Pyroptosis in inflammatory diseases and cancer

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., & Shao, F. (2015) · Nature · doi:10.1038/nature15514 · Cited by 6,659

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Wang, Y., Gao, W., Shi, X., Ding, J., Liu, W., He, H., Wang, K., & Shao, F. (2017) · Nature · doi:10.1038/nature22393 · Cited by 3,199

Pore-forming activity and structural autoinhibition of the gasdermin family

Ding, J., Wang, K., Liu, W., She, Y., Sun, Q., Shi, J., Sun, H., Wang, D.-C., & Shao, F. (2016) · Nature · doi:10.1038/nature18590 · Cited by 2,771

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., & Fitzgerald, K. A. (2009) · Nature · doi:10.1038/nature07725 · Cited by 2,627

Non-canonical inflammasome activation targets caspase-11

Kayagaki, N., Warming, S., Lamkanfi, M., Walle, L. V., Louie, S., Dong, J., Newton, K., Qu, Y., Liu, J., Heldens, S., et al. (2011) · Nature · doi:10.1038/nature10558 · Cited by 2,530

Inflammatory caspases are innate immune receptors for intracellular LPS

Shi, J., Zhao, Y., Wang, Y., Gao, W., Ding, J., Li, P., Hu, L., & Shao, F. (2014) · Nature · doi:10.1038/nature13683 · Cited by 2,285

Targeting the NLRP3 inflammasome in inflammatory diseases

Mangan, M. S. J., Olhava, E. J., Roush, W. R., Seidel, H. M., Glick, G. D., & Latz, E. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.97 · Cited by 1,885

Overview of the IL ‐1 family in innate inflammation and acquired immunity

Dinarello, C. A. (2018) · Immunological Reviews · doi:10.1111/imr.12621 · Cited by 1,866

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

Zhang, Z., Zhang, Y., Xia, S., Kong, Q., Li, S., Liu, X., Junqueira, C., Meza-Sosa, K. F., Mok, T. M. Y., Ansara, J., et al. (2020) · Nature · doi:10.1038/s41586-020-2071-9 · Cited by 1,686

The gasdermins, a protein family executing cell death and inflammation

Broz, P., Pelegrín, P., & Shao, F. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0228-2 · Cited by 1,641

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

Rogers, C., Fernandes-Alnemri, T., Mayes, L., Alnemri, D., Cingolani, G., & Alnemri, E. S. (2017) · Nature Communications · doi:10.1038/ncomms14128 · Cited by 1,510 · cited 3×

Hepatic stellate cells as key target in liver fibrosis

Higashi, T., Friedman, S. L., & Hoshida, Y. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.05.007 · Cited by 1,485

Pro-inflammatory programmed cell death

Cookson, B. T., & Brennan, M. A. (2001) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01936-3 · Cited by 1,414

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

Miao, E. A., Leaf, I. A., Treuting, P. M., Mao, D. P., Dors, M., Sarkar, A., Warren, S. E., Wewers, M. D., & Aderem, A. (2010) · Nature Immunology · doi:10.1038/ni.1960 · Cited by 1,336

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

Zhou, Z., He, H., Wang, K., Shi, X., Wang, Y., Su, Y., Wang, Y., Li, D., Liu, W., Zhang, Y., et al. (2020) · Science · doi:10.1126/science.aaz7548 · Cited by 1,317

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

Zhao, Y., Yang, J., Shi, J., Gong, Y.-N., Lu, Q., Xu, H., Liu, L., & Shao, F. (2011) · Nature · doi:10.1038/nature10510 · Cited by 1,270

Shigella flexneri induces apoptosis in infected macrophages

Zychlinsky, A., Prevost, M. C., & Sansonetti, P. J. (1992) · Nature · doi:10.1038/358167a0 · Cited by 1,262

Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages

Fink, S. L., & Cookson, B. T. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00751.x · Cited by 1,110

