The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Whey Protein Supplementation Preserves Postprandial Myofibrillar Protein Synthesis during Short-Term Energy Restriction in Overweight and Obese Adults
Open accessAbstract
Background Higher dietary energy as protein during weight loss results in a greater loss of fat mass and retention of muscle mass; however, the impact of protein quality on the rates of myofibrillar protein synthesis (MPS) and lipolysis, processes that are important in the maintenance of muscle and loss of fat, respectively, are unknown.Objective We aimed to determine how the consumption of different sources of proteins (soy or whey) during a controlled short-term (14-d) hypoenergetic diet affected MPS and lipolysis.Methods Men (n = 19) and women (n = 21) (age 35-65 y; body mass index 28-50 kg/m(2)) completed a 14-d controlled hypoenergetic diet (-750 kcal/d). Participants were randomly assigned, double blind, to receive twice-daily supplements of isolated whey (27 g/supplement) or soy (26 g/supplement), providing a total protein intake of 1.3 ± 0.1 g/(kg · d), or isoenergetic carbohydrate (25 g maltodextrin/supplement) resulting in a total protein intake of 0.7 ± 0.1 g/(kg · d). Before and after the dietary intervention, primed continuous infusions of L-[ring-(13)C6] phenylalanine and [(2)H5]-glycerol were used to measure postabsorptive and postprandial rates of MPS and lipolysis.Results Preintervention, MPS was stimulated more (P < 0.05) with ingestion of whey than with soy or carbohydrate. Postintervention, postabsorptive MPS decreased similarly in all groups (all P < 0.05). Postprandial MPS was reduced by 9 ± 1% in the whey group, which was less (P < 0.05) than the reduction in soy and carbohydrate groups (28 ± 5% and 31 ± 5%, respectively; both P < 0.05) after the intervention. Lipolysis was suppressed during the postprandial period (P < 0.05), but more so with ingestion of carbohydrate (P < 0.05) than soy or whey.Conclusion We conclude that whey protein supplementation attenuated the decline in postprandial rates of MPS after weight loss, which may be of importance in the preservation of lean mass during longer-term weight loss interventions. This trial was registered at clinicaltrials.gov as NCT01530646.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“There is also, during weight loss, research showing that a caloric restriction diet and the associated energy deficit may impair the muscle protein synthesis response to resistance exercise, limiting hypertrophic adaptations and the resources required to build new muscle tissue [7, 54, 55].”
From The effects of a home-based resistance training programme on body composition and muscle function during weight loss in people living with overweight or obesity: a randomised controlled pilot trial (2025) · cites this paper as [54]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Nonetheless, recent data have shown that lower rates of MPS can also be restored by a higher dietary protein intake (3), particularly so with whey protein (30), which was the supplemental protein source used herein.”
From Higher compared with lower dietary protein during an energy deficit combined with intense exercise promotes greater lean mass gain and fat mass loss: a randomized trial (2016) · cites this paper as [30]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Current evidence suggests that the energy deficit likely reduces basal MPS (29) and may also have reduced the sensitivity of MPS to feeding (30,31).”
From Higher compared with lower dietary protein during an energy deficit combined with intense exercise promotes greater lean mass gain and fat mass loss: a randomized trial (2016) · cites this paper as [30]
Experimental — accuracy not yet measuredIn the citing paper
“Whey proteins are effective in stimulating postprandial muscle protein accretion, owing to their fast digestion and absorption kinetics and high leucine content180.”
From Sarcopenic obesity in older adults: a clinical overview (2024) · cites this paper as [180]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961
The underappreciated role of muscle in health and disease
Wolfe, R. R. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.3.475 · Cited by 1,641
Tang, J. E., Moore, D. R., Kujbida, G. W., Tarnopolsky, M. A., & Phillips, S. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00076.2009 · Cited by 998
Self-citationWeight loss regulates inflammation‐related genes in white adipose tissue of obese subjects
ClÉment, K., Viguerie, N., Poitou, C., Carette, C., Pelloux, V., Curat, C. A., Sicard, A., Rome, S., Benis, A., Zucker, J., et al. (2004) · The FASEB Journal · doi:10.1096/fj.04-2204com · Cited by 640
Frankenfield, D., Roth-Yousey, L., & Compher, C. (2005) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2005.02.005 · Cited by 623
Wycherley, T. P., Moran, L. J., Clifton, P. M., Noakes, M., & Brinkworth, G. D. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.044321 · Cited by 606
Regulation of peptide‐chain elongation in mammalian cells
Browne, G. J., & Proud, C. G. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.03290.x · Cited by 473
Krieger, J. W., Sitren, H. S., Daniels, M. J., & Langkamp-Henken, B. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.260 · Cited by 466
Dairy augmentation of total and central fat loss in obese subjects
Zemel, M. B., Richards, J., Mathis, S., Milstead, A., Gebhardt, L., & Silva, E. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802880 · Cited by 356
Churchward‐Venne, T. A., Burd, N. A., Mitchell, C. J., West, D. W. D., Philp, A., Marcotte, G. R., Baker, S. K., Baar, K., & Phillips, S. M. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.228833 · Cited by 314
Self-citation
Cited by
Sorted by citations
Preserving Healthy Muscle during Weight Loss
Cava, E., Yeat, N. C., & Mittendorfer, B. (2017) · Advances in Nutrition · doi:10.3945/an.116.014506 · Cited by 452
Protein "requirements" beyond the RDA: implications for optimizing health
Phillips, S. M., Chevalier, S., & Leidy, H. J. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0550 · Cited by 396
Self-citationSarcopenic obesity in older adults: a clinical overview
Prado, C. M., Batsis, J. A., Donini, L. M., Gonzalez, M. C., & Siervo, M. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00943-z · Cited by 355
Longland, T. M., Oikawa, S. Y., Mitchell, C. J., Devries, M. C., & Phillips, S. M. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.119339 · Cited by 271
Self-citationNutritional interventions to augment resistance training-induced skeletal muscle hypertrophy
Morton, R. W., McGlory, C., & Phillips, S. M. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00245 · Cited by 234
Self-citation
Metadata
- Authors
- Hector, A. J., Marcotte, G. R., Churchward-Venne, T. A., Murphy, C. H., Breen, L., von Allmen, M., Baker, S. K., & Phillips, S. M.
- Affiliations
- University of Birmingham (GB)
- McMaster University (CA)
- Corresponding author
- Phillips, Stuart M
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 145
- Issue
- 2
- Pages
- 246-252
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2143022335
- Cited by
- 119
- References
- 36
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 11 · 2023: 7 · 2022: 12 · 2021: 10 · 2020: 9 · 2019: 13 · 2018: 15 · 2017: 12 · 2016: 14 · 2015: 5
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Dairy Research Institute
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- whey protein supplementation, myofibrillar protein synthesis, lipolysis, caloric restriction, weight loss, soy protein, protein quality, muscle protein synthesis, fat loss, phenylalanine tracer, overweight and obesity, hypocaloric diet, carbohydrate supplementation, fat oxidation, substrate oxidation, lipoprotein lipase
- MeSH terms
- Whey Proteins, Adult, Aged, Energy Intake, Double-Blind Method, Female, Humans, Male, Middle Aged, Milk Proteins, Myofibrils, Obesity, Phenylalanine, Protein Biosynthesis, Weight Loss, Body Mass Index, Muscle, Skeletal, Postprandial Period, Dietary Supplements, Soybean Proteins, Caloric Restriction, Overweight
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
