Wnt genes

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

Thomas, K. R., & Capecchi, M. R. (1990) · Nature · doi:10.1038/346847a0 · Cited by 896

SOME POSSIBLE EFFECTS OF NURSING ON THE MAMMARY GLAND TUMOR INCIDENCE IN MICE

Bittner, J. J. (1936) · Science · doi:10.1126/science.84.2172.162 · Cited by 588

Wnt signaling: a common theme in animal development

Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A., & McMahon, A. P. (1993) · Cell · doi:10.1016/0092-8674(93)90627-3 · Cited by 2,154

Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?

Couse, J. F., & Korach, K. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0370 · Cited by 2,045

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

Jiang, J., & Struhl, G. (1998) · Nature · doi:10.1038/35154 · Cited by 1,735

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

Glinka, A., Wu, W., Delius, H., Monaghan, A. P., Blumenstock, C., & Niehrs, C. (1998) · Nature · doi:10.1038/34848 · Cited by 1,608

Wntless, a Conserved Membrane Protein Dedicated to the Secretion of Wnt Proteins from Signaling Cells

Bänziger, C., Soldini, D., Schütt, C., Zipperlen, P., Hausmann, G., & Basler, K. (2006) · Cell · doi:10.1016/j.cell.2006.02.049 · Cited by 764

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

Bafico, A., Liu, G., Yaniv, A., Gazit, A., & Aaronson, S. A. (2001) · Nature Cell Biology · doi:10.1038/35083081 · Cited by 772

β-catenin: a key mediator of Wnt signaling

Willert, K., & Nusse, R. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80068-3 · Cited by 753

Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos

Rocheleau, C. E., Downs, W. D., Lin, R., Wittmann, C., Bei, Y., Cha, Y.-H., Ali, M., Priess, J. R., & Mello, C. C. (1997) · Cell · doi:10.1016/s0092-8674(00)80531-0 · Cited by 660

Signal transduction through beta-catenin and specification of cell fate during embryogenesis.

Miller, J. R., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.20.2527 · Cited by 656

Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8

Wang, S., Krinks, M., Lin, K., Luyten, F. P., & Moos, M. (1997) · Cell · doi:10.1016/s0092-8674(00)81922-4 · Cited by 518

pangolinencodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila

Brunner, E., Peter, O., Schweizer, L., & Basler, K. (1997) · Nature · doi:10.1038/385829a0 · Cited by 493

Induction of the LIM homeobox gene Lmx1 by WNT6a establishes dorsoventral pattern in the vertebrate limb

Riddle, R. D., Ensini, M., Nelson, C., Tsuchida, T., Jessell, T. M., & Tabin, C. (1995) · Cell · doi:10.1016/0092-8674(95)90103-5 · Cited by 478

Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2

Wayman, G. A., Impey, S., Marks, D., Saneyoshi, T., Grant, W. F., Derkach, V., & Soderling, T. R. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.008 · Cited by 466

Analysis of Dishevelled signalling pathways during Xenopus development

Sokol, S. Y. (1996) · Current Biology · doi:10.1016/s0960-9822(96)00750-6 · Cited by 406

Modulation of Embryonic Intracellular Ca2+Signaling byWnt-5A

Slusarski, D. C., Yang-Snyder, J., Busa, W. B., & Moon, R. T. (1997) · Developmental Biology · doi:10.1006/dbio.1996.8463 · Cited by 404

Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

Fujino, T., Asaba, H., Kang, M.-J., Ikeda, Y., Sone, H., Takada, S., Kim, D.-H., Ioka, R. X., Ono, M., Tomoyori, H., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0133792100 · Cited by 336

Dishevelled Proteins Lead to Two Signaling Pathways

Li, L., Yuan, H., Xie, W., Mao, J., Caruso, A. M., McMahon, A., Sussman, D. J., & Wu, D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.1.129 · Cited by 290

POP-1 and Anterior–Posterior Fate Decisions in C. elegans Embryos

Lin, R., Hill, R. J., & Priess, J. R. (1998) · Cell · doi:10.1016/s0092-8674(00)80917-4 · Cited by 282

