Cited by 345Alzheimer's disease research and treatmentsMitochondrial Function and PathologyBiochemical Acid Research Studies

The DOI matches its Crossref record; 58 of the 59 references it cites were found in a registry or an index.

Abnormalities of mitochondrial enzymes in Alzheimer disease

Gibson, G. E., Sheu, K.-F. R., Blass, J. P.·1998·Journal of Neural Transmission

DOI 10.1007/s007020050099

Open this paper in CoChat — free account

Abstract

Abundant evidence, including critical information gathered by Prof. Siegfried Hoyer and his colleagues, indicates that abnormalities of cerebral metabolism are common in neurodegenerative diseases, including Alzheimer's Disease (AD). Alterations in mitochondrial enzymes likely underlie these deficits. Replicable reductions in AD brain occur in the pyruvate dehydrogenase complex (the link of glycolysis to the Kreb's cycle), the alpha-ketoglutarate dehydrogenase complex (KGDHC; the link of Kreb's cycle to glutamate metabolism) and cytochrome oxidase (the link of the Kreb's cycle to oxygen utilization). Available evidence suggests that deficiencies in KGDHC may be genetic in some cases, whereas evidence that the other two enzyme systems have a genetic component is lacking. Additional results indicate that the reductions can also be secondary to other causes including oxidative stress. A variety of data suggest that the mitochondrial insufficiencies contribute significantly to the pathophysiology of AD.

Integrity signals

Registry

Crossref · 10.1007/s007020050099

Cites

58 of 58 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

RETRACTED: Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease
Davis, R. E., Miller, S., Herrnstadt, C., Ghosh, S. S., Fahy, E., Shinobu, L. A., Galasko, D., Thal, L. J., Beal, M. F., Howell, N., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4526 · Cited by 341
Retracted
Oxidative stress hypothesis in Alzheimer’s disease
Markesbery, W. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00629-6 · Cited by 2,383
Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E
Reiman, E. M., Caselli, R. J., Yun, L. S., Chen, K., Bandy, D., Minoshima, S., Thibodeau, S. N., & Osborne, D. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603213341202 · Cited by 1,366
Apolipoprotein E Type 4 Allele and Cerebral Glucose Metabolism in Relatives at Risk for Familial Alzheimer Disease
Small, G. W. (1995) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1995.03520360056039 · Cited by 604
Cytochrome oxidase deficiency in Alzheimer’s disease
Parker, W. D., Filley, C. M., & Parks, J. K. (1990) · Neurology · doi:10.1212/wnl.40.8.1302 · Cited by 598 · cited 2×
“Deficiency of COX activity in platelets has been reported (Parker et al., 1990) and disputed (VanZuylen et al., 1992).”
Background
Brain cytochrome oxidase in Alzheimer's disease
Kish, S. J., Bergeron, C., Rajput, A., Dozic, S., Mastrogiacomo, F., Chang, L., Wilson, J. M., DiStefano, L. M., & Nobrega, J. N. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09439.x · Cited by 537
Nitric Oxide‐Mediated Mitochondrial Damage in the Brain: Mechanisms and Implications for Neurodegenerative Diseases
Bolaños, J. P., Almeida, Á., Stewart, V. C., Peuchen, S., Land, J. M., Clark, J. B., & Heales, S. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68062227.x · Cited by 519
Secreted Forms of β-Amyloid Precursor Protein Protect Hippocampal Neurons against Amyloid β-Peptide-Induced Oxidative Injury
Goodman, Y., & Mattson, M. P. (1994) · Experimental Neurology · doi:10.1006/exnr.1994.1107 · Cited by 449
Estimation of the Genetic Contribution of Presenilin-1 and -2 Mutations in a Population-Based Study of Presenile Alzheimer Disease
Cruts, M., van Duijn, C. M., Backhovens, H., den Broeck, M. V., Wehnert, A., Serneels, S., Sherrington, R., Hutton, M., Hardy, J., George‐Hyslop, P. S., et al. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.1.43 · Cited by 432
Reduced Activities of Thiamine-Dependent Enzymes in the Brains and Peripheral Tissues of Patients With Alzheimer's Disease
Gibson, G. E., Sheu, K. ‐. R., Blass, J. P., Baker, A., Carlson, K., Harding, B. N., & Perrino, P. (1988) · Archives of Neurology · doi:10.1001/archneur.1988.00520320022009 · Cited by 425

Flagged first, then by citations

Show all 59 references

1 of the 59 references couldn’t be matched to a known paper.

