Cited by 119Muscle metabolism and nutritionNutrition and Health in AgingMuscle Physiology and Disorders

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Whey Protein Supplementation Preserves Postprandial Myofibrillar Protein Synthesis during Short-Term Energy Restriction in Overweight and Obese Adults

Open access

Hector, Amy J, Marcotte, George R, Churchward-Venne, Tyler A, Murphy, Caoileann H, Breen, Leigh, von Allmen, Mark, Baker, Steven K, Phillips, Stuart M·2015·The Journal of Nutrition

DOI 10.3945/jn.114.200832

Open this paper in CoChat — free account Open PDF

Abstract

Background Higher dietary energy as protein during weight loss results in a greater loss of fat mass and retention of muscle mass; however, the impact of protein quality on the rates of myofibrillar protein synthesis (MPS) and lipolysis, processes that are important in the maintenance of muscle and loss of fat, respectively, are unknown.Objective We aimed to determine how the consumption of different sources of proteins (soy or whey) during a controlled short-term (14-d) hypoenergetic diet affected MPS and lipolysis.Methods Men (n = 19) and women (n = 21) (age 35-65 y; body mass index 28-50 kg/m(2)) completed a 14-d controlled hypoenergetic diet (-750 kcal/d). Participants were randomly assigned, double blind, to receive twice-daily supplements of isolated whey (27 g/supplement) or soy (26 g/supplement), providing a total protein intake of 1.3 ± 0.1 g/(kg · d), or isoenergetic carbohydrate (25 g maltodextrin/supplement) resulting in a total protein intake of 0.7 ± 0.1 g/(kg · d). Before and after the dietary intervention, primed continuous infusions of L-[ring-(13)C6] phenylalanine and [(2)H5]-glycerol were used to measure postabsorptive and postprandial rates of MPS and lipolysis.Results Preintervention, MPS was stimulated more (P < 0.05) with ingestion of whey than with soy or carbohydrate. Postintervention, postabsorptive MPS decreased similarly in all groups (all P < 0.05). Postprandial MPS was reduced by 9 ± 1% in the whey group, which was less (P < 0.05) than the reduction in soy and carbohydrate groups (28 ± 5% and 31 ± 5%, respectively; both P < 0.05) after the intervention. Lipolysis was suppressed during the postprandial period (P < 0.05), but more so with ingestion of carbohydrate (P < 0.05) than soy or whey.Conclusion We conclude that whey protein supplementation attenuated the decline in postprandial rates of MPS after weight loss, which may be of importance in the preservation of lean mass during longer-term weight loss interventions. This trial was registered at clinicaltrials.gov as NCT01530646.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3945/jn.114.200832

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome
Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961
The underappreciated role of muscle in health and disease
Wolfe, R. R. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.3.475 · Cited by 1,641
Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men
Tang, J. E., Moore, D. R., Kujbida, G. W., Tarnopolsky, M. A., & Phillips, S. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00076.2009 · Cited by 998
Self-citation
Weight loss regulates inflammation‐related genes in white adipose tissue of obese subjects
ClÉment, K., Viguerie, N., Poitou, C., Carette, C., Pelloux, V., Curat, C. A., Sicard, A., Rome, S., Benis, A., Zucker, J., et al. (2004) · The FASEB Journal · doi:10.1096/fj.04-2204com · Cited by 640
Comparison of Predictive Equations for Resting Metabolic Rate in Healthy Nonobese and Obese Adults: A Systematic Review
Frankenfield, D., Roth-Yousey, L., & Compher, C. (2005) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2005.02.005 · Cited by 623
Effects of energy-restricted high-protein, low-fat compared with standard-protein, low-fat diets: a meta-analysis of randomized controlled trials
Wycherley, T. P., Moran, L. J., Clifton, P. M., Noakes, M., & Brinkworth, G. D. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.044321 · Cited by 606
Regulation of peptide‐chain elongation in mammalian cells
Browne, G. J., & Proud, C. G. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.03290.x · Cited by 473
Effects of variation in protein and carbohydrate intake on body mass and composition during energy restriction: a meta-regression
Krieger, J. W., Sitren, H. S., Daniels, M. J., & Langkamp-Henken, B. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.260 · Cited by 466
Dairy augmentation of total and central fat loss in obese subjects
Zemel, M. B., Richards, J., Mathis, S., Milstead, A., Gebhardt, L., & Silva, E. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802880 · Cited by 356
Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men
Churchward‐Venne, T. A., Burd, N. A., Mitchell, C. J., West, D. W. D., Philp, A., Marcotte, G. R., Baker, S. K., Baar, K., & Phillips, S. M. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.228833 · Cited by 314
Self-citation

Show all 36 references

Sorted by citations

Preserving Healthy Muscle during Weight Loss
Cava, E., Yeat, N. C., & Mittendorfer, B. (2017) · Advances in Nutrition · doi:10.3945/an.116.014506 · Cited by 452
Protein "requirements" beyond the RDA: implications for optimizing health
Phillips, S. M., Chevalier, S., & Leidy, H. J. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2015-0550 · Cited by 396
Self-citation
Sarcopenic obesity in older adults: a clinical overview
Prado, C. M., Batsis, J. A., Donini, L. M., Gonzalez, M. C., & Siervo, M. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00943-z · Cited by 355
Higher compared with lower dietary protein during an energy deficit combined with intense exercise promotes greater lean mass gain and fat mass loss: a randomized trial
Longland, T. M., Oikawa, S. Y., Mitchell, C. J., Devries, M. C., & Phillips, S. M. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.119339 · Cited by 271
Self-citation
Nutritional interventions to augment resistance training-induced skeletal muscle hypertrophy
Morton, R. W., McGlory, C., & Phillips, S. M. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00245 · Cited by 234
Self-citation
Exercise and nutrition strategies to counteract sarcopenic obesity
Trouwborst, I., Verreijen, A., Memelink, R., Massanet, P., Boirie, Y., Weijs, P., & Tieland, M. (2018) · Nutrients · doi:10.3390/nu10050605 · Cited by 210
Strategies to Prevent Sarcopenia in the Aging Process: Role of Protein Intake and Exercise
Rogeri, P. S., Zanella, R., Martins, G. L., Garcia, M. D. A., Leite, G., Lugaresi, R., Gasparini, S. O., Sperandio, G. A., Ferreira, L. H. B., Souza-Junior, T. P., et al. (2021) · Nutrients · doi:10.3390/nu14010052 · Cited by 181
Whey protein–pectin soluble complexes for beverage applications
Wagoner, T. B., & Foegeding, E. A. (2016) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2016.08.027 · Cited by 160
Dairy bioactive proteins and peptides: a narrative review
Auestad, N., & Layman, D. K. (2021) · Nutrition Reviews · doi:10.1093/nutrit/nuab097 · Cited by 153
Resistance Training and Protein Supplementation Increase Strength After Bariatric Surgery: A Randomized Controlled Trial
Oppert, J., Bellicha, A., Roda, C., Bouillot, J., Torcivia, A., Clément, K., Poitou, C., & Ciangura, C. (2018) · Obesity · doi:10.1002/oby.22317 · Cited by 140
Protein recommendations for weight loss in elite athletes: a focus on body composition and performance
Hector, A. J., & Phillips, S. M. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2017-0273 · Cited by 137
Self-citation
Effect of a high protein diet and/or resistance exercise on the preservation of fat free mass during weight loss in overweight and obese older adults: a randomized controlled trial
Verreijen, A. M., Engberink, M. F., Memelink, R. G., van der Plas, S. E., Visser, M., & Weijs, P. J. M. (2017) · Nutrition Journal · doi:10.1186/s12937-017-0229-6 · Cited by 121
The Muscle Protein Synthetic Response to Meal Ingestion Following Resistance-Type Exercise
Trommelen, J., Betz, M. W., & van Loon, L. J. C. (2019) · Sports Medicine · doi:10.1007/s40279-019-01053-5 · Cited by 117
Anabolic Resistance of Muscle Protein Turnover Comes in Various Shapes and Sizes
Paulussen, K. J. M., McKenna, C. F., Beals, J. W., Wilund, K. R., Salvador, A. F., & Burd, N. A. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.615849 · Cited by 115
The effects of branched-chain amino acids on muscle protein synthesis, muscle protein breakdown and associated molecular signalling responses in humans: an update
Kaspy, M. S., Hannaian, S. J., Bell, Z. W., & Churchward‐Venne, T. A. (2023) · Nutrition Research Reviews · doi:10.1017/s0954422423000197 · Cited by 117
Self-citation
Recent Advances in the Characterization of Skeletal Muscle and Whole-Body Protein Responses to Dietary Protein and Exercise during Negative Energy Balance
Carbone, J. W., McClung, J. P., & Pasiakos, S. M. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy087 · Cited by 93
Pronounced energy restriction with elevated protein intake results in no change in proteolysis and reductions in skeletal muscle protein synthesis that are mitigated by resistance exercise
Hector, A. J., McGlory, C., Damas, F., Mazara, N., Baker, S. K., & Phillips, S. M. (2018) · The FASEB Journal · doi:10.1096/fj.201700158rr · Cited by 91
Self-citation