Wnt and TGF-β Expression in the Sponge Amphimedon queenslandica and the Origin of Metazoan Embryonic Patterning

Adamska, M., Degnan, S. M., Green, K. M., Adamski, M., Craigie, A., Larroux, C., & Degnan, B. M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001031 · Cited by 257

Casein kinase 2 associates with and phosphorylates Dishevelled

Willert, K., Brink, M., Wodarz, A., Varmus, H., & Nusse, R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.11.3089 · Cited by 249

The WNT system: background and its role in bone

Lerner, U. H., & Ohlsson, C. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12368 · Cited by 228

wingless and patched are negative regulators of the morphogenetic furrow and can affect tissue polarity in the developing Drosophila compound eye

Ma, C., & Moses, K. (1995) · Development · doi:10.1242/dev.121.8.2279 · Cited by 210

The C. elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomously

Herman, M. A., Vassilieva, L. L., Horvitz, H. R., Shaw, J. E., & Herman, R. K. (1995) · Cell · doi:10.1016/0092-8674(95)90238-4 · Cited by 199

Novel E-cadherin-mediated adhesion in peripheral nerve: Schwann cell architecture is stabilized by autotypic adherens junctions

Fannon, A. M., Sherman, D. L., Ilyina-Gragerova, G., Brophy, P. J., Friedrich, V. L., & Colman, D. R. (1995) · The Journal of cell biology · doi:10.1083/jcb.129.1.189 · Cited by 181

Wnt family proteins are secreted and associated with the cell surface.

Smolich, B. D., McMahon, J. A., McMahon, A. P., & Papkoff, J. (1993) · Molecular Biology of the Cell · doi:10.1091/mbc.4.12.1267 · Cited by 172

Glucocorticoid-induced bone loss in mice can be reversed by the actions of parathyroid hormone and risedronate on different pathways for bone formation and mineralization

Yao, W., Cheng, Z., Pham, A., Busse, C., Zimmermann, E. A., Ritchie, R. O., & Lane, N. E. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23954 · Cited by 128

Severe Hypercholesterolemia, Impaired Fat Tolerance, and Advanced Atherosclerosis in Mice Lacking Both Low Density Lipoprotein Receptor-related Protein 5 and Apolipoprotein E

Magoori, K., Kang, M.-J., Ito, M. R., Kakuuchi, H., Ioka, R. X., Kamataki, A., Kim, D.-H., Asaba, H., Iwasaki, S., Takei, Y. A., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211987200 · Cited by 111

Wnt-7a Induces Presynaptic Colocalization of α7-Nicotinic Acetylcholine Receptors and Adenomatous Polyposis Coli in Hippocampal Neurons

Farías, G. G., Vallés, A. S., Colombres, M., Godoy, J. A., Toledo, E. M., Lukas, R. J., Barrantes, F. J., & Inestrosa, N. C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3934-06.2007 · Cited by 108

M1 muscarinic receptor activation protects neurons from β-amyloid toxicity. A role for Wnt signaling pathway

Farías, G. G., Godoy, J. A., Hernández, F., Avila, J., Fisher, A., & Inestrosa, N. C. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.07.016 · Cited by 59

Gene expression profiling of human blastocysts from in vivo and ‘rescue IVM’ with or without melatonin treatment

Hao, Y., Zhang, Z., Han, D., Cao, Y., Zhou, P., Wei, Z., Lv, M., & Chen, D. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6742 · Cited by 23

The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

Bruguera, E. S., Mahoney, J. P., & Weis, W. I. (2025) · eLife · doi:10.7554/elife.96743 · Cited by 9

The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

Bruguera, E. S., Mahoney, J. P., & Weis, W. I. (2025) · eLife · doi:10.7554/elife.96743.3 · Cited by 2

The lipocone superfamily, a unifying theme in metabolism of lipids, peptidoglycan and exopolysaccharides, inter-organismal conflicts and immunity

Burroughs, A. M., Nicastro, G. G., & Aravind, L. (2025) · eLife · doi:10.7554/elife.108061 · Cited by 2