Cited by 258Maternal Mental Health During Pregnancy and PostpartumStress Responses and CortisolChild and Adolescent Psychosocial and Emotional Development

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Prenatal maternal depression associates with microstructure of right amygdala in neonates at birth.

Rifkin-Graboi, Anne, Bai, Jordan, Chen, Helen, Hameed, Waseem Bak’r, Sim, Lit Wee, Tint, Mya Thway, Leutscher-Broekman, Birit, Chong, Yap-Seng, Gluckman, Peter D., Fortier, Marielle V., Meaney, Michael J., Qiu, Anqi·2013·Biological Psychiatry

DOI 10.1016/j.biopsych.2013.06.019

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Abstract

Background Antenatal maternal cortisol levels associate with alterations in the amygdala, a structure associated with emotion regulation, in the offspring. However, because offspring brain and behavior are commonly assessed years after birth, the timing of such maternal influences is unclear. This study aimed to examine the association between antenatal maternal depressive symptomatology and neonatal amygdala volume and microstructure and thus establish evidence for the transgenerational transmission of vulnerability for affective disorders during prenatal development.Methods Our study recruited Asian mothers at 10 to 13 weeks pregnancy and assessed maternal depression at 26 weeks gestation using the Edinburgh Postnatal Depression Scale. Structural magnetic resonance imaging and diffusion tensor imaging were performed with 157 nonsedated, 6- to 14-day-old newborns and then analyzed to extract the volume, fractional anisotropy, and axial diffusivity values of the amygdala.Results Adjusting for household income, maternal age, and smoking exposure, postconceptual age at magnetic resonance imaging, and birth weight, we found significantly lower fractional anisotropy (p = .009) and axial diffusivity (p = .028), but not volume (p = .993), in the right amygdala in the infants of mothers with high compared with those with low-normal Edinburgh Postnatal Depression Scale scores.Conclusions The results reveal a significant relation between antenatal maternal depression and the neonatal microstructure of the right amygdala, a brain region closely associated with stress reactivity and vulnerability for mood anxiety disorders. These findings suggest the prenatal transmission of vulnerability for depression from mother to child and that interventions targeting maternal depression should begin early in pregnancy.

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Authors: Rifkin-Graboi, A., Bai, J., Chen, H., Hameed, W. B., Sim, L. W., Tint, M. T., Leutscher-Broekman, B., Chong, Y.-S., Gluckman, P. D., Fortier, M. V., Meaney, M. J., & Qiu, A.
Affiliations: Singapore Institute for Clinical Sciences (SG)
KK Women's and Children's Hospital (SG)
National University of Singapore (SG)
Douglas Mental Health University Institute (CA)
Corresponding author: Qiu, Anqi
ORCID: Rifkin-Graboi, Anne
Chen, Helen
Tint, Mya Thway
Chong, Yap-Seng
Gluckman, Peter D.
Fortier, Marielle V.
Meaney, Michael J.
Qiu, Anqi
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2013-12
Volume: 74
Issue: 11
Pages: 837-844
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2013.06.019
OpenAlex: W2005527520
Cited by: 258
References: 66
Citations by year: 2026: 16 · 2025: 16 · 2024: 17 · 2023: 14 · 2022: 17 · 2021: 29 · 2020: 33 · 2019: 25 · 2018: 18 · 2017: 23 · 2016: 21 · 2015: 16 · 2014: 10 · 2013: 3
FWCI: 17.00
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
National University of Singapore (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: Agency for Science, Technology and Research (SICS-09/1/1/001)
National Medical Research Council (NMRC/CBRG12nov057, NMRC/TCR/004-NUS/2008)
National University of Singapore (NUSYIA FY10 P07)
Ministry of Education - Singapore (MOE2012-T2-2-130)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords: maternal depression, antenatal depression, fractional anisotropy, axial diffusivity, transgenerational transmission, prenatal stress, maternal cortisol, mood disorders, stress reactivity
MeSH terms: Adult, Amygdala, Depression, Female, Humans, Infant, Newborn, Male, Pregnancy, Prenatal Exposure Delayed Effects, Singapore, Magnetic Resonance Angiography, Asian People, Diffusion Tensor Imaging

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Prenatal maternal depression associates with microstructure of right amygdala in neonates at birth.

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