Muscle Protein Synthesis and Whole-Body Protein Turnover Responses to Ingesting Essential Amino Acids, Intact Protein, and Protein-Containing Mixed Meals with Considerations for Energy Deficit
Gwin, J. A., Church, D. D., Wolfe, R. R., Ferrando, A. A., & Pasiakos, S. M. (2020) · Nutrients · doi:10.3390/nu12082457 · Cited by 93
Obesity Alters the Muscle Protein Synthetic Response to Nutrition and Exercise
Beals, J. W., Burd, N. A., Moore, D. R., & van Vliet, S. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00087 · Cited by 88
Innovative applications of whey protein for sustainable dairy industry: Environmental and technological perspectives—A comprehensive review
El-Aidie, S. A.-A. M., & Khalifa, G. S. A. (2024) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.13319 · Cited by 80
Prospective views for whey protein and/or resistance training against age-related sarcopenia
Liao, Y., Peng, Z., Chen, L., Zhang, Y., Cheng, Q., Nüssler, A. K., Bao, W., Liu, L., & Yang, W. (2019) · Aging and Disease · doi:10.14336/ad.2018.0325 · Cited by 68
Whey Protein Supplementation Enhances Body Fat and Weight Loss in Women Long After Bariatric Surgery: a Randomized Controlled Trial
Gomes, D. L., Moehlecke, M., da Silva, F. B. L., Dutra, E. S., Schaan, B. D., & de Carvalho, K. M. B. (2016) · Obesity Surgery · doi:10.1007/s11695-016-2308-8 · Cited by 70
Protein intake and lean body mass preservation during energy intake restriction in overweight older adults
Backx, E. M. P., Tieland, M., Borgonjen-van den Berg, K. J., Claessen, P. R., van Loon, L. J. C., & de Groot, L. C. P. G. M. (2016) · International Journal of Obesity · doi:10.1038/ijo.2015.182 · Cited by 66
Synergetic effects of whey protein isolate and naringin on physical and oxidative stability of oil-in-water emulsions
Hu, J., Zheng, H., Chen, X., Li, X., Xu, Y., & Xu, M. (2019) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2019.105517 · Cited by 66
Stability, microstructure, and digestibility of whey protein isolate – Tremella fuciformis polysaccharide complexes
Hu, J., Zhao, T., Li, S., Wang, Z., Wen, C., Wang, H., Yu, C., & Ji, C. (2018) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2018.11.005 · Cited by 62
The effects of whey protein with or without carbohydrates on resistance training adaptations
Hulmi, J. J., Laakso, M., Mero, A. A., Häkkinen, K., Ahtiainen, J. P., & Peltonen, H. (2015) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-015-0109-4 · Cited by 61
Whey Protein Supplementation Improves Body Composition and Cardiovascular Risk Factors in Overweight and Obese Patients: A Systematic Review and Meta-Analysis
Wirunsawanya, K., Upala, S., Jaruvongvanich, V., & Sanguankeo, A. (2017) · Journal of the American College of Nutrition · doi:10.1080/07315724.2017.1344591 · Cited by 68
Dairy Intake Enhances Body Weight and Composition Changes during Energy Restriction in 18–50-Year-Old Adults—A Meta-Analysis of Randomized Controlled Trials
Stonehouse, W., Wycherley, T. P., Luscombe‐Marsh, N. D., Taylor, P. J., Brinkworth, G. D., & Riley, M. D. (2016) · Nutrients · doi:10.3390/nu8070394 · Cited by 60
Milk proteins: Processing, gastric coagulation, amino acid availability and muscle protein synthesis
Horstman, A. M. H., & Huppertz, T. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2078782 · Cited by 59
Guava flavored whey-beverage processed by cold plasma: Physical characteristics, thermal behavior and microstructure
Silveira, M. R., Coutinho, N. M., Rocha, R. S., Moraes, J., Esmerino, E. A., Pimentel, T. C., Freitas, M. Q., Silva, M. C., Raices, R. S. L., Ranadheera, C. S., et al. (2018) · Food Research International · doi:10.1016/j.foodres.2018.10.033 · Cited by 58
Altered anabolic signalling and reduced stimulation of myofibrillar protein synthesis after feeding and resistance exercise in people with obesity
Beals, J. W., Skinner, S. K., McKenna, C. F., Poozhikunnel, E. G., Farooqi, S. A., van Vliet, S., Martinez, I. G., ULANOV, A. V., Li, Z., Paluska, S. A., et al. (2018) · The Journal of Physiology · doi:10.1113/jp276210 · Cited by 56
Dietary Protein for Training Adaptation and Body Composition Manipulation in Track and Field Athletes
Witard, O. C., Garthe, I., & Phillips, S. M. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0267 · Cited by 67
Self-citation
Multi-omics reveals functional genomic and metabolic mechanisms of milk production and quality in dairy cows
Sun, H., Zhou, M., Wang, O., Chen, Y., Liu, J., & Guan, L. L. (2019) · Bioinformatics · doi:10.1093/bioinformatics/btz951 · Cited by 58
Dietary protein supplementation in the elderly for limiting muscle mass loss
