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Cited by 47Memory and Neural MechanismsSpatial Cognition and NavigationMemory Processes and Influences

Impoverished descriptions of familiar routes in three cases of hippocampal/medial temporal lobe amnesia

Herdman, Katherine A., Calarco, Navona, Moscovitch, Morris, Hirshhorn, Marnie, Rosenbaum, R. Shayna·2015·Cortex
DOI 10.1016/j.cortex.2015.06.008
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Abstract

Recent research has challenged classic theories of hippocampal function in spatial memory with findings that the hippocampus may be necessary for detailed representations of environments learned long ago, but not for remembering the gist or schematic aspects that are sufficient for navigating within those environments (Rosenbaum et al., 2000; Rosenbaum, Winocur, Binns, & Moscovitch, 2012). We aimed to probe further distinctions between detailed and schematic representations of familiar environments in three cases of hippocampal/medial temporal lobe (MTL) amnesia by testing them on a route description task and mental navigation tasks that assess the identity and location of landmarks, and distances and directions between them. The amnesic cases could describe basic directions along known, imagined routes, estimate distance and direction between well-known landmarks, and produce sketch maps with accurate layouts, suggestive of intact schematic representations. However, findings that their route descriptions lack richness of detail, along with impoverished sketch maps and poor landmark recognition, substantiates previous findings that detailed representations are hippocampus-dependent.

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Crossref · 10.1016/j.cortex.2015.06.008

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  • K.C., an individual with bilateral HPC damage, could produce accurate sketch maps of the overall layout of his hometown and judge relative distances and directions between its major landmarks.

    “This was demonstrated in the case K.C., an individual with bilateral HPC damage, who could produce accurate sketch maps of the overall layout of his hometown (Fig. 3) and judge relative distances and directions between its major landmarks 27,81,82 .”

    From From cognitive maps to spatial schemas (2023) · cites this paper as [81]

  • K.C. was impaired in remembering minor landmarks and perceptual details of familiar environments, despite largely intact visuoperceptual processing abilities and semantic knowledge of those same places.

    “K.C. was impaired, however, in remembering minor landmarks and perceptual details of familiar environments, despite having largely intact visuoperceptual processing abilities and semantic knowledge of those same places.”

    From From cognitive maps to spatial schemas (2023) · cites this paper as [81]

  • K.C. and other individuals with hippocampal amnesia were still able to navigate familiar environments using only a schematic form of their spatial representation.

    “Notably, K.C. and other individuals with hippocampal amnesia were still able to navigate familiar environments using only a schematic form of their spatial representation 81,82 .”

    From From cognitive maps to spatial schemas (2023) · cites this paper as [81]

  • In individuals with bilateral HPC damage, memory for details or surface properties is lost.

    “whereas memory for details or surface properties is lost [80][81][82]123,124 .”

    From From cognitive maps to spatial schemas (2023) · cites this paper as [81]

  • In individuals with bilateral HPC damage, the gist or overall layout of a familiar environment learned before the onset of HPC damage is preserved.

    “Neuropsychological evidence in individuals with bilateral HPC damage, such as K.C. described above 80 , indicates that the gist or overall layout of a familiar environment learned before the onset of HPC damage is preserved 3,[80][81][82][122][123][124] , whereas memory for details or surface properties is lost [80][81][82]123,124 .”

    From From cognitive maps to spatial schemas (2023) · cites this paper as [81]

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Authors
Herdman, K. A., Calarco, N., Moscovitch, M., Hirshhorn, M., & Rosenbaum, R. S.
Affiliations
  • York University (CA)
  • University of Toronto (CA)
Corresponding author
  • Herdman, Katherine A.
  • Rosenbaum, R. Shayna
ORCID
Venue
Cortex
Publisher
Elsevier BV
Published
2015-10
Volume
71
Pages
248-263
ISSN
0010-9452 (ISSN-L)
DOI
10.1016/j.cortex.2015.06.008
OpenAlex
W836987179
Cited by
46
References
56
Citations by year
2026: 4 · 2025: 4 · 2024: 8 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 3
FWCI
2.41
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Cortex (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Natural Sciences and Engineering Research Council of Canada (NSERC) (2014-06704)
  • Canadian Institutes of Health Research (CIHR) (MGP 6694)
  • Canadian Institutes of Health Research (CIHR) Master's Award
  • Queen Elizabeth II Graduate Scholarship in Science and Technology (QEII-GSST)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
hippocampal amnesia, medial temporal lobe amnesia, spatial memory, route description, schematic representation, landmark detection, mental navigation, sketch maps, hippocampal function
MeSH terms
Adult, Aged, Amnesia, Distance Perception, Hippocampus, Humans, Male, Middle Aged, Neural Pathways, Orientation, Psychomotor Performance, Space Perception, Temporal Lobe, Head Injuries, Closed, Encephalitis, Herpes Simplex

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