Early interfaced neural activity from chronic amputated nerves
Open accessAbstract
Direct interfacing of transected peripheral nerves with advanced robotic prosthetic devices has been proposed as a strategy for achieving natural motor control and sensory perception of such bionic substitutes, thus fully functionally replacing missing limbs in amputees. Multi-electrode arrays placed in the brain and peripheral nerves have been used successfully to convey neural control of prosthetic devices to the user. However, reactive gliosis, micro hemorrhages, axonopathy and excessive inflammation currently limit their long-term use. Here we demonstrate that enticement of peripheral nerve regeneration through a non-obstructive multi-electrode array, after either acute or chronic nerve amputation, offers a viable alternative to obtain early neural recordings and to enhance long-term interfacing of nerve activity. Non-restrictive electrode arrays placed in the path of regenerating nerve fibers allowed the recording of action potentials as early as 8 days post-implantation with high signal-to-noise ratio, as long as 3 months in some animals, and with minimal inflammation at the nerve tissue-metal electrode interface. Our findings suggest that regenerative multi-electrode arrays of open design allow early and stable interfacing of neural activity from amputated peripheral nerves and might contribute towards conveying full neural control and sensory feedback to users of robotic prosthetic devices.
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The regenerative multielectrode array demonstrated good results after interfacing with chronically amputated nerves in a rat study; axons grew through the array and nerve signals were obtained as early as 1 week post-operatively, with increasing signal amplitudes as more electrodes became active within the first 3 weeks.
“The regenerative multielectrode array, which is a MEA inside a regenerative tube, demonstrated good results after interfacing with chronically amputated nerves in a rat study. The axons grew through the array and the nerve signals were obtained as early as 1 week post-operatively, with increasing signal amplitudes as more electrodes were becoming active within the first 3 weeks [123].”
From Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review (2020) · cites this paper as [123]
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Experimental — accuracy not yet measuredRegeneration through a regenerative electrode can take 1 week to up to a month.
“The regeneration through the electrode can take 1 week (Garde et al., 2009) to up to a month (Mensinger et al., 2000)”
From Update on Peripheral Nerve Electrodes for Closed-Loop Neuroprosthetics (2018) · cites this paper as Garde et al., 2009
The most common complications of the regenerative multielectrode array were wire breakage and infection.
“The most common complications were wire breakage and infection.”
From Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review (2020) · cites this paper as [123]
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- Authors
- Garde, K.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Garde, Kshitija
- Venue
- Frontiers in Neuroengineering
- Publisher
- Frontiers Media SA
- Published
- 2009
- Volume
- 2
- Pages
- 5-5
- ISSN
- 1662-6443 (ISSN-L)
- PMC
- PMC2691654
- OpenAlex
- W2065676588
- Cited by
- 56
- References
- 54
- Citations by year
- 2023: 4 · 2022: 1 · 2021: 7 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 7 · 2014: 5 · 2013: 3 · 2012: 3
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neuroengineering (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Advanced Research Projects Agency
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Keywords
- peripheral nerve regeneration, microelectrode arrays, neural recording, robotic prosthetics, sensory feedback, inflammation, action potential, amputees
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