Neurodegenerative diseases and oxidative stress

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

Lipton, S. A., Choi, Y.-B., Pan, Z.-H., Lei, S. Z., Chen, H.-S. V., Sucher, N. J., Loscalzo, J., Singel, D. J., & Stamler, J. S. (1993) · Nature · doi:10.1038/364626a0 · Cited by 2,433

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380

Gene expression profile of aging and its retardation by caloric restriction

Lee, C.-K., Klopp, R. G., Weindruch, R., & Prolla, T. A. (1999) · Science · doi:10.1126/science.285.5432.1390 · Cited by 1,473

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

Hensley, K., Carney, J. M., Mattson, M. P., Aksenova, M., Harris, M., Wu, J. F., Floyd, R. A., & Butterfield, D. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3270 · Cited by 1,086

Free radical theory of aging

Harman, D. (1992) · Mutation Research/DNAging · doi:10.1016/0921-8734(92)90030-s · Cited by 902

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain

Mecocci, P., MacGarvey, U., Kaufman, A. E., Koontz, D., Shoffner, J. M., Wallace, D. C., & Beal, M. F. (1993) · Annals of Neurology · doi:10.1002/ana.410340416 · Cited by 757

Gene Microarrays in Hippocampal Aging: Statistical Profiling Identifies Novel Processes Correlated with Cognitive Impairment

Blalock, E. M., Chen, K.-C., Sharrow, K., Herman, J. P., Porter, N. M., Foster, T. C., & Landfield, P. W. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03807.2003 · Cited by 570

Nitric Oxide and Peroxynitrite in Health and Disease

Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

Uttara, B., Singh, A., Zamboni, P., & Mahajan, R. (2009) · Current Neuropharmacology · doi:10.2174/157015909787602823 · Cited by 3,378

Oxidative stress response and Nrf2 signaling in aging

Zhang, H., Davies, K. J. A., & Forman, H. J. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.036 · Cited by 804

Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue

Massudi, H., Grant, R., Braidy, N., Guest, J., Farnsworth, B., & Guillemin, G. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042357 · Cited by 545

Alzheimer's disease, β‐amyloid, glutamate, NMDA receptors and memantine – searching for the connections

Danysz, W., & Parsons, C. G. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02057.x · Cited by 500

The mechanism of mitochondrial superoxide production by the cytochrome bc1 complex

Dröse, S., & Brandt, U. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803236200 · Cited by 386

Melatonin: Action as antioxidant and potential applications in human disease and aging

Bonnefont-Rousselot, D., & Collin, F. (2010) · Toxicology · doi:10.1016/j.tox.2010.04.008 · Cited by 320

Oxidative and nitrosative stress in Parkinson's disease

Tsang, A. H. K., & Chung, K. K. K. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.12.006 · Cited by 300

Traumatic stress, oxidative stress and post-traumatic stress disorder: neurodegeneration and the accelerated-aging hypothesis

Miller, M. W., & Sadeh, N. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.111 · Cited by 288

Rotenone Model of Parkinson Disease

Panov, A., Dikalov, S., Shalbuyeva, N., Taylor, G., Sherer, T., & Greenamyre, J. T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508628200 · Cited by 288

Recent advances in our understanding of neurodegeneration

Jellinger, K. A. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0240-y · Cited by 274

Glutamate Transporters and the Excitotoxic Path to Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis

Foran, E., & Trotti, D. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2444 · Cited by 268

Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: Evidence for disease‐associated changes

Beasley, C. L., Pennington, K., Behan, A., Wait, R., Dunn, M. J., & Cotter, D. (2006) · PROTEOMICS · doi:10.1002/pmic.200500069 · Cited by 263

Ceramides in Alzheimer’s Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and A β Accumulation

Jazvinšćak Jembrek, M., Hof, P. R., & Šimić, G. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/346783 · Cited by 244

Nitric oxide and nitroxidative stress in Alzheimer's disease

Malinski, T. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-11208 · Cited by 220

The beneficial effects of fruit polyphenols on brain aging

Lau, F. C., Shukitt-Hale, B., & Joseph, J. A. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.08.007 · Cited by 217

Long-term exercise treatment reduces oxidative stress in the hippocampus of aging rats

Marosi, K., Bori, Z., Hart, N., Sárga, L., Koltai, E., Radák, Z., & Nyakas, C. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.001 · Cited by 186

Targeted delivery of siRNA to macrophages for anti-inflammatory treatment.

