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Expression of the histocompatibility glycoprotein HLA-DR in neurological disease

McGeer, P. L., Itagaki, S., McGeer, E. G.·1988·Acta Neuropathologica

DOI 10.1007/bf00689592

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Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR
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Increased senile plaques without microglia in Alzheimer's disease
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“There are numerous reports of increased HLA and MHC class II expression with brain injury and disease processes in both rodent models and human post-mortem brain tissue [23].”
Background
The MHC class II transactivator modulates seeded alpha-synuclein pathology and dopaminergic neurodegeneration in an in vivo rat model of Parkinson's disease
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Network Dynamics‐based Subtyping of Alzheimer's Disease With Microglial Genetic Risk Factors
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Authors: McGeer, P. L., Itagaki, S., & McGeer, E. G.
Venue: Acta Neuropathologica
Publisher: Springer Science and Business Media LLC
Published: 1988
Volume: 76
Issue: 6
Pages: 550-557
ISSN: 0001-6322 (ISSN-L)
1432-0533
DOI: 10.1007/bf00689592
OpenAlex: W2046957687
Cited by: 420
References: 2
FWCI: 12.40
Type: journal article
Language: en
Open access: closed

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Expression of the histocompatibility glycoprotein HLA-DR in neurological disease

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