Adipokines: A treasure trove for the discovery of biomarkers for metabolic disorders

Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity

Alberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., Fruchart, J.-C., James, W. P. T., Loria, C. M., & Smith, S. C. (2009) · Circulation · doi:10.1161/circulationaha.109.192644 · Cited by 14,860

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518

Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics

Ong, S.-E., Blagoev, B., Kratchmarova, I., Kristensen, D. B., Steen, H., Pandey, A., & Mann, M. (2002) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m200025-mcp200 · Cited by 5,574

Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents

Ross, P. L., Huang, Y. N., Marchese, J. N., Williamson, B., Parker, K., Hattan, S., Khainovski, N., Pillai, S., Dey, S., Daniels, S., et al. (2004) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m400129-mcp200 · Cited by 4,401

Abdominal obesity and metabolic syndrome

Després, J.-P., & Lemieux, I. (2006) · Nature · doi:10.1038/nature05488 · Cited by 4,354

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543

Obesity and insulin resistance

Kahn, B. B., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10842 · Cited by 3,225

Understanding Adipocyte Differentiation

GREGOIRE, F. M., SMAS, C. M., & SUL, H. S. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.3.783 · Cited by 2,376

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.

Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2391 · Cited by 2,292

Difference gel electrophoresis. A single gel method for detecting changes in protein extracts

Ünlü, M., Morgan, M. E., & Minden, J. S. (1997) · ELECTROPHORESIS · doi:10.1002/elps.1150181133 · Cited by 2,179

Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk

Després, J.-P., Lemieux, I., Bergeron, J., Pibarot, P., Mathieu, P., Larose, E., Rodés-Cabau, J., Bertrand, O. F., & Poirier, P. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.159228 · Cited by 1,589

Comparison of the Release of Adipokines by Adipose Tissue, Adipose Tissue Matrix, and Adipocytes from Visceral and Subcutaneous Abdominal Adipose Tissues of Obese Humans

Fain, J. N., Madan, A. K., Hiler, M. L., Cheema, P., & Bahouth, S. W. (2004) · Endocrinology · doi:10.1210/en.2003-1336 · Cited by 1,572

Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1 H NMR spectroscopy study

Krssak, M., Falk Petersen, K., Dresner, A., DiPietro, L., Vogel, S. M., Rothman, D. L., Shulman, G. I., & Roden, M. (1999) · Diabetologia · doi:10.1007/s001250051123 · Cited by 1,264

Obesity and the Metabolic Syndrome in Developing Countries

Misra, A., & Khurana, L. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1595 · Cited by 1,219

Comparison of Label-free Methods for Quantifying Human Proteins by Shotgun Proteomics

Old, W. M., Meyer-Arendt, K., Aveline-Wolf, L., Pierce, K. G., Mendoza, A., Sevinsky, J. R., Resing, K. A., & Ahn, N. G. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m500084-mcp200 · Cited by 1,206

Monocyte chemoattractant protein 1 in obesity and insulin resistance

Sartipy, P., & Loskutoff, D. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1133870100 · Cited by 1,201

Feature-based prediction of non-classical and leaderless protein secretion

Bendtsen, J. D., Jensen, L. J., Blom, N., von Heijne, G., & Brunak, S. (2004) · Protein Engineering Design and Selection · doi:10.1093/protein/gzh037 · Cited by 1,186

Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism

Cao, H., Gerhold, K., Mayers, J. R., Wiest, M. M., Watkins, S. M., & Hotamisligil, G. S. (2008) · Cell · doi:10.1016/j.cell.2008.07.048 · Cited by 1,139

Immunophenotype of Human Adipose-Derived Cells: Temporal Changes in Stromal-Associated and Stem Cell–Associated Markers

Mitchell, J. B., McIntosh, K., Zvonic, S., Garrett, S., Floyd, Z. E., Kloster, A., Di Halvorsen, Y., Storms, R. W., Goh, B., Kilroy, G., et al. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0234 · Cited by 1,124

