Microglial priming in Alzheimer’s disease

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works

Global prevalence of dementia: a Delphi consensus study

Ferri, C. P., Prince, M. J., Brayne, C., Brodaty, H., Fratiglioni, L., Ganguli, M., Hall, K. S., Hasegawa, K., Hendrie, H. C., Huang, Y., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67889-0 · Cited by 5,336 · see citing works

Monocyte and macrophage heterogeneity

Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190 · see citing works

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875 · see citing works

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089 · cited 1× · see citing works

Complement: a key system for immune surveillance and homeostasis

Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology · doi:10.1038/ni.1923 · Cited by 3,654 · cited 2× · see citing works

Alzheimer’s Disease

Scheltens, P., Blennow, K., Breteler, M. M. B., de Strooper, B., Frisoni, G. B., Salloway, S., & Van der Flier, W. M. (2016) · The Lancet · doi:10.1016/s0140-6736(15)01124-1 · Cited by 3,125 · see citing works

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

Heneka, M. T., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., et al. (2013) · Nature · doi:10.1038/nature11729 · Cited by 2,898 · see citing works

Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease

Jonsson, T., Stefansson, H., Steinberg, S., Jonsdottir, I., Jonsson, P. V., Snaedal, J., Bjornsson, S., Huttenlocher, J., Levey, A. I., Lah, J. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211103 · Cited by 2,558 · see citing works

Tau in physiology and pathology

Wang, Y., & Mandelkow, E. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.1 · Cited by 2,251 · see citing works

Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

Yoshiyama, Y., Higuchi, M., Zhang, B., Huang, S.-M., Iwata, N., Saido, T. C., Maeda, J., Suhara, T., Trojanowski, J. Q., & Lee, V. M.-Y. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.010 · Cited by 2,208 · see citing works

Immune attack: the role of inflammation in Alzheimer disease

Heppner, F. L., Ransohoff, R. M., & Becher, B. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3880 · Cited by 2,134 · see citing works

Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.016 · Cited by 2,087 · see citing works

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology &amp; Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050 · cited 1× · see citing works

Neuroinflammation in Alzheimer's disease: current evidence and future directions

Calsolaro, V., & Edison, P. (2016) · Alzheimer's &amp; Dementia · doi:10.1016/j.jalz.2016.02.010 · Cited by 1,726 · see citing works

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

Zhang, B., Gaiteri, C., Bodea, L.-G., Wang, Z., McElwee, J., Podtelezhnikov, A. A., Zhang, C., Xie, T., Tran, L., Dobrin, R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.030 · Cited by 1,657 · see citing works

Local self-renewal can sustain CNS microglia maintenance and function throughout adult life

Ajami, B., Bennett, J. L., Krieger, C., Tetzlaff, W., & Rossi, F. M. V. (2007) · Nature Neuroscience · doi:10.1038/nn2014 · Cited by 1,643 · see citing works

Microglia in neurodegenerative disease

Perry, V. H., Nicoll, J. A. R., & Holmes, C. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.17 · Cited by 1,543 · see citing works

Microglial interactions with synapses are modulated by visual experience

Tremblay, M.-È., Lowery, R. L., & Majewska, A. K. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000527 · Cited by 1,542 · see citing works

The microglial sensome revealed by direct RNA sequencing

Hickman, S. E., Kingery, N. D., Ohsumi, T. K., Borowsky, M. L., Wang, L.-C., Means, T. K., & El Khoury, J. (2013) · Nature Neuroscience · doi:10.1038/nn.3554 · Cited by 1,511 · see citing works

Innate immune activation in neurodegenerative disease

Heneka, M. T., Kummer, M. P., & Latz, E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3705 · Cited by 1,437 · see citing works

Activation of microglial cells by β-amyloid protein and interferon-γ

Meda, L., Cassatella, M. A., Szendrei, G. I., Otvos, L., Baron, P., Villalba, M., Ferrari, D., & Rossi, F. (1995) · Nature · doi:10.1038/374647a0 · Cited by 1,314 · see citing works

Astrocytes are active players in cerebral innate immunity

Farina, C., Aloisi, F., & Meinl, E. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.01.005 · Cited by 1,304 · see citing works

Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease.

(2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2305-5839.2015.03.49 · Cited by 1,288 · see citing works

Microglia development and function

Nayak, D., Roth, T. L., & McGavern, D. B. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120240 · Cited by 1,154 · see citing works

Amyloid Precursor Protein Trafficking, Processing, and Function

Thinakaran, G., & Koo, E. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800019200 · Cited by 1,141 · see citing works

Microglial priming in neurodegenerative disease

Perry, V. H., & Holmes, C. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.38 · Cited by 1,127 · see citing works

Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

Mildner, A., Schmidt, H., Nitsche, M., Merkler, D., Hanisch, U.-K., Mack, M., Heikenwalder, M., Brück, W., Priller, J., & Prinz, M. (2007) · Nature Neuroscience · doi:10.1038/nn2015 · Cited by 1,089 · see citing works

Microglial Activation and Chronic Neurodegeneration

Lull, M. E., & Block, M. L. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.014 · Cited by 1,047 · see citing works

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

Meyer-Luehmann, M., Spires-Jones, T. L., Prada, C., Garcia-Alloza, M., de Calignon, A., Rozkalne, A., Koenigsknecht-Talboo, J., Holtzman, D. M., Bacskai, B. J., & Hyman, B. T. (2008) · Nature · doi:10.1038/nature06616 · Cited by 987 · see citing works

Maternal immune activation and abnormal brain development across CNS disorders

Knuesel, I., Chicha, L., Britschgi, M., Schobel, S. A., Bodmer, M., Hellings, J. A., Toovey, S., & Prinssen, E. P. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.187 · Cited by 880 · see citing works

Microglia: Scapegoat, saboteur, or something else?

Aguzzi, A., Barres, B. A., & Bennett, M. L. (2013) · Science · doi:10.1126/science.1227901 · Cited by 836 · see citing works

Review: microglia of the aged brain: primed to be activated and resistant to regulation

Norden, D. M., & Godbout, J. P. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01306.x · Cited by 792 · see citing works

Inflammatory processes in Alzheimer's disease

Heneka, M. T., & O'Banion, M. K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.017 · Cited by 782 · see citing works

Microglia and neurodegeneration: The role of systemic inflammation

Cunningham, C. (2013) · Glia · doi:10.1002/glia.22350 · Cited by 769 · see citing works

The Role of Markers of Inflammation in Traumatic Brain Injury

Woodcock, T. M., & Morganti-Kossmann, M. C. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00018 · Cited by 719 · see citing works

Proteopathic tau seeding predicts tauopathy in vivo

Holmes, B. B., Furman, J. L., Mahan, T. E., Yamasaki, T. R., Mirbaha, H., Eades, W. C., Belaygorod, L., Cairns, N. J., Holtzman, D. M., & Diamond, M. I. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411649111 · Cited by 696 · see citing works

Neuroinflammation, Oxidative Stress and the Pathogenesis of Alzheimers Disease

Agostinho, P., A. Cunha, R., & Oliveira, C. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210793176572 · Cited by 685 · see citing works

Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration

Perry, V. H., & Teeling, J. L. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0382-8 · Cited by 599 · see citing works

Meta-analysis of modifiable risk factors for Alzheimer's disease

Xu, W., Tan, L., Wang, H.-F., Jiang, T., Tan, M.-S., Tan, L., Zhao, Q.-F., Li, J.-Q., Wang, J., & Yu, J.-T. (2015) · Journal of Neurology, Neurosurgery &amp; Psychiatry · doi:10.1136/jnnp-2015-310548 · Cited by 573 · see citing works

Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains

Walker, D. G., & Lue, L.-F. (2015) · Alzheimer's Research &amp; Therapy · doi:10.1186/s13195-015-0139-9 · Cited by 562 · see citing works

