Morphological brain measures of cortico‐limbic inhibition related to resilience
Open accessAbstract
Resilience is the ability to adequately adapt and respond to homeostatic perturbations. Although resilience has been associated with positive health outcomes, the neuro‐biological basis of resilience is poorly understood. The aim of the study was to identify associations between regional brain morphology and trait resilience with a focus on resilience‐related morphological differences in brain regions involved in cortico‐limbic inhibition. The relationship between resilience and measures of affect were also investigated. Forty‐eight healthy subjects completed structural MRI scans. Self‐reported resilience was measured using the Connor and Davidson Resilience Scale. Segmentation and regional parcellation of images was performed to yield a total of 165 regions. Gray matter volume (GMV), cortical thickness, surface area, and mean curvature were calculated for each region. Regression models were used to identify associations between morphology of regions belonging to executive control and emotional arousal brain networks and trait resilience (total and subscales) while controlling for age, sex, and total GMV. Correlations were also conducted between resilience scores and affect scores. Significant associations were found between GM changes in hypothesized brain regions (subparietal sulcus, intraparietal sulcus, amygdala, anterior mid cingulate cortex, and subgenual cingulate cortex) and resilience scores. There were significant positive correlations between resilience and positive affect and negative correlations with negative affect. Resilience was associated with brain morphology of regions involved in cognitive and affective processes related to cortico‐limbic inhibition. Brain signatures associated with resilience may be a biomarker of vulnerability to disease. © 2016 Wiley Periodicals, Inc.
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Individuals with low psychological resilience seem to have compromised control of brain circuits involved in emotion and fear and poor cortico-limbic inhibition, representing a dysregulated emotional response to stress that may result in elevated cortisol exposure.
“Moreover, individuals with low psychological resilience seem to have compromised control of brain circuits involved in emotion and fear [97] and poor cortico-limbic inhibition, representing a dysregulated emotional response to stress that may result in elevated cortisol exposure [98].”
From The prospective association of adolescent loneliness and low resilience with anxiety and depression in young adulthood: The HUNT study (2025) · cites this paper as [98]
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The Contribution of Physical Exercise to Brain Resilience
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Modelling resilience in adolescence and adversity: a novel framework to inform research and practice
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Autonomic and Brain Morphological Predictors of Stress Resilience
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Resilience, pain, and the brain: Relationships differ by sociodemographics
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Parker, C. H., Naliboff, B. D., Shih, W., Presson, A. P., Kilpatrick, L. A., Gupta, A., Liu, C., Keefer, L., Sauk, J. S., Hirten, R. P., et al. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.08.043 · Cited by 41 · see citing works
Self-citationStress-resilience impacts psychological wellbeing as evidenced by brain–gut microbiome interactions
An, E., Delgadillo, D. R., Yang, J., Agarwal, R., Labus, J. S., Pawar, S., Leitman, M., Kilpatrick, L. A., Bhatt, R. R., Vora, P. P., et al. (2024) · Nature Mental Health · doi:10.1038/s44220-024-00266-6 · Cited by 45 · see citing works
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Resilience and cortical thickness: a MRI study
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Structural brain alterations in older adults exposed to early-life adversity
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A systematic review of the neural correlates of well-being reveals no consistent associations
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Park, H. R. P., Quidé, Y., Schofield, P. R., Williams, L. M., & Gatt, J. M. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01849-6 · Cited by 24 · see citing works
Sacu, S., Wackerhagen, C., Erk, S., Romanczuk‐Seiferth, N., Schwarz, K., Schweiger, J. I., Tost, H., Meyer‐Lindenberg, A., Heinz, A., Razi, A., et al. (2022) · Psychological Medicine · doi:10.1017/s0033291722000824 · Cited by 23 · see citing works
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Psychological factors to predict chronic diarrhea and constipation in Korean high school students
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High Thought Control Ability, High Resilience: The Effect of Temporal Cortex and Insula Connectivity
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Chen, H., Liu, P., Chen, X., Liu, J., Tang, H., Tian, Y., Wang, X., Lu, F., & Zhou, J. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03169-3 · Cited by 15 · see citing works
Using Cognitive Neuroscience to Improve Mental Health Treatment: A Comprehensive Review
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Zhan, N., Xu, Y., Pu, J., Wang, W., Xie, Z., & Huang, H. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1396417 · Cited by 11 · see citing works
Neurocognitive correlates of psychological resilience: Event-related potential studies
Ding, X., Fang, H., Liu, Y., Zheng, L. P., Zhu, X., Duan, H., & Wu, J. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.06.023 · Cited by 10 · see citing works
Regional gray matter volume correlates with anxiety, apathy, and resilience in geriatric depression
Krause, B., Siddarth, P., Milillo, M. M., Kilpatrick, L. A., Narr, K. L., & Lavretsky, H. (2023) · International Psychogeriatrics · doi:10.1017/s1041610223000510 · Cited by 11 · see citing works
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“Moreover, individuals with low psychological resilience seem to have compromised control of brain circuits involved in emotion and fear [97] and poor cortico-limbic inhibition, representing a dysregulated emotional response to stress that may result in elevated cortisol exposure [98].”
Dezachyo, O., Kozak, S., Bar‐Haim, Y., Censor, N., & Dayan, E. (2021) · eNeuro · doi:10.1523/eneuro.0277-21.2021 · Cited by 7 · see citing works
Macro- and microstructural gray matter alterations in sexually assaulted women
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Infancia y Agenda 2030: aprendiendo a percibir la ciudad desde las emociones de los escolares
García, A. G., Hernández, A. J. M., & Alonso, C. C. (2021) · Didáctica Geográfica · doi:10.21138/dg.577 · Cited by 6 · see citing works
Resilience signaling and hormesis in brain health and disease
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Hormesis, Resilience and Mental Health: Enhancing Public Health and Therapeutic Options
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The Current State of Research on Resilience, and Its Relationship to Education
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Volumetric brain correlates of approach-avoidance behavior and their relation to chronic back pain
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Amygdala and hippocampal volumes as neural correlates of resilience and loneliness in older adults
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- Authors
- Gupta, A., Love, A., Kilpatrick, L. A., Labus, J. S., Bhatt, R., Chang, L., Tillisch, K., Naliboff, B., & Mayer, E. A.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Gupta, Arpana
- ORCID
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2016-12-28
- Volume
- 95
- Issue
- 9
- Pages
- 1760-1775
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- PMC
- PMC5512424
- OpenAlex
- W2565215840
- Cited by
- 54
- References
- 101
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 5 · 2021: 11 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 1
- FWCI
- 6.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (DK106528, DK048351, DK064539, DK041301)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- resilience, trait resilience, brain structure, gray matter volume, cortical thickness, surface area, mean curvature, amygdala, anterior midcingulate cortex, subgenual anterior cingulate cortex, intraparietal sulcus, positive affect, negative affect, executive function, emotional arousal
- MeSH terms
- Adolescent, Adult, Brain, Female, Humans, Inhibition, Psychological, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Resilience, Psychological, Young Adult
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