The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Open accessAbstract
Summary Brown fat defends against hypothermia and obesity through thermogenesis mediated by mitochondrial UCP1. Recent data suggest that there are two distinct types of brown fat: classical brown fat derived from a myf-5 cellular lineage and UCP1-positive cells that emerge in white fat from a non-myf-5 lineage. Here we report the cloning of “beige” cells from murine white fat depots. Beige cells resemble white fat cells in having extremely low basal expression of UCP1, but like classical brown fat, they respond to cyclic AMP stimulation with high UCP1 expression and respiration rates. Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin. Finally, we show that deposits of brown fat previously observed in adult humans are composed of beige adipose cells. These data illustrate a new cell type with therapeutic potential in mouse and human.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810
Self-citationCold-Activated Brown Adipose Tissue in Healthy Men
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452
Self-citationFunctional Brown Adipose Tissue in Healthy Adults
Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N.-J., Enerbäck, S., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808949 · Cited by 3,058
Self-citationPRDM16 controls a brown fat/skeletal muscle switch
Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347 · cited 3×
“The ‘‘brown-like’’ cells within white adipose depots are not derived from the myf-5 lineage and have been called ‘‘beige’’ or ‘‘brite’’ cells (Ishibashi and Seale, 2010; Petrovic et al., 2010; Seale et al., 2008).”
BackgroundSelf-citationMuscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis
Joe, A. W. B., Yi, L., Natarajan, A., Le Grand, F., So, L., Wang, J., Rudnicki, M. A., & Rossi, F. M. V. (2010) · Nature Cell Biology · doi:10.1038/ncb2015 · Cited by 1,690
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., et al. (2012) · Genes & Development · doi:10.1101/gad.177857.111 · Cited by 1,478 · cited 2×
“Other polypeptide hormones that brown white adipose tissues in rodents, such as FGF21 (Fisher et al., 2012) and ANP (Bordicchia et al.”
BackgroundPetrovic, N., Walden, T. B., Shabalina, I. G., Timmons, J. A., Cannon, B., & Nedergaard, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.053942 · Cited by 1,263
Bordicchia, M., Liu, D., Amri, E.-Z., Ailhaud, G., Dessì-Fulgheri, P., Zhang, C., Takahashi, N., Sarzani, R., & Collins, S. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59701 · Cited by 872
Guerra, C., Koza, R. A., Yamashita, H., Walsh, K., & Kozak, L. P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3155 · Cited by 635
Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes
Himms-Hagen, J., Melnyk, A., Zingaretti, M. C., Ceresi, E., Barbatelli, G., & Cinti, S. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.3.c670 · Cited by 593
Cited by
Items 101–127 of 127
Craft, C. S., Pietka, T. A., Schappe, T., Coleman, T., Combs, M. D., Klein, S., Abumrad, N. A., & Mecham, R. P. (2014) · Diabetes · doi:10.2337/db13-1604 · Cited by 73
No evidence of white adipocyte browning after endurance exercise training in obese men
Tsiloulis, T., Carey, A. L., Bayliss, J., Canny, B., Meex, R. C. R., & Watt, M. J. (2018) · International Journal of Obesity · doi:10.1038/ijo.2017.295 · Cited by 70
Estradiol effects on hypothalamic AMPK and BAT thermogenesis: A gateway for obesity treatment?
López, M., & Tena-Sempere, M. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.03.014 · Cited by 70
A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding
Dodd, G. T., Andrews, Z. B., Simonds, S. E., Michael, N. J., DeVeer, M., Brüning, J. C., Spanswick, D., Cowley, M. A., & Tiganis, T. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.013 · Cited by 66
Paulo, E., Wu, D., Wang, Y., Zhang, Y., Wu, Y., Swaney, D. L., Soucheray, M., Jimenez-Morales, D., Chawla, A., Krogan, N. J., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-29333-6 · Cited by 59
Chemical compound-based direct reprogramming for future clinical applications.