Lancha, A. H., Zanella, R., Tanabe, S. G. O., Andriamihaja, M., & Blachier, F. (2016) · Amino Acids · doi:10.1007/s00726-016-2355-4 · Cited by 61
Effect of resistance training and protein intake pattern on myofibrillar protein synthesis and proteome kinetics in older men in energy restriction
Murphy, C. H., Shankaran, M., Churchward‐Venne, T. A., Mitchell, C. J., Kolar, N. M., Burke, L. M., Hawley, J. A., Kassis, A. N., Karagounis, L. G., Li, K. W., et al. (2018) · The Journal of Physiology · doi:10.1113/jp275246 · Cited by 52
Self-citation
Intermittent fasting two days versus one day per week, matched for total energy intake and expenditure, increases weight loss in overweight/obese men and women
Arciero, P. J., Arciero, K. M., Poe, M., Mohr, A. E., Ives, S. J., Arciero, A., Boyce, M. K., Zhang, J., Haas, M., Valdez, E., et al. (2022) · Nutrition Journal · doi:10.1186/s12937-022-00790-0 · Cited by 51
Amino acids regulating skeletal muscle metabolism: mechanisms of action, physical training dosage recommendations and adverse effects
Li, G., Li, Z., & Liu, J. (2024) · Nutrition & Metabolism · doi:10.1186/s12986-024-00820-0 · Cited by 66
Soy Products Ameliorate Obesity-Related Anthropometric Indicators in Overweight or Obese Asian and Non-Menopausal Women: A Meta-Analysis of Randomized Controlled Trials
Mu, Y., Kou, T., Wei, B., Lu, X., Liu, J., Tian, H., Zhang, W., Liu, B., Li, H., Cui, W., et al. (2019) · Nutrients · doi:10.3390/nu11112790 · Cited by 48
Animal, Plant, Collagen and Blended Dietary Proteins: Effects on Musculoskeletal Outcomes
Deane, C. S., Bass, J. J., Crossland, H., Phillips, B. E., & Atherton, P. J. (2020) · Nutrients · doi:10.3390/nu12092670 · Cited by 48
Prolonged Calorie Restriction Downregulates Skeletal Muscle mTORC1 Signaling Independent of Dietary Protein Intake and Associated microRNA Expression
Margolis, L. M., Rivas, D. A., Berrone, M., Ezzyat, Y., Young, A., McClung, J. P., Fielding, R. A., & Pasiakos, S. M. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00445 · Cited by 40
Supplementing an energy adequate, higher protein diet with protein does not enhance fat-free mass restoration after short-term severe negative energy balance
Berryman, C. E., Sepowitz, J. J., McClung, H. L., Lieberman, H. R., Farina, E. K., McClung, J. P., Ferrando, A. A., & Pasiakos, S. M. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01039.2016 · Cited by 43
Nutritional Strategies to Combat Type 2 Diabetes in Aging Adults: The Importance of Protein
Beaudry, K. M., & Devries, M. C. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00138 · Cited by 41
Protein-pacing caloric-restriction enhances body composition similarly in obese men and women during weight loss and sustains efficacy during long-term weight maintenance
Arciero, P., Edmonds, R., He, F., Ward, E., Gumpricht, E., Mohr, A., Ormsbee, M., & Astrup, A. (2016) · Nutrients · doi:10.3390/nu8080476 · Cited by 36
Chitosan and chitosan oligosaccharide influence digestibility of whey protein isolate through electrostatic interaction
Wang, L., Wang, L., Wen, C., Wang, N., Yan, C., Shen, C., & Song, S. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.09.258 · Cited by 38
Caloric restriction induces anabolic resistance to resistance exercise
Murphy, C., & Koehler, K. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04354-0 · Cited by 38
Self-citation
Implication of diet and exercise on the management of age‐related sarcopenic obesity in Asians
Kim, Y. J., Moon, S., Yu, J. M., & Chung, H. S. (2022) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.14442 · Cited by 36
The impact and utility of very low-calorie diets: the role of exercise and protein in preserving skeletal muscle mass
Janssen, T. A. H., Van Every, D. W., & Phillips, S. M. (2023) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000980 · Cited by 33
Self-citation
Effect of a Whey Protein Supplement on Preservation of Fat Free Mass in Overweight and Obese Individuals on an Energy Restricted Very Low Caloric Diet
Larsen, A. E., Bibby, B. M., & Hansen, M. (2018) · Nutrients · doi:10.3390/nu10121918 · Cited by 35
Effects of Testosterone on Mixed-Muscle Protein Synthesis and Proteome Dynamics During Energy Deficit
Howard, E. E., Shankaran, M., Evans, W. J., Berryman, C. E., Margolis, L. M., Lieberman, H. R., Karl, J. P., Young, A., Montano, M. A., Matthews, M. D., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac295 · Cited by 32
Nutritional Management and Physical Activity in the Treatment of Sarcopenic Obesity: A Review of the Literature
Assyov, Y. S., Nedeva, I., Spassov, B., Gerganova, A., Velikov, T., Kamenov, Z. A., & Velikova, T. V. (2024) · Nutrients · doi:10.3390/nu16152560 · Cited by 33
