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A MicroRNA Imparts Robustness against Environmental Fluctuation during Development
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“One of the primary functions of miRNAs is to maintain cellular homeostasis in the presence of cellular stressors, perturbagens or disease conditions [11, 107–109].”
From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [11]
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A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., Pfeffer, S., Rice, A., Kamphorst, A. O., Landthaler, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.040 · Cited by 3,626
The impact of microRNAs on protein output
Baek, D., Villén, J., Shin, C., Camargo, F. D., Gygi, S. P., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07242 · Cited by 3,592
Widespread changes in protein synthesis induced by microRNAs
Selbach, M., Schwanhäusser, B., Thierfelder, N., Fang, Z., Khanin, R., & Rajewsky, N. (2008) · Nature · doi:10.1038/nature07228 · Cited by 3,429 · cited 1×
“Most targeted genes are only modestly repressed by miRNAs, which indicates that miRNAs primarily tune gene expression (Baek et al., 2008; Nakahara et al., 2005; Selbach et al., 2008).”
CANALIZATION OF DEVELOPMENT AND THE INHERITANCE OF ACQUIRED CHARACTERS
WADDINGTON, C. H. (1942) · Nature · doi:10.1038/150563a0 · Cited by 3,255 · cited 1×
“Canalization and miRNAs Waddington coined the word canalization to describe how development is buffered against perturbation (Siegal and Bergman, 2002; Waddington, 1942).”
Transcriptional Regulatory Networks in Saccharomyces cerevisiae
Lee, T. I., Rinaldi, N. J., Robert, F., Odom, D. T., Bar-Joseph, Z., Gerber, G. K., Hannett, N. M., Harbison, C. T., Thompson, C. M., Simon, I., et al. (2002) · Science · doi:10.1126/science.1075090 · Cited by 2,956
Kitano, H. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1471 · Cited by 2,278
Stark, A., Brennecke, J., Bushati, N., Russell, R. B., & Cohen, S. M. (2005) · Cell · doi:10.1016/j.cell.2005.11.023 · Cited by 1,080
Most Caenorhabditis elegans microRNAs Are Individually Not Essential for Development or Viability
Miska, E. A., Alvarez-Saavedra, E., Abbott, A. L., Lau, N. C., Hellman, A. B., McGonagle, S. M., Bartel, D. P., Ambros, V. R., & Horvitz, H. R. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030215 · Cited by 484 · cited 1×
“It also explains why miRNAs frequently appear dispensable under uniform laboratory conditions (Bushati and Cohen, 2007; Leaman et al., 2005; Miska et al., 2007).”
Research works printed but not linked: 51
- Artavanis-Tsakonas, 1999, Notch signaling: cell fate control and signal integration in development, Science, 284, 770, 10.1126/science.284.5415.770 · DOI · Paper page
- Barolo, 2004, New Drosophila transgenic reporters: insulated P-element vectors expressing fast-maturing RFP, Biotechniques, 36, 436, 10.2144/04363ST03 · DOI
- Bushati, 2007, microRNA functions, Annu. Rev. Cell Dev. Biol., 23, 175, 10.1146/annurev.cellbio.23.090506.123406 · DOI · Paper page
- Carthew, 2009, Origins and mechanisms of miRNAs and siRNAs, Cell, 136, 642, 10.1016/j.cell.2009.01.035 · DOI
- Cave, 2005, A DNA transcription code for cell-specific gene activation by notch signaling, Curr. Biol., 15, 94, 10.1016/j.cub.2004.12.070 · DOI
- Cooper, 2000, Spatially restricted factors cooperate with notch in the regulation of Enhancer of split genes, Dev. Biol., 221, 390, 10.1006/dbio.2000.9691 · DOI
- Correa-Medina, 2008, MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas, Gene Expr Patterns., 9, 193, 10.1016/j.gep.2008.12.003 · DOI
- Flores, 2000, Combinatorial signaling in the specification of unique cell fates, Cell, 103, 75, 10.1016/S0092-8674(00)00106-9 · DOI
- Freeman, 2000, Feedback control of intercellular signalling in development, Nature, 408, 313, 10.1038/35042500 · DOI
- Gibson, 1996, Effect of polymorphism in the Drosophila regulatory gene Ultrabithorax on homeotic stability, Science, 271, 200, 10.1126/science.271.5246.200 · DOI
- Griffiths-Jones, 2006, miRBase: microRNA sequences, targets and gene nomenclature, Nucleic Acids Res., 34, D140, 10.1093/nar/gkj112 · DOI · Paper page
- Hartman, 2001, Principles for the buffering of genetic variation, Science, 291, 1001, 10.1126/science.1056072 · DOI · Paper page