A bioorthogonal system reveals antitumour immune function of pyroptosis

Wang, Q., Wang, Y., Ding, J., Wang, C., Zhou, X., Gao, W., Huang, H., Shao, F., & Liu, Z. (2020) · Nature · doi:10.1038/s41586-020-2079-1 · Cited by 1,083

Regulation of inflammasome activation

Man, S. M., & Kanneganti, T. (2015) · Immunological Reviews · doi:10.1111/imr.12296 · Cited by 1,064

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

Orning, P., Weng, D., Starheim, K., Ratner, D., Best, Z., Lee, B., Brooks, A., Xia, S., Wu, H., Kelliher, M. A., et al. (2018) · Science · doi:10.1126/science.aau2818 · Cited by 1,029

Inflammasome activation and regulation: toward a better understanding of complex mechanisms

Zheng, D., Liwinski, T., & Elinav, E. (2020) · Cell Discovery · doi:10.1038/s41421-020-0167-x · Cited by 1,026

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

Hou, J., Zhao, R., Xia, W., Chang, C.-W., You, Y., Hsu, J.-M., Nie, L., Chen, Y., Wang, Y.-C., Liu, C., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0575-z · Cited by 962

The NLR Gene Family: A Standard Nomenclature

Ting, J. P.-Y., Lovering, R. C., Alnemri, E. S., Bertin, J., Boss, J. M., Davis, B. K., Flavell, R. A., Girardin, S. E., Godzik, A., Harton, J. A., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.005 · Cited by 955

Caspases in Cell Death, Inflammation, and Pyroptosis

Kesavardhana, S., Malireddi, R. K. S., & Kanneganti, T.-D. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-073119-095439 · Cited by 923

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

Gordon, R., Albornoz, E. A., Christie, D. C., Langley, M. R., Kumar, V., Mantovani, S., Robertson, A. A. B., Butler, M. S., Rowe, D. B., O’Neill, L. A., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aah4066 · Cited by 897

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

Sarhan, J., Liu, B. C., Muendlein, H. I., Li, P., Nilson, R., Tang, A. Y., Rongvaux, A., Bunnell, S. C., Shao, F., Green, D. R., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1809548115 · Cited by 883

NINJ1 mediates plasma membrane rupture during lytic cell death

Kayagaki, N., Kornfeld, O. S., Lee, B. L., Stowe, I. B., O’Rourke, K., Li, Q., Sandoval, W., Yan, D., Kang, J., Xu, M., et al. (2021) · Nature · doi:10.1038/s41586-021-03218-7 · Cited by 857

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

Xu, H., Yang, J., Gao, W., Li, L., Li, P., Zhang, L., Gong, Y.-N., Peng, X., Xi, J. J., Chen, S., et al. (2014) · Nature · doi:10.1038/nature13449 · Cited by 850

Initiation and perpetuation of NLRP 3 inflammasome activation and assembly

Elliott, E. I., & Sutterwala, F. S. (2015) · Immunological Reviews · doi:10.1111/imr.12286 · Cited by 821

The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1

Hersh, D., Monack, D. M., Smith, M. R., Ghori, N., Falkow, S., & Zychlinsky, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2396 · Cited by 788

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

Rühl, S., Shkarina, K., Demarco, B., Heilig, R., Santos, J. C., & Broz, P. (2018) · Science · doi:10.1126/science.aar7607 · Cited by 742

Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death

Chowdhury, D., & Lieberman, J. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090404 · Cited by 700

The NLRP3 inflammasome in acute myocardial infarction

Toldo, S., & Abbate, A. (2018) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.161 · Cited by 665

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis

Zhou, B., Zhang, J.-Y., Liu, X.-S., Chen, H.-Z., Ai, Y.-L., Cheng, K., Sun, R.-Y., Zhou, D., Han, J., & Wu, Q. (2018) · Cell Research · doi:10.1038/s41422-018-0090-y · Cited by 660