Skeletal muscle adaptation to immobilization and subsequent retraining in elderly men: No effect of anti-inflammatory medication
Dideriksen, K., Boesen, A., Kristiansen, J., Magnusson, S. P., Schjerling, P., Holm, L., & Kjær, M. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.05.009 · Cited by 27
Essential amino acid-enriched whey enhances post-exercise whole-body protein balance during energy deficit more than iso-nitrogenous whey or a mixed-macronutrient meal: a randomized, crossover study
Gwin, J. A., Church, D. D., Hatch‐McChesney, A., Allen, J. T., Wilson, M. A., Varanoske, A. N., Carrigan, C. T., Murphy, N. E., Margolis, L. M., Carbone, J. W., et al. (2021) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00401-5 · Cited by 27
Achieving an optimal fat loss phase in resistance-trained athletes: a narrative review
Ruiz-Castellano, C., Espinar, S., Contreras, C., Mata, F., Aragon, A. A., & Martínez-Sanz, J. M. (2021) · Nutrients · doi:10.3390/nu13093255 · Cited by 24
Possible Role of Nutrition in Prevention of Sarcopenia and Falls
Schneider, D., & Trence, D. (2019) · Endocrine Practice · doi:10.4158/ep-2019-0144 · Cited by 26
Circulating and skeletal muscle microRNA profiles are more sensitive to sustained aerobic exercise than energy balance in males
Margolis, L. M., Hatch‐McChesney, A., Allen, J. T., DiBella, M. N., Carrigan, C. T., Murphy, N. E., Karl, J. P., Gwin, J. A., Hennigar, S. R., McClung, J. P., et al. (2022) · The Journal of Physiology · doi:10.1113/jp283209 · Cited by 24
The effects of protein intake higher than the recommended value on body composition changes after bariatric surgery: A meta-analysis of randomized controlled trials
Golzarand, M., Toolabi, K., & Mirmiran, P. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.01.031 · Cited by 22
Proprietary alpha-amylase inhibitor formulation from white kidney bean (Phaseolus vulgaris L.) promotes weight and fat loss: a 12-week, double-blind, placebo-controlled, randomized trial
Jäger, R., Sawan, S. A., Purpura, M., Grube, B., Roske, Y., Costa, P. D. M., & Chong, P.-W. (2024) · Scientific Reports · doi:10.1038/s41598-024-63443-8 · Cited by 25
Body Position Modulates Gastric Emptying and Affects the Post-Prandial Rise in Plasma Amino Acid Concentrations Following Protein Ingestion in Humans
Holwerda, A. M., Lenaerts, K., Bierau, J., & van Loon, L. J. C. (2016) · Nutrients · doi:10.3390/nu8040221 · Cited by 22
Severe energy deficit at high altitude inhibits skeletal muscle mTORC1‐mediated anabolic signaling without increased ubiquitin proteasome activity
Margolis, L. M., Carbone, J. W., Berryman, C. E., Carrigan, C. T., Murphy, N. E., Ferrando, A. A., Young, A., & Pasiakos, S. M. (2018) · The FASEB Journal · doi:10.1096/fj.201800163rr · Cited by 19
Effects of whey protein supplementation on adiposity, body weight, and glycemic parameters: A synthesis of evidence
Giglio, B. M., Lobo, P. C. B., & Pimentel, G. D. (2023) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2022.09.014 · Cited by 18
Pre-habilitation with exercise and high whey-protein-based meal replacement therapy promotes weight loss and preserve muscle mass before bariatric surgery
Ho, C. Y., Samwil, S. N. M., Kahairudin, Z., Jamhuri, N., & Aziz, A. A. (2023) · Asian Journal of Surgery · doi:10.1016/j.asjsur.2023.03.026 · Cited by 18
Pathophysiological-Based Nutritional Interventions in Cirrhotic Patients with Sarcopenic Obesity: A State-of-the-Art Narrative Review
Santangeli, E., Abbati, C., Chen, R., di Carlo, A., Leoni, S., Piscaglia, F., & Ferri, S. (2024) · Nutrients · doi:10.3390/nu16030427 · Cited by 21
Health Benefits of Whey or Colostrum Supplementation in Adults ≥35 Years; a Systematic Review
Blair, M., Kellow, N. J., Dordevic, A. L., Evans, S., Caissutti, J., & McCaffrey, T. A. (2020) · Nutrients · doi:10.3390/nu12020299 · Cited by 17
Integrated Myofibrillar Protein Synthesis in Recovery From Unaccustomed and Accustomed Resistance Exercise With and Without Multi-ingredient Supplementation in Overweight Older Men
Bell, K. E., Brook, M. S., Snijders, T., Kumbhare, D. A., Parise, G., Smith, K., Atherton, P. J., & Phillips, S. M. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00040 · Cited by 19
Self-citation
Comparing the effects of whey and casein supplementation on nutritional status and immune parameters in patients with chronic liver disease: a randomised double-blind controlled trial
Mizubuti, Y., Vieira, É. L. M., Silva, T. A., D’ALESSANDRO, M. C. D. O., Generoso, S. V., Teixeira, A. L., Lima, A. S., & Correia, M. I. T. D. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520003219 · Cited by 15
Nutrition and physical activity countermeasures for sarcopenia: Time to get personal?