Sorted by citations

Oxidative stress and mitochondrial dysfunction in Alzheimer’s disease
Wang, X., Wang, W., Li, L., Perry, G., Lee, H.-G., & Zhu, X. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.10.015 · Cited by 1,357
Amyloid beta, mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and Alzheimer’s disease
Reddy, P. H., & Beal, M. F. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.12.002 · Cited by 975
Mitochondrial Dysfunction in Neurodegenerative Diseases
Johri, A., & Beal, M. F. (2012) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.192138 · Cited by 806
History and progress of hypotheses and clinical trials for Alzheimer’s disease
Liu, P.-P., Xie, Y., Meng, X.-Y., & Kang, J.-S. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0063-8 · Cited by 723
Alzheimer's Disease: From Pathology to Therapeutic Approaches
Jakob‐Roetne, R., & Jacobsen, H. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200802808 · Cited by 626
Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment
Butterfield, D. A., Reed, T., Newman, S. F., & Sultana, R. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.037 · Cited by 564
The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review
Manoharan, S., Guillemin, G. J., Abiramasundari, R. S., Essa, M. M., Akbar, M., & Akbar, M. D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8590578 · Cited by 523
Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases
Giorgi, C., Marchi, S., Simões, I. C. M., Ren, Z., Morciano, G., Perrone, M., Patalas‐Krawczyk, P., Borchard, S., Jędrak, P., Pierzynowska, K., et al. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.05.006 · Cited by 484
Metal dyshomeostasis and oxidative stress in Alzheimer’s disease
Greenough, M. A., Camakaris, J., & Bush, A. I. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.08.014 · Cited by 447
Inhibition of Krebs Cycle Enzymes by Hydrogen Peroxide: A Key Role of α-Ketoglutarate Dehydrogenase in Limiting NADH Production under Oxidative Stress
Tretter, L., & Ádám‐Vizi, V. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-24-08972.2000 · Cited by 422
Oxidative stress signalling in Alzheimer's disease
Zhu, X., Raina, A. K., Lee, H., Casadesús, G., Smith, M. A., & Perry, G. L. (2004) · Brain Research · doi:10.1016/j.brainres.2004.01.012 · Cited by 396
Cellular and Molecular Mechanisms Underlying Perturbed Energy Metabolism and Neuronal Degeneration in Alzheimer's and Parkinson's Diseases
Mattson, M. P., Pedersen, W. A., Duan, W., Culmsee, C., & Camandola, S. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07824.x · Cited by 343
Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer’s disease
Manczak, M., & Reddy, P. H. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds360 · Cited by 348
Oxidative Stress Signaling in Alzheimers Disease
Su, B., Wang, X., Nunomura, A., Moreira, P., Lee, H.-G., Perry, G., Smith, M., & Zhu, X. (2008) · Current Alzheimer Research · doi:10.2174/156720508786898451 · Cited by 344
Oxidative stress in Alzheimer's disease
Chauhan, V. P. S., & Chauhan, A. (2006) · Pathophysiology · doi:10.1016/j.pathophys.2006.05.004 · Cited by 349
Causes of oxidative stress in Alzheimer disease
Zhu, X., Su, B., Wang, X., Smith, M. A., & Perry, G. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7218-4 · Cited by 336
Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease
Reddy, P. H., McWeeney, S. K., Park, B. S., Mańczak, M., Gutala, R. V., Partovi, D., Jung, Y., Yau, V., Searles, R. P., Mori, M., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh140 · Cited by 332
Amyloid‐Beta Interaction with Mitochondria
Pagani, L., & Eckert, A. (2011) · International Journal of Alzheimer’s Disease · doi:10.4061/2011/925050 · Cited by 309
Brain aging, Alzheimer's disease, and mitochondria
Swerdlow, R. H. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.08.012 · Cited by 306
“Examples include two dehydrogenase enzymes, pyruvate dehydrogenase and ketoglutarate dehydrogenase [124].”
Background
Abnormal mitochondrial dynamics and neurodegenerative diseases
Su, B., Wang, X., Zheng, L., Perry, G. L., Smith, M. A., & Zhu, X. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.09.013 · Cited by 301
Are mitochondria critical in the pathogenesis of Alzheimer's disease?
Reddy, P. H., & Beal, M. F. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.03.004 · Cited by 294
Amyloid β-induced Changes in Nitric Oxide Production and Mitochondrial Activity Lead to Apoptosis
