Biochemical, physiological and medical aspects of ubiquinone function

Regulation of the mevalonate pathway

Goldstein, J. L., & Brown, M. S. (1990) · Nature · doi:10.1038/343425a0 · Cited by 5,394

Metal-catalyzed oxidation of proteins. Physiological consequences

Stadtman, E. R., & Oliver, C. N. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52199-2 · Cited by 862

Transition metals as catalysts of “autoxidation” reactions

Miller, D. (1990) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(90)90148-c · Cited by 739

Age‐related changes in the lipid compositions of rat and human tissues

Kalén, A., Appelkvist, E., & Dallner, G. (1989) · Lipids · doi:10.1007/bf02535072 · Cited by 425

Ferroptosis: Mechanisms and links with diseases

Yan, H.-F., Zou, T., Tuo, Q.-Z., Xu, S., Li, H., Belaidi, A. A., & Lei, P. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00428-9 · Cited by 1,471

Triggering and modulation of apoptosis by oxidative stress

Chandra, J., Samali, A., & Orrenius, S. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00302-6 · Cited by 1,335

The development of the concept of ferroptosis

Hirschhorn, T., & Stockwell, B. R. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.043 · Cited by 1,052

Metabolism and function of coenzyme Q

Turunen, M., Olsson, J., & Dallner, G. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2003.11.012 · Cited by 1,026

Role of mitochondria in oxidative stress and ageing

Lenaz, G. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00120-0 · Cited by 650

Antioxidant Therapy in Acute Central Nervous System Injury: Current State

Gilgun-Sherki, Y., Rosenbaum, Z., Melamed, E., & Offen, D. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.271 · Cited by 568

Coenzyme Q 10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects

Matthews, R. T., Yang, L., Browne, S., Baik, M., & Beal, M. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8892 · Cited by 557

The antioxidant role of coenzyme Q

Bentinger, M., Brismar, K., & Dallner, G. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.02.006 · Cited by 543

Molecular mechanisms of ferroptosis and their involvement in brain diseases

Costa, I., Barbosa, D. J., Benfeito, S., Silva, V., Chavarria, D., Borges, F., Remião, F., & Silva, R. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108373 · Cited by 402

Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects

Shults, C. W., Haas, R. H., Passov, D., & Beal, M. F. (1997) · Annals of Neurology · doi:10.1002/ana.410420221 · Cited by 326

Antioxidant and prooxidant properties of mitochondrial Coenzyme Q

James, A. M., Smith, R. A. J., & Murphy, M. P. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.12.025 · Cited by 292

Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice

Beal, M. F., Matthews, R. T., Tieleman, A., & Shults, C. W. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01192-x · Cited by 256

Antioxidant and bioenergetic coupling between neurons and astrocytes

Fernandez-Fernandez, S., Almeida, A., & Bolaños, J. P. (2012) · Biochemical Journal · doi:10.1042/bj20111943 · Cited by 247

Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations

Bhagavan, H. N., & Chopra, R. K. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.03.003 · Cited by 243

Randomized, Double-blind, Placebo-Controlled Trial on Symptomatic Effects of Coenzyme Q10 in Parkinson Disease

Storch, A. (2007) · Archives of Neurology · doi:10.1001/archneur.64.7.nct60005 · Cited by 205

Coenzyme Q10 Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases

Gutierrez-Mariscal, F. M., Arenas-de Larriva, A. P., Limia-Perez, L., Romero-Cabrera, J. L., Yubero-Serrano, E. M., & López-Miranda, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217870 · Cited by 190

Mitochondrial bioenergetics in aging

Lenaz, G., D’Aurelio, M., Merlo Pich, M., Genova, M. L., Ventura, B., Bovina, C., Formiggini, G., & Parenti Castelli, G. (2000) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00177-8 · Cited by 189

Disorders of Human Coenzyme Q10 Metabolism: An Overview

Hargreaves, I., Heaton, R. A., & Mantle, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186695 · Cited by 182

Clinical applications of coenzyme Q₁₀

Garrido-Maraver, J. (2014) · Frontiers in Bioscience · doi:10.2741/4231 · Cited by 178

Mitochondrial membrane depolarization and the selective death of dopaminergic neurons by rotenone: protective effect of coenzyme Q10

Moon, Y., Lee, K. H., Park, J., Geum, D., & Kim, K. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03112.x · Cited by 174

The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase

Pollard, P., Wortham, N., & Tomlinson, I. (2003) · Annals of Medicine · doi:10.1080/07853890310018458 · Cited by 159

Kinetics of integrated electron transfer in the mitochondrial respiratory chain: random collisions vs. solid state electron channeling

Lenaz, G., & Genova, M. L. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00263.2006 · Cited by 155

Untitled work

Kayser (1999) · doi:10.1097/00000542-199902000-00031 · Cited by 159

Oxidant/antioxidant imbalance and the risk of Alzheimer's disease

Moneim, A. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666150325182702 · Cited by 136

Effect of Coenzyme Q10 Intake on Endogenous Coenzyme Q Content, Mitochondrial Electron Transport Chain, Antioxidative Defenses, and Life Span of Mice

Sohal, R. S., Kamzalov, S., Sumien, N., Ferguson, M., Rebrin, I., Heinrich, K. R., & Forster, M. J. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.037 · Cited by 131

The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions

Pallotti, F., Bergamini, C., Lamperti, C., & Fato, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010128 · Cited by 109

Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats

Aboul-Fotouh, S. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.12.027 · Cited by 97

Coenzyme Q10 Depletion in Medical and Neuropsychiatric Disorders: Potential Repercussions and Therapeutic Implications