Murphy, C. H., & Roche, H. M. (2018) · Nutrition Bulletin · doi:10.1111/nbu.12351 · Cited by 15
Self-citation
Nutrition policy: developing scientific recommendations for food-based dietary guidelines for older adults living independently in Ireland
Lyons, O. C., Flynn, M. A. T., Corish, C. A., Gibney, E. R., Kerr, M. A., McKenna, M. J., McNulty, H., McSorley, E. M., Nugent, A. P., O'Brien, C., et al. (2022) · Proceedings of The Nutrition Society · doi:10.1017/s0029665122001008 · Cited by 17
Effect of Whey Protein in Conjunction With a Caloric-Restricted Diet and Resistance Training
Dudgeon, W. D., Kelley, E. P., & Scheett, T. P. (2015) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001196 · Cited by 14
Protein metabolism and physical training: any need for amino acid supplementation?
POORTMANS, J. R., & Carpentier, A. (2016) · Nutrire · doi:10.1186/s41110-016-0022-x · Cited by 15
Within-Day Amino Acid Intakes and Nitrogen Balance in Male Collegiate Swimmers during the General Preparation Phase
Matsuda, T., Kato, H., Suzuki, H., Mizugaki, A., Ezaki, T., & Ogita, F. (2018) · Nutrients · doi:10.3390/nu10111809 · Cited by 15
Milk proteins and human health
Poppitt, S. D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815251-5.00018-9 · Cited by 16
Current and future strategies for the nutritional management of cardiometabolic complications of androgen deprivation therapy for prostate cancer
Turner, L., Poole, K., Faithfull, S., & Griffin, B. A. (2017) · Nutrition Research Reviews · doi:10.1017/s0954422417000087 · Cited by 13
Effects of a Milk-Based Meal Replacement Program on Weight and Metabolic Characteristics in Adults with Severe Obesity
Rafey, M. F., Murphy, C. F., Abdalgwad, R., Kilkelly, K., Griffin, H., Beatty, N., O’Shea, P. M., Collins, C. G., McGrath, R. B., Hynes, M., et al. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s226327 · Cited by 13
Self-citation
Nutritional Challenges of Incretin-Based Obesity Management Medications: Implications for Clinical Practice
Ben‐Porat, T., Dagan, S. S., Côté, M., Miner, C. J., & Buch, A. (2025) · Advances in Nutrition · doi:10.1016/j.advnut.2025.100522 · Cited by 14
Comparison of the effect of soya protein and whey protein on body composition: A meta-analysis of randomised clinical trials
Piri Damaghi, M., Mirzababaei, A., Moradi, S., Daneshzad, E., Tavakoli, A., Clark, C. C. T., & Mirzaei, K. (2022) · British Journal of Nutrition · doi:10.1017/s0007114521001550 · Cited by 11
Muscle Building and Maintenance in the Elderly: the Use of Protein
Barkoukis, H. (2016) · Current nutrition reports · doi:10.1007/s13668-016-0163-9 · Cited by 5
Importance of Cheese Whey Processing: Supplements for Sports Activities – a Review
Fassina, P., Nunes, G. Q., Adami, F. S., Goettert, M. I., & de Souza, C. F. V. (2019) · Polish Journal of Food and Nutrition Sciences · doi:10.31883/pjfns-2019-0008 · Cited by 11
Recomendaciones de actividad física y ejercicio en el paciente adulto sometido a cirugía bariátrica. Documento de Consenso
CANCINO-RAMÍREZ, J., Troncoso-Ortiz, E. J., Pino-Zúñiga, J., Olivares, M., Escaffi, M. J., RIFFO, A., Donoso, I. A. P., M., M. V., & González-Rojas, L. (2019) · Revista médica de Chile · doi:10.4067/s0034-98872019001101468 · Cited by 10
Whey protein supplementation 2 hours after a lower protein breakfast restores plasma essential amino acid availability comparable to a higher protein breakfast in overweight adults
Hudson, J., Paddon‐Jones, D., & Campbell, W. W. (2017) · Nutrition Research · doi:10.1016/j.nutres.2017.09.007 · Cited by 10
Dose-Response of Myofibrillar Protein Synthesis To Ingested Whey Protein During Energy Restriction in Overweight Postmenopausal Women: A Randomized, Controlled Trial
Larsen, M. S., Witard, O. C., Holm, L., Scaife, P. J., Hansen, R., Smith, K., Tipton, K. D., Mose, M., Bengtsen, M. B., Lauritsen, K. M., et al. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.08.011 · Cited by 12