Protective effects of NSAIDs on the development of Alzheimer disease

Vlad, S. C., Miller, D. R., Kowall, N. W., & Felson, D. T. (2008) · Neurology · doi:10.1212/01.wnl.0000311269.57716.63 · Cited by 535 · see citing works

Sublime Microglia: Expanding Roles for the Guardians of the CNS

Salter, M. W., & Beggs, S. (2014) · Cell · doi:10.1016/j.cell.2014.06.008 · Cited by 531 · see citing works

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

Hsieh, C. L., Koike, M., Spusta, S. C., Niemi, E. C., Yenari, M., Nakamura, M. C., & Seaman, W. E. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06042.x · Cited by 475 · see citing works

Roles of microglia in brain development, tissue maintenance and repair

Michell‐Robinson, M. A., Touil, H., Healy, L. M., Owen, D. R., Durafourt, B. A., Bar‐Or, A., Antel, J. P., & Moore, C. S. (2015) · Brain · doi:10.1093/brain/awv066 · Cited by 421 · see citing works

Dark microglia: A new phenotype predominantly associated with pathological states

Bisht, K., Sharma, K. P., Lecours, C., Gabriela Sánchez, M., El Hajj, H., Milior, G., Olmos‐Alonso, A., Gómez‐Nicola, D., Luheshi, G., Vallières, L., et al. (2016) · Glia · doi:10.1002/glia.22966 · Cited by 421 · see citing works

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline

vom Berg, J., Prokop, S., Miller, K. R., Obst, J., Kälin, R. E., Lopategui-Cabezas, I., Wegner, A., Mair, F., Schipke, C. G., Peters, O., et al. (2012) · Nature Medicine · doi:10.1038/nm.2965 · Cited by 416 · see citing works

Reflex principles of immunological homeostasis

Andersson, U., & Tracey, K. J. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075015 · Cited by 414 · see citing works

Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease

Norden, D. M., Muccigrosso, M. M., & Godbout, J. P. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.10.028 · Cited by 413 · see citing works

The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function

Marsh, S. E., Abud, E. M., Lakatos, A., Karimzadeh, A., Yeung, S. T., Davtyan, H., Fote, G. M., Lau, L., Weinger, J. G., Lane, T. E., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525466113 · Cited by 411 · see citing works

Selective targeting of perivascular macrophages for clearance of β-amyloid in cerebral amyloid angiopathy

Hawkes, C. A., & McLaurin, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805453106 · Cited by 397 · see citing works

Inflammation and Alzheimer’s disease

Lee, Y.-J., Han, S. B., Nam, S.-Y., Oh, K.-W., & Hong, J. T. (2010) · Archives of Pharmacal Research · doi:10.1007/s12272-010-1006-7 · Cited by 396 · see citing works

Isolation of glia from Alzheimer’s mice reveals inflammation and dysfunction

Orre, M., Kamphuis, W., Osborn, L. M., Jansen, A. H. P., Kooijman, L., Bossers, K., & Hol, E. M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.06.004 · Cited by 394 · see citing works

Apolipoprotein E in Alzheimer's Disease: An Update

Yu, J.-T., Tan, L., & Hardy, J. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014300 · Cited by 394 · see citing works

Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an alzheimer’s mouse model

Ghosh, S., Wu, M. D., Shaftel, S. S., Kyrkanides, S., LaFerla, F. M., Olschowka, J. A., & O'Banion, M. K. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4361-12.2013 · Cited by 390 · see citing works

Targeting p38 MAPK pathway for the treatment of Alzheimer's disease

Munoz, L., & Ammit, A. J. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.11.010 · Cited by 370 · see citing works

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

Crotti, A., Benner, C., Kerman, B. E., Gosselin, D., Lagier-Tourenne, C., Zuccato, C., Cattaneo, E., Gage, F. H., Cleveland, D. W., & Glass, C. K. (2014) · Nature Neuroscience · doi:10.1038/nn.3668 · Cited by 333 · see citing works

The Multifaceted Profile of Activated Microglia

Lynch, M. A. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8077-9 · Cited by 323 · see citing works

Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain

Chen, Z., Jalabi, W., Hu, W., Park, H.-J., Gale, J. T., Kidd, G. J., Bernatowicz, R., Gossman, Z. C., Chen, J. T., Dutta, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms5486 · Cited by 319 · see citing works

Microglia–blood vessel interactions: a double-edged sword in brain pathologies

Dudvarski Stankovic, N., Teodorczyk, M., Ploen, R., Zipp, F., & Schmidt, M. H. H. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1524-y · Cited by 301 · see citing works

Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia

Sondag, C. M., Dhawan, G., & Combs, C. K. (2009) · Journal of Neuroinflammation · doi:10.1186/1742-2094-6-1 · Cited by 295 · see citing works

Microglia actions in Alzheimer's disease

Prokop, S., Miller, K. R., & Heppner, F. L. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1182-x · Cited by 291 · see citing works

Immune activation promotes depression 1 month after diffuse brain injury: a role for primed microglia

Fenn, A. M., Gensel, J. C., Huang, Y., Popovich, P. G., Lifshitz, J., & Godbout, J. P. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.014 · Cited by 283 · see citing works

Contribution of systemic inflammation to chronic neurodegeneration

Perry, V. H. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0722-x · Cited by 277 · see citing works

Neuroinflammation in Alzheimer&amp;rsquo;s disease

Zhang, F., & Jiang, L. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s75546 · Cited by 276 · see citing works

Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance

Kim, J., Castellano, J. M., Jiang, H., Basak, J. M., Parsadanian, M., Pham, V., Mason, S. M., Paul, S. M., & Holtzman, D. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.11.013 · Cited by 274 · see citing works

Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease

Villegas-Llerena, C., Phillips, A., Garcia-Reitboeck, P., Hardy, J., & Pocock, J. M. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.10.004 · Cited by 270 · see citing works

CD33 Alzheimer’s risk-altering polymorphism, CD33 expression, and exon 2 splicing

Malik, M., Simpson, J. F., Parikh, I., Wilfred, B. R., Fardo, D. W., Nelson, P. T., & Estus, S. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1224-13.2013 · Cited by 262 · see citing works

Review: Role of developmental inflammation and blood–brain barrier dysfunction in neurodevelopmental and neurodegenerative diseases

Stolp, H. B., & Dzięgielewska, K. M. (2008) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2008.01005.x · Cited by 259 · see citing works

Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies

Dujardin, S., Lécolle, K., Caillierez, R., Bégard, S., Zommer, N., Lachaud, C., Carrier, S., Dufour, N., Aurégan, G., Winderickx, J., et al. (2014) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-2-14 · Cited by 259 · see citing works

TREM2and Neurodegenerative Disease

Reitz, C., & Mayeux, R. P. (2013) · New England Journal of Medicine · doi:10.1056/nejmc1306509 · Cited by 254 · see citing works

Neuroinflammation in Alzheimer's Disease: Mechanisms, Pathologic Consequences, and Potential for Therapeutic Manipulation

Hensley, K. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1414 · Cited by 250 · see citing works

Microglial Aβ Receptors in Alzheimer’s Disease

Yu, Y., & Ye, R. D. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0101-6 · Cited by 247 · see citing works

Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo

Bolós, M., Llorens-Martín, M., Jurado-Arjona, J., Hernández, F., Rábano, A., & Avila, J. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-150704 · Cited by 234 · see citing works

The changing phenotype of microglia from homeostasis to disease

Luo, X., & Chen, S. (2012) · Translational Neurodegeneration · doi:10.1186/2047-9158-1-9 · Cited by 232 · see citing works

Age related changes in microglial phenotype vary between CNS regions: Grey versus white matter differences

Hart, A. D., Wyttenbach, A., Hugh Perry, V., & Teeling, J. L. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.11.006 · Cited by 230 · see citing works

Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation

Wong, W. T. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00022 · Cited by 227 · see citing works

Endotoxin-induced systemic inflammation activates microglia: [11C]PBR28 positron emission tomography in nonhuman primates

Hannestad, J. O., Gallezot, J., Schafbauer, T., Lim, K., Kloczynski, T., Morris, E. D., Carson, R. E., Ding, Y., & Cosgrove, K. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.06.055 · Cited by 213 · see citing works

Novel CSF biomarkers for Alzheimer’s disease and mild cognitive impairment

Hu, W. T., Chen‐Plotkin, A. S., Arnold, S. E., Grossman, M., Clark, C. M., Shaw, L. M. J., Pickering, E. H., Kühn, M., Chen, Y., McCluskey, L. F., et al. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0667-0 · Cited by 196 · see citing works

Neuroinflammatory phenotype in early Alzheimer's disease

Sudduth, T. L., Schmitt, F. A., Nelson, P. T., & Wilcock, D. M. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.09.012 · Cited by 194 · see citing works

Microglial Scavenger Receptors and Their Roles in the Pathogenesis of Alzheimer's Disease

Wilkinson, K., & Khoury, J. B. E. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/489456 · Cited by 186 · see citing works

Microglial Phenotype and Adaptation

Eggen, B. J. L., Raj, D. D. A., Hanisch, U., & Boddeke, H. W. G. M. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9490-4 · Cited by 176 · see citing works

Tau Oligomers and Fibrils Induce Activation of Microglial Cells

Morales, I., Jiménez, J. M., Mancilla, M., & Maccioni, R. B. (2013) · Journal of Alzheimer’s Disease · doi:10.3233/jad-131843 · Cited by 160 · see citing works

C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death

Kanmert, D., Cantlon, A., Muratore, C., Jin, M., O’Malley, T. T., Lee, G. S., Young‐Pearse, T. L., Selkoe, D. J., & Walsh, D. M. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0387-15.2015 · Cited by 159 · see citing works

C3-dependent mechanism of microglial priming relevant to multiple sclerosis

Ramaglia, V., Hughes, T. R., Donev, R., Ruseva, M. M., Wu, X., Huitinga, I., Baas, F., Neal, J., & Morgan, B. P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111924109 · Cited by 151 · see citing works

Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice

Rocha, E. M., Smith, G. A., Park, E. Y. H., Cao, H., Graham, A.-R., Brown, E., McLean, J. R., Hayes, M. A., Beagan, J. A., Izen, S. C., et al. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6307 · Cited by 144 · see citing works

Neuroinflammation in Alzheimer’s Disease

Reinisch, V. M., Krause, D., & Müller, N. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1071-7_9 · Cited by 140 · see citing works

Glial cell dysregulation: a new perspective on Alzheimer disease

Rommy von Bernhardi, M. (2007) · Neurotoxicity Research · doi:10.1007/bf03033906 · Cited by 138 · see citing works

Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer’s brains

Ando, K., Brion, J.-P., Stygelbout, V., Suain, V., Authelet, M., Dedecker, R., Chanut, A., Lacor, P., Lavaur, J., Sazdovitch, V., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1111-z · Cited by 136 · see citing works

Increased blood-brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model

Takeda, S., Sato, N., Ikimura, K., Nishino, H., Rakugi, H., & Morishita, R. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.02.010 · Cited by 135 · see citing works

Microglial Malfunction: The Third Rail in the Development of Alzheimer's Disease

Mhatre, S. D., Tsai, C. A., Rubin, A. J., James, M. L., & Andreasson, K. I. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.08.006 · Cited by 134 · see citing works

Neurobiology of microglial action in CNS injuries: Receptor-mediated signaling mechanisms and functional roles

Hu, X., Liou, A. K. F., Leak, R. K., Xu, M., An, C., Suenaga, J., Shi, Y., Gao, Y., Zheng, P., & Chen, J. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.06.002 · Cited by 131 · see citing works

Statins in the prevention of dementia and Alzheimer's disease: A meta‐analysis of observational studies and an assessment of confounding

Wong, W. B., Lin, V. W., Boudreau, D. M., & Devine, E. B. (2012) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.3381 · Cited by 124 · see citing works

Systemic inflammation induces axon injury during brain inflammation

Moreno, B., Jukes, J., Vergara‐Irigaray, N., Errea, O., Villoslada, P., Perry, V. H., & Newman, T. A. (2011) · Annals of Neurology · doi:10.1002/ana.22550 · Cited by 118 · see citing works

Increase in the density of resting microglia precedes neuritic plaque formation and microglial activation in a transgenic model of Alzheimer's disease

Rodríguez, J. J., Witton, J., Olabarria, M., Noristani, H. N., & Verkhratsky, A. (2010) · Cell Death &amp; Disease · doi:10.1038/cddis.2009.2 · Cited by 114 · see citing works

Reactive microgliosis: extracellular μ-calpain and microglia-mediated dopaminergic neurotoxicity

Levesque, S., Wilson, B. C., Gregoria, V., Thorpe, L. B., Dallas, S., Polikov, V. S., Hong, J., & Block, M. L. (2010) · Brain · doi:10.1093/brain/awp333 · Cited by 110 · see citing works

Infection, systemic inflammation, and Alzheimer's disease

Lim, S., Rodríguez‐Ortiz, C. J., & Kitazawa, M. (2015) · Microbes and Infection · doi:10.1016/j.micinf.2015.04.004 · Cited by 109 · see citing works

System xC− is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice

Mesci, P., Zaïdi, S., Lobsiger, C. S., Millecamps, S., Escartin, C., Seilhean, D., Sato, H., Mallat, M., & Boillée, S. (2014) · Brain · doi:10.1093/brain/awu312 · Cited by 107 · see citing works

Tau Overexpression Impacts a Neuroinflammation Gene Expression Network Perturbed in Alzheimer’s Disease

Wes, P. D., Easton, A. E., Corradi, J., Barten, D. M., Devidze, N., DeCarr, L. B., Truong, A. B., He, A., Barrezueta, N. X., Polson, C. T., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106050 · Cited by 105 · see citing works

MAC1 mediates LPS-induced production of superoxide by microglia: The role of pattern recognition receptors in dopaminergic neurotoxicity

Pei, Z., Pang, H., Qian, L., Yang, S., Wang, T., Zhang, W., Wu, X., Dallas, S., Wilson, B., Reece, J. M., et al. (2007) · Glia · doi:10.1002/glia.20545 · Cited by 105 · see citing works

Microglial Activation in Alzheimers Disease

Schlachetzki, J. C. M., & Hüll, M. (2009) · Current Alzheimer Research · doi:10.2174/156720509790147179 · Cited by 102 · see citing works

In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks

Burgold, S., Bittner, T., Dorostkar, M. M., Kieser, D., Fuhrmann, M., Mitteregger, G., Kretzschmar, H. A., Schmidt, B., & Herms, J. W. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0787-6 · Cited by 98 · see citing works

Morphine and HIV‐Tat increase microglial‐free radical production and oxidative stress: possible role in cytokine regulation

Turchan-Cholewo, J. T., Dimayuga, F. O., Gupta, S., Keller, J. N., Knapp, P. E., Hauser, K. F., & Bruce‐Keller, A. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05756.x · Cited by 98 · see citing works

Microglia in Alzheimer's Disease: It's All About Context

Weitz, T. M., & Town, T. (2012) · International Journal of Alzheimer's Disease · doi:10.1155/2012/314185 · Cited by 95 · see citing works

Novel Disease-Modifying Therapies for Alzheimer's Disease

Jiang, T., Yu, J., & Tan, L. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120640 · Cited by 93 · see citing works

Differential pathways for interleukin-1β production activated by chromogranin A and amyloid β in microglia