- Hobert, 2006, Architecture of a microRNA-controlled gene regulatory network that diversifies neuronal cell fates, Cold Spring Harb. Symp. Quant. Biol., 71, 181, 10.1101/sqb.2006.71.006 · DOI
- Hornstein, 2006, Canalization of development by microRNAs, Nat. Genet., 38, S20, 10.1038/ng1803 · DOI · Paper page
- Jafar-Nejad, 2003, Senseless acts as a binary switch during sensory organ precursor selection, Genes Dev., 17, 2966, 10.1101/gad.1122403 · DOI
- Jander, 2002, Allometry and resolution of bee eyes (Apoidea), Arthropod Struct Dev, 30, 179, 10.1016/S1467-8039(01)00035-4 · DOI
- Jarman, 1994, Atonal is the proneural gene for Drosophila photoreceptors, Nature, 369, 398, 10.1038/369398a0 · DOI
- Joglekar, 2009, Expression of islet-specific microRNAs during human pancreatic development, Gene Expr. Patterns, 9, 109, 10.1016/j.gep.2008.10.001 · DOI
- Kefas, 2008, microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma, Cancer Res., 68, 3566, 10.1158/0008-5472.CAN-07-6639 · DOI · Paper page
- Lai, 2005, Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs, Genes Dev., 19, 1067, 10.1101/gad.1291905 · DOI
- Leaman, 2005, Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development, Cell, 121, 1097, 10.1016/j.cell.2005.04.016 · DOI
- Li, 1997, Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack, Cell, 90, 469, 10.1016/S0092-8674(00)80507-3 · DOI
- Li, 2005, A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye, Cell, 123, 1267, 10.1016/j.cell.2005.10.040 · DOI · Paper page
- Mangan, 2003, Structure and function of the feed-forward loop network motif, Proc. Natl. Acad. Sci. USA, 100, 11980, 10.1073/pnas.2133841100 · DOI · Paper page
- Mangan, 2003, The coherent feedforward loop serves as a sign-sensitive delay element in transcription networks, J. Mol. Biol., 334, 197, 10.1016/j.jmb.2003.09.049 · DOI
- Martinez, 2008, A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity, Genes Dev., 22, 2535, 10.1101/gad.1678608 · DOI
- Meiklejohn, 2002, A single mode of canalization, Trends Ecol. Evol., 17, 468, 10.1016/S0169-5347(02)02596-X · DOI
- Meir, 2002, Robustness, flexibility, and the role of lateral inhibition in the neurogenic network, Curr. Biol., 12, 778, 10.1016/S0960-9822(02)00839-4 · DOI
- Melen, 2005, Threshold responses to morphogen gradients by zero-order ultrasensitivity, Mol Syst Biol, 10.1038/msb4100036 · DOI
- Milo, 2002, Network motifs: simple building blocks of complex networks, Science, 298, 824, 10.1126/science.298.5594.824 · DOI · Paper page
- Mumm, 2000, Notch signaling: from the outside in, Dev. Biol., 228, 151
- Nakahara, 2005, Targets of microRNA regulation in the Drosophila oocyte proteome, Proc. Natl. Acad. Sci. USA, 102, 12023, 10.1073/pnas.0500053102 · DOI
- Nellesen, 1999, Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators, Dev. Biol., 213, 33, 10.1006/dbio.1999.9324 · DOI
- Powell, 2004, The proneural proteins Atonal and Scute regulate neural target genes through different E-box binding sites, Mol. Cell. Biol., 24, 9517, 10.1128/MCB.24.21.9517-9526.2004 · DOI
- Prochnik, 2007, Evidence for a microRNA expansion in the bilaterian ancestor, Dev. Genes Evol., 217, 73, 10.1007/s00427-006-0116-1 · DOI
- Proulx, 2005, The opportunity for canalization and the evolution of genetic networks, Am. Nat., 165, 147, 10.1086/426873 · DOI
- Rendel, 1959, Canalization of the scute phenotype of Drosophila, Evolution Int. J. Org. Evolution, 13, 425, 10.2307/2406126 · DOI
- Rendel, 1960, Selection for canalization of the scute phenotype in Drosophila melanogaster, Aust. J. Biol. Sci., 13, 36, 10.1071/BI9600036 · DOI
- Rohrbaugh, 2002, Notch activation of yan expression is antagonized by RTK/pointed signaling in the Drosophila eye, Curr. Biol., 12, 576, 10.1016/S0960-9822(02)00743-1 · DOI
- Siegal, 2002, Waddington's canalization revisited: developmental stability and evolution, Proc. Natl. Acad. Sci. USA, 99, 10528, 10.1073/pnas.102303999 · DOI
- Spirin, 2003, Protein complexes and functional modules in molecular networks, Proc. Natl. Acad. Sci. USA, 100, 12123, 10.1073/pnas.2032324100 · DOI
- Stark, 2003, Identification of Drosophila microRNA targets, PLoS Biol., 1, e60, 10.1371/journal.pbio.0000060 · DOI