Keil, U., Bonert, A., Marques, C. A., Scherping, I., Weyermann, J., Strosznajder, J. B., Müller-Spahn, F., Haass, C., Czech, C., Pradier, L., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405600200 · Cited by 287
Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease
Reddy, P. H. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.03.042 · Cited by 266
Protein Oxidation and Lipid Peroxidation in Brain of Subjects with Alzheimer's Disease: Insights into Mechanism of Neurodegeneration from Redox Proteomics
Rukhsana Sultana, A., Marzia Perluigi, A., & Butterfield, D. A. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.2021 · Cited by 261
Mitochondrial Dysfunction in Alzheimer’s Disease and the Rationale for Bioenergetics Based Therapies
Onyango, I. G., Dennis, J., & Khan, S. M. (2016) · Aging and Disease · doi:10.14336/ad.2015.1007 · Cited by 260
Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance
Raefsky, S. M., & Mattson, M. P. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.045 · Cited by 280
Amyloid-β and Mitochondria in Aging and Alzheimer's Disease: Implications for Synaptic Damage and Cognitive Decline
Reddy, P. H., Mańczak, M., Mao, P., Calkins, M. J., Reddy, A. P., & Shirendeb, U. P. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100504 · Cited by 247
Pathogenesis of Alzheimer's disease.
Swerdlow, R. H. (2007) · PubMed Central · Cited by 237
Mitochondrial Medicine for Aging and Neurodegenerative Diseases
Reddy, P. H. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8044-z · Cited by 230
Mitochondria as a Therapeutic Target for Aging and Neurodegenerative Diseases
Reddy, P. H., & Reddy, T. P. (2011) · Current Alzheimer Research · doi:10.2174/156720511795745401 · Cited by 233
Effects of cannabidiol interactions with Wnt/β-catenin pathway and PPARγ on oxidative stress and neuroinflammation in Alzheimer's disease
Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J.-N. (2017) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmx073 · Cited by 226
Role of mitochondrial dysfunction, oxidative stress and autophagy in progression of Alzheimer's disease
Bhatia, V., & Sharma, S. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.117253 · Cited by 228
Oxidant/Antioxidant Imbalance in Alzheimer’s Disease: Therapeutic and Diagnostic Prospects
Wojsiat, J., Zoltowska, K. M., Laskowska-Kaszub, K., & Wojda, U. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6435861 · Cited by 221
Mitochondrial Dysfunction and Synaptic Transmission Failure in Alzheimer’s Disease
Guo, L., Tian, J., & Du, H. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-160702 · Cited by 211
Mitochondrial dysfunction in microglia: a novel perspective for pathogenesis of Alzheimer’s disease
Li, Y., Xia, X., Wang, Y., & Zheng, J. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02613-9 · Cited by 231
Oxidative imbalance in patients with mild cognitive impairment and Alzheimer’s disease
GUIDI, I., GALIMBERTI, D., LONATI, S., NOVEMBRINO, C., BAMONTI, F., TIRITICCO, M., FENOGLIO, C., VENTURELLI, E., BARON, P., & BRESOLIN, N. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.01.001 · Cited by 203
Mitochondrial mechanisms of estrogen neuroprotection
Simpkins, J. W., Yi, K. D., Yang, S., & Dykens, J. A. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.11.013 · Cited by 207
Molecular links between Alzheimer’s disease and diabetes mellitus
Yang, Y., & Song, W. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.07.009 · Cited by 211
Redox Reactions of Copper Complexes Formed with Different β-Amyloid Peptides and Their Neuropathalogical Relevance
Jiang, D., Men, L., Wang, J., Zhang, Y., Chickenyen, S., Wang, Y., & Zhou, F. (2007) · Biochemistry · doi:10.1021/bi700508n · Cited by 204
The sinister face of heme oxygenase-1 in brain aging and disease
Schipper, H. M., Song, W., Tavitian, A., & Cressatti, M. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.06.008 · Cited by 206
Proteasome Inhibition Alters Neural Mitochondrial Homeostasis and Mitochondria Turnover
Sullivan, P. G., Dragicevic, N., Deng, J., Bai, Y., Dimayuga, E. R., Ding, Q., Chen, Q., Bruce‐Keller, A. J., & Keller, J. N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313579200 · Cited by 202
Inherent Abnormalities in Energy Metabolism in Alzheimer Disease: Interaction with Cerebrovascular Compromise