Adipose Tissue

Scherer, P. E. (2006) · Diabetes · doi:10.2337/db06-0263 · Cited by 1,066

Adiponectin Reduces Atherosclerosis in Apolipoprotein E-Deficient Mice

Okamoto, Y., Kihara, S., Ouchi, N., Nishida, M., Arita, Y., Kumada, M., Ohashi, K., Sakai, N., Shimomura, I., Kobayashi, H., et al. (2002) · Circulation · doi:10.1161/01.cir.0000042707.50032.19 · Cited by 1,030

Apelin, a Newly Identified Adipokine Up-Regulated by Insulin and Obesity

Boucher, J., Masri, B., Daviaud, D., Gesta, S., Guigné, C., Mazzucotelli, A., Castan-Laurell, I., Tack, I., Knibiehler, B., Carpéné, C., et al. (2005) · Endocrinology · doi:10.1210/en.2004-1427 · Cited by 910

A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC)

Ong, S.-E., & Mann, M. (2006) · Nature Protocols · doi:10.1038/nprot.2006.427 · Cited by 896

Insulin-sensitive obesity

Klöting, N., Fasshauer, M., Dietrich, A., Kovacs, P., Schön, M. R., Kern, M., Stumvoll, M., & Blüher, M. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00586.2009 · Cited by 856

Proteolytic 18O Labeling for Comparative Proteomics: Model Studies with Two Serotypes of Adenovirus

Yao, X., Freas, A., Ramirez, J., Demirev, P. A., & Fenselau, C. (2001) · Analytical Chemistry · doi:10.1021/ac001404c · Cited by 759

Visceral adipose tissue-derived serine protease inhibitor: A unique insulin-sensitizing adipocytokine in obesity

Hida, K., Wada, J., Eguchi, J., Zhang, H., Baba, M., Seida, A., Hashimoto, I., Okada, T., Yasuhara, A., Nakatsuka, A., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504703102 · Cited by 719

Potential Role of TNF-α in the Pathogenesis of Insulin Resistance and Type 2 Diabetes

Moller, D. E. (2000) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(00)00272-1 · Cited by 718

Adipocyte-Derived Plasma Protein Adiponectin Acts as a Platelet-Derived Growth Factor-BB–Binding Protein and Regulates Growth Factor–Induced Common Postreceptor Signal in Vascular Smooth Muscle Cell

Arita, Y., Kihara, S., Ouchi, N., Maeda, K., Kuriyama, H., Okamoto, Y., Kumada, M., Hotta, K., Nishida, M., Takahashi, M., et al. (2002) · Circulation · doi:10.1161/01.cir.0000018622.84402.ff · Cited by 695

Secretion of the galectin family of mammalian carbohydrate-binding proteins

Hughes, R. (1999) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(99)00177-4 · Cited by 636

The distinction of metabolically ‘healthy’ from ‘unhealthy’ obese individuals

Blüher, M. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283346ccc · Cited by 632

The epidemiology of obesity and asthma

Ford, E. S. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.11.050 · Cited by 618

Leptin secretion from subcutaneous and visceral adipose tissue in women.

Van Harmelen, V, Reynisdottir, S., Eriksson, P., Thörne, A., Hoffstedt, J., Lönnqvist, F., & Arner, P. (1998) · Diabetes · doi:10.2337/diabetes.47.6.913 · Cited by 611

Machine learning approaches for the prediction of signal peptides and other protein sorting signals

Nielsen, H., Brunak, S., & von Heijne, G. (1999) · Protein Engineering, Design and Selection · doi:10.1093/protein/12.1.3 · Cited by 608

From Blood Monocytes to Adipose Tissue-Resident Macrophages

Curat, C. A., Miranville, A., Sengenès, C., Diehl, M., Tonus, C., Busse, R., & Bouloumié, A. (2004) · Diabetes · doi:10.2337/diabetes.53.5.1285 · Cited by 600

Signalling role of adipose tissue: adipokines and inflammation in obesity

Trayhurn, P., & Wood, I. S. (2005) · Biochemical Society Transactions · doi:10.1042/bst0331078 · Cited by 588

Plasma Adiponectin Concentrations Predict Insulin Sensitivity of Both Glucose and Lipid Metabolism

Tschritter, O., Fritsche, A., Thamer, C., Haap, M., Shirkavand, F., Rahe, S., Staiger, H., Maerker, E., Häring, H., & Stumvoll, M. (2003) · Diabetes · doi:10.2337/diabetes.52.2.239 · Cited by 585

Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome

Lamers, D., Famulla, S., Wronkowitz, N., Hartwig, S., Lehr, S., Ouwens, D. M., Eckardt, K., Kaufman, J. M., Ryden, M., Müller, S., et al. (2011) · Diabetes · doi:10.2337/db10-1707 · Cited by 582

Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation

Wabitsch, M., Brenner, R., Melzner, I., Braun, M., Möller, P., Heinze, E., Debatin, K.-M., & Hauner, H. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801520 · Cited by 562

“Vasocrine” signalling from perivascular fat: a mechanism linking insulin resistance to vascular disease

Yudkin, J. S., Eringa, E., & Stehouwer, C. D. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66585-3 · Cited by 549

Monocyte Chemoattractant Protein-1 Release Is Higher in Visceral than Subcutaneous Human Adipose Tissue (AT): Implication of Macrophages Resident in the AT

Bruun, J. M., Lihn, A. S., Pedersen, S. B., & Richelsen, B. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1696 · Cited by 535

Lipid accumulation in non-adipose tissue and lipotoxicity

van Herpen, N. A., & Schrauwen-Hinderling, V. B. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.11.049 · Cited by 500

Visceral Obesity: The Link Among Inflammation, Hypertension, and Cardiovascular Disease

Mathieu, P., Poirier, P., Pibarot, P., Lemieux, I., & Després, J.-P. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.110320 · Cited by 490

Brefeldin A, a drug that blocks secretion, prevents the assembly of non-clathrin-coated buds on Golgi cisternae

Orcl, L., Tagaya, M., Amherdt, M., Perrelet, A., Donaldson, J. G., Lippincott-Schwartz, J., Klausner, R. D., & Rothman, J. E. (1991) · Cell · doi:10.1016/0092-8674(91)90273-2 · Cited by 466

Rapid ‘de novo’ peptide sequencing by a combination of nanoelectrospray, isotopic labeling and a quadrupole/time-of-flight mass spectrometer

Shevchenko, A., Chernushevich, I., Ens, W., Standing, K. G., Thomson, B., Wilm, M., & Mann, M. (1997) · Rapid Communications in Mass Spectrometry · doi:10.1002/(sici)1097-0231(19970615)11:9<1015::aid-rcm958>3.0.co;2-h · Cited by 454

Importance of Weight Management in Type 2 Diabetes: Review with Meta-analysis of Clinical Studies

Anderson, J. W., Kendall, C. W. C., & Jenkins, D. J. A. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719316 · Cited by 448

Properties of 13C-Substituted Arginine in Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)

Ong, S.-E., Kratchmarova, I., & Mann, M. (2003) · Journal of Proteome Research · doi:10.1021/pr0255708 · Cited by 432

Differential Regulation of Adiponectin Secretion from Cultured Human Omental and Subcutaneous Adipocytes: Effects of Insulin and Rosiglitazone

Motoshima, H., Wu, X., Sinha, M. K., Hardy, V. E., Rosato, E. L., Barbot, D. J., Rosato, F. E., & Goldstein, B. J. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020635 · Cited by 427

Label-free, normalized quantification of complex mass spectrometry data for proteomic analysis

Griffin, N. M., Yu, J., Long, F., Oh, P., Shore, S., Li, Y., Koziol, J. A., & Schnitzer, J. E. (2010) · Nature Biotechnology · doi:10.1038/nbt.1592 · Cited by 402

Detecting Differential and Correlated Protein Expression in Label-Free Shotgun Proteomics

Zhang, B., VerBerkmoes, N. C., Langston, M. A., Uberbacher, E., Hettich, R. L., & Samatova, N. F. (2006) · Journal of Proteome Research · doi:10.1021/pr0600273 · Cited by 394

Comparison of different depletion strategies for improved resolution in proteomic analysis of human serum samples

Björhall, K., Miliotis, T., & Davidsson, P. (2005) · PROTEOMICS · doi:10.1002/pmic.200400900 · Cited by 384

Distinct Transcriptional Profiles of Adipogenesisin Vivo and in Vitro

Soukas, A., Socci, N. D., Saatkamp, B. D., Novelli, S., & Friedman, J. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104421200 · Cited by 368

