Cited by 438Muscle metabolism and nutritionMuscle Physiology and DisordersNutrition and Health in Aging

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Dietary Protein Distribution Positively Influences 24-h Muscle Protein Synthesis in Healthy Adults

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Mamerow, Madonna M., Mettler, Joni A., English, Kirk L., Casperson, Shanon L., Arentson-Lantz, Emily, Sheffield-Moore, Melinda, Layman, Donald K., Paddon-Jones, Douglas·2014·The Journal of Nutrition

DOI 10.3945/jn.113.185280PMC PMC4018950

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Abstract

The RDA for protein describes the quantity that should be consumed daily to meet population needs and to prevent deficiency. Protein consumption in many countries exceeds the RDA; however, intake is often skewed toward the evening meal, whereas breakfast is typically carbohydrate rich and low in protein. We examined the effects of protein distribution on 24-h skeletal muscle protein synthesis in healthy adult men and women (n = 8; age: 36.9 ± 3.1 y; BMI: 25.7 ± 0.8 kg/m2). By using a 7-d crossover feeding design with a 30-d washout period, we measured changes in muscle protein synthesis in response to isoenergetic and isonitrogenous diets with protein at breakfast, lunch, and dinner distributed evenly (EVEN; 31.5 ± 1.3, 29.9 ± 1.6, and 32.7 ± 1.6 g protein, respectively) or skewed (SKEW; 10.7 ± 0.8, 16.0 ± 0.5, and 63.4 ± 3.7 g protein, respectively). Over 24-h periods on days 1 and 7, venous blood samples and vastus lateralis muscle biopsy samples were obtained during primed (2.0 μmol/kg) constant infusion [0.06 μmol/(kg⋅min)] of l-[ring-13C6]phenylalanine. The 24-h mixed muscle protein fractional synthesis rate was 25% higher in the EVEN (0.075 ± 0.006%/h) vs. the SKEW (0.056 ± 0.006%/h) protein distribution groups (P = 0.003). This pattern was maintained after 7 d of habituation to each diet (EVEN vs. SKEW: 0.077 ± 0.006 vs. 0.056 ± 0.006%/h; P = 0.001). The consumption of a moderate amount of protein at each meal stimulated 24-h muscle protein synthesis more effectively than skewing protein intake toward the evening meal.

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Background
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Self-citation
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Self-citation
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Authors: Mamerow, M. M., Mettler, J. A., English, K. L., Casperson, S. L., Arentson-Lantz, E., Sheffield-Moore, M., Layman, D. K., & Paddon-Jones, D.
Affiliations: The University of Texas Medical Branch at Galveston (US)
University of Illinois Urbana-Champaign (US)
ORCID: Mettler, Joni A.
English, Kirk L.
Casperson, Shanon L.
Layman, Donald K.
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2014-06
Volume: 144
Issue: 6
Pages: 876-880
ISSN: 0022-3166 (ISSN-L)
DOI: 10.3945/jn.113.185280
PMC: PMC4018950
OpenAlex: W2118131565
Semantic Scholar: 705b036b0a8f54749584f50d1f453aedb519aa9f
Cited by: 438
References: 31
Citations by year: 2026: 31 · 2025: 29 · 2024: 30 · 2023: 28 · 2022: 39 · 2021: 38 · 2020: 46 · 2019: 38 · 2018: 36 · 2017: 38 · 2016: 35 · 2015: 35 · 2014: 15
FWCI: 20.42
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3162 d)
Locations: Journal of Nutrition (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: University of Texas Medical Branch (UL1TR000071)
National Center for Research Resources (P30 AG024832)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Keywords: meal timing, skeletal muscle protein synthesis, protein intake, phenylalanine tracer, protein requirements
MeSH terms: Adult, Energy Intake, Diet, Dietary Carbohydrates, Dietary Proteins, Female, Humans, Male, Middle Aged, Muscle Proteins, Phenylalanine, Tissue Distribution, Body Mass Index, Cross-Over Studies, Quadriceps Muscle, Meals, Healthy Volunteers

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Dietary Protein Distribution Positively Influences 24-h Muscle Protein Synthesis in Healthy Adults

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