Regulation of inflammasome activation

Man, Si Ming; Kanneganti, Thirumala‐Devi

doi:10.1111/imr.12296

Cited by 1,064

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Regulation of inflammasome activation

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Man, Si Ming, Kanneganti, Thirumala‐Devi·2015·Immunological Reviews

DOI 10.1111/imr.12296

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Abstract

Summary: Inflammasome biology is one of the most exciting and rapidly growing areas in immunology. Over the past 10 years, inflammasomes have been recognized for their roles in the host defense against invading pathogens and in the development of cancer, auto‐inflammatory, metabolic, and neurodegenerative diseases. Assembly of an inflammasome complex requires cytosolic sensing of pathogen‐associated molecular patterns or danger‐associated molecular patterns by a nucleotide‐binding domain and leucine‐rich repeat receptor (NLR) or absent in melanoma 2 (AIM2)‐like receptors (ALR). NLR s and ALR s engage caspase‐1, in most cases requiring the adapter protein apoptosis‐associated speck‐like protein containing a CARD (ASC), to catalyze proteolytic cleavage of pro‐interleukin‐1β (pro‐IL‐1β) and pro‐IL‐18 and drive pyroptosis. Recent studies indicate that caspase‐8, caspase‐11, IL‐1R–associated kinases (IRAK), and receptor‐interacting protein (RIP) kinases contribute to inflammasome functions. In addition, post‐translational modifications, including ubiquitination, deubiquitination, phosphorylation, and degradation control almost every aspect of inflammasome activities. Genetic studies indicate that mutations in NLRP 1, NLRP 3, NLRC 4, and AIM 2 are linked with the development of auto‐inflammatory diseases, enterocolitis, and cancer. Overall, these findings transform our understanding of the basic biology and clinical relevance of inflammasomes. In this review, we provide an overview of the latest development of inflammasome research and discuss how inflammasome activities govern health and disease.

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Authors: Man, S. M., & Kanneganti, T.
Venue: Immunological Reviews
Publisher: Wiley
Published: 2015-04-16
Volume: 265
Issue: 1
Pages: 6-21
ISSN: 0105-2896 (ISSN-L)
1600-065X
DOI: 10.1111/imr.12296
OpenAlex: W2005410446
Cited by: 1,064
References: 36
FWCI: 5.15
Type: journal article
Language: en
Open access: green
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders: St. Jude Children's Research Hospital and the Australian National Health and Medical Research Council RG Menzies Early Career fellowship
National Institutes of Health (AR056296, CA163507, AI101935)
American Lebanese Syrian Associated Charities

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Regulation of inflammasome activation

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