Stress psychobiology in the context of addiction medicine
Abstract
In this chapter, we briefly review the basic biology of psychological stress and the stress response. We propose that psychological stress and the neurobiology of the stress response play in substance use initiation, maintenance, and relapse. The proposed mechanisms for this include, on the one hand, the complex interactions between biological mediators of the stress response and the dopaminergic reward system and, on the other hand, mediators of the stress response and other systems crucial in moderating key addiction-related behaviors such as endogenous opioids, the sympathetic-adrenal-medullary system, and endocannabinoids. Exciting new avenues of study including genomics, sex as a moderator of the stress response, and behavioral addictions (gambling, hypersexuality, dysfunctional internet use, and food as an addictive substance) are also briefly presented within the context of stress as a moderator of the addictive process.
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HIV transmission risk is notably high among men who have sex with men and women, especially those with histories of childhood sexual abuse and current traumatic stress or depression.
“For instance, HIV transmission risk is notably high among men who have sex with men and women (MSMW), especially those with histories of childhood sexual abuse and current traumatic stress or depression.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [84]
Emerging research highlights the role of stress in behavioral addictions, including hypersexual behavior, gambling, dysfunctional internet use, and food addiction.
“Emerging research highlights the role of stress in behavioral addictions, including hypersexual behavior, gambling, dysfunctional internet use, and food addiction.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [84]
Stress and the neurobiology of the stress response play critical roles in substance use initiation, maintenance, and relapse.
“Stress and the neurobiology of the stress response play critical roles in substance use initiation, maintenance, and relapse.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [84]
Stress mediators interact with the dopaminergic reward system and other systems involved in addiction, such as endogenous opioids, the SAM system, and endocannabinoids.
“Stress mediators interact with the dopaminergic reward system and other systems involved in addiction, such as endogenous opioids, the SAM system, and endocannabinoids.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [84]
BSRPs have been shown to be more effective than general health promotion interventions in reducing risky sexual behaviors and depression symptoms in MSMW with histories of childhood sexual abuse and current traumatic stress or depression.
“BSRPs have been shown to be more effective than general health promotion interventions in reducing risky sexual behaviors and depression symptoms in this population.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [84]
Adolescence is a critical period for the maturation of behavior, dopamine systems, and the HPA axis.
“Additionally, adolescence is a critical period for the maturation of behavior, dopamine systems, and the HPA axis.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [84]
Stress during adolescence can increase sensitivity to drugs of abuse and alter the final maturation of cortical dopamine, potentially through mechanisms involving D2 dopamine receptor regulation and glucocorticoid-facilitated pruning of dopamine fibers.
“Stress during adolescence can increase sensitivity to drugs of abuse and alter the final maturation of cortical dopamine, potentially through mechanisms involving D2 dopamine receptor regulation and the glucocorticoid-facilitated pruning of dopamine fibers [83,84,85].”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [84]
Previous situations of reduced well-being and impaired social environment have been found to be associated with overeating and being overweight as well as increased substance and screen use.
“Previous situations of reduced well-being and impaired social environment have been found to be associated with overeating and being overweight as well as increased substance and screen use [3-5].”
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Self-citation
- Authors
- Lemieux, A., & al'Absi, M.
- Affiliations
- University of Minnesota (US)
- ORCID
- Lemieux, Andrine
- Venue
- Progress in Brain Research
- Publisher
- Elsevier
- Published
- 2016
- Volume
- 223
- Pages
- 43-62
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W2264911963
- Cited by
- 29
- References
- 123
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 1
- FWCI
- 15.15
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- psychological stress, stress response, addiction, substance use initiation, relapse, dopaminergic reward system, endogenous opioids, sympathoadrenal system, endocannabinoids, sex differences, behavioral addiction, gambling addiction, hypersexuality, food addiction, genomics
- MeSH terms
- Animals, Gambling, Humans, Reward, Stress, Psychological, Behavior, Addictive, Substance-Related Disorders, Internet
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