Kim, S.-S., Ye, C., Kumar, P., Chiu, I., Subramanya, S., Wu, H., Shankar, P., & Manjunath, N. (2010) · Molecular Therapy · doi:10.1038/mt.2010.27 · Cited by 176

Aging and Gene Expression in the Primate Brain

Fraser, H. B., Khaitovich, P., Plotkin, J. B., Pääbo, S., & Eisen, M. B. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030274 · Cited by 172

Dissection of Regulatory Networks that Are Altered in Disease via Differential Co-expression

Amar, D., Safer, H., & Shamir, R. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002955 · Cited by 169

Doxycycline Suppresses Microglial Activation by Inhibiting the P38 MAPK and NF-KB Signaling Pathways

Santa-Cecília, F. V., Socias, B., Ouidja, M. O., Sepulveda-Diaz, J. E., Acuña, L., Silva, R. L., Michel, P. P., Del-Bel, E., Cunha, T. M., & Raisman-Vozari, R. (2016) · Neurotoxicity Research · doi:10.1007/s12640-015-9592-2 · Cited by 165

Turnover of resident retinal microglia in the normal adult mouse

Xu, H., Chen, M., Mayer, E. J., Forrester, J. V., & Dick, A. D. (2007) · Glia · doi:10.1002/glia.20535 · Cited by 153

Astrocyte–neuron interactions in neurological disorders

Ricci, G., Volpi, L., Pasquali, L., Petrozzi, L., & Siciliano, G. (2009) · Journal of Biological Physics · doi:10.1007/s10867-009-9157-9 · Cited by 155

Antioxidant activities of an exopolysaccharide isolated and purified from marine Pseudomonas PF-6

Ye, S., Liu, F., Wang, J., Wang, H., & Zhang, M. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.08.057 · Cited by 138

Centella asiatica modulates antioxidant and mitochondrial pathways and improves cognitive function in mice

Gray, N. E., Harris, C. J., Quinn, J. F., & Soumyanath, A. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.01.013 · Cited by 123

Implications for the kynurenine pathway and quinolinic acid in amyotrophic lateral sclerosis

Guillemin, G. J., Meininger, V., & Brew, B. J. (2005) · Neurodegenerative Diseases · doi:10.1159/000089622 · Cited by 105

Antioxidant activity and phenolic content of pressurised liquid and solid–liquid extracts from four Irish origin macroalgae

Heffernan, N., Smyth, T. J., FitzGerald, R. J., Soler‐Vila, A., & Brunton, N. (2014) · International Journal of Food Science & Technology · doi:10.1111/ijfs.12512 · Cited by 93

The vascular contribution to Alzheimer's disease

Altman, R., & Rutledge, J. C. (2010) · Clinical Science · doi:10.1042/cs20100094 · Cited by 93

The NRF2 transcriptional target, OSGIN1, contributes to monomethyl fumarate-mediated cytoprotection in human astrocytes

Brennan, M. S., Matos, M. F., Richter, K. E., Li, B., & Scannevin, R. H. (2017) · Scientific Reports · doi:10.1038/srep42054 · Cited by 87

Centella asiatica increases hippocampal synaptic density and improves memory and executive function in aged mice

Gray, N. E., Zweig, J. A., Caruso, M., Martin, M. D., Zhu, J. Y., Quinn, J. F., & Soumyanath, A. (2018) · Brain and Behavior · doi:10.1002/brb3.1024 · Cited by 76

Pituitary adenylate cyclase-activating polypeptide protects astroglial cells against oxidative stress-induced apoptosis: PACAP prevents H2O2-induced astrocyte cell death

Masmoudi-Kouki, O., Douiri, S., Hamdi, Y., Kaddour, H., Bahdoudi, S., Vaudry, D., Basille, M., Leprince, J., Fournier, A., Vaudry, H., et al. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07185.x · Cited by 66

Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration

Reith, R. M., Way, S., McKenna, J., Haines, K., & Gambello, M. J. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.02.014 · Cited by 65

The Neuroprotective Effect of Liraglutide is Mediated by Glucagon-Like Peptide 1 Receptor-Mediated Activation of cAMP/PKA/CREB Pathway

Bao, Y., Jiang, L., Chen, H., Zou, J., Liu, Z., & Shi, Y. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430199 · Cited by 60

Destination Brain: the Past, Present, and Future of Therapeutic Gene Delivery

Joshi, C. R., Labhasetwar, V., & Ghorpade, A. (2017) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-016-9724-3 · Cited by 55

The Neuroprotective Effect of Picroside II from Hu-Huang-Lian against Oxidative Stress

Li, T., Liu, J.-W., Zhang, X.-D., Guo, M.-C., & Ji, G. (2007) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x0700517x · Cited by 41

Accelerated Aging during Chronic Oxidative Stress: A Role for PARP-1

Boesten, D. M. P. H. J., de Vos-Houben, J. M. J., Timmermans, L., den Hartog, G. J. M., Bast, A., & Hageman, G. J. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/680414 · Cited by 37

The insect molting hormone 20-hydroxyecdysone protects dopaminergic neurons against MPTP-induced neurotoxicity in a mouse model of Parkinson’s disease

Lim, H.-S., Moon, B. C., Lee, J., Choi, G., & Park, G. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.07.010 · Cited by 30

Differential recruitment of PKC isoforms in HeLa cells during redox stress

Rimessi, A., Rizzuto, R., & Pinton, P. (2007) · Cell Stress & Chaperones · doi:10.1379/csc-211.1 · Cited by 27