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

Yang, D., He, Y., Muñoz-Planillo, R., Liu, Q., & Núñez, G. (2015) · Immunity · doi:10.1016/j.immuni.2015.10.009 · Cited by 596

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice

Dempsey, C., Rubio Araiz, A., Bryson, K. J., Finucane, O., Larkin, C., Mills, E. L., Robertson, A. A. B., Cooper, M. A., O'Neill, L. A. J., & Lynch, M. A. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.12.014 · Cited by 571

Caspase‐11 activates a canonical NLRP3 inflammasome by promoting K + efflux

Rühl, S., & Broz, P. (2015) · European Journal of Immunology · doi:10.1002/eji.201545772 · Cited by 539

Caspase-1 initiates apoptosis in the absence of gasdermin D

Tsuchiya, K., Nakajima, S., Hosojima, S., Thi Nguyen, D., Hattori, T., Manh Le, T., Hori, O., Mahib, M. R., Yamaguchi, Y., Miura, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09753-2 · Cited by 495

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

Conos, S. A., Chen, K. W., De Nardo, D., Hara, H., Whitehead, L., Núñez, G., Masters, S. L., Murphy, J. M., Schroder, K., Vaux, D. L., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613305114 · Cited by 485

Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells

Yu, J., Li, S., Qi, J., Chen, Z., Wu, Y., Guo, J., Wang, K., Sun, X., & Zheng, J. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1441-4 · Cited by 483

NLRP3 inflammasome: Its regulation and involvement in atherosclerosis

Hoseini, Z., Sepahvand, F., Rashidi, B., Sahebkar, A., Masoudifar, A., & Mirzaei, H. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.25930 · Cited by 458

Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation

Zhang, C.-C., Li, C.-G., Wang, Y.-F., Xu, L.-H., He, X.-H., Zeng, Q.-Z., Zeng, C.-Y., Mai, F.-Y., Hu, B., & Ouyang, D.-Y. (2019) · Apoptosis · doi:10.1007/s10495-019-01515-1 · Cited by 442

Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice

Xu, B., Jiang, M., Chu, Y., Wang, W., Chen, D., Li, X., Zhang, Z., Zhang, D., Fan, D., Nie, Y., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2017.11.040 · Cited by 426

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

Evavold, C. L., Hafner-Bratkovič, I., Devant, P., D’Andrea, J. M., Ngwa, E. M., Boršić, E., Doench, J. G., LaFleur, M. W., Sharpe, A. H., Thiagarajah, J. R., et al. (2021) · Cell · doi:10.1016/j.cell.2021.06.028 · Cited by 417

Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions

Aglietti, R. A., & Dueber, E. C. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.01.003 · Cited by 407

Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3/miR‐223/NLRP3 axis

Zhang, Y., Liu, X., Bai, X., Lin, Y., Li, Z., Fu, J., Li, M., Zhao, T., Yang, H., Xu, R., et al. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12449 · Cited by 399

The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8

Zhang, J.-Y., Zhou, B., Sun, R.-Y., Ai, Y.-L., Cheng, K., Li, F.-N., Wang, B.-R., Liu, F.-J., Jiang, Z.-H., Wang, W.-J., et al. (2021) · Cell Research · doi:10.1038/s41422-021-00506-9 · Cited by 392

Pyroptosis and host cell death responses during Salmonella infection

Fink, S. L., & Cookson, B. T. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01036.x · Cited by 383

Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury

Toldo, S., Mauro, A. G., Cutter, Z., & Abbate, A. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00158.2018 · Cited by 369

Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death

Feng, S., Fox, D., & Man, S. M. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.07.002 · Cited by 353

Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer’s disease

Tan, M.-S., Tan, L., Jiang, T., Zhu, X.-C., Wang, H.-F., Jia, C.-D., & Yu, J.-T. (2014) · Cell Death & Disease · doi:10.1038/cddis.2014.348 · Cited by 347

Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release

Kahlenberg, J. M., & Dubyak, G. R. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00494.2003 · Cited by 337

