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Dynamics of genomic innovation in the unicellular ancestry of animals

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Grau-Bové, Xavier, Torruella, Guifré, Donachie, Stuart, Suga, Hiroshi, Leonard, Guy, Richards, Thomas A, Ruiz-Trillo, Iñaki·2017·eLife
DOI 10.7554/elife.26036
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Abstract

Which genomic innovations underpinned the origin of multicellular animals is still an open debate. Here, we investigate this question by reconstructing the genome architecture and gene family diversity of ancestral premetazoans, aiming to date the emergence of animal-like traits. Our comparative analysis involves genomes from animals and their closest unicellular relatives (the Holozoa), including four new genomes: three Ichthyosporea and Corallochytrium limacisporum. Here, we show that the earliest animals were shaped by dynamic changes in genome architecture before the emergence of multicellularity: an early burst of gene diversity in the ancestor of Holozoa, enriched in transcription factors and cell adhesion machinery, was followed by multiple and differently-timed episodes of synteny disruption, intron gain and genome expansions. Thus, the foundations of animal genome architecture were laid before the origin of complex multicellularity – highlighting the necessity of a unicellular perspective to understand early animal evolution.

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Metadata

Authors
Grau-Bové, X., Torruella, G., Donachie, S., Suga, H., Leonard, G., Richards, T. A., & Ruiz-Trillo, I.
Venue
eLife
Publisher
eLife Sciences Publications, Ltd
Published
2017-07-20
Volume
6
ISSN
2050-084X (ISSN-L)
DOI
10.7554/elife.26036
OpenAlex
W2738668379
Cited by
164
References
31
FWCI
16.53
Type
journal article
Language
en
Open access
gold
Licence
Funders
  • Ministerio de Economía y Competitividad (BFU2014-57779-P, BFU-2011-23434)
  • European Commission (ERC-2012-Co -616960)
  • Generalitat de Catalunya (2014 SGR 619)

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Grau-Bové, X., Torruella, G., Donachie, S., Suga, H., Leonard, G., Richards, T. A., & Ruiz-Trillo, I. (2017). Dynamics of genomic innovation in the unicellular ancestry of animals. eLife. https://doi.org/10.7554/elife.26036

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