Blass, J. P., Sheu, R. K.-F., & Gibson, G. E. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06370.x · Cited by 204
Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease
Zhu, X., Perry, G. L., Moreira, P. I., Aliev, G., Cash, A., Hirai, K., & Smith, M. A. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9207 · Cited by 195
Mitochondrial medicine--molecular pathology of defective oxidative phosphorylation.
Fosslien, E. (2001) · PubMed · Cited by 186
Mitochondrial Dysfunction in Aging and Alzheimer's Disease: Strategies to Protect Neurons
Reddy, P. H. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1754 · Cited by 188
Role of Mitochondria in Neurodegenerative Diseases: Mitochondria as a Therapeutic Target in Alzheimer's Disease
Reddy, P. H. (2009) · CNS Spectrums · doi:10.1017/s1092852900024901 · Cited by 192
Overview of Alzheimer’s Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal Compounds
Singh, S. K., Srivastav, S., Yadav, A. K., Srikrishna, S., & Perry, G. L. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/7361613 · Cited by 196
JNK: A Stress-Activated Protein Kinase Therapeutic Strategies and Involvement in Alzheimer’s and Various Neurodegenerative Abnormalities
Mehan, S., Meena, H., Sharma, D., & Sankhla, R. (2010) · Journal of Molecular Neuroscience · doi:10.1007/s12031-010-9454-6 · Cited by 185
Mitochondrial alterations near amyloid plaques in an Alzheimer’s disease mouse model
Xie, H., Guan, J., Borrelli, L. A., Xu, J., Serrano-Pozo, A., & Bacskai, B. J. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1836-13.2013 · Cited by 185
“Mitochondrial enzymes important for metabolism, including cytochrome c oxidase (COX), -ketoglutarate dehydrogenase complex, and pyruvate dehydrogenase complex have been shown to be altered (Parker, et al., 1990; Gibson et al., 1998; Maurer et al., 2000).”
Background
Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer’s disease
Kandimalla, R. J. L., Mańczak, M., Fry, D., Yeguvapalli, S., Sesaki, H., & Reddy, P. H. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw312 · Cited by 182
The α-Ketoglutarate–Dehydrogenase Complex: A Mediator Between Mitochondria and Oxidative Stress in Neurodegeneration
Gibson, G. E., Blass, J. P., Beal, M. F., & Bunik, V. I. (2005) · Molecular Neurobiology · doi:10.1385/mn:31:1-3:043 · Cited by 181
Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer’s disease
Mańczak, M., Kandimalla, R. J. L., Fry, D., Sesaki, H., & Reddy, P. H. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw330 · Cited by 180
Mitochondrial dysfunction - the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-β toxicity
Eckert, A., Schmitt, K., & Götz, J. (2011) · Alzheimer's Research & Therapy · doi:10.1186/alzrt74 · Cited by 177
Brain iron deposition and the free radical-mitochondrial theory of ageing
Schipper, H. M. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.02.001 · Cited by 176
Role of mitochondrial homeostasis and dynamics in Alzheimer's disease
Selfridge, J. E., E, L., Lu, J., & Swerdlow, R. H. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.057 · Cited by 175
Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease
Sun, Y., Ma, C., Sun, H. J., Wang, H., Wei, P., Zhou, Z., Wang, H., Pi, C., Shi, Y., & He, X. (2020) · Journal of Diabetes Research · doi:10.1155/2020/4981814 · Cited by 181
Caspase-cleaved Tau Expression Induces Mitochondrial Dysfunction in Immortalized Cortical Neurons
Quintanilla, R. A., Matthews-Roberson, T. A., Dolan, P. J., & Johnson, G. V. W. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808908200 · Cited by 170
Defective mitophagy and synaptic degeneration in Alzheimer's disease: Focus on aging, mitochondria and synapse
Morton, H., Kshirsagar, S., Orlov, E., Bunquin, L. E., Sawant, N. A., Boleng, L., George, M., Basu, T., Ramasubramanian, B., Pradeepkiran, J. A., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.07.013 · Cited by 172
Amyloid-β-Induced Mitochondrial Dysfunction
Chen, J. X., & Yan, S. D. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-12208 · Cited by 168
Stabilization of mitochondrial function by Ginkgo biloba extract (EGb 761)
Abdel-Kader, R. M., Hauptmann, S., Keil, U., Scherping, I., Leuner, K., Eckert, A., & Müller, W. E. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.09.011 · Cited by 167
White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer's Disease
