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Meta-analysis of the factor structures of four depression questionnaires: Beck, CES-D, Hamilton, and Zung
Abstract
Four separate metaanalyses of factor analyses were conducted for the Beck Depression Inventory (BDI), the Center for Epidemiological Studies Depression Scale (CES-D), the Hamilton Rating Scale for Depression (HRSD), and the Zung Self-Rating Depression Scale (SDS). The total number of participants (N) and studies (k) included in each of the metaanalyses were the following: BDI (N = 13,643, k = 33), CES-D (N = 22,340, k = 28), HRSD (N = 2,606, k = 17), and SDS (N = 12,621, k = 13). Metaanalysis results suggest that the specific depression symptom factors within each test appear to be relatively robust and well established and match fairly closely previously hypothesized factor structures. A general Depression Severity factor and a small Somatic Symptoms factor are found in all four tests and two tests had a small Positive Affect factor. There were fewer common specific depression symptom factors across tests than expected.
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“9% according to the more conservative BDI-13 (Shafer, 2006)”
From Persistent psychopathology and neurocognitive impairment in COVID-19 survivors: effect of inflammatory biomarkers at three-month follow-up (2021) · cites this paper as Shafer, 2006
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“and “As Good”; and four-item interpersonal relationships (IR) indicators: “Failure,” “Fearful,” “Unfriendly,” and “Disliked” (Mui et al., 2001; Shafer, 2006).”
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Evaluation of the evidence for the trauma and fantasy models of dissociation.
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“For example, Shafer (2006) conducted a meta-analysis of four commonly used depression scales (the Beck Depression Inventory, Center for Epidemiologic Studies Depression Scale, Hamilton Rating Scale for Depression, and Zung Self-Rating Depression Scale), finding all four to be reliably…”
MethodThe 52 symptoms of major depression: lack of content overlap among seven common depression scales
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“7 Factor analyses suggest that the CES-D (Radloff, 1977) consists of four factors rather than one global factor (Shafer, 2006).”
Fried, E. I., Eidhof, M. B., Palić, S., Costantini, G., Dijk, H. M. H., Bockting, C., Engelhard, I. M., Armour, C., Nielsen, A. B. S., & Karstoft, K. (2018) · Clinical Psychological Science · doi:10.1177/2167702617745092 · Cited by 508
“…regarding both the number and nature of the extracted factors (e.g., PTSD; Armour, Műllerová, et al., 2015; and depression; Gullion & Rush, 1998; Shafer, 2006; van Loo, de Jonge, Romeijn, Kessler, & Schoevers, 2012), and recent articles have called for more replication work especially for…”
BackgroundGander, F., Proyer, R. T., Ruch, W., & Wyss, T. (2013) · Journal of Happiness Studies · doi:10.1007/s10902-012-9380-0 · Cited by 444
“The CES-D was developed to assess a broad range of depressive symptoms in the general population and represents one of the most frequently used depression measures (Shafer 2006).”
MethodHowells, A., Ivtzan, I., & Eiroa-Orosa, F. J. (2016) · Journal of Happiness Studies · doi:10.1007/s10902-014-9589-1 · Cited by 407
Depression, emotional eating and long-term weight changes: a population-based prospective study
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“The CES-D seems to be the only test that includes an interpersonal factor, but the other widely used instruments, such as the Beck Depression Inventory (BDI), the Hamilton Rating Scale for Depression (HRSD), and the Zung Self-rating Depression Scale (SDS) (16) do not have such a factor.”
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Modeling psychopathology structure: a symptom-level analysis of Axis I and II disorders
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“The current model, for example, is consistent with structural studies of depression that distinguish between cognitive and somatic components (Shafer, 2006).”
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Fried, E. I., Nesse, R. M., Zivin, K., Guille, C., & Sen, S. (2013) · Psychological Medicine · doi:10.1017/s0033291713002900 · Cited by 321
“Received 1 March 2013; Revised 12 September 2013; Accepted 2 November 2013 Key words: Depression, depressive symptoms, DSM, heterogeneity, psychiatric diagnosis, residency.”