Takeda, Y., Harada, Y., Yoshikawa, T., & Dai, P. (2018) · Bioscience Reports · doi:10.1042/bsr20171650 · Cited by 57
Singh, R., Braga, M., Reddy, S. T., Lee, S.-J., Parveen, M., Grijalva, V., Vergnes, L., & Pervin, S. (2017) · Endocrinology · doi:10.1210/en.2016-1607 · Cited by 54
The role of autophagy in brown and beige adipose tissue plasticity
Cairó, M., & Villarroya, J. (2020) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-019-00708-1 · Cited by 53
Ikeda, Y., Watanabe, H., Shiuchi, T., Hamano, H., Horinouchi, Y., Imanishi, M., Goda, M., Zamami, Y., Takechi, K., Izawa-Ishizawa, Y., et al. (2020) · Diabetologia · doi:10.1007/s00125-020-05153-0 · Cited by 53
Effects of irisin on the differentiation and browning of human visceral white adipocytes.
(2019) · Europe PMC (PubMed Central) · Cited by 50
Looking on the “brite” side exercise-induced browning of white adipose tissue
Townsend, L. K., & Wright, D. C. (2019) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2177-1 · Cited by 44
Pervin, S., Reddy, S. T., & Singh, R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.653179 · Cited by 42
The Potential Role of Irisin in Vascular Function and Atherosclerosis: A Review
Byun, K., & Lee, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197184 · Cited by 38
Bargut, T. C. L., Martins, F. F., Santos, L. P., Aguila, M. B., & Mandarim-de-Lacerda, C. A. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.12.003 · Cited by 34
(2018) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-63912-7.00015-1 · Cited by 30
Mathew, D., Zhou, P., Pywell, C. M., van der Veen, D. R., Shao, J., Xi, Y., Bonar, N. A., Hummel, A. D., Chapman, S., Leevy, W. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073064 · Cited by 30
Ma, Y., Nenkov, M., Chen, Y., & Gaßler, N. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158352 · Cited by 28
Moienneia, N., & Attarzadeh Hosseini, S. R. (2016) · Obesity Medicine · doi:10.1016/j.obmed.2015.12.002 · Cited by 26
Pyrżak, B., Demkow, U., & Kucharska, A. M. (2015) · Advances in experimental medicine and biology · doi:10.1007/5584_2015_149 · Cited by 26
Pereira, M. P., Ferreira, L. A. A., da Silva, F. H. S., Christoffolete, M. A., Metsios, G. S., Chaves, V. E., de França, S. A., Damazo, A. S., Flouris, A. D., & Kawashita, N. H. (2017) · Nutrition · doi:10.1016/j.nut.2017.05.007 · Cited by 24
Hypothalamic control of adipose tissue
Stefanidis, A., Wiedmann, N. M., Adler, E. S., & Oldfield, B. J. (2014) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2014.08.001 · Cited by 22
Sellayah, D. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2018-00363 · Cited by 21
MicroRNA-33 Inhibits Adaptive Thermogenesis and Adipose Tissue Beiging
Afonso, M. S., Verma, N., van Solingen, C., Cyr, Y., Sharma, M., Perie, L., Corr, E. M., Schlegel, M., Shanley, L. C., Peled, D., et al. (2021) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.120.315798 · Cited by 21
Mendes, C., Gomes, G., Belpiede, L. T., do Carmo Buonfiglio, D., Motta-Teixeira, L. C., Amaral, F. G., & Cipolla-Neto, J. (2021) · Life Sciences · doi:10.1016/j.lfs.2020.118769 · Cited by 17
Kou, G., Hu, Y., Jiang, Z., Li, Z., Li, P., Song, H., Chen, Q., Zhou, Z., & Lyu, Q. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103860 · Cited by 14
Cong, H., Zhong, W., Wang, Y., Ikuyama, S., Fan, B., & Gu, J. (2018) · Journal of Diabetes Research · doi:10.1155/2018/9713259 · Cited by 9
Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming
Holman, C. D., Sakers, A. P., Calhoun, R. P., Cheng, L., Fein, E. C., Jacobs, C., Tsai, L., Rosen, E. D., & Seale, P. (2024) · eLife · doi:10.7554/elife.87756.3 · Cited by 8
Metadata
- Authors
- Wu, J., Boström, P., Sparks, L. M., Ye, L., Choi, J. H., Giang, A.-H., Khandekar, M., Virtanen, K. A., Nuutila, P., Schaart, G., Huang, K., Tu, H., van Marken Lichtenbelt, W. D., Hoeks, J., Enerbäck, S., Schrauwen, P., & Spiegelman, B. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 150
- Issue
- 2
- Pages
- 366-376
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2027753197
- Cited by
- 3,319
- References
- 12
- FWCI
- 135.86
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