Morris, G., Anderson, G., Berk, M., & Maes, M. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8477-8 · Cited by 96

Coenzyme Q10: From bench to clinic in aging diseases, a translational review

Gutierrez-Mariscal, F. M., Yubero-Serrano, E. M., Villalba, J. M., & Lopez-Miranda, J. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1442316 · Cited by 92

The Effect of HMG-CoA Reductase Inhibitors on Coenzyme Q10: Possible Biochemical/Clinical Implications

Hargreaves, I. P., Duncan, A. J., Heales, S. J. R., & Land, J. M. (2005) · Drug Safety · doi:10.2165/00002018-200528080-00002 · Cited by 91

Coenzyme Q and Its Role in the Dietary Therapy against Aging

Varela-López, A., Giampieri, F., Battino, M., & Quiles, J. (2016) · Molecules · doi:10.3390/molecules21030373 · Cited by 86

Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction

Yang, Y.-K., Wang, L.-P., Chen, L., Yao, X.-P., Yang, K.-Q., Gao, L.-G., & Zhou, X.-L. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.08.002 · Cited by 78

PON1 and Mediterranean Diet

Lou-Bonafonte, J., Gabás-Rivera, C., Navarro, M., & Osada, J. (2015) · Nutrients · doi:10.3390/nu7064068 · Cited by 64

Coenzyme Q10 Prevents Accelerated Cardiac Aging in a Rat Model of Poor Maternal Nutrition and Accelerated Postnatal Growth

Tarry-Adkins, J. L., Blackmore, H. L., Martin-Gronert, M. S., Fernandez-Twinn, D. S., McConnell, J. M., Hargreaves, I. P., Giussani, D. A., & Ozanne, S. E. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.09.004 · Cited by 47

Coenzyme Q10 Supplementation Reverses Age-Related Impairments in Spatial Learning and Lowers Protein Oxidation

Shetty, R. A., Forster, M. J., & Sumien, N. (2013) · AGE · doi:10.1007/s11357-012-9484-9 · Cited by 47

Delineation of Neuroprotective Effects and Possible Benefits of AntioxidantsTherapy for the Treatment of Alzheimer's Diseases by Targeting Mitochondrial-Derived Reactive Oxygen Species: Bench to Bedside

Walia, V., Kaushik, D., Mittal, V., Kumar, K., Verma, R., Parashar, J., Akter, R., Rahman, M. H., Bhatia, S., Al-Harrasi, A., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02617-1 · Cited by 47

Prolonged Intake of Coenzyme Q10 Impairs Cognitive Functions in Mice

Sumien, N., Heinrich, K. R., Shetty, R. A., Sohal, R. S., & Forster, M. J. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.110437 · Cited by 46

Reduced Coenzyme Q10 Supplementation Decelerates Senescence in SAMP1 Mice

Yan, J., Fujii, K., Yao, J., Kishida, H., Hosoe, K., Sawashita, J., Takeda, T., Mori, M., & Higuchi, K. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2005.11.007 · Cited by 45

Effect of pretreatment with coenzyme Q10 on isoproterenol-induced cardiotoxicity and cardiac hypertrophy in rats

Ghule, A. E., Kulkarni, C. P., Bodhankar, S. L., & Pandit, V. A. (2009) · Current Therapeutic Research · doi:10.1016/j.curtheres.2009.12.004 · Cited by 41

Inhibition of Stress Induced Premature Senescence in Presenilin-1 Mutated Cells with Water Soluble Coenzyme Q10

Ma, D., Stokes, K., Mahngar, K., Domazet-Damjanov, D., Sikorska, M., & Pandey, S. (2014) · Mitochondrion · doi:10.1016/j.mito.2014.07.004 · Cited by 39

Combination of Coenzyme Q10 Intake and Moderate Physical Activity Counteracts Mitochondrial Dysfunctions in a SAMP8 Mouse Model

Andreani, C., Bartolacci, C., Guescini, M., Battistelli, M., Stocchi, V., Orlando, F., Provinciali, M., Amici, A., Marchini, C., Tiano, L., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8936251 · Cited by 37

A genome-scale database and reconstruction of Caenorhabditis elegans metabolism

Gebauer, J., Gentsch, C., Mansfeld, J., Schmeißer, K., Waschina, S., Brandes, S., Klimmasch, L., Zamboni, N., Zarse, K., Schuster, S., et al. (2016) · Cell Systems · doi:10.1016/j.cels.2016.04.017 · Cited by 33

Coenzyme Q9 Provides Cardioprotection after Converting into Coenzyme Q10

Lekli, I., Das, S., Das, S., Mukherjee, S., Bak, I., Juhasz, B., Bagchi, D., Trimurtulu, G., Krishnaraju, A. V., Sengupta, K., et al. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf800035f · Cited by 15

Chronic Kidney Disease and Coenzyme Q10 Supplementation

Hargreaves, I., Mantle, D., & Milford, D. (2019) · Journal of Kidney Care · doi:10.12968/jokc.2019.4.2.82 · Cited by 12

Coenzyme Q10 Alleviates Chronic Nucleoside Reverse Transcriptase Inhibitor-Induced Premature Endothelial Senescence

Chen, Y.-F., Hebert, V. Y., Stadler, K., Xue, S. Y., Slaybaugh, K., Luttrell-Williams, E., Glover, M. C., Krzywanski, D. M., & Dugas, T. R. (2019) · Cardiovascular Toxicology · doi:10.1007/s12012-019-09520-1 · Cited by 10