Stress-related anhedonia is associated with ventral striatum reactivity to reward and transdiagnostic psychiatric symptomatology
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BACKGROUND: Early life stress (ELS) is consistently associated with increased risk for subsequent psychopathology. Individual differences in neural response to reward may confer vulnerability to stress-related psychopathology. Using data from the ongoing Duke Neurogenetics Study, the present study examined whether reward-related ventral striatum (VS) reactivity moderates the relationship between retrospectively reported ELS and anhedonic symptomatology. We further assessed whether individual differences in reward-related VS reactivity were associated with other depressive symptoms and problematic alcohol use via stress-related anhedonic symptoms and substance use-associated coping. METHOD: Blood oxygen level-dependent functional magnetic resonance imaging (fMRI) was collected while participants (n = 906) completed a card-guessing task, which robustly elicits VS reactivity. ELS, anhedonic symptoms, other depressive symptoms, coping behavior, and alcohol use behavior were assessed with self-report questionnaires. Linear regressions were run to examine whether VS reactivity moderated the relationship between ELS and anhedonic symptoms. Structural equation models examined whether this moderation was indirectly associated with other depression symptoms and problematic alcohol use through its association with anhedonia. RESULTS: Analyses of data from 820 participants passing quality control procedures revealed that the VS × ELS interaction was associated with anhedonic symptoms (p = 0.011). Moreover, structural equation models indirectly linked this interaction to non-anhedonic depression symptoms and problematic alcohol use through anhedonic symptoms and substance-related coping. CONCLUSIONS: These findings suggest that reduced VS reactivity to reward is associated with increased risk for anhedonia in individuals exposed to ELS. Such stress-related anhedonia is further associated with other depressive symptoms and problematic alcohol use through substance-related coping.
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Many human studies link lower basal ganglia activation during reward anticipation or receipt to depressive symptoms, and this activation often mediates the ELS-depression relationship.
“in many of the human studies reviewed, decreased activation in regions of the basal ganglia to the anticipation or receipt of reward was not only associated with depressive symptoms (Dillon et al., 2009; Goff et al., 2013), but often found to mediate the relationship between ELS and depression (Corral-Frías et al., 2015; Hanson et al., 2015).”
From The effects of early life stress on reward processing (2018) · cites this paper as Corral-Frías et al., 2015
Diminished ventral striatum activity in response to anticipation of monetary reward is associated with anhedonia in adolescents, and ventral striatum activity in response to reward may be moderated by exposure to early life stress.
“Diminished activity in the ventral striatum in response to anticipation of monetary reward has been associated with anhedonia in adolescents, and ventral striatum activity in response to reward may be moderated by exposure to early life stress (192).”
From A transdiagnostic perspective on social anhedonia (2019) · cites this paper as [192]
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“, 2013), but often found to mediate the relationship between ELS and depression (Corral-Frías et al., 2015; Hanson et al., 2015).”
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Impact of Early Life Stress on Reward Circuit Function and Regulation
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Plasticity of the Reward Circuitry After Early-Life Adversity: Mechanisms and Significance
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Brain mechanisms mediating effects of stress on reward sensitivity
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Neurobiological Markers of Resilience to Early-Life Adversity During Adolescence
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Early Life Stress and Gut Microbiome Dysbiosis: A Narrative Review
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Neuroimaging resilience to trauma: convergent evidence and challenges for future researchPreprint
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Value-Directed Remembering: A Dual-Process Perspective
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Hormonal Control of Maternal Behavior in Nonhuman Mammals
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Eckstrand, K., Talbot, A., Govani, V. N., Hart, K. H., Brodnick, Z. M., Ryan, N. D., Jones, N. P., Phillips, M. L., & Forbes, E. E. (2026) · European Journal of Psychotraumatology · doi:10.1080/20008066.2025.2611512 · Cited by 1 · see citing works
- Authors
- Corral-Frías, N. S., Nikolova, Y. S., Michalski, L. J., Baranger, D. A. A., Hariri, A. R., & Bogdan, R.
- Affiliations
- Washington University in St. Louis (US)
- Duke University (US)
- Corresponding author
- Corral-Frías, N. S.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2015-04-08
- Volume
- 45
- Issue
- 12
- Pages
- 2605-2617
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- PMC
- PMC4700837
- OpenAlex
- W2113504879
- Cited by
- 132
- References
- 95
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 8 · 2023: 10 · 2022: 17 · 2021: 15 · 2020: 24 · 2019: 12 · 2018: 8 · 2017: 10 · 2016: 12 · 2015: 3
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute on Aging (R01AG045231, AG045231)
- National Institute of Mental Health (MH014677, T32MH014677)
- National Institute on Drug Abuse (MH014677, R01DA033369, DA031579, DA033369, R01DA031579)
- National Institute of General Medical Sciences (T32GM008151, T32GM081739)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- early life stress, anhedonia, ventral striatum, reward processing, depression, alcohol abuse, substance use coping, transdiagnostic symptoms, moderating effect
- MeSH terms
- Adaptation, Psychological, Adolescent, Adult, Alcohol Drinking, Depression, Female, Humans, Magnetic Resonance Imaging, Male, North Carolina, Psychological Tests, Reward, Stress, Psychological, Students, Universities, Linear Models, Sex Distribution, Young Adult, Anhedonia, Ventral Striatum
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