Wu, Z., Sun, L., Hashioka, S., Yu, S., Schwab, C., Okada, R., Hayashi, Y., McGeer, P. L., & Nakanishi, H. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.05.018 · Cited by 89 · see citing works

Physical Activity Reduces the Risk of Dementia in Mild Cognitive Impairment Subjects: A Cohort Study

Grande, G., Vanacore, N., Maggiore, L., Cucumo, V., Ghiretti, R., Galimberti, D., Scarpini, E. A., Mariani, C. B., & Clerici, F. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131808 · Cited by 86 · see citing works

Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening

Wood, L. B., Winslow, A. R., Proctor, E. A., McGuone, D., Mordes, D. A., Frosch, M. P., Hyman, B. T., Lauffenburger, D. A., & Haigis, K. M. (2015) · Scientific Reports · doi:10.1038/srep16622 · Cited by 83 · see citing works

Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

Yoshiyama, Y., Higuchi, M., Zhang, B., Huang, S.-M., Iwata, N., Saido, T. C., Maeda, J., Suhara, T., Trojanowski, J. Q., & Lee, V. M. ‐. (2007) · Neuron · doi:10.1016/j.neuron.2007.03.022 · Cited by 78 · see citing works

Viral CNS infections: role of glial pattern recognition receptors in neuroinflammation

Furr, S. R., & Marriott, I. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00201 · Cited by 77 · see citing works

Mechanisms Underlying Interferon-γ-Induced Priming of Microglial Reactive Oxygen Species Production

Spencer, N. G., Schilling, T., Miralles, F., & Eder, C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162497 · Cited by 72 · see citing works

Attenuation of microglial activation in a mouse model of Alzheimer’s disease via NFAT inhibition

Rojanathammanee, L., Floden, A. M., Manocha, G. D., & Combs, C. K. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0255-2 · Cited by 71 · see citing works

Modeling of Pathological Traits in Alzheimer's Disease Based on Systemic Extracellular Signaling Proteome

Britschgi, M., Rufibach, K., Huang, S. L. B., Clark, C. M., Kaye, J. A., Li, G., Peskind, E. R., Quinn, J. F., Galasko, D. R., & Wyss‐Coray, T. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.008862 · Cited by 71 · see citing works

Inflammatory Cytokines at the Summits of Pathological Signal Cascades in Brain Diseases

Steinman, L. (2013) · Science Signaling · doi:10.1126/scisignal.2003898 · Cited by 70 · see citing works

Microglia in Alzheimer’s Disease

Li, Y., Tan, M., Jiang, T., & Tan, L. (2014) · BioMed Research International · doi:10.1155/2014/437483 · Cited by 66 · see citing works

Enhanced microglial pro‐inflammatory response to lipopolysaccharide correlates with brain infiltration and blood–brain barrier dysregulation in a mouse model of telomere shortening

Raj, D. D. A., Moser, J., van der Pol, S. M. A., van Os, R. P., Holtman, I. R., Brouwer, N., Oeseburg, H., Schaafsma, W., Wesseling, E. M., den Dunnen, W. F. A., et al. (2015) · Aging Cell · doi:10.1111/acel.12370 · Cited by 63 · see citing works

Microglia induce neurotoxicity via intraneuronal Zn2+ release and a K+ current surge

Knoch, M. E., Hartnett, K. A., Hara, H., Kandler, K., & Aizenman, E. (2007) · Glia · doi:10.1002/glia.20592 · Cited by 63 · see citing works

Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer’s disease cohorts

Tan, L., Wang, H.-F., Tan, M., Tan, C., Zhu, X., Miao, D., Yu, W.-J., Jiang, T., Tan, L., Yu, J., et al. (2016) · Scientific Reports · doi:10.1038/srep26027 · Cited by 63 · see citing works

Microglia as a critical player in both developmental and late-life CNS pathologies

Derecki, N. C., Katzmarski, N., Kipnis, J., & Meyer-Luehmann, M. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1321-z · Cited by 61 · see citing works

The role of glial cells in Alzheimer disease: potential therapeutic implications

Cabezas, I. L., Batista, A. H., & Rol, G. P. (2014) · Neurología (English Edition) · doi:10.1016/j.nrleng.2012.10.009 · Cited by 57 · see citing works

Acute cognitive impairment after lateral fluid percussion brain injury recovers by 1 month: evaluation by conditioned fear response.

Lifshitz, J., Witgen, B., & Grady, M. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.11.014 · Cited by 54 · see citing works

Exposure to HIV-1 Tat in brain impairs sensorimotor gating and activates microglia in limbic and extralimbic brain regions of male mice

Paris, J. J., Singh, H. D., Carey, A. N., & McLaughlin, J. P. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.05.021 · Cited by 53 · see citing works

Papel de la glía en la enfermedad de Alzheimer. Futuras implicaciones terapéuticas

Cabezas, I. L., Batista, A. H., & Rol, G. P. (2012) · Neurología · doi:10.1016/j.nrl.2012.10.006 · Cited by 50 · see citing works

Mechanisms of hypothermia‐induced cell protection mediated by microglial cells in vitro

Diestel, A., Troeller, S., Billecke, N., Sauer, I. M., Berger, F. F., & Schmitt, K. R. L. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07128.x · Cited by 39 · see citing works

Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer’s disease

McCarter, J. F., Liebscher, S., Bachhuber, T., Abou‐Ajram, C., Hübener, M., Hyman, B. T., Haass, C., & Meyer‐Luehmann, M. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1137-2 · Cited by 39 · see citing works

Microglial response to Alzheimer’s disease is differentially modulated by voluntary wheel running and enriched environments

Rodriguez, J. J., Noristani, H. N., & Verkhratsky, A. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0693-5 · Cited by 38 · see citing works

Magnetic Resonance Spectroscopy discriminates the response to microglial stimulation of wild type and Alzheimer’s disease models

Pardon, M., Lopez, M. Y., Ding, Y., Marjańska, M., Prior, M. J. W., Brignell, C. J., Parhizkar, S., Agostini, A., Bai, L., Auer, D. P., et al. (2016) · Scientific Reports · doi:10.1038/srep19880 · Cited by 36 · see citing works

Regulation of Immune Cell Infiltration into the CNS by Regional Neural Inputs Explained by the Gate Theory

Arima, Y., Kamimura, D., Sabharwal, L., Yamada, M., Bando, H., Ogura, H., Atsumi, T., & Murakami, M. (2013) · Mediators of Inflammation · doi:10.1155/2013/898165 · Cited by 34 · see citing works

Injury-Induced Neurogenesis: Consideration of Resident Microglia as Supportive of Neural Progenitor Cells

McPherson, C. A., Kraft, A. D., & Harry, G. J. (2010) · Neurotoxicity Research · doi:10.1007/s12640-010-9199-6 · Cited by 32 · see citing works

Alzheimer’s Disease-like Early-phase Brain Pathogenesis: Self-curing Amelioration of Neurodegeneration from Pro-inflammatory ‘Wounding’ to Anti-inflammatory ‘Healing’

Jiang, H., Liao, T., Zhong, G., Zhang, J., Chen, Y., Wang, Q., & Zeng, Q.-P. (2017) · Current Alzheimer Research · doi:10.2174/1567205014666170417111420 · Cited by 16 · see citing works

[Blood-brain barrier and blood-nerve barrier in neuroinflammatory diseases].

