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Cited by 1,581

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

Open access
Jaiswal, Siddhartha, Jamieson, Catriona H.M., Pang, Wendy W., Park, Christopher Y., Chao, Mark P., Majeti, Ravindra, Traver, David, van Rooijen, Nico, Weissman, Irving L.·2009·Cell
DOI 10.1016/j.cell.2009.05.046
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Abstract

Summary Macrophages clear pathogens and damaged or aged cells from the blood stream via phagocytosis. Cell-surface CD47 interacts with its receptor on macrophages, SIRPα, to inhibit phagocytosis of normal, healthy cells. We find that mobilizing cytokines and inflammatory stimuli cause CD47 to be transiently up-regulated on mouse hematopoietic stem cells (HSCs) and progenitors just prior to and during their migratory phase, and that the level of CD47 on these cells determines the probability that they are engulfed in vivo. CD47 is also constitutively up-regulated on mouse and human myeloid leukemias and over-expression of CD47 on a myeloid leukemia line increases its pathogenicity by allowing it to evade phagocytosis. We conclude that CD47 up-regulation is an important mechanism that provides protection to normal HSCs during inflammation-mediated mobilization, and that leukemic progenitors co-opt this ability in order to evade macrophage killing.

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Metadata

Authors
Jaiswal, S., Jamieson, C. H. M., Pang, W. W., Park, C. Y., Chao, M. P., Majeti, R., Traver, D., van Rooijen, N., & Weissman, I. L.
Venue
Cell
Publisher
Elsevier BV
Published
2009-07
Volume
138
Issue
2
Pages
271-285
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2009.05.046
OpenAlex
W2103746815
Cited by
1,581
References
5
FWCI
18.46
Type
journal article
Language
en
Open access
bronze

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