The effects of a home-based resistance training programme on body composition and muscle function during weight loss in people living with overweight or obesity: a randomised controlled pilot trial
Binmahfoz, A., Johnston, L., Dunning, E., Gray, C. M., & Gray, S. R. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-00986-1 · Cited by 8
“There is also, during weight loss, research showing that a caloric restriction diet and the associated energy deficit may impair the muscle protein synthesis response to resistance exercise, limiting hypertrophic adaptations and the resources required to build new muscle tissue [7, 54, 55].”
Does eating less or exercising more to reduce energy availability produce distinct metabolic responses?
Halsey, L. G., Areta, J. L., & Koehler, K. (2023) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2022.0217 · Cited by 8
The Impact of Protein in Post-Menopausal Women on Muscle Mass and Strength: A Narrative Review
Black, K. E., & Matkin-Hussey, P. A. (2024) · Physiologia · doi:10.3390/physiologia4030016 · Cited by 10
Complexation behavior of Auricularia auricula polysaccharide and whey protein isolate: Characterization and potential beverage application
Zhao, Y., Shui, D., Li, S., Lin, X., Liang, H., Zhang, S., & Ji, C. (2022) · Journal of Food Processing and Preservation · doi:10.1111/jfpp.16340 · Cited by 8
The Skeletal Muscle Response to Energy Deficiency: A Life History Perspective
Júnior, G. N. D. O., Pinto, R. S., Shirley, M. K., Longman, D. P., Koehler, K., Saunders, B., Roschel, H., & Dolan, E. (2022) · Adaptive Human Behavior and Physiology · doi:10.1007/s40750-021-00182-4 · Cited by 10
Are plant-based and omnivorous diets the same for muscle hypertrophy? A narrative review of possible challenges of plant-based diets in resistance-trained athletes
Ashtary‐Larky, D. (2025) · Nutrition · doi:10.1016/j.nut.2025.112742 · Cited by 7
Changes in alanine aminotransferase in adults with severe and complicated obesity during a milk-based meal replacement programme
Abdalgwad, R., Rafey, M. F., Murphy, C., Ioana, I., O’Shea, P. M., Slattery, E., Davenport, C., O’Keeffe, D. T., & Finucane, F. M. (2020) · Nutrition & Metabolism · doi:10.1186/s12986-020-00512-5 · Cited by 6
Self-citation
Digging deep for nutrients and metabolites derived from high dietary protein intake and their potential functions in metabolic health
Gilsenan, S., Leong, D., Cotter, P. D., Brennan, L., & Nilaweera, K. N. (2024) · Nutrition Research Reviews · doi:10.1017/s0954422424000374 · Cited by 5
Association between whey protein, regional fat mass, and strength in resistance-trained men: a cross-sectional study
Batista, A., Monteiro, C. P., Borrego, R., Matias, C. N., Teixeira, F. J., Valamatos, M. J., de Oliveira, A. C. C., Reis, J. F., Mendes, L., & Sardinha, L. B. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0143 · Cited by 6
Physical Activity Level and Dietary Intake Associated with Fat-Free Muscle Mass Changes During Intentional Weight Loss in Overweight and Obese Subjects
Gariballa, S., Al‐Bluwi, G. S. M., & Yasin, J. (2024) · Nutrients · doi:10.3390/nu16234044 · Cited by 7
Anabolic signaling and response in sarcopenia as a model for microgravity induced muscle deconditioning: A systematic review
Rundfeldt, L. C., Gunga, H., & Steinach, M. (2019) · REACH · doi:10.1016/j.reach.2019.100025 · Cited by 5
Glucagon‐Like Peptide‐1 Receptor Agonism and Muscle Health: Vascular and Myocellular Effects on Glucose and Protein Metabolism
Katsanos, C. S., Liu, Z., & Atherton, P. J. (2026) · Comprehensive physiology · doi:10.1002/cph4.70126 · Cited by 6
Understanding sarcopenic obesity in young adults in clinical practice: a review of three unsolved questions
Ghoch, M. E., Rossi, A. P., Verde, L., Barrea, L., Muscogiuri, G., Savastano, S., & Colao, A. (2022) · Panminerva Medica · doi:10.23736/s0031-0808.22.04784-x · Cited by 4
