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Herpesvirus-Specific CD8 T Cell Immunity in Old Age: Cytomegalovirus Impairs the Response to a Coresident EBV Infection
Open accessAbstract
Aging in humans is associated with increased infections and the reduced proliferative capacity of T cells, part of the more global phenomenon termed immune senescence. The etiology of immune senescence is unknown but the accumulation of virus-specific memory T cells may be a contributory factor. We have examined CD8 T cell responses to two persistent herpesvirus infections, CMV and EBV, and to a recurrent virus infection, influenza, in different age cohorts of healthy donors using HLA-peptide tetramers and intracellular cytokine detection. Of these, CMV appears to be the most immunogenic, with the CD8 T cell response representing over 10% of the CD8 pool in many elderly donors. Interestingly, the effect of age upon EBV-specific responses depends upon donor CMV sero-status. In CMV seropositive donors, the magnitude of the EBV-specific immune response is stable with age, but in CMV seronegative donors, the response to EBV increases significantly with age. By contrast, the influenza-specific CD8 T cell immune response decreases with age, independent of CMV status. The functional activity of the herpesvirus-specific immune response decreases in elderly donors, although the characteristic phenotypes of CMV- and EBV-specific memory populations are retained. This demonstrates that aging is associated with a marked accumulation of CMV-specific CD8 T cells together with a decrease in immediate effector function. Moreover, infection with CMV can reduce prevailing levels of immunity to EBV, another persistent virus. These results suggest that carriage of CMV may be detrimental to the immunocompetent host by suppressing heterologous virus-specific immunity during aging.
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Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846
Phenotypic Analysis of Antigen-Specific T Lymphocytes
Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (1996) · Science · doi:10.1126/science.274.5284.94 · Cited by 3,544 · cited 1×
“Tetramers were made as described elsewhere (20) with minor modifications.”
MethodSelf-citationImmunological memory and protective immunity: understanding their relation
Ahmed, R., & Gray, D. (1996) · Science · doi:10.1126/science.272.5258.54 · Cited by 1,775 · cited 1×
“Primary infection leads to the activation of naive CD8 T cells, which expand and differentiate into effector cells and ultimately give rise to a long-lived memory T cell population (1).”
BackgroundMonteiro, J., Batliwalla, F., Ostrer, H., & Gregersen, P. K. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.10.3587 · Cited by 376
Cited by
Sylwester, A. W., Mitchell, B. L., Edgar, J. B., Taormina, C., Pelte, C., Ruchti, F., Sleath, P. R., Grabstein, K. H., Hosken, N. A., Kern, F., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050882 · Cited by 1,339
The aging of the immune system
Weiskopf, D., Weinberger, B., & Grubeck-Loebenstein, B. (2009) · Transplant International · doi:10.1111/j.1432-2277.2009.00927.x · Cited by 908
Cellular responses to viral infection in humans: lessons from Epstein–Barr virus
Hislop, A. D., Taylor, G. S., Sauce, D., & Rickinson, A. B. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141553 · Cited by 766
Self-citationT cell responses to cytomegalovirus
Klenerman, P., & Oxenius, A. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.38 · Cited by 483
Human immunosenescence: is it infectious?