Maeda, T., & Kanda, T. (2013) · PubMed · Cited by 9 · see citing works

Glial activation and inflammation along the Alzheimer’s disease continuum

Nordengen, K., Kirsebom, B.-E., Henjum, K., Selnes, P., Gísladóttir, B., Wettergreen, M., Torsetnes, S. B., Grøntvedt, G. R., Waterloo, K. K., Aarsland, D., et al. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1399-2 · Cited by 274 · see citing works

Neuroinflammation and Functional Connectivity in Alzheimer's Disease: Interactive Influences on Cognitive Performance

Passamonti, L., Tsvetanov, K. A., Jones, P. S., Bevan-Jones, W. R., Arnold, R., Borchert, R. J., Mak, E., Su, L., O'Brien, J. T., & Rowe, J. B. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.2574-18.2019 · Cited by 220 · see citing works

Alzheimer’s Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia

Eshraghi, M., Adlimoghaddam, A., Mahmoodzadeh, A., Sharifzad, F., Yasavoli-Sharahi, H., Lorzadeh, S., Albensi, B. C., & Ghavami, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073330 · Cited by 158 · see citing works

Eriodictyol Attenuates LPS-Induced Neuroinflammation, Amyloidogenesis, and Cognitive Impairments via the Inhibition of NF-κB in Male C57BL/6J Mice and BV2 Microglial Cells

He, P., Yan, S., Zheng, J., Gao, Y., Zhang, S., Liu, Z., Liu, X., & Xiao, C. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b03731 · Cited by 120 · see citing works

The Obese Brain: Mechanisms of Systemic and Local Inflammation, and Interventions to Reverse the Cognitive Deficit

Salas-Venegas, V., Flores-Torres, R. P., Rodríguez-Cortés, Y. M., Rodríguez-Retana, D., Carreto, R. J. R., Concepción-Carrillo, L. E., Pérez-Flores, L. J., Alarcón‐Aguilar, A., López‐Díazguerrero, N. E., Gómez‐González, B., et al. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.798995 · Cited by 118 · see citing works

Masitinib for mild-to-moderate Alzheimer’s disease: results from a randomized, placebo-controlled, phase 3, clinical trial

Dubois, B., López‐Arrieta, J., Lipschitz, S., Doskas, T. K., Spiru, L., Moroz, S., Venger, O., Vermersch, P., Moussy, A., Mansfield, C. D., et al. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01169-x · Cited by 110 · see citing works

Treatment of Alzheimer’s Disease: Beyond Symptomatic Therapies

Buccellato, F. R., D’Anca, M., Tartaglia, G. M., Del Fabbro, M., Scarpini, E., & Galimberti, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813900 · Cited by 94 · see citing works

Short-term exposure to ambient air quality of the most polluted Indian cities due to lockdown amid SARS-CoV-2

Mahato, S., & Ghosh, K. G. (2020) · Environmental Research · doi:10.1016/j.envres.2020.109835 · Cited by 74 · see citing works

Microglial response to experimental periodontitis in a murine model of Alzheimer’s disease

Kantarcı, A., Tognoni, C. M., Yaghmoor, W., Marghalani, A. A., Stephens, D. N., Ahn, J.-Y., Carreras, I., & Dedeoglu, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-75517-4 · Cited by 67 · see citing works

Adolescent Binge Alcohol Enhances Early Alzheimer’s Disease Pathology in Adulthood Through Proinflammatory Neuroimmune Activation

Barnett, A., David, E., Rohlman, A., Nikolova, V. D., Moy, S. S., Vetreno, R. P., & Coleman, L. G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.884170 · Cited by 62 · see citing works

Elevated Expression of MiR-17 in Microglia of Alzheimer’s Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation

Estfanous, S. Z. K., Daily, K. P., Eltobgy, M. M., Deems, N. P., Anne, M. N. K., Krause, K., Badr, A., Hamilton, K., Carafice, C., Hegazi, A., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.705581 · Cited by 63 · see citing works

Functional and Phenotypic Diversity of Microglia: Implication for Microglia-Based Therapies for Alzheimer’s Disease

Xu, Y., Au, N. P. B., & Ma, C. H. E. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.896852 · Cited by 63 · see citing works

Microglial response to aging and neuroinflammation in the development of neurodegenerative diseases

Han, T., Xu, Y., Sun, L., Hashimoto, M., & Wei, J. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.385845 · Cited by 60 · see citing works

Ibrutinib modulates Aβ/tau pathology, neuroinflammation, and cognitive function in mouse models of Alzheimer's disease

Lee, H., Jeon, S. G., Kim, J., Kang, R. J., Kim, S., Han, K., Park, H., Kim, K., Sung, Y. M., Nam, H. Y., et al. (2021) · Aging Cell · doi:10.1111/acel.13332 · Cited by 61 · see citing works

Alcohol impairs hippocampal function: From NMDA receptor synaptic transmission to mitochondrial function

Mira, R. G., Tapia‐Rojas, C., Maria Jose Perez, J., Jara, C., Vergara, E. H., Quintanilla, R. A., & Cerpa, W. F. (2019) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2019.107628 · Cited by 56 · see citing works

SARS-CoV-2 involvement in central nervous system tissue damage

Sabra, M., Kobeissy, F. H., Bizri, M., Haidar, M. A., Shakkour, Z., Reslan, M. A., Al-Haj, N., Chamoun, P., Habashy, K. J., Kaafarani, H., et al. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.327323 · Cited by 57 · see citing works

Inhibition of Colony-Stimulating Factor 1 Receptor by PLX3397 Prevents Amyloid Beta Pathology and Rescues Dopaminergic Signaling in Aging 5xFAD Mice

Son, Y., Jeong, Y. J., Shin, N., Oh, S. J., Nam, K. R., Choi, H., Choi, J. Y., & Lee, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155553 · Cited by 52 · see citing works

Periodontal Infection Aggravates C1q-Mediated Microglial Activation and Synapse Pruning in Alzheimer’s Mice

Hao, X., Li, Z., Li, W., Katz, J., Michalek, S. M., Barnum, S. R., Pozzo‐Miller, L. D., Saito, T., Saido, T. C., Wang, Q., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.816640 · Cited by 53 · see citing works

Towards an adiposity-related disease framework for the diagnosis and management of obesities

Perdomo, C. M., Avilés-Olmos, I., Dicker, D., & Frühbeck, G. (2023) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-023-09797-2 · Cited by 51 · see citing works

Time for the systems-level integration of aging: Resilience enhancing strategies to prevent Alzheimer’s disease

Hampel, H. J., Lista, S., Néri, C., & Vergallo, A. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101662 · Cited by 46 · see citing works

More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke

Sanchez‐Bezanilla, S., Hood, R. J., Collins‐Praino, L. E., Turner, R. J., Walker, F. R., Nilsson, M., & Ong, L. K. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x211005877 · Cited by 47 · see citing works

Transcriptomic and functional studies reveal undermined chemotactic and angiostimulatory properties of aged microglia during stroke recovery

Jiang, L., Mu, H., Xu, F., Xie, D., Su, W., Xu, J., Sun, Z., Liu, S., Luo, J., Shi, Y., et al. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20902542 · Cited by 45 · see citing works

Neuropathology of the Alzheimer's continuum: an update

Jellinger, K. A. (2020) · Free Neuropathology · doi:10.17879/freeneuropathology-2020-3050 · Cited by 45 · see citing works

Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease

Shin, H. J., Kim, I. S., Choi, S. G., Lee, K., Park, H., Shin, J., Kim, D., Beom, J., Yi, Y. Y., Gupta, D. P., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00715-x · Cited by 42 · see citing works

Pathophysiological Role of Microglial Activation Induced by Blood-Borne Proteins in Alzheimer’s Disease

Kim, S., Sharma, C., Jung, U. J., & Kim, S. R. (2023) · Biomedicines · doi:10.3390/biomedicines11051383 · Cited by 40 · see citing works

Dexmedetomidine protects aged rats from postoperative cognitive dysfunction by alleviating hippocampal inflammation

Chen, N., Chen, X., Xie, J., Wu, C., & Qian, J. X. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10438 · Cited by 39 · see citing works

Deleterious Alteration of Glia in the Brain of Alzheimer’s Disease

Kim, E., Otgontenger, U., Jamsranjav, A., & Kim, S. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186676 · Cited by 41 · see citing works

Monomeric C‐reactive protein: A novel biomarker predicting neurodegenerative disease and vascular dysfunction

Pastorello, Y., Carare, R. O., Bănescu, C. V., Potempa, L. A., Napoli, M. D., & SLEVIN, M. A. (2023) · Brain Pathology · doi:10.1111/bpa.13164 · Cited by 36 · see citing works

High-Fat Diets in Animal Models of Alzheimer’s Disease: How Can Eating Too Much Fat Increase Alzheimer’s Disease Risk?

