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Cited by 419

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Differentially Activated Macrophages Orchestrate Myogenic Precursor Cell Fate During Human Skeletal Muscle Regeneration

Open access
Saclier, Marielle, Yacoub-Youssef, Houda, Mackey, Abigail L., Arnold, Ludovic, Ardjoune, Hamida, Magnan, Mélanie, Sailhan, Frédéric, Chelly, Jamel, Pavlath, Grace K., Mounier, Rémi, Kjaer, Michael, Chazaud, Bénédicte·2013·Stem Cells
DOI 10.1002/stem.1288
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Abstract

Macrophages (MPs) exert either beneficial or deleterious effects on tissue repair, depending on their activation/polarization state. They are crucial for adult skeletal muscle repair, notably by acting on myogenic precursor cells. However, these interactions have not been fully characterized. Here, we explored both in vitro and in vivo, in human, the interactions of differentially activated MPs with myogenic precursor cells (MPCs) during adult myogenesis and skeletal muscle regeneration. We showed in vitro that through the differential secretion of cytokines and growth factors, proinflammatory MPs inhibited MPC fusion while anti-inflammatory MPs strongly promoted MPC differentiation by increasing their commitment into differentiated myocytes and the formation of mature myotubes. Furthermore, the in vivo time course of expression of myogenic and MP markers was studied in regenerating human healthy muscle after damage. We observed that regenerating areas containing proliferating MPCs were preferentially associated with MPs expressing proinflammatory markers. In the same muscle, regenerating areas containing differentiating myogenin-positive MPCs were preferentially coupled to MPs harboring anti-inflammatory markers. These data demonstrate for the first time in human that MPs sequentially orchestrate adult myogenesis during regeneration of damaged skeletal muscle. These results support the emerging concept that inflammation, through MP activation, controls stem cell fate and coordinates tissue repair.

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Crossref · 10.1002/stem.1288

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Metadata

Authors
Saclier, M., Yacoub-Youssef, H., Mackey, A. L., Arnold, L., Ardjoune, H., Magnan, M., Sailhan, F., Chelly, J., Pavlath, G. K., Mounier, R., Kjaer, M., & Chazaud, B.
Venue
Stem Cells
Publisher
Oxford University Press (OUP)
Published
2013-02-01
Volume
31
Issue
2
Pages
384-396
ISSN
  • 1066-5099 (ISSN-L)
  • 1549-4918
DOI
10.1002/stem.1288
OpenAlex
W2080238836
Cited by
419
References
13
FWCI
7.20
Type
journal article
Language
en
Open access
green

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