Flexible and highly biocompatible nanofiber-based electrodes for neural surface interfacing
Abstract
Polyimide (PI)-based electrodes have been widely used as flexible biosensors in implantable device applications for recording biological signals. However, the long-term quality of neural signals obtained from PI-based nerve electrodes tends to decrease due to nerve damage by neural tissue compression, mechanical mismatch, and insufficient fluid exchange between the neural tissue and electrodes. Here, we resolve these problems with a developed PI nanofiber (NF)-based nerve electrode for stable neural signal recording, which can be fabricated via electrospinning and inkjet printing. We demonstrate an NF-based nerve electrode that can be simply fabricated and easily applied due to its high permeability, flexibility, and biocompatibility. Furthermore, the electrode can record stable neural signals for extended periods of time, resulting in decreased mechanical mismatch, neural compression, and contact area. NF-based electrodes with highly flexible and body-fluid-permeable properties could enable future neural interfacing applications.
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Reducing the thickness of the substrate and the metal layer can decrease the mechanical mismatch to some extent, such as in 2D extraneural electrodes based on polyimide and parylene-C.
“Reducing the thickness of the substrate and the metal layer can decrease the mechanical mismatch to some extent, such as the more recently developed 2D extraneural electrodes, which are based on polyimide (PI) and parylene-C (9–12).”
From Climbing-inspired twining electrodes using shape memory for peripheral nerve stimulation and recording (2019) · cites this paper as [12]
The average CDC (~9.7 mC/cm2) and the impedance magnitude (~156 ohms) at 1 kHz are comparable to those of previously reported extraneural electrodes.
“In addition, the average CDC (~9.7 mC/cm2) and the impedance magnitude (~156 ohms) at 1 kHz are comparable to those of previously reported extraneural electrodes (12, 40).”
From Climbing-inspired twining electrodes using shape memory for peripheral nerve stimulation and recording (2019) · cites this paper as [12]
The observed increase in CNAP peak potentials with increasing applied current amplitudes is consistent with the literature.
“which are consistent with the literature (10, 12, 54)”
From Climbing-inspired twining electrodes using shape memory for peripheral nerve stimulation and recording (2019) · cites this paper as [12]
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- Authors
- Heo, D. N., Kim, H.-J., Lee, Y. J., Heo, M., Lee, S. J., Lee, D., Do, S. H., Lee, S. H., & Kwon, I. K.
- Affiliations
- George Washington University (US)
- Konkuk University (KR)
- Korea Institute of Science and Technology (KR)
- Kyung Hee University (KR)
- Corresponding author
- Do, Sun Hee
- Lee, Soo Hyun
- Kwon, Il Keun
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-02-17
- Volume
- 11
- Issue
- 3
- Pages
- 2961-2971
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W2588510267
- Cited by
- 86
- References
- 62
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 7 · 2023: 11 · 2022: 14 · 2021: 12 · 2020: 6 · 2019: 8 · 2018: 8 · 2017: 4
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- ACS Nano (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Korea Health Industry Development Institute (HI14C2241)
- National Research Foundation of Korea (NRF-2012R1A5A2051388, NRF-2014R1A1A3052557)
- Korea Institute of Science and Technology (2E26180)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
- Keywords
- polyimide nanofibers, neural recording, flexible electrodes, biocompatibility, electrospinning, inkjet printing, mechanical mismatch, long-term neural recording
- MeSH terms
- Animals, Biocompatible Materials, Electrodes, Male, Nerve Tissue, Resins, Synthetic, Surface Properties, Rats, Sprague-Dawley, Rats, Nanofibers
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