Morin, A. J. S., Moullec, G., Maïano, C., Layet, L., Just, J.-L., & Ninot, G. (2011) · Revue d Épidémiologie et de Santé Publique · doi:10.1016/j.respe.2011.03.061 · Cited by 297
“These findings have recently been confirmed in the Shafer [1] meta-analysis of 28 studies published between 1977 and 2001.”
InfluentialWang, Y., & Gorenstein, C. (2013) · Clinics · doi:10.6061/clinics/2013(09)15 · Cited by 306
“Summarizing the factor structure of the existing BDI investigations through meta-analysis (35), much of the data variability can be explained by the common dimension of "severity of depression" and by the other part, ‘‘somatic symptoms.”
BackgroundMeasuring depression: comparison and integration of three scales in the GENDEP study
Uher, R., FARMER, A. E., Maier, W., Rietschel, M., Hauser, J., Marušić, A., Mors, O. N., Elkin, A., Williamson, R. J., Schmael, C., et al. (2007) · Psychological Medicine · doi:10.1017/s0033291707001730 · Cited by 290
“A number of studies have addressed the dimensionality of depression scales by means of factor analysis, and found that most scales are better described as comprising 3–6 dimensions (Shafer, 2006).”
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Fried, E. I., Flake, J. K., & Robinaugh, D. J. (2022) · Nature Reviews Psychology · doi:10.1038/s44159-022-00050-2 · Cited by 314
“Notably, replication of factor structures is poor across instruments 56 , poor within instruments across samples 33,54–61 and poor even within the same instrument in different subsets of the same sample 62 .”
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Chekroud, A. M., Gueorguieva, R., Krumholz, H. M., Trivedi, M. H., Krystal, J. H., & McCarthy, G. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.0025 · Cited by 276
“Dr Krystal has the following patents and inventions: (1) dopamine and noradrenergic reuptake inhibitors in treatment of schizophrenia (patent No.”
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“Sound psychometric properties have been reported for the 21-item original version of the BDI across several populations (e.g., Beck and Steer, 1984; Knight, 1984; Gatewood-Colwell et al., 1989; Ambrosini et al., 1991; Shafer, 2006; Nuevo et al., 2009b).”
MethodHepatitis C infection, antiviral treatment and mental health: A European expert consensus statement
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“However, although cut-offs are used in scientific investigations to define depression, these scales are not diagnostic instruments and a diagnosis of depression should be confirmed by an experienced psychiatrist using the official diagnostic criteria (ICD-10, DSM-IV) [76] [77].”
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“According to Shafer, the CES-D is a balanced and comprehensive instrument [2] and is the only instrument which assesses interpersonal aspects.”
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Proyer, R. T., Gander, F., Wellenzohn, S., & Ruch, W. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00456 · Cited by 250
“A broad range of variables (ten dependent variables) were assessed at pre-test, after two weeks (before switching groups), and after another two weeks.”
BackgroundInflammation and the dimensions of depression: A review
Majd, M., Saunders, E. F. H., & Engeland, C. G. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100800 · Cited by 229
Dimensions of depressive symptoms and smoking cessation
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“This idea is congruent with the notion that depression scales, such as the CESD, measure multiple specific, lower order factors and a general, higher order depression factor (Shafer, 2006) and that both levels of depression may influence smoking outcomes.”
BackgroundResultInfluentialIs it valid to measure suicidal ideation by depression rating scales?
Desseilles, M., Perroud, N. A., Guillaume, S., Jaussent, I., Genty, C., Malafosse, A., & Courtet, P. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.11.013 · Cited by 208
“This question has been addressed by using Principal Component Analysis (PCA) (Shafer, 2006) and a three-factor solution was derived from several depression scale (Uher et al., 2008).”
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“The structure of the CES-D scale has been widely studied, and a recent meta-analysis of 28 studies (29) concluded that a 4-factor structure (1 = negative affect, 2 = somatic and retarded activity, 3 = lack of positive affect, and 4 = interpersonal) best described the CES-D scale consistent with the structure originall…”
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Conceptualizing the closet: Differentiating stigma concealment and nondisclosure processes.
