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In vivo delivery of CRISPR-Cas9 therapeutics: Progress and challenges
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“Recent methods employ a smaller strain of Cas-9 from Staphylococcus aureus (SaCas-9) instead of the more commonly used SpCas-9 to allow packaging of sgRNA and Cas-9 in the same AAVs.54,61”
From Mechanism and Applications of CRISPR/Cas-9-Mediated Genome Editing (2021) · cites this paper as [61]
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“Viral vectors are the natural experts for in vivo CRISPR/Cas-9 delivery.61”
From Mechanism and Applications of CRISPR/Cas-9-Mediated Genome Editing (2021) · cites this paper as [61]
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“Vectors, such as adenoviral vectors (AVs), adeno-associated viruses (AAVs), and lentivirus vectors (LVs) are currently being widely used as delivery methods due to their higher delivery efficiency relative to physical and chemical methods.”
From Mechanism and Applications of CRISPR/Cas-9-Mediated Genome Editing (2021) · cites this paper as [61]
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Metadata
- Authors
- Behr, M., Zhou, J., Xu, B., & Zhang, H.
- Venue
- Acta Pharmaceutica Sinica B
- Publisher
- Elsevier BV
- Published
- 2021-08
- Volume
- 11
- Issue
- 8
- Pages
- 2150-2171
- ISSN
- 2211-3835
- PMC
- PMC8424283
- Cited by
- 210
- References
- 39
- Language
- en
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