Valentin‐Escalera, J., Leclerc, M., & Calon, F. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-230118 · Cited by 35 · see citing works

Role of microglia autophagy and mitophagy in age-related neurodegenerative diseases

Lin, M., Yu, H., Xie, Q., Xu, Z., & Shang, P. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1100133 · Cited by 37 · see citing works

Brain amyloid in virally suppressed HIV-associated neurocognitive disorder

Howdle, G. C., Quidé, Y., Kassem, M. S., JOHNSON, K., Rae, C. D., Brew, B. J., & Cysique, L. A. (2020) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000739 · Cited by 33 · see citing works

Aging and Progression of Beta-Amyloid Pathology in Alzheimer’s Disease Correlates with Microglial Heme-Oxygenase-1 Overexpression

Fernández‐Mendívil, C., Arreola, M. A., Hohsfield, L. A., Green, K. N., & López, M. G. (2020) · Antioxidants · doi:10.3390/antiox9070644 · Cited by 33 · see citing works

Development of postoperative delirium prediction models in patients undergoing cardiovascular surgery using machine learning algorithms

Nagata, C., Hata, M., Miyazaki, Y., Masuda, H., Wada, T., Kimura, T., Fujii, M., Sakurai, Y., Matsubara, Y., Yoshida, K., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-48418-5 · Cited by 32 · see citing works

Microbiota-brain interaction: The role of gut-derived proteins in addressing various neurological disorders including Parkinson’s (PD) and Alzheimer’s diseases (AD)

Taj, T., Kaushik, M., Islam, A., Das, J., Kumar, B., Hussain, M. S., Ramzan, M., Ashique, S., Tariq, M., Sridhar, S. B., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118861 · Cited by 33 · see citing works

New Insights into Microglial Mechanisms of Memory Impairment in Alzheimer’s Disease

Li, N., Deng, M., Hu, G., Li, N., Yuan, H., & Zhou, Y. (2022) · Biomolecules · doi:10.3390/biom12111722 · Cited by 30 · see citing works

Targeting Microglia in Neuroinflammation: H3 Receptor Antagonists as a Novel Therapeutic Approach for Alzheimer’s Disease, Parkinson’s Disease, and Autism Spectrum Disorder

Thomas, S. D., Abdalla, S., Eissa, N., Akour, A., Jha, N., Ojha, S., & Sadek, B. (2024) · Pharmaceuticals · doi:10.3390/ph17070831 · Cited by 24 · see citing works

The Impact of Ageing on the CNS Immune Response in Alzheimer’s Disease

Chee, S. E. J., & Solito, E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.738511 · Cited by 27 · see citing works

Amyloid-β mediates intestinal dysfunction and enteric neurons loss in Alzheimer's disease transgenic mouse

Liu, G., Yu, Q., Zhu, H., Tan, B., Yu, H., Li, X., Lu, Y., & Li, H. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04948-9 · Cited by 27 · see citing works

Genetics of Alzheimer’s disease

König, T., & Stögmann, E. (2021) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-021-00819-9 · Cited by 28 · see citing works

MSC Secretome as a Promising Tool for Neuroprotection and Neuroregeneration in a Model of Intracerebral Hemorrhage

Karagyaur, M. N., Станиславович, Д. С., Basalova, N. A., Aleksandrushkina, N. A., Sagaradze, G. D., Danilova, N. V., Malkov, P. G., Popov, V. S., Никитична, С. М., Efimenko, A. Y., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13122031 · Cited by 27 · see citing works

Fluid Candidate Biomarkers for Alzheimer’s Disease: A Precision Medicine Approach

Prete, E. D., Beatino, M. F., Campese, N., Giampietri, L., Siciliano, G., Ceravolo, R., & Baldacci, F. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10040221 · Cited by 27 · see citing works

A New Generation of IMiDs as Treatments for Neuroinflammatory and Neurodegenerative Disorders

Kopp, K. O., Greer, M. E., Glotfelty, E. J., Hsueh, S., Tweedie, D., Kim, D. S., Reale, M., Vargesson, N., & Greig, N. H. (2023) · Biomolecules · doi:10.3390/biom13050747 · Cited by 24 · see citing works

Short-term high fat diet impairs memory, exacerbates the neuroimmune response, and evokes synaptic degradation via a complement-dependent mechanism in a mouse model of Alzheimer’s disease

Mackey-Alfonso, S. E., Butler, M. J., Taylor, A., Williams-Medina, A. R., Muscat, S. M., Fu, H., & Barrientos, R. M. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.07.021 · Cited by 24 · see citing works

Gap Junctions and Connexins in Microglia-Related Oxidative Stress and Neuroinflammation: Perspectives for Drug Discovery

Caruso, G., Pietro, L. D., & Caraci, F. (2023) · Biomolecules · doi:10.3390/biom13030505 · Cited by 23 · see citing works

NVP-BEZ235 (Dactolisib) Has Protective Effects in a Transgenic Mouse Model of Alzheimer’s Disease

Bellozi, P. M. Q., Gomes, G. F., de Oliveira, L. R., Olmo, I. G., Vieira, É. L. M., Ribeiro, F. M., Fiebich, B. L., & de Oliveira, A. C. P. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01345 · Cited by 22 · see citing works

Role of obesity-related anthropometric indicators on cognitive function in obese older adults: A systematic review and meta-analysis

Phirom, K., Nantakool, S., Chuatrakoon, B., & Rerkasem, K. (2025) · Public Health · doi:10.1016/j.puhe.2025.01.040 · Cited by 18 · see citing works

Systemic Inflammation Causes Microglial Dysfunction With a Vascular AD phenotype

Bathini, P., Dupanloup, I., Zenaro, E., Terrabuio, E., Fischer, A., Ballabani, E., Doucey, M., & Alberi, L. A. (2022) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2022.100568 · Cited by 20 · see citing works

Chronic consumption of a hypercaloric diet increases neuroinflammation and brain senescence, promoting cognitive decline in middle-aged female Wistar rats

Salas-Venegas, V., Santín-Márquez, R., Carreto, R. J. R., Rodríguez-Cortés, Y. M., Cano-Martı́nez, A., Luna‐López, A., Chavarría, A., Königsberg, M., & López‐Díazguerrero, N. E. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1162747 · Cited by 20 · see citing works

DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer’s disease

Daily, K. P., Badr, A., Eltobgy, M. M., Estfanous, S. Z. K., Whitham, O. D., Tan, M. H., Carafice, C., Krause, K., McNamara, A. J., Hamilton, K., et al. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01390-2 · Cited by 19 · see citing works

Intermittent hypoxia treatments cause cellular priming in human microglia

Felice, M. D., Germelli, L., Piccarducci, R., Pozzo, E. D., Giacomelli, C., Baccaglini‐Frank, A., & Martini, C. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17682 · Cited by 16 · see citing works

Investigations on a polyherbal formulation for treatment of cognitive impairment in a cholinergic dysfunctional rodent model

Rajendran, K., Chellappan, D. R., Sankaranarayanan, S., Ramakrishnan, V., & Krishnan, U. M. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104890 · Cited by 17 · see citing works

Aging and neuropathic pain: Mitochondria-to-glia cascade, system mechanisms, and therapeutic strategies