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“The CES-D is one of themost frequently used depression measures and was evaluated as a very balanced and representative measure in a meta-analysis that compared different widely used depression measures (Shafer, 2006).”
MethodA Genome-Wide Association Study of Depressive Symptoms
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“86) and relatively stable genetic determinants over the life span were observed in an Australian Twin study (53,54,65,67,68).”
BackgroundTemporal Relationship Between Depression and Dementia
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“Shafer (2006) conducted a relatively recent meta-analysis which investigated the CES-D factor structure with over 22,000 participants, from 21 CES-D studies.”
Maternal depression and developmental disability: Research critique
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“In addition, to identify suspected major depression, a CES-D cutoff value of C16 is widely used [5, 6, 19–21].”
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Psychometric Properties of “Community Assessment of Psychic Experiences”: Review and Meta-analyses
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Time Period and Birth Cohort Differences in Depressive Symptoms in the U.S., 1982–2013
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“’’ These subscales have also been found in previous research (e.g., Gatz and Hurwicz 1990; Shafer 2006).”
ResultResidual symptoms and recurrence during maintenance treatment of late-life depression
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“The use of HAM-D subscales to measure residual symptoms is another potential limitation of our study, however, a recent meta-analysis of the HAM-D factor structure (Shafer, 2006) suggests a very similar factor solution, and earlier studies strongly support the existence of an anxiety factor (Bagby et al.”
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“In a recent review, Shafer (2006) identified 28 studies performing factor analysis of the CES-D between 1977 and 2001 (total N = 22,340) and presented metaanalytical evidence supporting separate positive and negative factors.”
InfluentialEvidence for Multiple Genetic Factors Underlying DSM-IV Criteria for Major Depression
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“The most commonly identified factors in MDD are a depression severity factor and a somatic factor (Shafer, 2006).”
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Measurement equivalence of the CES-D 8 in the general population in Belgium: a gender perspective
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“International literature shows the CES-D 20 to have good psychometric properties (17, 36, 49).”
BackgroundVentral striatum reactivity to reward and recent life stress interact to predict positive affect
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Positive Psychotherapy for Smoking Cessation: A Pilot Randomized Controlled Trial
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Kim, G., DeCoster, J., Huang, C.-H. S., & Chiriboga, D. A. (2011) · Cultural Diversity & Ethnic Minority Psychology · doi:10.1037/a0025434 · Cited by 125
Caught in a bad romance: Perfectionism, conflict, and depression in romantic relationships.
Mackinnon, S. P., Sherry, S., Antony, M. M., Stewart, S. H., Sherry, D. L., & Hartling, N. (2012) · Journal of Family Psychology · doi:10.1037/a0027402 · Cited by 140
Anhedonia as a component of the tobacco withdrawal syndrome.
Cook, J. W., Piper, M. E., Leventhal, A. M., Schlam, T. R., Fiore, M. C., & Baker, T. B. (2014) · Journal of Abnormal Psychology · doi:10.1037/abn0000016 · Cited by 123
“However, substantial psychopathology symptom data show that anhedonia is psychometrically distinct from negative affect forms of distress (Cook, Spring, McChargue, & Hedeker, 2004; Leventhal, Chasson, Tapia, Miller, & Pettit, 2006; Shafer, 2006).”
BackgroundYang, L., Jia, C.-X., & Qin, P. (2015) · BMC Psychiatry · doi:10.1186/s12888-015-0458-1 · Cited by 134
Assessment of late-life depression via self-report measures: a review
Balsamo, M., Cataldi, F., Carlucci, L., Padulo, C., & Fairfield, B. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s178943 · Cited by 137
Park, P., Godil, S. S., Mendenhall, S. K., Zuckerman, S. L., Shau, D. N., & McGirt, M. J. (2014) · Journal of Neurosurgery Spine · doi:10.3171/2014.3.spine1320 · Cited by 120
Dombrovski, A. Y., Cyranowski, J. M., Mulsant, B. H., Houck, P. R., Buysse, D. J., Andreescu, C., Thase, M. E., Mallinger, A. G., & Frank, E. (2008) · Depression and Anxiety · doi:10.1002/da.20467 · Cited by 116
“the HRSD-17 factor structure.([20]) We chose the above cutoffs rather than continuous subscale scores because of the limited internal consistency of the HRSD-17 subscales,([9,19]) probably reflecting insufficient unidimensionality of the scale as a whole.”