Energy Restriction Suppresses Muscle Protein Synthesis, and High Protein Diets Extend Protein Half-Lives Across the Muscle Proteome in Obese Female Zucker Rats
Varanoske, A. N., Shankaran, M., Hennigar, S. R., Berryman, C. E., Margolis, L. M., Field, T., Palacios, H. H., Nyangau, E., Mohammed, H., Kelly, A. M., et al. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab181 · Cited by 5
Effects of Supplementation with Milk Proteins on Body Composition and Anthropometric Parameters: A Systematic Review and Dose–Response Meta-Analysis
Mohammadi, S., Ashtary‐Larky, D., Alaghemand, N., Alnsour, A. F., Shokouhifar, S., Borzabadi, A., Mehrbod, M., Candow, D. G., Forbes, S. C., António, J., et al. (2025) · Nutrients · doi:10.3390/nu17243877 · Cited by 3
Examining widely held propositions on human dietary protein needs and benefits: a critical review of the science that shapes both the data and our understanding of an essential macronutrient
Kanter, M. M., Aaron, S., Austad, S. N., Brown, A. W., Burd, N. A., Campbell, W. W., Cope, M. B., Davis, T. A., Erdman, J. W., Freitas, M., et al. (2026) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2026.2658728 · Cited by 3
Self-citation
Effects of milk proteins supplementation on muscle protein synthesis
Casagranda, M., Zanella, P. B., Vieira, A., & Macedo, R. C. O. (2019) · Nutrition & Food Science · doi:10.1108/nfs-11-2018-0328 · Cited by 5
Whey Protein and Muscle Protection
Boirie‌, Y. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-810422-4.00015-4 · Cited by 3
Muscle preservation during hospitalization: energy balance, protein intake, and habitual physical activity
Fuchs, C. J., & van Loon, L. J. C. (2025) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000001154 · Cited by 2
The Effect of Sex and Protein Supplementation on Protein Turnover and Muscle Function during a 36-H Military Field Exercise in Energy Deficit
O’Leary, T. J., Coombs, C. V., Edwards, V. C., Blacker, S. D., Knight, R. L., Koivula, F. N. M., Smith, K., Atherton, P. J., Wilkinson, D. J., Cegielski, J., et al. (2025) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003749 · Cited by 2

Authors: Hector, A. J., Marcotte, G. R., Churchward-Venne, T. A., Murphy, C. H., Breen, L., von Allmen, M., Baker, S. K., & Phillips, S. M.
Affiliations: University of Birmingham (GB)
McMaster University (CA)
Corresponding author: Phillips, Stuart M
ORCID: Marcotte, George R
Murphy, Caoileann H
Breen, Leigh
Baker, Steven K
Phillips, Stuart M
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2015-02
Volume: 145
Issue: 2
Pages: 246-252
ISSN: 0022-3166 (ISSN-L)
DOI: 10.3945/jn.114.200832
OpenAlex: W2143022335
Cited by: 119
References: 36
Citations by year: 2026: 3 · 2025: 8 · 2024: 11 · 2023: 7 · 2022: 12 · 2021: 10 · 2020: 9 · 2019: 13 · 2018: 15 · 2017: 12 · 2016: 14 · 2015: 5
FWCI: 5.15
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2922 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: Dairy Research Institute
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: whey protein supplementation, myofibrillar protein synthesis, lipolysis, caloric restriction, weight loss, soy protein, protein quality, muscle protein synthesis, fat loss, phenylalanine tracer, overweight and obesity, hypocaloric diet, carbohydrate supplementation, fat oxidation, substrate oxidation, lipoprotein lipase
MeSH terms: Whey Proteins, Adult, Aged, Energy Intake, Double-Blind Method, Female, Humans, Male, Middle Aged, Milk Proteins, Myofibrils, Obesity, Phenylalanine, Protein Biosynthesis, Weight Loss, Body Mass Index, Muscle, Skeletal, Postprandial Period, Dietary Supplements, Soybean Proteins, Caloric Restriction, Overweight

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Whey Protein Supplementation Preserves Postprandial Myofibrillar Protein Synthesis during Short-Term Energy Restriction in Overweight and Obese Adults

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks