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Cited by 403

The DOI matches its Crossref record; 145 of the 145 references it cites were found in a registry or an index.

The rapid spread of carbapenem-resistant Enterobacteriaceae

Open access
Potter, Robert F., D’Souza, Alaric W., Dantas, Gautam·2016·Drug Resistance Updates
DOI 10.1016/j.drup.2016.09.002
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Abstract

Carbapenems, our one-time silver bullet for multidrug resistant bacterial infections, are now threatened by widespread dissemination of carbapenem-resistant Enterobacteriaceae (CRE). Successful expansion of Enterobacteriaceae clonal groups and frequent horizontal gene transfer of carbapenemase expressing plasmids are causing increasing carbapenem resistance. Recent advances in genetic and phenotypic detection facilitate global surveillance of CRE diversity and prevalence. In particular, whole genome sequencing enabled efficient tracking, annotation, and study of genetic elements colocalized with carbapenemase genes on chromosomes and on plasmids. Improved characterization helps detail the co-occurrence of other antibiotic resistance genes in CRE isolates and helps identify pan-drug resistance mechanisms. The novel β-lactamase inhibitor, avibactam, combined with ceftazidime or aztreonam, is a promising CRE treatment compared to current colistin or tigecycline regimens. To halt increasing CRE-associated morbidity and mortality, we must continue quality, cooperative monitoring and urgently investigate novel treatments.

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Metadata

Authors
Potter, R. F., D’Souza, A. W., & Dantas, G.
Venue
Drug Resistance Updates
Publisher
Elsevier BV
Published
2016-11
Volume
29
Pages
30-46
ISSN
1368-7646 (ISSN-L)
DOI
10.1016/j.drup.2016.09.002
OpenAlex
W2522806486
Cited by
403
References
145
FWCI
11.77
Type
journal article
Language
en
Open access
green

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.