The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction

van Hout, G. P. J., Bosch, L., Ellenbroek, G. H. J. M., de Haan, J. J., van Solinge, W. W., Cooper, M. A., Arslan, F., de Jager, S. C. A., Robertson, A. A. B., Pasterkamp, G., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw247 · Cited by 331

Microenvironment‐Responsive Prodrug‐Induced Pyroptosis Boosts Cancer Immunotherapy

Xiao, Y., Zhang, T., Ma, X., Yang, Q., Yang, L., Yang, S., Liang, M., Xu, Z., & Sun, Z. (2021) · Advanced Science · doi:10.1002/advs.202101840 · Cited by 325

Pyroptosis, metabolism, and tumor immune microenvironment

Du, T., Gao, J., Li, P., Wang, Y., Qi, Q., Liu, X., Li, J., Wang, C., & Du, L. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.492 · Cited by 324

Early innate immune responses to bacterial LPS

Rosadini, C. V., & Kagan, J. C. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2016.10.005 · Cited by 323

Activation of Pyroptosis by Membrane‐Anchoring AIE Photosensitizer Design: New Prospect for Photodynamic Cancer Cell Ablation

Wu, M., Liu, X., Chen, H., Duan, Y., Liu, J., Pan, Y., & Liu, B. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202016399 · Cited by 315

Human and Mouse Granzyme A Induce a Proinflammatory Cytokine Response

Metkar, S. S., Menaa, C., Pardo, J., Wang, B., Wallich, R., Freudenberg, M., Kim, S., Raja, S. M., Shi, L., Simon, M. M., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.08.014 · Cited by 303

Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity

Hou, J., Hsu, J.-M., & Hung, M.-C. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.09.003 · Cited by 301

Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection

Aachoui, Y., Sagulenko, V., Miao, E. A., & Stacey, K. J. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.04.004 · Cited by 296

Involvement of the AIM2, NLRC4, and NLRP3 Inflammasomes in Caspase-1 Activation by Listeria monocytogenes

Wu, J., Fernandes-Alnemri, T., & Alnemri, E. S. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9425-2 · Cited by 290

HMGB1 released from GSDME-mediated pyroptotic epithelial cells participates in the tumorigenesis of colitis-associated colorectal cancer through the ERK1/2 pathway

Tan, G., Huang, C., Chen, J., & Zhi, F. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00985-0 · Cited by 290

Inhibition of double‐strand DNA‐sensing cGAS ameliorates brain injury after ischemic stroke

Li, Q., Cao, Y., Dang, C., Han, B., Han, R., Ma, H., Hao, J., & Wang, L. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.201911002 · Cited by 273

Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke

Xu, P., Zhang, X., Liu, Q., Xie, Y., Shi, X., Chen, J., Li, Y., Guo, H., Sun, R., Hong, Y., et al. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1777-9 · Cited by 270

Epigenetics-Based Tumor Cells Pyroptosis for Enhancing the Immunological Effect of Chemotherapeutic Nanocarriers

Fan, J.-X., Deng, R.-H., Wang, H., Liu, X.-H., Wang, X.-N., Qin, R., Jin, X., Lei, T.-R., Zheng, D., Zhou, P.-H., et al. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b03245 · Cited by 265

A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury After Ischemia–Reperfusion in the Mouse

Marchetti, C., Chojnacki, J., Toldo, S., Mezzaroma, E., Tranchida, N., Rose, S. W., Federici, M., Van Tassell, B. W., Zhang, S., & Abbate, A. (2014) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000053 · Cited by 264

Programming cell pyroptosis with biomimetic nanoparticles for solid tumor immunotherapy

Zhao, P., Wang, M., Chen, M., Chen, Z., Peng, X., Zhou, F., Song, J., & Qu, J. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120142 · Cited by 263

Alcohol dysregulates miR-148a in hepatocytes through FoxO1, facilitating pyroptosis via TXNIP overexpression

