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Redox regulation of stem/progenitor cells and bone marrow niche

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Urao, Norifumi, Ushio-Fukai, Masuko·2013·Free Radical Biology and Medicine
DOI 10.1016/j.freeradbiomed.2012.10.532
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Abstract

Bone marrow (BM)-derived stem and progenitor cell functions including self-renewal, differentiation, survival, migration, proliferation and mobilization are regulated by unique cell-intrinsic signals and -extrinsic signals provided by their microenvironment, also termed the ‘niche’. Reactive oxygen species (ROS), especially hydrogen peroxide (H2O2), play important roles in regulating stem and progenitor cell function in various physiologic and pathologic responses. The low level of H2O2 in quiescent hematopoietic stem cells (HSCs) contributes to maintain their stemness, whereas a higher level of H2O2 within HSCs or their niche promotes differentiation, proliferation, migration, and survival of HSCs or stem/progenitor cells. Major sources of ROS are NADPH oxidase and mitochondria. In response to ischemic injury, ROS derived from NADPH oxidase are increased in the BM microenvironment, which is required for hypoxia and HIF1α expression and expansion throughout the BM. This, in turn, promotes progenitor cell expansion and mobilization from BM, leading to reparative neovascularization and tissue repair. In pathophysiological states such as aging, atherosclerosis, heart failure, hypertension and diabetes, excess amounts of ROS create an inflammatory and oxidative microenvironment, which induces cell damage and apoptosis of stem and progenitor cells. Understanding the molecular mechanisms of how ROS regulate the functions of stem and progenitor cells and their niche in physiological and pathological conditions will lead to the development of novel therapeutic strategies.

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Cited by

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Metadata

Authors
Urao, N., & Ushio-Fukai, M.
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
2013-01
Volume
54
Pages
26-39
ISSN
0891-5849 (ISSN-L)
DOI
10.1016/j.freeradbiomed.2012.10.532
OpenAlex
W2020712259
Cited by
168
References
17
FWCI
10.37
Type
journal article
Language
en
Open access
green
Licence
Funders
  • National Institutes of Health (077524, HL077524-S1)
  • American Heart Association (0970336N, 09POST2250151, 12SDG12060100)

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CoChat. (2026). Citation check: Redox regulation of stem/progenitor cells and bone marrow niche. https://app.cochat.ai/papers/10.1016/j.freeradbiomed.2012.10.532
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Urao, N., & Ushio-Fukai, M. (2013). Redox regulation of stem/progenitor cells and bone marrow niche. Free Radical Biology and Medicine. https://doi.org/10.1016/j.freeradbiomed.2012.10.532

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