Pawelec, G., Akbar, A., Caruso, C., Solana, R., Grubeck‐Loebenstein, B., & Wikby, A. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00271.x · Cited by 405
Wertheimer, A. M., Bennett, M. S., Park, B., Uhrlaub, J. L., Martinez, C., Pulko, V., Currier, N. L., Nikolich-Žugich, D., Kaye, J., & Nikolich-Žugich, J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301721 · Cited by 352
Fletcher, J. M., Vukmanovic-Stejic, M., Dunne, P. J., Birch, K. E., Cook, J. E., Jackson, S. E., Salmon, M., Rustin, M. H., & Akbar, A. N. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.12.8218 · Cited by 296
Cytomegalovirus Infection: A Driving Force in Human T Cell Immunosenescence
KOCH, S., LARBI, A., ÖZCELIK, D., SOLANA, R., GOUTTEFANGEAS, C., ATTIG, S., WIKBY, A., STRINDHALL, J., FRANCESCHI, C., & PAWELEC, G. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1396.043 · Cited by 242
Cytomegalovirus infection is associated with increased mortality in the older population
Savva, G. M., Pachnio, A., Kaul, B., Morgan, K., Huppert, F. A., Brayne, C., & Moss, P. A. H. (2013) · Aging Cell · doi:10.1111/acel.12059 · Cited by 216
Self-citationPourgheysari, B., Khan, N., Best, D., Bruton, R., Nayak, L., & Moss, P. A. H. (2007) · Journal of Virology · doi:10.1128/jvi.01262-06 · Cited by 214
Self-citationAcquired and intrinsic resistance in cancer immunotherapy
Kelderman, S., Schumacher, T. N. M., & Haanen, J. B. A. G. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.07.011 · Cited by 197
Memory T cell homeostasis and senescence during aging
Akbar, A. N., & Fletcher, J. M. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.07.019 · Cited by 194
Vescovini, R., Biasini, C., Fagnoni, F. F., Telera, A. R., Zanlari, L., Pedrazzoni, M., Bucci, L., Monti, D., Medici, M. C., Chezzi, C., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.4283 · Cited by 173
Lurain, N. S., Hanson, B. A., Martinson, J., Leurgans, S. E., Landay, A. L., Bennett, D. A., & Schneider, J. A. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit210 · Cited by 159
. Persistent viral infections and immune aging.
Brunner, S., Herndler-Brandstetter, D., Weinberger, B., & Grubeck-Loebenstein, B. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.08.003 · Cited by 143
Significance of bystander T cell activation in microbial infection
Lee, H., Jeong, S., & Shin, E.-C. (2022) · Nature Immunology · doi:10.1038/s41590-021-00985-3 · Cited by 134
Cicin-Sain, L., Brien, J. D., Uhrlaub, J. L., Drabig, A., Marandu, T. F., & Nikolich-Zugich, J. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002849 · Cited by 126
Weltevrede, M., Eilers, R., de Melker, H. E., & van Baarle, D. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.02.005 · Cited by 128
Naive T cells: The crux of cellular immune aging?
Appay, V., & Sauce, D. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.003 · Cited by 118
Libri, V., Azevedo, R. I., Jackson, S. E., Di Mitri, D., Lachmann, R., Fuhrmann, S., Vukmanovic-Stejic, M., Yong, K., Battistini, L., Kern, F., et al. (2011) · Immunology · doi:10.1111/j.1365-2567.2010.03386.x · Cited by 111
Is immunosenescence influenced by our lifetime “dose” of exercise?
Turner, J. E. (2016) · Biogerontology · doi:10.1007/s10522-016-9642-z · Cited by 112
Telomerase in T Lymphocytes: Use It and Lose It?
Akbar, A. N., & Vukmanovic-Stejic, M. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6689 · Cited by 96
Derhovanessian, E., Maier, A. B., Hähnel, K., McElhaney, J. E., Slagboom, E. P., & Pawelec, G. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303361 · Cited by 93
Age-Associated Increase of Low-Avidity Cytomegalovirus-Specific CD8+ T Cells That Re-Express CD45RA
Griffiths, S. J., Riddell, N. E., Masters, J., Libri, V., Henson, S. M., Wertheimer, A., Wallace, D., Sims, S., Rivino, L., Larbi, A., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203267 · Cited by 82
The silent war of CMV in aging and HIV infection
Effros, R. B. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.09.003 · Cited by 63
van Leeuwen, E. M. M., Koning, J. J., Remmerswaal, E. B. M., van Baarle, D., van Lier, R. A. W., & ten Berge, I. J. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.4998 · Cited by 50
Vescovini, R., Fagnoni, F. F., Telera, A. R., Bucci, L., Pedrazzoni, M., Magalini, F., Stella, A., Pasin, F., Medici, M. C., Calderaro, A., et al. (2014) · AGE · doi:10.1007/s11357-013-9594-z · Cited by 48
Haeseker, M. B., Pijpers, E., Dukers-Muijrers, N. H., Nelemans, P., Hoebe, C. J., Bruggeman, C. A., Verbon, A., & Goossens, V. J. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-30 · Cited by 46
Metadata
- Authors
- Khan, N., Hislop, A., Gudgeon, N., Cobbold, M., Khanna, R., Nayak, L., Rickinson, A. B., & Moss, P. A. H.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-12
- Volume
- 173
- Issue
- 12
- Pages
- 7481-7489
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2163782912
- Cited by
- 351
- References
- 4
- FWCI
- 12.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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