Klosinski, L. P., Yao, J., Yin, F., Fonteh, A. N., Harrington, M. G., Christensen, T. A., Trushina, E. V., & Brinton, R. D. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.11.002 · Cited by 163
Zn2+ Inhibits α-Ketoglutarate-stimulated Mitochondrial Respiration and the Isolated α-Ketoglutarate Dehydrogenase Complex
Brown, A. M., Kristal, B. S., Effron, M. S., Shestopalov, A. I., Ullucci, P. A., Sheu, K. ‐. R., Blass, J. P., & Cooper, A. J. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.18.13441 · Cited by 164
Brain metabolism and brain disease: Is metabolic deficiency the proximate cause of Alzheimer dementia?
Blass, J. P. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.10087 · Cited by 165
GSK3β, CREB, and BDNF in peripheral blood of patients with Alzheimer's disease and depression
Pláteník, J., Fišar, Z., Buchal, R., Jirák, R., Kitzlerová, E., Zvěřová, M., & Raboch, J. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.12.001 · Cited by 164
Mitochondrial ATP-synthase in the entorhinal cortex is a target of oxidative stress at stages I/II of Alzheimer’s disease pathology
Terni, B., Boada, J., Portero‐Otin, M., Pamplona, R., & Ferrer, I. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00266.x · Cited by 159
Estrogen actions on mitochondria--physiological and pathological implications.
Simpkins, J., Yang, S.-H., Sarkar, S., & Pearce, V. P. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.04.013 · Cited by 155
Natural Antioxidant Anthocyanins—A Hidden Therapeutic Candidate in Metabolic Disorders with Major Focus in Neurodegeneration
Ullah, R., Khan, M., Shah, S. A., Saeed, K. M., & Kim, M. O. (2019) · Nutrients · doi:10.3390/nu11061195 · Cited by 158
Mitoenergetic failure in Alzheimer disease
Parihar, M. S., & Brewer, G. J. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00232.2006 · Cited by 153
A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease
Salek, R. M., Xia, J., Innes, A. E., Sweatman, B. C., Adalbert, R., Randle, S. J., McGowan, E. M., Emson, P. C., & Griffin, J. L. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.04.001 · Cited by 148
Oxidative Imbalance in Alzheimer's Disease
Zhu, X., Lee, H., Casadesús, G., Ávila, J., Drew, K. L., Perry, G. L., & Smith, M. A. (2005) · Molecular Neurobiology · doi:10.1385/mn:31:1-3:205 · Cited by 146
Stabilization of Mitochondrial Membrane Potential and Improvement of Neuronal Energy Metabolism by Ginkgo Biloba Extract EGb 761
Eckert, A., Keil, U., Scherping, I., Hauptmann, S., & MÜLLER, W. E. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1352.023 · Cited by 145
Autophagocytosis of Mitochondria Is Prominent in Alzheimer Disease
Moreira, P. I., Siedlak, S. L., Wang, X., Santos, M. S., Oliveira, C. R., Tabaton, M., Nunomura, A., Szweda, L. I., Aliev, G. M., Smith, M. A., et al. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000240476.73532.b0 · Cited by 145
Mitochondrial mechanisms of estrogen neuroprotection.
Simpkins, J., & Dykens, J. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.04.007 · Cited by 7
Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation
Yang, L., Youngblood, H. A., Wu, C., & Zhang, Q. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00197-z · Cited by 147
Oxidative Damage and Cognitive Dysfunction: Antioxidant Treatments to Promote Healthy Brain Aging
Head, E. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9808-4 · Cited by 140
Evidence for Sub-Haplogroup H5 of Mitochondrial DNA as a Risk Factor for Late Onset Alzheimer's Disease
Santoro, A., Balbi, V., Balducci, E., Pirazzini, C., Rosini, F., Tavano, F., Achilli, A., Siviero, P., Minicuci, N., Bellavista, E., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012037 · Cited by 134
Insights into Mitochondrial Dysfunction: Aging, Amyloid-β, and Tau–A Deleterious Trio
Schmitt, K., Grimm, A., Wilkaniec, A., Strosznajder, J. B., Götz, J., & Eckert, A. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4400 · Cited by 132
Metabolic Risk Factors of Sporadic Alzheimer's Disease: Implications in the Pathology, Pathogenesis and Treatment
Chakrabarti, S., Kumar Khemka, V., Banerjee, A., Chatterjee, G., Ganguly, A., & Biswas, A. (2015) · Aging and disease · doi:10.14336/ad.2014.002 · Cited by 134
Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases
Shadfar, S., Parakh, S., Jamali, M. S., & Atkin, J. D. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00350-4 · Cited by 148
The α‐Ketoglutarate Dehydrogenase Complex