- Tang, 1997, PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism, Cell, 90, 459, 10.1016/S0092-8674(00)80506-1 · DOI
- Tessmar-Raible, 2007, Conserved sensory-neurosecretory cell types in annelid and fish forebrain: insights into hypothalamus evolution, Cell, 129, 1389, 10.1016/j.cell.2007.04.041 · DOI · Paper page
- Treier, 1995, JUN cooperates with the ETS domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye, Cell, 83, 753, 10.1016/0092-8674(95)90188-4 · DOI
- Tsang, 2007, MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals, Mol. Cell, 26, 753, 10.1016/j.molcel.2007.05.018 · DOI · Paper page
- Voas, 2004, Signal integration during development: insights from the Drosophila eye, Dev. Dyn., 229, 162, 10.1002/dvdy.10449 · DOI
- Waddington, 1953, Genetic assimilation of an acquired character, Evolution Int. J. Org. Evolution, 7, 118, 10.2307/2405747 · DOI
- Webster, 2008, Regulation of epidermal growth factor receptor signaling in human cancer cells by microRNA-7, J Biol Chem, 284, 5731, 10.1074/jbc.M804280200 · DOI
- Wienholds, 2005, MicroRNA expression in zebrafish embryonic development, Science, 309, 310, 10.1126/science.1114519 · DOI · Paper page
- Xu, 2000, Overlapping activators and repressors delimit transcriptional response to receptor tyrosine kinase signals in the Drosophila eye, Cell, 103, 87, 10.1016/S0092-8674(00)00107-0 · DOI
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Evolution of microRNA diversity and regulation in animals
Berezikov, E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3079 · Cited by 712
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Frankel, N., Davis, G. K., Vargas, D., Wang, S., Payre, F., & Stern, D. L. (2010) · Nature · doi:10.1038/nature09158 · Cited by 510
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Goentoro, L., Shoval, O., Kirschner, M. W., & Alon, U. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.11.018 · Cited by 424
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Battich, N., Stoeger, T., & Pelkmans, L. (2015) · Cell · doi:10.1016/j.cell.2015.11.018 · Cited by 324
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Mori, M., Nakagami, H., Rodriguez-Araujo, G., Nimura, K., & Kaneda, Y. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001314 · Cited by 243
“physiological and pathological phenomena and might be therapeutic targets [18–19,44–46].”
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Millan, M. J. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.11.015 · Cited by 229
Rosa, A., & Brivanlou, A. H. (2011) · The EMBO Journal · doi:10.1038/emboj.2010.319 · Cited by 198
MiRNAs confer phenotypic robustness to gene networks by suppressing biological noise
Siciliano, V., Garzilli, I., Fracassi, C., Criscuolo, S., Ventre, S., & di Bernardo, D. (2013) · Nature Communications · doi:10.1038/ncomms3364 · Cited by 166
The Utility of Paradoxical Components in Biological Circuits
Hart, Y., & Alon, U. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.004 · Cited by 151
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DeVeale, B., Swindlehurst-Chan, J., & Blelloch, R. (2021) · Nature Reviews Genetics · doi:10.1038/s41576-020-00309-5 · Cited by 121
Environmental regulation of the neural epigenome
Caldji, C., Hellstrom, I. C., Zhang, T.-Y., Diorio, J., & Meaney, M. J. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.032 · Cited by 82
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Qian, Q., Zhang, J., He, F.-P., Bao, W.-X., Zheng, T.-T., Zhou, D.-M., Pan, H.-Y., Zhang, H., Zhang, X.-Q., He, X., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201801846r · Cited by 70
Penning, A., Snoeck, S., Ormaechea, O. R., Ayyildiz, D., Polzer, O., Buitrago-Arango, M., Capobianco, R., de Winter, F., Balusu, S., Verhaagen, J., et al. (2026) · Acta Neuropathologica Communications · doi:10.1186/s40478-026-02228-8 · Cited by 6
Metadata
- Authors
- Li, X., Cassidy, J. J., Reinke, C. A., Fischboeck, S., & Carthew, R. W.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 137
- Issue
- 2
- Pages
- 273-282
- ISSN
- 0092-8674
- PMC
- PMC2674871
- Cited by
- 431
- References
- 8
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1604 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
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