Atypical Hemispheric Specialization for Faces in Infants at Risk for Autism Spectrum Disorder
Open accessAbstract
Among the many experimental findings that tend to distinguish those with and without autism spectrum disorder (ASD) are face processing deficits, reduced hemispheric specialization, and atypical neurostructural and functional connectivity. To investigate the earliest manifestations of these features, we examined lateralization of event‐related gamma‐band coherence to faces during the first year of life in infants at high risk for autism (HRA; defined as having an older sibling with ASD) who were compared with low‐risk comparison (LRC) infants, defined as having no family history of ASD. Participants included 49 HRA and 46 LRC infants who contributed a total of 127 data sets at 6 and 12 months. Electroencephalography was recorded while infants viewed images of familiar/unfamiliar faces. Event‐related gamma‐band (30–50 Hz) phase coherence between anterior–posterior electrode pairs for left and right hemispheres was computed. Developmental trajectories for lateralization of intra‐hemispheric coherence were significantly different in HRA and LRC infants: by 12 months, HRA infants showed significantly greater leftward lateralization compared with LRC infants who showed rightward lateralization. Preliminary results indicate that infants who later met criteria for ASD were those that showed the greatest leftward lateralization. HRA infants demonstrate an aberrant pattern of leftward lateralization of intra‐hemispheric coherence by the end of the first year of life, suggesting that the network specialized for face processing may develop atypically. Further, infants with the greatest leftward asymmetry at 12 months where those that later met criteria for ASD, providing support to the growing body of evidence that atypical hemispheric specialization may be an early neurobiological marker for ASD. Autism Res 2015, 8: 187–198. © 2015 International Society for Autism Research, Wiley Periodicals, Inc.
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Infants at high risk for ASD, regardless of whether they ultimately meet diagnostic criteria for ASD, have different developmental trajectories within the first year of life compared to low-risk infants.
“There is now accumulating evidence from electroencephalographic (EEG) studies suggesting that infants at high risk for ASD, regardless of whether they ultimately meet diagnostic criteria for ASD, have different developmental trajectories within the first year of life compared to low-risk infants [10–20].”
From EEG power at 3 months in infants at high familial risk for autism (2017) · cites this paper as [14]
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- Authors
- Keehn, B., Vogel‐Farley, V., Tager‐Flusberg, H., & Nelson, C. A.
- Affiliations
- Purdue University West Lafayette (US)
- Boston Children's Hospital (US)
- Department of Psychological and Brain Sciences Boston University Boston Massachusetts
- Corresponding author
- Nelson, Charles A.
- Venue
- Autism Research
- Publisher
- Wiley
- Published
- 2015-03-25
- Volume
- 8
- Issue
- 2
- Pages
- 187-198
- ISSN
- 1939-3792 (ISSN-L)
- 1939-3806
- PMC
- PMC4412772
- OpenAlex
- W2164667414
- Cited by
- 63
- References
- 81
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 2 · 2020: 6 · 2019: 6 · 2018: 2 · 2017: 10 · 2016: 9 · 2015: 2
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Autism Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- OpenBU (Boston University) (submittedVersion)
- Funders
- NIH (R01-DC010290)
- The Simons Foundation (137186)
- Autism Speaks Translation Postdoctoral Fellowship (7629)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Keywords
- autism spectrum disorder, high-risk infants, face processing, hemispheric lateralization, gamma-band coherence, developmental trajectories, neurobiological markers, infants, family history of autism
- MeSH terms
- Autism Spectrum Disorder, Brain, Cross-Sectional Studies, Dominance, Cerebral, Electroencephalography, Face, Female, Humans, Infant, Longitudinal Studies, Male, Pattern Recognition, Visual, Photic Stimulation, Recognition, Psychology
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