Quantitation of peptides and proteins by matrix-assisted laser desorption/ionization mass spectrometry using18O-labeled internal standards

Mirgorodskaya, O. A., Kozmin, Y. P., Titov, M. I., K�rner, R., S�nksen, C. P., & Roepstorff, P. (2000) · Rapid Communications in Mass Spectrometry · doi:10.1002/1097-0231(20000730)14:14<1226::aid-rcm14>3.0.co;2-v · Cited by 368

Secretion of Adiponectin and Regulation of apM1 Gene Expression in Human Visceral Adipose Tissue

Halleux, C. M., Takahashi, M., Delporte, M. L., Detry, R., Funahashi, T., Matsuzawa, Y., & Brichard, S. M. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5904 · Cited by 344

Effect of leptin on allergic airway responses in mice

Shore, S. A., Schwartzman, I. N., Mellema, M. S., Flynt, L., Imrich, A., & Johnston, R. A. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.10.007 · Cited by 329

18 O Labeling: a tool for proteomics

Stewart, I. I., Thomson, T., & Figeys, D. (2001) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.525 · Cited by 327

Adiposity Elevates Plasma MCP-1 Levels Leading to the Increased CD11b-positive Monocytes in Mice

Takahashi, K., Mizuarai, S., Araki, H., Mashiko, S., Ishihara, A., Kanatani, A., Itadani, H., & Kotani, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309895200 · Cited by 327

Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice

Shore, S. A., Terry, R. D., Flynt, L., Xu, A., & Hug, C. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.04.021 · Cited by 320

Link between obesity and type 2 diabetes

Golay, A., & Ybarra, J. (2005) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2005.07.010 · Cited by 301

Protease‐catalyzed incorporation of 18O into peptide fragments and its application for protein sequencing by electrospray and matrix‐assisted laser desorption/ionization mass spectrometry

Schnölzer, M., Jedrzejewski, P., & Lehmann, W. D. (1996) · ELECTROPHORESIS · doi:10.1002/elps.1150170517 · Cited by 295

Protective vascular and myocardial effects of adiponectin

Goldstein, B. J., Scalia, R. G., & Ma, X. L. (2009) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1398 · Cited by 287

Differences among techniques for high‐abundant protein depletion

Zolotarjova, N., Martosella, J., Nicol, G., Bailey, J., Boyes, B. E., & Barrett, W. C. (2005) · PROTEOMICS · doi:10.1002/pmic.200402021 · Cited by 282

Resistin, Adiponectin, and Risk of Heart Failure

Frankel, D. S., Vasan, R. S., D'Agostino, R. B., Benjamin, E. J., Levy, D., Wang, T. J., & Meigs, J. B. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.07.073 · Cited by 255

A Proteomic Approach for Identification of Secreted Proteins during the Differentiation of 3T3-L1 Preadipocytes to Adipocytes

Kratchmarova, I., Kalume, D. E., Blagoev, B., Scherer, P. E., Podtelejnikov, A. V., Molina, H., Bickel, P. E., Andersen, J. S., Fernandez, M. M., Bunkenborg, J., et al. (2002) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m200006-mcp200 · Cited by 249

The role of epicardial and perivascular adipose tissue in the pathophysiology of cardiovascular disease

Ouwens, D. M., Sell, H., Greulich, S., & Eckel, J. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01141.x · Cited by 235

Characterization of the Human Visceral Adipose Tissue Secretome

Alvarez-Llamas, G., Szalowska, E., de Vries, M. P., Weening, D., Landman, K., Hoek, A., Wolffenbuttel, B. H. R., Roelofsen, H., & Vonk, R. J. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600265-mcp200 · Cited by 231

Albumin depletion of human plasma also removes low abundance proteins including the cytokines

Granger, J., Siddiqui, J., Copeland, S., & Remick, D. (2005) · PROTEOMICS · doi:10.1002/pmic.200401331 · Cited by 228

Monocyte Chemotactic Protein-1 Is a Potential Player in the Negative Cross-Talk between Adipose Tissue and Skeletal Muscle