Majumdar, S., Samaiya, P. K., Gupta, S. K., Krishnamurthy, S., & Prajapati, S. K. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103042 · Cited by 16 · see citing works

Immunological Interfaces: The COVID-19 Pandemic and Depression

Perlmutter, A. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.657004 · Cited by 17 · see citing works

Dietary fat: a potent microglial influencer

Ceasrine, A. M., & Bilbo, S. D. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.12.005 · Cited by 16 · see citing works

Reactive gliosis and neuroinflammation: prime suspects in the pathophysiology of post-acute neuroCOVID-19 syndrome

Saucier, J., Comeau, D., Robichaud, G. A., & Chamard-Witkowski, L. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1221266 · Cited by 16 · see citing works

Decoding natural products for neuroprotection: Pathway networks and structural insights for drug development

Ghosh, S., Debnath, I., Bhunia, S., Nandi, S., Ashique, S., Nayak, A., Mallick, S., & Basak, S. (2025) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2025.09.005 · Cited by 15 · see citing works

Possible Implications of Obesity-Primed Microglia that Could Contribute to Stroke-Associated Damage

Carreto, R. J. R., Rodríguez-Cortés, Y. M., Guerrero, H. T., & Chavarría, A. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01329-5 · Cited by 15 · see citing works

Recent Trends in Active and Passive Immunotherapies of Alzheimer’s Disease

Alshamrani, M. (2023) · Antibodies · doi:10.3390/antib12020041 · Cited by 16 · see citing works

Decoding molecular mechanisms: brain aging and Alzheimer’s disease

Hayat, M., Syed, R. A., Qaiser, H., Uzair, M., Al-Regaiey, K., Khallaf, R. A., Albassam, L. A. M., Kaleem, I., Wang, X., Wang, R., et al. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01403 · Cited by 14 · see citing works

Microglial modulation as a therapeutic strategy in Alzheimer's disease: Focus on microglial preconditioning approaches

Yassaghi, Y., Nazerian, Y., Ghasemi, M., Nazerian, A., Sayehmiri, F., Perry, G. L., & Pourbadie, H. G. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18554 · Cited by 14 · see citing works

Glaucocalyxin A as a natural product increases amyloid β clearance and decreases tau phosphorylation involving the mammalian target of rapamycin signaling pathway

Zhou, T., Zhuang, J., Wang, Z., Zhou, Y., Li, W., Wang, Z., & Zhu, Z. (2019) · Neuroreport · doi:10.1097/wnr.0000000000001202 · Cited by 14 · see citing works

Pathological and neurophysiological outcomes of seeding human-derived tau pathology in the APP-KI NL-G-F and NL-NL mouse models of Alzheimer’s Disease

Tok, S., Maurin, H., Delay, C., Crauwels, D., Manyakov, N. V., der Elst, W. V., Moechars, D., & Drinkenburg, W. H. I. M. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01393-w · Cited by 13 · see citing works

Neurological Manifestations Following Traumatic Brain Injury: Role of Behavioral, Neuroinflammation, Excitotoxicity, Nrf-2 and Nitric Oxide

Goyal, L., & Singh, S. (2024) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273318552240708055413 · Cited by 13 · see citing works

Epileptic seizures induced by pentylenetetrazole kindling accelerate Alzheimer-like neuropathology in 5×FAD mice

Zou, Y., Wang, C., Li, H., Zhong, M., Lin, J., Hu, Y., Chen, Z., & Gan, C. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1500105 · Cited by 13 · see citing works

Traumatic Brain Injury and Opioids: Twin Plagues of the Twenty-First Century.

Jammoul, M., Jammoul, D., Wang, K. K. W., Kobeissy, F. H., & Depalma, R. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.05.013 · Cited by 12 · see citing works

Urokinase-Type Plasminogen Activator Enhances the Neuroprotective Activity of Brain-Derived Neurotrophic Factor in a Model of Intracerebral Hemorrhage

Станиславович, Д. С., Литвинова, С. А., Efimenko, A. Y., Aleksandrushkina, N. A., Basalova, N. A., Abakumov, M. A., Danilova, N. V., Malkov, P. G., Balabanyan, V. Y., Безуглова, Т. В., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10061346 · Cited by 12 · see citing works

The Role of Glia Telomere Dysfunction in the Pathogenesis of Central Nervous System Diseases

Papageorgakopoulou, M. A., Bania, A., Lagogianni, I.-A., Birmpas, K., & Assimakopoulou, M. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03947-6 · Cited by 11 · see citing works

Potential anti-neuroinflammatory compounds from Australian plants – A review

Singh, A., Raju, R., & Münch, G. W. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104897 · Cited by 11 · see citing works

Neuroprotective Effects of Apple‐Derived Drinks in a Mice Model of Inflammation

Alvariño, R., Alonso, E., Alfonso, A., & Botana, L. M. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201901017 · Cited by 11 · see citing works

Overexpression of microRNA-381-3p ameliorates hypoxia/ischemia-induced neuronal damage and microglial inflammation via regulating the C-C chemokine receptor type 2 /nuclear transcription factor-kappa B axis

Che, Y., He, J., Li, X., Wu, D., Zhang, Y., & Gui-cai, Y. (2022) · Bioengineered · doi:10.1080/21655979.2022.2038448 · Cited by 10 · see citing works

Single cell profiling of Hofbauer cells and fetal brain microglia reveals shared programs and functionsPreprint

Ceasrine, A. M., Batorsky, R., Shook, L. L., Kışlal, S., Bordt, E. A., Devlin, B. A., Perlis, R. H., Slonim, D. K., Bilbo, S. D., & Edlow, A. G. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.03.471177 · Cited by 10 · see citing works

Beyond Support Cells: Astrocytic Autophagy as a Central Regulator of CNS Homeostasis and Neurodegenerative Diseases

Lee, J. H., Chang, W. S., Min, S. S., Song, D., & Yoo, H. (2025) · Cells · doi:10.3390/cells14171342 · Cited by 8 · see citing works

Research progress in the mechanism of acupuncture regulating microglia in the treatment of Alzheimer’s disease

Liu, J., Zhou, J., You, C., Xia, H., Gao, Y., Liu, Y., & Gong, X. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1435082 · Cited by 9 · see citing works

Gliosis, misfolded protein aggregation, and neuronal loss in a guinea pig model of pulmonary tuberculosis

Latham, A. S., Geer, C. E., Ackart, D. F., Anderson, I. K., Vittoria, K. M., Podell, B. K., Basaraba, R. J., & Moreno, J. A. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1157652 · Cited by 8 · see citing works

Dynamic neuroinflammatory profiles predict Alzheimer’s disease pathology in microglia-containing cerebral organoidsPreprint

Kuhn, M. K., Kang, R. Y., Kim, C., Tagay, Y., Morris, N., Tabdanov, E. D., Elcheva, I. A., & Proctor, E. A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.16.567220 · Cited by 8 · see citing works

Effect of bioactive extracts from Eucalyptus globulus leaves in experimental models of Alzheimer’s disease

Moreira, P., Macedo, J., Matos, P., Bicker, J., Fortuna, A. C., Figueirinha, A., Salgueiro, L., Batista, M. T., da Silva, A. P., Silva, S., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117652 · Cited by 7 · see citing works

Hearing modulation affects Alzheimer’s disease progression linked to brain inflammation: a study in mouse models

Ko, Y., Ryu, Y., Han, S.-J., Park, H. J., Choi, M., Kim, B. C., Jeong, H., Jang, S., Jo, J., Lee, S., et al. (2024) · Molecular Medicine · doi:10.1186/s10020-024-01040-1 · Cited by 7 · see citing works

Blood Analytes as Biomarkers of Mechanisms Involved in Alzheimer’s Disease Progression

