Cited by 419Gut microbiota and healthBariatric Surgery and OutcomesAdipokines, Inflammation, and Metabolic Diseases

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Gut microbiota after gastric bypass in human obesity: increased richness and associations of bacterial genera with adipose tissue genes

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Kong, Ling-Chun, Tap, Julien, Aron-Wisnewsky, Judith, Pelloux, Veronique, Basdevant, Arnaud, Bouillot, Jean-Luc, Zucker, Jean-Daniel, Doré, Joël, Clément, Karine·2013·The American Journal of Clinical Nutrition

DOI 10.3945/ajcn.113.058743

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Abstract

Background Roux-en-Y gastric bypass (RYGB) surgery is one of the most efficient procedures for treating morbid obesity and results in weight-loss and improvements in metabolism and inflammation.Objective We examined the impact of RYGB on modifications of gut microbiota and its potential associations with changes in gene expression in white adipose tissue (WAT).Design Gut microbiota were profiled from fecal samples by using pyrosequencing in morbidly obese individuals, explored before (0 mo), 3 mo after, and 6 mo after RYGB. WAT gene expression was studied at 0 and 3 mo. We explored associations between microbial genera and differentially expressed genes in WAT and clinical markers.Results The richness of gut microbiota increased after RYGB; 37% of increased bacteria belonged to Proteobacteria. The associations between gut microbiota composition and WAT gene expression increased after RYGB. Fourteen discriminant bacterial genera (7 were dominant and 7 were subdominant) and 202 WAT genes changed after RYGB. Variations in bacterial genera correlated with changes in both clinical phenotype and adipose tissue gene expression. Some genes encode metabolic and inflammatory genes. Almost half of the correlations were independent of the change in calorie intake.Conclusion These results show an increase in gut microbiota richness and in the number of associations between gut microbiota and WAT genes after RYGB in obesity. Variations of gut microbiota were associated with changes in WAT gene expression. These findings stimulate deeper explorations of the mechanisms linking gut microbiome and WAT pathological alterations in human obesity and its changes after weight loss.

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Authors: Kong, L.-C., Tap, J., Aron-Wisnewsky, J., Pelloux, V., Basdevant, A., Bouillot, J.-L., Zucker, J.-D., Doré, J., & Clément, K.
Affiliations: Microbiologie de l’alimentation au service de la santé (FR)
Institut National de la Recherche Agronomique (FR)
Assistance Publique – Hôpitaux de Paris (FR)
Hôpital Ambroise-Paré (FR)
Institut de Recherche pour le Développement (FR)
ORCID: Tap, Julien
Basdevant, Arnaud
Bouillot, Jean-Luc
Zucker, Jean-Daniel
Clément, Karine
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2013-07
Volume: 98
Issue: 1
Pages: 16-24
ISSN: 0002-9165 (ISSN-L)
DOI: 10.3945/ajcn.113.058743
OpenAlex: W2155185912
Cited by: 416
References: 48
Citations by year: 2026: 8 · 2025: 16 · 2024: 30 · 2023: 22 · 2022: 44 · 2021: 34 · 2020: 43 · 2019: 38 · 2018: 35 · 2017: 38 · 2016: 34 · 2015: 39 · 2014: 30 · 2013: 5
FWCI: 16.11
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3519 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Agence Nationale de la Recherche (ANR-11-DPBS-0001)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: gut microbiota, Roux-en-Y gastric bypass, morbid obesity, Proteobacteria, bacterial genera, weight loss, bariatric surgery, inflammation, metabolic genes
MeSH terms: DNA, Bacterial, Feces, Female, Follow-Up Studies, Multigene Family, Humans, Inflammation, Obesity, Morbid, RNA, Ribosomal, 16S, Gastric Bypass, Weight Loss, Nutrition Assessment, Gene Expression Regulation, Bacterial, Computational Biology, Gastrointestinal Tract, Microarray Analysis, Adipose Tissue, White, Metagenome

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Gut microbiota after gastric bypass in human obesity: increased richness and associations of bacterial genera with adipose tissue genes

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