Sell, H., Dietze-Schroeder, D., Kaiser, U., & Eckel, J. (2006) · Endocrinology · doi:10.1210/en.2005-0969 · Cited by 225

Characterization of the human blood plasma proteome

Shen, Y., Kim, J., Strittmatter, E. F., Jacobs, J. M., Camp, D. G., Fang, R., Tolié, N., Moore, R. J., & Smith, R. D. (2005) · PROTEOMICS · doi:10.1002/pmic.200401246 · Cited by 225

Non-alcoholic fatty liver disease: the hepatic consequence of obesity and the metabolic syndrome

Moore, J. B. (2010) · Proceedings of the Nutrition Society · doi:10.1017/s0029665110000030 · Cited by 217

Identification of Extracellular and Intracellular Signaling Components of the Mammary Adipose Tissue and Its Interstitial Fluid in High Risk Breast Cancer Patients

Celis, J. E., Moreira, J. M. A., Cabezón, T., Gromov, P., Friis, E., Rank, F., & Gromova, I. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m500030-mcp200 · Cited by 215

Secreted proteins from adipose tissue and skeletal muscle – adipokines, myokines and adipose/muscle cross-talk

Trayhurn, P., Drevon, C. A., & Eckel, J. (2011) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2010.535835 · Cited by 214

Proteomic Analysis of Tumor Necrosis Factor-α-Induced Secretome of Human Adipose Tissue-Derived Mesenchymal Stem Cells

Lee, M. J., Kim, J., Kim, M. Y., Bae, Y.-S., Ryu, S. H., Lee, T. G., & Kim, J. H. (2010) · Journal of Proteome Research · doi:10.1021/pr900898n · Cited by 209

Secretome of Primary Cultures of Human Adipose-derived Stem Cells

Zvonic, S., Lefevre, M., Kilroy, G., Floyd, Z. E., DeLany, J. P., Kheterpal, I., Gravois, A., Dow, R., White, A., Wu, X., et al. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600217-mcp200 · Cited by 208

Responses to ozone are increased in obese mice

Shore, S. A., Rivera-Sanchez, Y. M., Schwartzman, I. N., & Johnston, R. A. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00336.2003 · Cited by 197

Obesity and cardiovascular disease: From pathophysiology to risk stratification

Marinou, K., Tousoulis, D., Antonopoulos, A. S., Stefanadi, E., & Stefanadis, C. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2009.03.135 · Cited by 190

Cardiovascular effects of leptin

Sweeney, G. (2010) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.224 · Cited by 184

Profiling of the secreted proteins during 3T3-L1 adipocyte differentiation leads to the identification of novel adipokines

Wang, P., Mariman, E., Keijer, J., Bouwman, F., Noben, J.-P., Robben, J., & Renes, J. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4256-z · Cited by 181

Pigment Epithelium-Derived Factor Contributes to Insulin Resistance in Obesity

Crowe, S., Wu, L. E., Economou, C., Turpin, S. M., Matzaris, M., Hoehn, K. L., Hevener, A. L., James, D. E., Duh, E. J., & Watt, M. J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.06.001 · Cited by 180

Dissection of Proteolytic 18O Labeling: Endoprotease-Catalyzed 16O-to-18O Exchange of Truncated Peptide Substrates

Yao, X., Afonso, C., & Fenselau, C. (2003) · Journal of Proteome Research · doi:10.1021/pr025572s · Cited by 168

A Proteomic Approach for Quantitation of Phosphorylation Using Stable Isotope Labeling in Cell Culture

Ibarrola, N., Kalume, D. E., Gronborg, M., Iwahori, A., & Pandey, A. (2003) · Analytical Chemistry · doi:10.1021/ac034931f · Cited by 160

Autocrine Action of Adiponectin on Human Fat Cells Prevents the Release of Insulin Resistance-Inducing Factors

Dietze‐Schroeder, D., Sell, H., Uhlig, M., Koenen, M., & Eckel, J. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2003 · Cited by 160

Pigment epithelium-derived factor (PEDF) is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells

Famulla, S., Lamers, D., Hartwig, S., Paßlack, W., Horrighs, A., Cramer, A., Lehr, S., Sell, H., & Eckel, J. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.212 · Cited by 158

Proteolytic 18O Labeling for Comparative Proteomics: Evaluation of Endoprotease Glu-C as the Catalytic Agent

Reynolds, K. J., Yao, X., & Fenselau, C. (2002) · Journal of Proteome Research · doi:10.1021/pr0100016 · Cited by 156

Chemokines as risk factors for type 2 diabetes: results from the MONICA/KORA Augsburg study, 1984–2002

Herder, C., Baumert, J., Thorand, B., Köenig, W., de Jager, W., Meisinger, C., Illig, T., Martin, S., & Kolb, H. (2006) · Diabetologia · doi:10.1007/s00125-006-0190-y · Cited by 154

Proteomic Analysis of Astrocytic Secretion in the Mouse

Lafon‐Cazal, M., Adjali, O., Galéotti, N., Poncet, J., Jouin, P., Homburger, V., Bockaert, J., & Marin, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211980200 · Cited by 148

Interleukin-6 and insulin sensitivity: friend or foe?

Carey, A. L., & Febbraio, M. A. (2004) · Diabetologia · doi:10.1007/s00125-004-1447-y · Cited by 143

Getting the message across: mechanisms of physiological cross talk by adipose tissue

Lee, D.-E., Kehlenbrink, S., Lee, H., Hawkins, M. A., & Yudkin, J. S. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00015.2009 · Cited by 143

Temporal Profiling of the Adipocyte Proteome during Differentiation Using a Five-Plex SILAC Based Strategy

Molina, H., Yang, Y., Ruch, T. R., Kim, J. W., Mortensen, P., Otto, T. C., Nalli, A., Tang, Q.-Q., Lane, M. D., Chaerkady, R., et al. (2008) · Journal of Proteome Research · doi:10.1021/pr800650r · Cited by 142

Interleukin-6 production by contracting human skeletal muscle: autocrine regulation by IL-6

Keller, P., Keller, C., Carey, A. L., Jauffred, S., Fischer, C. P., Steensberg, A., & Pedersen, B. K. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.048 · Cited by 138

Quantitative Proteomic Analysis of the Secretory Proteins from Rat Adipose Cells Using a 2D Liquid Chromatography−MS/MS Approach

Chen, X., Cushman, S. W., Pannell, L. K., & Hess, S. Y. (2005) · Journal of Proteome Research · doi:10.1021/pr049772a · Cited by 131

Glucocorticoids reciprocally regulate expression of the CCAAT/enhancer-binding protein alpha and delta genes in 3T3-L1 adipocytes and white adipose tissue.

MacDougald, O. A., Cornelius, P. K., Lin, F., Chen, S. S., & Lane, M. D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32271-8 · Cited by 127

Temporal Profiling of the Secretome during Adipogenesis in Humans

Zhong, J., Krawczyk, S. A., Chaerkady, R., Huang, H., Goel, R., Bader, J. S., Wong, G. W., Corkey, B. E., & Pandey, A. (2010) · Journal of Proteome Research · doi:10.1021/pr100521c · Cited by 120

Epidemiology of childhood type 2 diabetes and obesity

Shaw, J. E. (2007) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2007.00329.x · Cited by 119

Identification of miR‐21 targets in breast cancer cells using a quantitative proteomic approach

Yang, Y., Chaerkady, R., Beer, M., Mendell, J. T., & Pandey, A. (2009) · PROTEOMICS · doi:10.1002/pmic.200800551 · Cited by 119

Adipose tissue inflammation: novel insight into the role of macrophages and lymphocytes

Sell, H., & Eckel, J. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32833aab7f · Cited by 115

Pro-inflammatory responses in human monocytes are β1-adrenergic receptor subtype dependent

Grisanti, L. A., Evanson, J., Marchus, E., Jorissen, H., Woster, A. P., DeKrey, W. L., Sauter, E. R., Combs, C. K., & Porter, J. E. (2010) · Molecular Immunology · doi:10.1016/j.molimm.2009.12.013 · Cited by 108

Quantitative Mass Spectrometry-based Proteomics Reveals the Dynamic Range of Primary Mouse Astrocyte Protein Secretion

Greco, T. M., Seeholzer, S. H., Mak, A., Spruce, L. A., & Ischiropoulos, H. (2010) · Journal of Proteome Research · doi:10.1021/pr100134n · Cited by 105