Baldini, A., Greco, A., Lomi, M., Giannelli, R., Canale, P., Diana, A., Dolciotti, C., Carratore, R. D., & Bongioanni, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113289 · Cited by 6 · see citing works

Redox-sensitive high mobility group box 1 (HMGB1) protein is a multipotent regulator in the pathogenesis of Alzheimer's disease

Salminen, A. (2026) · Neurochemistry International · doi:10.1016/j.neuint.2026.106115 · Cited by 5 · see citing works

Towards a Deeper Understanding: Utilizing Machine Learning to Investigate the Association between Obesity and Cognitive Decline—A Systematic Review

Veneziani, I., Grimaldi, A., Marra, A., Morini, E., Culicetto, L., Marino, S., Quartarone, A., & Maresca, G. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13082307 · Cited by 5 · see citing works

Microglial Drivers of Alzheimer's Disease Pathology: An Evolution of Diverse Participating States

Kuhn, M. K., & Proctor, E. A. (2024) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.26723 · Cited by 5 · see citing works

MRI detects blood-brain barrier alterations in a rat model of Alzheimer’s disease and lung infection

Ohene, Y., Morrey, W. J., Powell, E., Smethers, K. F., Luka, N., South, K., Berks, M., Lawrence, C. B., Parker, G. J. M., Parkes, L. M., et al. (2025) · npj Imaging · doi:10.1038/s44303-025-00071-5 · Cited by 6 · see citing works

Uncovering active ingredients and mechanisms of Pholiota adiposa in the treatment of Alzheimer’s disease based on network pharmacology and bioinformatics

Ma, X., Zhiming, H., Mingwen, S., Hong, W., Tao, Y., Jun, X., & Gong, N. (2025) · Scientific Reports · doi:10.1038/s41598-025-94861-x · Cited by 5 · see citing works

Perinatal asphyxia and Alzheimer's disease: is there a correlation?

Arruda, B. P., Martins, P. P., Kihara, A. H., & Takada, S. H. (2025) · Frontiers in Pediatrics · doi:10.3389/fped.2025.1567719 · Cited by 5 · see citing works

Development and validation of a LC-MS/MS assay for quantifying the uptake of docosahexaenoic acid-d5 into mouse microglia

Low, Y. L., Pan, Y., Short, J. L., & Nicolazzo, J. A. (2020) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2020.113575 · Cited by 5 · see citing works

The Impact of Edentulism and Periodontitis on Cognition

Berard, L., & Zhou, M. (2023) · Journal of the California Dental Association · doi:10.1080/19424396.2023.2289696 · Cited by 4 · see citing works

Microglial Hemoxygenase-1 Deletion Reduces Inflammation in the Retina of Old Mice with Tauopathy

Fernández‐Albarral, J. A., Salobrar‐García, E., Matamoros, J. A., Fernández‐Mendívil, C., del Sastre, E., Chen, L., de Hoz, R., López‐Cuenca, I., Sánchez-Puebla, L., Ramirez, J. M., et al. (2022) · Antioxidants · doi:10.3390/antiox11112151 · Cited by 4 · see citing works

Neuroinflammation-Modulating Agent SB1617 Enhances LC3-Associated Phagocytosis to Mitigate Tau Pathology

Cho, H., Choi, B. Y., Shin, Y., Suh, S. W., & Park, S. B. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00508 · Cited by 4 · see citing works

Single Cell Profiling of Hofbauer Cells and Fetal Brain Microglia Reveals Shared Programs and FunctionsPreprint

Caesarine, A., Batorsky, R., Shook, L. L., Kışlal, S., Bordt, E. A., Devlin, B. A., Perlis, R. H., Slonim, D. K., Bilbo, S. D., & Edlow, A. G. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3985607 · Cited by 4 · see citing works

DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates neuroinflammation and amyloid-β deposition in Alzheimer’s disease The Ohio State University College of MedicinePreprint

Daily, K. P., Badr, A., Eltobgy, M. M., Estfanous, S. Z. K., Whitham, O. D., Tan, M. H., Carafice, C., Krause, K., McNamara, A. J., Hamilton, K., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.30.555526 · Cited by 4 · see citing works

Herpesvirus initiation of dementias and autoimmune diseases

Roe, K. (2025) · Journal of NeuroVirology · doi:10.1007/s13365-025-01265-8 · Cited by 3 · see citing works

Piracetam reverses scopolamine-induced memory disorder in mice: an animal model using behavioral, oxidative, and cholinesterase biomarkers

Lima, V. D. S., Emerick, G. L., Sinhorin, V. D. G., Lima, R. R. D. S., da Silva, H. S., da Silva, K. F., de Sousa, A. C. A., Silveira, F. R., Saito, A. L. M., Estevam, E. L., et al. (2025) · Neuroscience Letters · doi:10.1016/j.neulet.2025.138462 · Cited by 3 · see citing works

Improvement of cognitive performance by a nutraceutical formulation: Underlying mechanisms revealed by laboratory studies

Shea, T. B. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.07.039 · Cited by 3 · see citing works

LPS-Induced Neuroinflammation in Neurodegenerative Diseases: A Double-Edged Sword?

Mohammadi, A., Aghajan, A., Alipour, M., Ghorbani, A., Limoodehi, S. M., & Hedayati, M. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06004-6 · Cited by 2 · see citing works

Stimulus-Based ApoE Alzheimer’s Disease Induction Model Using Microglia-Containing Brain Organoids for Drug Discovery

Yuan, N. Y., Richards, W. D., Parham, K. T., Clark, S. G., & Lebakken, C. S. (2026) · Cells · doi:10.3390/cells15141266 · Cited by 2 · see citing works

Lamotrigine enhances the neuroprotective effects of memantine on aluminum chloride-induced behavioral changes in rats

Abdel‐Aal, R. A., Farghaly, H. S. M., & Zakaria, A. (2018) · Journal of Current Medical Research and Practice · doi:10.4103/jcmrp.jcmrp_110_18 · Cited by 2 · see citing works

Neuroinflammation in Huntington’s Disease

Lee, J. D., Lo, M. W., Fung, J. N., & Woodruff, T. M. (2021) · Neuromethods · doi:10.1007/978-1-0716-1712-0_9 · Cited by 2 · see citing works

Metabolic and epigenetic regulation of microglia memory in neurological disorders

Wang, X., Jia, Y., Yan, X. Z., & Wang, Y. (2026) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiag085 · Cited by 1 · see citing works

Chromatin Dynamics and Genetic Variation Combine to Regulate Innate Immune Memory.

Kim, J. S., & Ciernia, A. V. (2020) · PubMed

Generating a Mouse Model of Symptomatic and Asymptomatic Intracerebral Hemorrhage by Applying High-Pressure Focused Ultrasound

Collier, C. M. D. (2021) · doi:10.7916/d8-t17q-d393

Microglial Activation and Priming in Alzheimer’s Disease: State of the Art and Future Perspectives

Bivona, G., Iemmolo, M., Agnello, L., Sasso, B. L., Gambino, C. M., Giglio, R. V., Scazzone, C., Ghersi, G., & Ciaccio, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24010884 · Cited by 71 · see citing works

Microglial priming and Alzheimer’s disease: a possible role for (early) immune challenges and epigenetics?

Hoeijmakers, L., Heinen, Y., van Dam, A.-M., Lucassen, P. J., & Korosi, A. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00398 · Cited by 85 · see citing works

Microglial priming of antigen presentation and adaptive stimulation in Alzheimer’s disease

Das, R., & Chinnathambi, S. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03132-2 · Cited by 147 · see citing works

Microglia and Alzheimer’s Disease

Merighi, S., Nigro, M., Travagli, A., & Gessi, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112990 · Cited by 236 · see citing works

Targeting microglia: A new strategy for the treatment of Alzheimer's disease

Zheng, M., Yang, M., Su, W., Tian, L., & Gao, W. (2026) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2026.578966