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Cited by 308

The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.

Maternal obesity and neurodevelopmental and psychiatric disorders in offspring

Open access
Edlow, Andrea G.·2017·Prenatal Diagnosis
DOI 10.1002/pd.4932
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Abstract

There is a growing body of evidence from both human epidemiologic and animal studies that prenatal and lactational exposure to maternal obesity and high‐fat diet are associated with neurodevelopmental and psychiatric disorders in offspring. These disorders include cognitive impairment, autism spectrum disorders, attention deficit hyperactivity disorder, cerebral palsy, anxiety and depression, schizophrenia, and eating disorders. This review synthesizes human and animal data linking maternal obesity and high‐fat diet consumption to abnormal fetal brain development and neurodevelopmental and psychiatric morbidity in offspring. In addition, it highlights key mechanisms by which maternal obesity and maternal diet might impact fetal and offspring neurodevelopment, including neuroinflammation; increased oxidative stress, dysregulated insulin, glucose, and leptin signaling; dysregulated serotonergic and dopaminergic signaling; and perturbations in synaptic plasticity. Finally, the review summarizes available evidence regarding investigational therapeutic approaches to mitigate the harmful effects of maternal obesity on fetal and offspring neurodevelopment. © 2016 John Wiley & Sons, Ltd.

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Metadata

Authors
Edlow, A. G.
Venue
Prenatal Diagnosis
Publisher
Wiley
Published
2016-11-07
Volume
37
Issue
1
Pages
95-110
ISSN
  • 0197-3851 (ISSN-L)
  • 1097-0223
DOI
10.1002/pd.4932
OpenAlex
W2525747862
Cited by
308
References
137
FWCI
19.00
Type
journal article
Language
en
Open access
green

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