Effects of Tumor Necrosis Factor-α on Insulin Action in Cultured Human Muscle Cells

Halse, R., Pearson, S. L., McCormack, J. G., Yeaman, S. J., & Taylor, R. (2001) · Diabetes · doi:10.2337/diabetes.50.5.1102 · Cited by 100

Comparison of spectral counting and metabolic stable isotope labeling for use with quantitative microbial proteomics

Hendrickson, E. L., Xia, Q., Wang, T., Leigh, J. A., & Hackett, M. (2006) · The Analyst · doi:10.1039/b610957h · Cited by 91

Advances in quantitative proteomics using stable isotope tags

Flory, M. R., Griffin, T. J., Martin, D. B., & Aebersold, R. H. (2002) · Trends in biotechnology · doi:10.1016/s1471-1931(02)00203-3 · Cited by 89

Microarray analysis of gene expression during early adipocyte differentiation

Burton, G. R., Guan, Y., Nagarajan, R., & McGehee, R. E. (2002) · Gene · doi:10.1016/s0378-1119(02)00726-6 · Cited by 88

Adenovirus-Mediated Adiponectin Expression Augments Skeletal Muscle Insulin Sensitivity in Male Wistar Rats

Satoh, H., Nguyen, M. T., Trujillo, M., Imamura, T., Usui, I., Scherer, P. E., & Olefsky, J. M. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1304 · Cited by 85

Effect of massive weight loss induced by bariatric surgery on serum levels of interleukin-18 and monocyte-chemoattractant-protein-1 in morbid obesity

Schernthaner, G.-H., Kopp, H.-P., Kriwanek, S., Krzyzanowska, K., Satler, M., Koppensteiner, R., & Schernthaner, G. (2006) · Obesity Surgery · doi:10.1381/096089206777346763 · Cited by 83

Protein array technology to detect HER2 (erbB-2)-induced ‘cytokine signature’ in breast cancer

Vázquez‐Martín, A., Colomer, R., & Menéndez, J. A. (2007) · European Journal of Cancer · doi:10.1016/j.ejca.2007.01.037 · Cited by 83

Comparative analysis of the secretory proteome of human adipose stromal vascular fraction cells during adipogenesis

Kim, J. J., Choi, Y. S., Lim, S., Yea, K., Yoon, J. H., Jun, D., Ha, S. H., Kim, J., Kim, J. H., Suh, P., et al. (2009) · PROTEOMICS · doi:10.1002/pmic.200900218 · Cited by 76

The Adipocyte as a Secretory Organ: Mechanisms of Vesicle Transport and Secretory Pathways

Bradley, R. L. (2001) · Recent Progress in Hormone Research · doi:10.1210/rp.56.1.329 · Cited by 76

Secretome analysis of rat adipose tissues shows location-specific roles for each depot type

Roca-Rivada, A., Alonso, J., Al–Massadi, O., Castelao, C., Peinado, J. R., Seoane, L. M., Casanueva, F. F., & Pardo, M. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.03.010 · Cited by 75

Adipose tissue changes in obesity

Coppack, S. W. (2005) · Biochemical Society Transactions · doi:10.1042/bst0331049 · Cited by 73

Oleic acid and adipokines synergize in inducing proliferation and inflammatory signalling in human vascular smooth muscle cells

Lamers, D., Schlich, R., Greulich, S., Sasson, S., Sell, H., & Eckel, J. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01099.x · Cited by 70

Identification of Novel Human Adipocyte Secreted Proteins by Using SGBS Cells

Rosenow, A., Arrey, T. N., Bouwman, F. G., Noben, J., Wabitsch, M., Mariman, E. C. M., Karas, M., & Renes, J. (2010) · Journal of Proteome Research · doi:10.1021/pr100621g · Cited by 68

Chemotactic cytokines, obesity and type 2 diabetes:in vivoandin vitroevidence for a possible causal correlation? Symposium on ‘Frontiers in adipose tissue biology’

Sell, H., & Eckel, J. (2009) · Proceedings of The Nutrition Society · doi:10.1017/s0029665109990218 · Cited by 68