Sheu, K. R., & Blass, J. P. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07818.x · Cited by 125
Early dysregulation of the mitochondrial proteome in a mouse model of Alzheimer's disease
Chou, J. L., Shenoy, D. V., Thomas, N., Choudhary, P. K., LaFerla, F. M., Goodman, S. R., & Breen, G. A. M. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2010.12.012 · Cited by 123
Mitochondrial dysfunction and Alzheimer's disease
Maruszak, A., & Żekanowski, C. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.07.004 · Cited by 124
Chronic Aluminum Intake Causes Alzheimer's Disease: Applying Sir Austin Bradford Hill's Causality Criteria
Walton, J. R. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132204 · Cited by 126
Neuronal mitochondrial amelioration by feeding acetyl‐L‐carnitine and lipoic acid to aged rats
Aliev, G., Liu, J., Shenk, J. C., Fischbach, K., Pacheco, G. J., Chen, S. G., Obrenovich, M. E., Ward, W. F., Richardson, A. G., Smith, M. A., et al. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00324.x · Cited by 124
Amyloid Beta Resistance in Nerve Cell Lines Is Mediated by the Warburg Effect
Newington, J. T., Pitts, A., Chien, A., Arseneault, R., Schubert, D. A., & Cumming, R. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019191 · Cited by 121
Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions
Chee, F. C., Mudher, A. K., Cuttle, M. F., Newman, T. A., Mackay, D., Lovestone, S., & Shepherd, D. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.05.029 · Cited by 119
Phospholipases A2Mediate Amyloid-β Peptide-Induced Mitochondrial Dysfunction
Zhu, D., Lai, Y., Shelat, P. B., Hu, C., Sun, G. Y., & Lee, J. C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3505-06.2006 · Cited by 119
Mitochondrial failures in Alzheimer's disease
Zhu, X., Smith, M. A., Perry, G. L., & Aliev, G. (2004) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/153331750401900611 · Cited by 125
Mitochondrial Lon protease is a human stress protein
Ngo, J. K., & Davies, K. J. A. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.12.024 · Cited by 119
TDP-43 proteinopathy and mitochondrial abnormalities in neurodegeneration
Gao, J., Wang, L., Yan, T., Perry, G. L., & Wang, X. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.103396 · Cited by 124
Emerging neuroprotective strategies for Alzheimer's disease: dietary restriction, telomerase activation, and stem cell therapy
Mattson, M. P. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00115-7 · Cited by 118
Mitochondria-Division Inhibitor 1 Protects Against Amyloid-β induced Mitochondrial Fragmentation and Synaptic Damage in Alzheimer’s Disease
Reddy, P. H., Manczak, M., & Yin, X. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170051 · Cited by 116
Acrolein inhibits NADH-linked mitochondrial enzyme activity: Implications for Alzheimer's disease
Pocernich, C. B., & Butterfield, D. A. (2003) · Neurotoxicity Research · doi:10.1007/bf03033161 · Cited by 111
Mitochondrial aging and dysfunction in Alzheimer's disease
Sullivan, P. G., & Brown, M. R. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.12.007 · Cited by 114
Inhibitors of Catalase-Amyloid Interactions Protect Cells from β-Amyloid-Induced Oxidative Stress and Toxicity
Habib, L. K., Lee, M. T. C., & Yang, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.132860 · Cited by 114
Poly(ADP-ribose) Polymerase-1 in Amyloid Beta Toxicity and Alzheimer's Disease
Strosznajder, J. B., Czapski, G. A., Adamczyk, A., & Strosznajder, R. P. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8258-9 · Cited by 109
Mitochondria, Cybrids, Aging, and Alzheimer's Disease
Swerdlow, R. H., Koppel, S., Weidling, I., Hayley, C., Ji, Y., & Wilkins, H. M. (2017) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2016.12.017 · Cited by 106
Central and Peripheral Metabolic Defects Contribute to the Pathogenesis of Alzheimer's Disease: Targeting Mitochondria for Diagnosis and Prevention
Peng, Y., Gao, P., Shi, L., Chen, L., Liu, J., & Long, J. (2020) · Antioxidants & Redox Signaling · doi:10.1089/ars.2019.7763 · Cited by 110
Thiamine-Dependent Processes and Treatment Strategies in Neurodegeneration
Gibson, G. E., & Blass, J. P. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1766 · Cited by 107
Mitochondrial Dynamics in Alzheimerʼs Disease
Bonda, D., Wang, X., Perry, G. L., Smith, M. A., & Zhu, X. (2010) · Drugs & Aging · doi:10.2165/11532140-000000000-00000 · Cited by 106

