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The deep population history of northern East Asia from the Late Pleistocene to the Holocene

Mao, Xiaowei, Zhang, Hucai, Qiao, Shiyu, Liu, Yichen, Chang, Fengqin, Xie, Ping, Zhang, Ming, Wang, Tianyi, Li, Mian, Cao, Peng, Yang, Ruowei, Liu, Feng, Dai, Qingyan, Feng, Xiaotian, Ping, Wanjing, Lei, Chuzhao, Olsen, John W., Bennett, E. Andrew, Fu, Qiaomei·2021·Cell
DOI 10.1016/j.cell.2021.04.040
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Abstract

Northern East Asia was inhabited by modern humans as early as 40 thousand years ago (ka), as demonstrated by the Tianyuan individual. Using genome-wide data obtained from 25 individuals dated to 33.6-3.4 ka from the Amur region, we show that Tianyuan-related ancestry was widespread in northern East Asia before the Last Glacial Maximum (LGM). At the close of the LGM stadial, the earliest northern East Asian appeared in the Amur region, and this population is basal to ancient northern East Asians. Human populations in the Amur region have maintained genetic continuity from 14 ka, and these early inhabitants represent the closest East Asian source known for Ancient Paleo-Siberians. We also observed that EDAR V370A was likely to have been elevated to high frequency after the LGM, suggesting the possible timing for its selection. This study provides a deep look into the population dynamics of northern East Asia.

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  • The Yana River occupants apparently did not develop any genetic adaptations to vitamin D deficiency related to low UV radiation during the winter months.

    “They apparently did not develop any genetic adaptations to vitamin D deficiency related to low UV radiation during the winter months [70,79].”

    From Beringia and the peopling of the Western Hemisphere (2023) · cites this paper as [70]

  • The same East Asian lineage is present in the Amur River Basin at 33 ka and 19 ka.

    “The same lineage is present in the Amur River Basin at 33 ka and 19 ka (i.e. before and at the end of the LGM) [70].”

    From Beringia and the peopling of the Western Hemisphere (2023) · cites this paper as [70]

  • They also include a variant of EDAR V370A, which was under strong positive selection pressure during the LGM and appears to be an adaptation to vitamin D deficiency (due to low UV radiation) related to nursing infants.

    “They also include a variant of EDAR V370A, which was under strong positive selection pressure during the LGM and appears to be an adaptation to vitamin D deficiency (due to low UV radiation) related to nursing infants [70,79].”

    From Beringia and the peopling of the Western Hemisphere (2023) · cites this paper as [70]

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Metadata

Authors
Mao, X., Zhang, H., Qiao, S., Liu, Y., Chang, F., Xie, P., Zhang, M., Wang, T., Li, M., Cao, P., Yang, R., Liu, F., Dai, Q., Feng, X., Ping, W., Lei, C., Olsen, J. W., Bennett, E. A., & Fu, Q.
ORCID
Venue
Cell
Publisher
Elsevier BV
Published
2021-06
Volume
184
Issue
12
Pages
3256-3266.e13
ISSN
0092-8674
DOI
10.1016/j.cell.2021.04.040
Cited by
198
References
30
Language
en
Licence
Funders
  • Howard Hughes Medical Institute (55008731, 2018VCA0016)
  • National Natural Science Foundation of China (91731303, 41820104008, 41630102, 41925009, 41672021)
  • Ministry of Health of the People's Republic of China (XDB26000000)
  • Chinese Academy of Sciences (QYZDB-SSW-DQC003, XDA1905010)
  • Zhengzhou University (XKZDJC202006)
  • National Key Research and Development Program of China (2016YFE0203700)

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