Combinatorial hexapeptide ligand libraries (ProteoMiner™): An innovative fractionation tool for differential quantitative clinical proteomics

Hartwig, S., Czibere, A. G., Kotzka, J., Paßlack, W., Haas, R. R., Eckel, J., & Lehr, S. (2009) · Archives of Physiology and Biochemistry · doi:10.1080/13813450903154224 · Cited by 65

Central regulation of energy balance: inputs, outputs and leptin resistance

Arch, J. R. S. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2004407 · Cited by 63

Depletion of High-Abundance Proteins in Plasma by Immunoaffinity Subtraction for Two-Dimensional Difference Gel Electrophoresis Analysis

Dardé, V. M., Barderas, M. G., & Vivanco, F. (2006) · Humana Press eBooks · doi:10.1385/1-59745-214-9:351 · Cited by 57

Cardiorespiratory Fitness and Insulin Sensitivity in Overweight or Obese Subjects May Be Linked Through Intrahepatic Lipid Content

Haufe, S., Engeli, S., Budziarek, P., Utz, W., Schulz‐Menger, J., Hermsdorf, M., Wiesner, S., Otto, C., Haas, V. K., de Greiff, A., et al. (2010) · Diabetes · doi:10.2337/db09-1200 · Cited by 56

Comparison of Isotope-labeled Amino Acid Incorporation Rates (CILAIR) Provides a Quantitative Method to Study Tissue Secretomes

Roelofsen, H., Dijkstra, M., Weening, D., de Vries, M. P., Hoek, A., & Vonk, R. J. (2008) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m800254-mcp200 · Cited by 49

Monomeric Tartrate Resistant Acid Phosphatase Induces Insulin Sensitive Obesity

Lång, P., van Harmelen, V., Rydén, M., Kaaman, M., Parini, P., Carneheim, C., Cassady, A. I., Hume, D. A., Andersson, G. N., & Arner, P. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001713 · Cited by 46

Using gene expression to predict the secretome of differentiating human preadipocytes

Mutch, D. M., Rouault, C., Kéophiphath, M., Lacasa, D., & Clément, K. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.3 · Cited by 45

Peripheral Actions of Leptin and Its Involvement in Disease

Frühbeck, G., & Nutr, R. (2002) · Nutrition Reviews · doi:10.1301/002966402320634931 · Cited by 44

From lipodystrophy syndromes to diabetes mellitus

Joffe, B. I., Panz, V. R., & Raal, F. J. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04616-x · Cited by 41

Role of lipid-derived mediators in skeletal muscle insulin resistance

Taube, A., Eckardt, K., & Eckel, J. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00241.2009 · Cited by 40

Acid hydrolysis of silk fibroins and determination of the enrichment of isotopically labeled amino acids using precolumn derivatization and high-performance liquid chromatography–electrospray ionization–mass spectrometry

Hess, S. Y., van Beek, J. D., & Pannell, L. K. (2002) · Analytical Biochemistry · doi:10.1016/s0003-2697(02)00402-5 · Cited by 38

Protein Microarrays: Effective Tools for the Study of Inflammatory Diseases

Yu, X., Schneiderhan‐Marra, N., Hsu, H., Bachmann, J., & Joos, T. O. (2009) · Methods in molecular biology · doi:10.1007/978-1-60761-232-2_15 · Cited by 28

Obesity Is Associated with Bronchial Hyper-Responsiveness in Women

Sood, A., Dawson, B. K., Eid, W., Eagleton, L. E., Henkle, J. Q., & Hopkins-Price, P. L. (2005) · Journal of Asthma · doi:10.1080/02770900500371047 · Cited by 21

Adipokines in health and disease

Fasshauer, M., & Blüher, M. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.04.014 · Cited by 1,050

Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk

Stern, J. H., Rutkowski, J. M., & Scherer, P. E. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.011 · Cited by 1,031

Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis

Kalinkovich, A., & Livshits, G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.008 · Cited by 882

Metabolic syndrome update

Grundy, S. M. (2016) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2015.10.004 · Cited by 882

Targeting adipose tissue in the treatment of obesity-associated diabetes

Kusminski, C. M., Bickel, P. E., & Scherer, P. E. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.75 · Cited by 678