BackgroundFactors of PTSD: Differential specificity and external correlates
Gootzeit, J., & Markon, K. E. (2011) · Clinical Psychology Review · doi:10.1016/j.cpr.2011.06.005 · Cited by 118
Factor Structures of the Rosenberg Self-Esteem Scale
Huang, C., & Dong, N. (2011) · European Journal of Psychological Assessment · doi:10.1027/1015-5759/a000101 · Cited by 114
The BELLA Study Group, Barkmann, C., Erhart, M., & Schulte‐Markwort, M. (2008) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-008-1013-0 · Cited by 113
Giacobbe, P., Mayberg, H. S., & Lozano, A. M. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.04.028 · Cited by 112
Co‐morbid OSA and insomnia increases depression prevalence and severity in men
Lang, C. J., Appleton, S. L., Vakulin, A., McEvoy, R. D., Wittert, G. A., Martin, S. A., Catcheside, P. G., Antic, N. A., Lack, L., & Adams, R. J. (2017) · Respirology · doi:10.1111/resp.13064 · Cited by 111
Development of the CAT-ANX: A Computerized Adaptive Test for Anxiety
Gibbons, R. D., Weiss, D. J., Pilkonis, P. A., Frank, E., Moore, T., Kim, J. B., & Kupfer, D. J. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13020178 · Cited by 110
Andreescu, C., Chang, C.-C. H., Mulsant, B. H., & Ganguli, M. (2007) · International Psychogeriatrics · doi:10.1017/s1041610207006667 · Cited by 110
“We note that profiles 1 to 3 above – core mood, anhedonia/vegetative symptoms, and self-esteem/interpersonal difficulties – derived from the mCESD, are consistent with those described recently by Shafer (2006) in a metaanalysis of factor analyses of the original CES-D (Radloff, 1977).”
MethodPROMIS Pediatric Anger Scale: an item response theory analysis
Irwin, D. E., Stucky, B. D., Langer, M. M., Thissen, D., DeWitt, E. M., Lai, J., Yeatts, K. B., Varni, J. W., & DeWalt, D. A. (2011) · Quality of Life Research · doi:10.1007/s11136-011-9969-5 · Cited by 106
“These results of unidimensionality are consistent with a recent meta-analysis [34] and other published studies [35– 40].”
ResultSeo, E. H., Kim, S.-G., Kim, S. H., Kim, J. H., Park, J. H., & Yoon, H. (2018) · Annals of General Psychiatry · doi:10.1186/s12991-018-0223-1 · Cited by 113
Romera, I., Delgado-Cohen, H., Pérez, T., Caballero, L., & Gilaberte, I. (2008) · BMC Psychiatry · doi:10.1186/1471-244x-8-4 · Cited by 106
“There is evidence that patients with different depressive symptom profiles are likely to have different prognosis and therefore might require a different therapeutic approach [9].”
Factor Structure of the Center for Epidemiological Studies Depression Scale in Hong Kong Adolescents
Lee, S. W., Stewart, S. M., Byrne, B. M., Wong, J. P. S., Ho, S. Y., Lee, P. W. H., & Lam, T. (2008) · Journal of Personality Assessment · doi:10.1080/00223890701845385 · Cited by 105
“The findings have been inconsistent, although Shafer (2006) found the four-factor structure described by Radloff (1977) to be the most common.”
