Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 308

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Prefrontal cortex dysfunction in clinical depression

George, Mark S., Ketter, Terence A., Post, Robert M.·1994·Depression
DOI 10.1002/depr.3050020202
Open this paper in CoChat — free account

Abstract

The role of specific brain regions in the pathophysiology of clinical depression is poorly understood. However, one brain area, the prefrontal cortex, is emerging as likely being directly involved in clinical depression. The authors review accepted clinical diagnostic criteria for depression and show how these relate to the behavioral changes seen after prefrontal cortex damage in man and other animals. Information from structural (MRI, CT) and functional imaging (SPECT, PET) is then examined for direct evidence of prefrontal cortex abnormalities in clinically depressed subjects. Functional imaging studies, with few exceptions, demonstrate prefrontal lobe hypometabolism in primary and secondary depression, with severity of depression often correlating with the degree of frontal inactivity. These studies imply that dysfunction of the prefrontal cortex, particularly with respect to its role in modulating limbic activity, could conceivably produce many of the symptoms seen in clinical depression. Viewing clinical depression as a disease involving dysfunction of the prefrontal cortex and connected brain regions may prove helpful in both the clinical management of depression and in clarifying future avenues for research. Depression 2:59–72 (1994). © 1994 Wiley‐Liss, Inc.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/depr.3050020202

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 7 references

Cited by

Metadata

Authors
George, M. S., Ketter, T. A., & Post, R. M.
Venue
Depression
Publisher
Wiley
Published
1994-01
Volume
2
Issue
2
Pages
59-72
ISSN
  • 1062-6417 (ISSN-L)
  • 1522-7162
DOI
10.1002/depr.3050020202
OpenAlex
W2058688855
Cited by
308
References
7
FWCI
4.43
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.