Developmental changes in brain network hub connectivity in late adolescence
Open accessAbstract
The human brain undergoes substantial development throughout adolescence and into early adulthood. This maturational process is thought to include the refinement of connectivity between putative connectivity hub regions of the brain, which collectively form a dense core that enhances the functional integration of anatomically distributed, and functionally specialized, neural systems. Here, we used longitudinal diffusion magnetic resonance imaging to characterize changes in connectivity between 80 cortical and subcortical anatomical regions over a 2 year period in 31 adolescents between the ages of 15 and 19 years. Connectome-wide analysis indicated that only a small subset of connections showed evidence of statistically significant developmental change over the study period, with 8% and 6% of connections demonstrating decreased and increased structural connectivity, respectively. Nonetheless, these connections linked 93% and 90% of the 80 regions, respectively, pointing to a selective, yet anatomically distributed pattern of developmental changes that involves most of the brain. Hub regions showed a distinct tendency to be highly connected to each other, indicating robust "rich-club" organization. Moreover, connectivity between hubs was disproportionately influenced by development, such that connectivity between subcortical hubs decreased over time, whereas frontal-subcortical and frontal-parietal hub-hub connectivity increased over time. These findings suggest that late adolescence is characterized by selective, yet significant remodeling of hub-hub connectivity, with the topological organization of hubs shifting emphasis from subcortical hubs in favor of an increasingly prominent role for frontal hub regions.
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Across adolescence, significant changes in brain development occur with the maturation of reward-related regions preceding the development of prefrontal regions relevant for inhibitory control.
“Across adolescence, significant changes in brain development occur with the maturation of reward-related regions preceding the develop ment of prefrontal regions relevant for inhibitory control (Baker et al., 2015; Casey et al., 2005).”
From Age-dependent Effects of Tobacco Smoke and Nicotine on Cognition and the Brain: A Systematic Review of the Human and Animal Literature Comparing Adolescents and Adults. (2023) · cites this paper as Baker et al., 2015
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“Across adolescence, significant changes in brain development occur with the maturation of reward-related regions preceding the development of prefrontal regions relevant for inhibitory control (Baker et al., 2015; Casey et al., 2005).”
Background
- Authors
- Baker, S. T. E., Lubman, D. I., Yucel, M., Allen, N. B., Whittle, S., Fulcher, B. D., Zalesky, A., & Fornito, A.
- Affiliations
- The University of Melbourne (AU)
- Eastern Health (AU)
- Monash University (AU)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2015-06-17
- Volume
- 35
- Issue
- 24
- Pages
- 9078-9087
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6605159
- OpenAlex
- W1524688107
- Semantic Scholar
- d3f4b7fe9f45d173f5e57f39123a3af6a811a701
- Cited by
- 168
- References
- 66
- Citations by year
- 2026: 12 · 2025: 15 · 2024: 14 · 2023: 12 · 2022: 9 · 2021: 14 · 2020: 24 · 2019: 12 · 2018: 20 · 2017: 21 · 2016: 13 · 2015: 2
- FWCI
- 11.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion)
- Funders
- Medical Research Council
- Australian Research Council (1066779, FT130100589, DP0878136, DP1092637, 1050504)
- National Health and Medical Research Council (1007716, 1050504, 1089718, 350241, 1021973, 1066779, 1047648)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Complex Network Analysis Techniques
- Keywords
- late adolescence, structural connectivity, brain maturation, rich club, frontoparietal connectivity
- MeSH terms
- Adolescent, Age Factors, Brain, Brain Mapping, Female, Humans, Male, Nerve Net, Neural Pathways, Young Adult, Diffusion Tensor Imaging, Connectome
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