BackgroundFokkema, M., Smits, N., Kelderman, H., & Cuijpers, P. J. (2013) · Psychological Assessment · doi:10.1037/a0031669 · Cited by 104
Predictors of residual sleepiness in adequately treated obstructive sleep apnoea patients
Koutsourelakis, I., Perraki, E., Economou, N.-T., Dimitrokalli, P., Vagiakis, E., Roussos, C., & ZAKYNTHINOS, S. G. (2009) · European Respiratory Journal · doi:10.1183/09031936.00124708 · Cited by 105
Character Strengths – Stability, Change, and Relationships with Well-Being Changes
Gander, F., Hofmann, J., Proyer, R. T., & Ruch, W. (2019) · Applied Research in Quality of Life · doi:10.1007/s11482-018-9690-4 · Cited by 113
“The CES-D is one of the most frequently used measures for depressive symptoms and has good psychometric properties (Shafer, 2006).”
MethodDeverts, D. J., Cohen, S., DiLillo, V. G., Lewis, C. E., Kiefe, C. I., Whooley, M. A., & Matthews, K. A. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181ec4b98 · Cited by 104
“a recent meta-analysis of 28 studies (33).”
Morningness–eveningness, depressive symptoms, and emotional eating: A population-based study
Konttinen, H. M., Kronholm, E., Partonen, T., Kanerva, N., Männistö, S., & Haukkala, A. (2014) · Chronobiology International · doi:10.3109/07420528.2013.877922 · Cited by 107
“The structure of the CES-D scale has been widely studied, and a metaanalysis of 28 studies (Shafer, 2006) concluded that the 4-factor structure (negative affect, somatic and retarded activity, lack of positive affect, and interpersonal difficulties) proposed by Radloff (1977) best described the…”
BackgroundPagoto, S., Schneider, K. L., Whited, M. C., Oleski, J. L., Merriam, P. A., Appelhans, B. M., Ma, Y., Olendzki, B. C., Waring, M. E., Busch, A. M., et al. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.25 · Cited by 106
“One reason for the discrepancy is that the HRSD has a larger number of items pertaining to somatic symptoms relative to cognitive and behavioral symptoms compared to the BDI.[43] Obesity and its comorbid physical conditions (e.”
BackgroundProyer, R. T., Wellenzohn, S., Gander, F., & Ruch, W. (2015) · Applied Psychology: Health and Well-Being · doi:10.1111/aphw.12039 · Cited by 101
“The CES-D is frequently used in research (for an overview see Shafer, 2006).”
BackgroundMethodTUCKER, A. M., Liht, J., de Swardt, G., Jobson, G. A., Rebe, K. B., McIntyre, J. A., & Struthers, H. E. (2013) · AIDS Care · doi:10.1080/09540121.2013.859652 · Cited by 100
“Nevertheless, our preliminary checks for the congeneric measurement model indicated that the structure of the CES-D was not unidimensional (not unlike other research; see for example: Edwards, Cheavens, Heiy, & Cukrowicz, 2010; Giyeon, DeCoster, Chao-Hui, & Chiriboga, 2011; Shafer, 2006).”
Stattin, H., Enebrink, P., Özdemir, M., & Giannotta, F. (2015) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0039328 · Cited by 104
Metadata
- Authors
- Shafer, A. B.
- Corresponding author
- Shafer, Alan B.
- Venue
- Journal of Clinical Psychology
- Publisher
- Wiley
- Published
- 2005
- Volume
- 62
- Issue
- 1
- Pages
- 123-146
- ISSN
- 0021-9762 (ISSN-L)
- 1097-4679
- OpenAlex
- W2170701421
- Cited by
- 837
- References
- 111
- Citations by year
- 2026: 31 · 2025: 23 · 2024: 34 · 2023: 35 · 2022: 25 · 2021: 28 · 2020: 49 · 2019: 51 · 2018: 76 · 2017: 58 · 2016: 49 · 2015: 51 · 2014: 61 · 2013: 69 · 2012: 45
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Clinical Psychology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Decision Sciences › Management Science and Operations Research › Psychometric Methodologies and Testing
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- factor structure, Beck Depression Inventory, CES-D, Hamilton Depression Rating Scale, Zung Self-Rating Depression Scale, depression severity, somatic symptoms, positive affect
- MeSH terms
- Depressive Disorder, Factor Analysis, Statistical, Humans, Psychological Tests, Surveys and Questionnaires
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