillis, D. A., Kallini, K. M., Macbeth, J. C., Schmill, M. P., Schwartz, N. E., Hsiao, A., & Garland, T. (2022) · Behavioural Processes · doi:10.1016/j.beproc.2022.104650 · Cited by 15 · see citing works
Castillo‐Ruiz, A., Gars, A., Sturgeon, H., Ronczkowski, N. M., Pyaram, D. N., Dauriat, C. J. G., Chassaing, B., & Forger, N. G. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1130347 · Cited by 14 · see citing works
Tochitani, S., Furukawa, T., Bando, R., Kondo, S., Ito, T., Matsushima, Y., Kojima, T., Matsuzaki, H., & Fukuda, A. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab106 · Cited by 14 · see citing works
Self-citationMicrobial colonization history modulates anxiety-like and complex social behavior in mice
Kamimura, I., Kaneko, R., Morita, H., Mogi, K., & Kikusui, T. (2020) · Neuroscience Research · doi:10.1016/j.neures.2020.01.001 · Cited by 13 · see citing works
Early-life gut microbiota assembly patterns are conserved between laboratory and wild mice
Hanski, E., Raulo, A., & Knowles, S. C. L. (2024) · Communications Biology · doi:10.1038/s42003-024-07039-y · Cited by 12 · see citing works
Antibiotics-induced dysbiosis impacts dendritic morphology of adult mouse cortical interneurons
Nakhal, M. M., Mydeen, A. B., Yassin, L. K., Almazrouei, R., Alkamali, R., Alsulaimi, M., Elsaleh, R. I., BaniYas, S., Houqani, S. A., Al-Marzooq, F. I., et al. (2025) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2025.1557961 · Cited by 12 · see citing works
Synergism of Diet, Genetics, and Microbiome on Health
Das, P., Banka, R., Ghosh, J., Singh, K., Choudhury, S. R., & Koner, S. (2024) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/979-8-3693-5528-2.ch006 · Cited by 11 · see citing works
Li, K., Hu, Z., Ou, J., & Xia, K. (2019) · Global Clinical and Translational Research · doi:10.36316/gcatr.01.0006 · Cited by 11 · see citing works
Lin, C., Chen, Y., Tsai, T., & Pan, T. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7868-y · Cited by 11 · see citing works
- Authors
- Tochitani, S., Ikeno, T., Ito, T., Sakurai, A., Yamauchi, T., & Matsuzaki, H.
- Affiliations
- Kanazawa University (JP)
- University of Fukui (JP)
- Corresponding author
- Tochitani, Shiro
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2016-01-20
- Volume
- 11
- Issue
- 1
- Pages
- e0138293
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4720425
- OpenAlex
- W2285618695
- Cited by
- 157
- References
- 71
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 16 · 2023: 14 · 2022: 19 · 2021: 23 · 2020: 13 · 2019: 15 · 2018: 19 · 2017: 6 · 2016: 8
- FWCI
- 8.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- University of Fukui
- Yakult Bio-Science Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- maternal gut microbiota, non-absorbable antibiotics, offspring behavior, Lactobacillales, Clostridium XIVa, locomotor activity, exploratory behavior, postnatal development, foster rearing
- MeSH terms
- Gastrointestinal Microbiome, Animals, Animals, Newborn, Anti-Bacterial Agents, Behavior, Animal, Feces, Female, Motor Activity, Pregnancy, Mice, Gastrointestinal Absorption
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