Authors: Gibson, G. E., Sheu, K.-F. R., & Blass, J. P.
Affiliations: Cornell University (US)
ORCID: Gibson, G. E.
Venue: Journal of Neural Transmission
Publisher: Springer Science and Business Media LLC
Published: 1998-11-04
Volume: 105
Issue: 8-9
Pages: 855-870
ISSN: 0300-9564 (ISSN-L)
1435-1463
DOI: 10.1007/s007020050099
OpenAlex: W1989462226
Cited by: 345
References: 59
Citations by year: 2026: 6 · 2025: 7 · 2024: 7 · 2023: 14 · 2022: 14 · 2021: 12 · 2020: 20 · 2019: 12 · 2018: 11 · 2017: 15 · 2016: 23 · 2015: 19 · 2014: 7 · 2013: 14 · 2012: 12
FWCI: 4.29
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Neural Transmission (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r35ag009014-07)
National Institute on Aging (AG11921, AG 09014, R01AG014600, R01AG011921, AG-14600)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
Keywords: Alzheimer's disease, mitochondrial enzymes, pyruvate dehydrogenase complex, alpha-ketoglutarate dehydrogenase complex, cytochrome c oxidase, brain metabolism, neurodegeneration, oxidative stress, TCA cycle, glutamate metabolism, genetic deficiency
MeSH terms: Alzheimer Disease, Electron Transport Complex IV, Humans, Ketoglutarate Dehydrogenase Complex, Mitochondria, Pyruvate Dehydrogenase Complex, Oxidative Stress

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Abnormalities of mitochondrial enzymes in Alzheimer disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks