Meal timing and frequency: implications for cardiovascular disease prevention: A scientific statement from the american heart association
Open accessAbstract
Eating patterns are increasingly varied. Typical breakfast, lunch, and dinner meals are difficult to distinguish because skipping meals and snacking have become more prevalent. Such eating styles can have various effects on cardiometabolic health markers, namely obesity, lipid profile, insulin resistance, and blood pressure. In this statement, we review the cardiometabolic health effects of specific eating patterns: skipping breakfast, intermittent fasting, meal frequency (number of daily eating occasions), and timing of eating occasions. Furthermore, we propose definitions for meals, snacks, and eating occasions for use in research. Finally, data suggest that irregular eating patterns appear less favorable for achieving a healthy cardiometabolic profile. Intentional eating with mindful attention to the timing and frequency of eating occasions could lead to healthier lifestyle and cardiometabolic risk factor management.
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Epidemiological results indicate a potential negative effect of late evening meals on cardiometabolic health.
“Epidemiological results indicate a potential negative effect of late evening meals (LEM) on cardiometabolic health”
From Effects of consuming later evening meal<i>v</i>. earlier evening meal on weight loss during a weight loss diet: a randomised clinical trial (2021) · cites this paper as [18]
Meal timing can be seen as a potential new risk factor for metabolic diseases.
“As meal timing can be seen as a potential new risk factor for metabolic diseases, the aim to modify it in order to prevent chronic diseases through weight reduction seems clear (130)”
From Meal timing and its role in obesity and associated diseases (2024) · cites this paper as [130]
In intermittent fasting intervention studies, triglycerides decreased by 16% to 42%, with the greatest decreases associated with the greatest weight loss.
“Triglycerides decreased 16% to 42%, with the greatest decreases in triglycerides associated with the greatest weight loss.”
From 2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia (2021) · cites this paper as [69]
In intervention studies of intermittent fasting, after 3 to 24 weeks, participants had an average weight loss of 3% to 8%.
“After 3 to 24 weeks of intervention, participants had a 3% to 8% weight loss on average.”
From 2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia (2021) · cites this paper as [69]
Triglycerides are reduced with intermittent fasting in proportion to weight loss.
“Triglycerides are reduced with intermittent fasting in proportion to weight loss.”
From 2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia (2021) · cites this paper as [69]
With a 1-kg per week weight loss, triglycerides decreased approximately 30% to 40%; with a 0.25- to 0.5-kg per week weight loss, triglycerides decreased approximately 10% to 20%.
“With a 1-kg per week weight loss, triglycerides decreased ≈30% to 40%, and with a 0.25- to 0.5-kg per week weight loss, triglycerides decreased by ≈10% to 20%.”
From 2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia (2021) · cites this paper as [69]
Weight loss was greater with alternate-day fasting (0.75 kg/wk) than with periodic fasting (0.25 kg/wk).
“Weight loss was greater with alternate-day fasting (0.75 kg/wk) versus periodic fasting (0.25 kg/wk).”
From 2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia (2021) · cites this paper as [69]
Misalignment between the sleep-awake, fasting-feeding cycles, and the light-dark cycle disrupts natural oscillations of glucose, lipid metabolism, and blood pressure, eventually increasing risk of type 2 diabetes and cardiovascular disease.
“The resulting misalignment between the sleep-awake, fasting-feeding cycles, and the light-dark cycle subsequently disrupts the natural oscillations of physiologic processes such as glucose, lipid metabolism, and blood pressure, eventually manifesting itself as heightened risk of developing type 2 diabetes and cardiovascular disease (1–4).”
From Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health (2019) · cites this paper as [4]
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- Authors
- St-Onge, M.-P., Ard, J., Baskin, M. L., Chiuve, S. E., Johnson, H. M., Kris-Etherton, P., & Varady, K.
- Venue
- Circulation
- Published
- 2017-02-28
- Volume
- 135
- Issue
- 9
- Pages
- e96-e121
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC8532518
- OpenAlex
- W2582896210
- Cited by
- 728
- References
- 138
- Citations by year
- 2026: 38 · 2025: 77 · 2024: 92 · 2023: 93 · 2022: 100 · 2021: 105 · 2020: 90 · 2019: 61 · 2018: 46 · 2017: 25 · 2016: 1
- FWCI
- 7.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R56HL119945)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK079626)
- Topics
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Keywords
- meal timing, meal frequency, dietary habits, cardiovascular disease prevention, cardiometabolic health, breakfast skipping, intermittent fasting, snacking, obesity, lipid profile, insulin resistance, blood pressure, irregular eating, mindful eating
- MeSH terms
- American Heart Association, Cardiovascular Diseases, Humans, Obesity, Risk Factors, United States, Databases, Factual, Meals
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