Heo, M. J., Kim, T. H., You, J. S., Blaya, D., Sancho-Bru, P., & Kim, S. G. (2019) · Gut · doi:10.1136/gutjnl-2017-315123 · Cited by 255

Lipidomic biomarkers and mechanisms of lipotoxicity in non-alcoholic fatty liver disease

Svegliati-Baroni, G., Pierantonelli, I., Torquato, P., Marinelli, R., Ferreri, C., Chatgilialoglu, C., Bartolini, D., & Galli, F. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.05.029 · Cited by 249

IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cells

Ben-Sasson, S. Z., Hogg, A., Hu-Li, J., Wingfield, P., Chen, X., Crank, M., Caucheteux, S., Ratner-Hurevich, M., Berzofsky, J. A., Nir-Paz, R., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20122006 · Cited by 243

MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D

Gutierrez, K. D., Davis, M. A., Daniels, B. P., Olsen, T. M., Ralli-Jain, P., Tait, S. W. G., Gale, M., & Oberst, A. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601757 · Cited by 228

Metabolic drivers of non-alcoholic fatty liver disease

Bence, K. K., & Birnbaum, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101143 · Cited by 221

Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein

Chao, K. L., Kulakova, L., & Herzberg, O. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616783114 · Cited by 214

The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia

Zheng, Z., Deng, W., Bai, Y., Miao, R., Mei, S., Zhang, Z., Pan, Y., Wang, Y., Min, R., Deng, F., et al. (2021) · Science · doi:10.1126/science.abg0269 · Cited by 197

New mechanism of nerve injury in Alzheimer’s disease: β‐amyloid‐induced neuronal pyroptosis

Han, C., Yang, Y., Guan, Q., Zhang, X., Shen, H., Sheng, Y., Wang, J., Zhou, X., Li, W., Guo, L., et al. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15439 · Cited by 193

Metal–Organic Framework Nanoparticles Induce Pyroptosis in Cells Controlled by the Extracellular pH

Ploetz, E., Zimpel, A., Cauda, V., Bauer, D., Lamb, D. C., Haisch, C., Zahler, S., Vollmar, A. M., Wuttke, S., & Engelke, H. (2020) · Advanced Materials · doi:10.1002/adma.201907267 · Cited by 191

Liraglutide ameliorates non-alcoholic steatohepatitis by inhibiting NLRP3 inflammasome and pyroptosis activation via mitophagy

Yu, X., Hao, M., Liu, Y., Ma, X., Lin, W., Xu, Q., Zhou, H., Shao, N., & Kuang, H. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172715 · Cited by 190

Salmonella-induced cell death: apoptosis, necrosis or programmed cell death?

Boise, L. H., & Collins, C. M. (2001) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01937-5 · Cited by 180

The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries

Mitchell, P. S., Sandstrom, A., & Vance, R. E. (2019) · Current Opinion in Immunology · doi:10.1016/j.coi.2019.04.015 · Cited by 179

Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y12 receptor antagonist-treated rats provides long-term reduction in myocardial infarct size and preservation of ventricular function

Audia, J. P., Yang, X.-M., Crockett, E. S., Housley, N., Haq, E. U., O’Donnell, K., Cohen, M. V., Downey, J. M., & Alvarez, D. F. (2018) · Basic Research in Cardiology · doi:10.1007/s00395-018-0692-z · Cited by 178

The interleukin 1beta-converting enzyme, caspase 1, is activated during Shigella flexneri-induced apoptosis in human monocyte-derived macrophages

Hilbi, H., Chen, Y., Thirumalai, K., & Zychlinsky, A. (1997) · Infection and Immunity · doi:10.1128/iai.65.12.5165-5170.1997 · Cited by 163

Salidroside ameliorates Parkinson's disease by inhibiting NLRP3-dependent pyroptosis

Zhang, X., Zhang, Y., Li, R., Zhu, L., Fu, B., & Yan, T. (2020) · Aging · doi:10.18632/aging.103215 · Cited by 163

Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways

Mastrocola, R., Penna, C., Tullio, F., Femminò, S., Nigro, D., Chiazza, F., Serpe, L., Collotta, D., Alloatti, G., Cocco, M., et al. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/5271251 · Cited by 158

The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse

Toldo, S. A., Mauro, A. G., Cutter, Z., Tassell, B. W. V., Mezzaroma, E., Buono, M. G. D., Prestamburgo, A., Potere, N., & Abbate, A. (2019) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000658 · Cited by 158

Local delivery of arsenic trioxide nanoparticles for hepatocellular carcinoma treatment

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Colchicine Improves Survival, Left Ventricular Remodeling, and Chronic Cardiac Function After Acute Myocardial Infarction

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Simvastatin Suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis

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Granzymes Regulate Proinflammatory Cytokine Responses

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Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging

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Pyroptosis: An Inflammatory Link Between NAFLD and NASH With Potential Therapeutic Implications

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The selective NLRP3 inflammasome inhibitor MCC950 alleviates cholestatic liver injury and fibrosis in mice

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Granzyme A in Human Platelets Regulates the Synthesis of Proinflammatory Cytokines by Monocytes in Aging

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Caspase‐1 inhibition prevents neuronal death by targeting the canonical inflammasome pathway of pyroptosis in a murine model of cerebral ischemia

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MicroRNA-135b alleviates MPP+-mediated Parkinson’s disease in in vitro model through suppressing FoxO1-induced NLRP3 inflammasome and pyroptosis

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A Virus‐Spike Tumor‐Activatable Pyroptotic Agent

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Implantable Bioresponsive Nanoarray Enhances Postsurgical Immunotherapy by Activating Pyroptosis and Remodeling Tumor Microenvironment

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Inspired Epigenetic Modulation Synergy with Adenosine Inhibition Elicits Pyroptosis and Potentiates Cancer Immunotherapy

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Amelioration of Alcoholic Liver Steatosis by Dihydroquercetin through the Modulation of AMPK-Dependent Lipogenesis Mediated by P2X7R–NLRP3-Inflammasome Activation

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Engineered Biomimetic Nanoplatform Protects the Myocardium Against Ischemia/Reperfusion Injury by Inhibiting Pyroptosis

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The Caspase 1 Inhibitor VX-765 Protects the Isolated Rat Heart via the RISK Pathway

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Interleukin-1 Receptor Antagonist Modulates Liver Inflammation and Fibrosis in Mice in a Model-Dependent Manner

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Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis

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Ablation of GSDMD Improves Outcome of Ischemic Stroke Through Blocking Canonical and Non-canonical Inflammasomes Dependent Pyroptosis in Microglia

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Nanostructured toxins for the selective destruction of drug-resistant human CXCR4+ colorectal cancer stem cells

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An NIR‐Fluorophore‐Based Theranostic for Selective Initiation of Tumor Pyroptosis‐Induced Immunotherapy

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Asbestos-Induced Chronic Inflammation in Malignant Pleural Mesothelioma and Related Therapeutic Approaches—A Narrative Review

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Activation of Pyroptosis by Membrane‐Anchoring AIE Photosensitizer Design: New Prospect for Photodynamic Cancer Cell Ablation

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The protective effects of selenium-enriched Spirulina platensis on chronic alcohol-induced liver injury in mice

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Cutting Edge: Eosinophils Undergo Caspase-1–Mediated Pyroptosis in Response to Necrotic Liver Cells

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Picroside II suppresses chondrocyte pyroptosis through MAPK/NF-κB/NLRP3 signaling pathway alleviates osteoarthritis

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E3 ubiquitin ligase MARCH1 reduces inflammation and pyroptosis in cerebral ischemia-reperfusion injury via PCSK9 downregulation

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Targeting the mevalonate pathway enhances the efficacy of 5-fluorouracil by regulating pyroptosis

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