Cited by 29Stress Responses and CortisolNeurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

Stress psychobiology in the context of addiction medicine

Lemieux, Andrine, al'Absi, Mustafa·2016·Progress in Brain Research

Abstract

In this chapter, we briefly review the basic biology of psychological stress and the stress response. We propose that psychological stress and the neurobiology of the stress response play in substance use initiation, maintenance, and relapse. The proposed mechanisms for this include, on the one hand, the complex interactions between biological mediators of the stress response and the dopaminergic reward system and, on the other hand, mediators of the stress response and other systems crucial in moderating key addiction-related behaviors such as endogenous opioids, the sympathetic-adrenal-medullary system, and endocannabinoids. Exciting new avenues of study including genomics, sex as a moderator of the stress response, and behavioral addictions (gambling, hypersexuality, dysfunctional internet use, and food as an addictive substance) are also briefly presented within the context of stress as a moderator of the addictive process.

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Crossref · 10.1016/bs.pbr.2015.08.001

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Authors
Lemieux, A., & al'Absi, M.
Affiliations
University of Minnesota (US)
Venue
Progress in Brain Research
Publisher
Elsevier
Published
2016
Volume
223
Pages
43-62
ISSN
0079-6123 (ISSN-L)
OpenAlex
W2264911963
Cited by
29
References
123
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 1
FWCI
15.15
Type
book chapter
Language
en
Open access
closed
Locations
  • Progress in brain research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
psychological stress, stress response, addiction, substance use initiation, relapse, dopaminergic reward system, endogenous opioids, sympathoadrenal system, endocannabinoids, sex differences, behavioral addiction, gambling addiction, hypersexuality, food addiction, genomics
MeSH terms
Animals, Gambling, Humans, Reward, Stress, Psychological, Behavior, Addictive, Substance-Related Disorders, Internet

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