Cited by 3,002COVID-19 and Mental HealthChild and Adolescent Psychosocial and Emotional DevelopmentMaternal Mental Health During Pregnancy and Postpartum

Rapid Systematic Review: The Impact of Social Isolation and Loneliness on the Mental Health of Children and Adolescents in the Context of COVID-19

Open access
Loades, Maria Elizabeth, Chatburn, Eleanor, Higson-Sweeney, Nina, Reynolds, Shirley, Shafran, Roz, Brigden, Amberly, Linney, Catherine, McManus, Megan Niamh +2 more·2020·Journal of the American Academy of Child & Adolescent Psychiatry

Abstract

Objective Disease containment of COVID-19 has necessitated widespread social isolation. We aimed to establish what is known about how loneliness and disease containment measures impact on the mental health in children and adolescents. Method For this rapid review, we searched MEDLINE, PsycInfo, and Web of Science for articles published between January 1, 1946, and March 29, 2020. Results A total of 83 articles (80 studies) met inclusion criteria. Social isolation and loneliness increased the risk of depression, and possibly anxiety, in children and adolescents.

Integrity signals

Registry

Crossref · 10.1016/j.jaac.2020.05.009

Cites

93 of 93 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Claims the paper makes

35 of 75 cited sources checked · 18 supported · 2 flagged · accuracy not yet measured

  • Premisecitation

    Children and adolescents are already at higher risk of developing mental health problems compared to adults.

    “already at higher risk of developing mental health problems compared to adults3”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [3] Deighton, 2019, Prevalence of mental health problems in schools: poverty and other risk factors among 28 000 adolescents in England, Br J Psychiatry source

      The Abstract (page unavailable) reports mental health problems among adolescents and factors associated with increased odds within that group. The paper does not compare children or adolescents with adults, so it does not support the claimed higher risk relative to adults. (LLM, conf=0.85)

      Experimental — accuracy not yet measured
  • Premisecitation

    There are well established links between loneliness and mental health.

    “There are well established links between loneliness and mental health.8”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [8] Wang, 2017, Social isolation in mental health: a conceptual and methodological review, Soc Psychiatry Psychiatr Epidemiol source
  • Premisecitation

    Quarantine in adults generally has negative psychological effects including confusion, anger, and posttraumatic distress.

    “Quarantine in adults generally has negative psychological effects including confusion, anger, and posttraumatic distress.1 , 2”
    Quote in the paperSubstantial claim1 of 2 sources checked
    • cites [1] Brooks, 2020, The psychological impact of quarantine and how to reduce it: rapid review of the evidence, Lancet source
    • cites [2] Hossain

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • Findingcitation

    Three of four studies examining the longitudinal effect of loneliness on anxiety found that loneliness was associated with later anxiety.

    “Three of the four studies that examined the longitudinal effect of loneliness on anxiety found that loneliness was associated with later anxiety.63 , 71 , 78”
    Quote in the paperSubstantial claim2 of 3 sources checked
    • cites [63] Danneel, 2019, Internalizing problems in adolescence: linking loneliness, social anxiety symptoms, and depressive symptoms over time, J Abnorm Child Psychol source
    • cites [71] Mak, 2018, The role of family for youth friendships: examining a social anxiety mechanism, J Youth Adolesc source
    • cites [78] Wang, 2020, Family dysfunction and adolescents' anxiety and depression: a multiple mediation model, J Appl Dev Psychol source
  • Findingcitation

    In the single study reporting odds ratios, being lonely was associated with increased odds of being anxious by 1.63 to 5.49 times.

    “In the single study that reported odds ratios, being lonely was associated with increased odds of being anxious by 1.63 to 5.49 times.51”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [51] Stickley, 2016, Loneliness and its association with psychological and somatic health problems among Czech, Russian and U.S. adolescents, BMC Psychiatry source
  • May combine two claims. 34
  • Classified as probably not a substantial claim. 12
  • The quote only partly states this claim. 1
  • May combine two claims.

    Findingown data

    Seven studies stated that they measured the impact of social isolation on mental health, but their social isolation measures were subscales or questions from loneliness scales or strongly overlapped with loneliness, so they were considered together with loneliness studies.

    “Seven studies stated that they measured the impact of social isolation39 , 45 , 50 , 59 , 69 , 70 , 72 on mental health, but the social isolation measures used were either subscales or questions from loneliness scales, or strongly overlapped with the construct of loneliness. Therefore, we have considered them together with studies that measured loneliness.”
    Quote in the paperSubstantial claim2 of 3 sources checked
    • cites [39] Matthews, 2016, Social isolation, loneliness and depression in young adulthood: a behavioural genetic analysis, Soc Psychiatry Psychiatr Epidemiol source

      Split into 2 atoms — 1 confirmed, 0 partially supported, 1 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.

      Checked by a reasoning model — may be wrong.

      Experimental — accuracy not yet measured
    • cites [45] Richardson, 2019, The moderating role of sleep in the relationship between social isolation and internalising problems in early adolescence, Child Psychiatry Hum Dev source
    • cites [50] Stacciarini, 2015, Rural Latinos' mental wellbeing: a mixed-methods pilot study of family, environment and social isolation factors, Community Ment Health J source
  • May combine two claims.

    Premisecitation

    Self-help interventions including bibliotherapy and computerized therapy have shown a moderate positive effect size compared to control groups, although they are generally less effective than face-to-face therapies.

    “Self-help interventions including bibliotherapy99 and computerized therapy100 have shown a moderate positive effect size when compared to control groups although they are generally less effective than face to face therapies.101”
    Quote in the paperSubstantial claim3 of 3 sources checked
    • cites [99] Creswell, 2017, Clinical outcomes and cost-effectiveness of brief guided parent-delivered cognitive behavioural therapy and solution-focused brief therapy for treatment of childhood anxiety disorders: a randomised controlled trial, Lancet Psychiatry source

      Citation 101 is attached to the claim that self-help interventions are generally less effective than face-to-face therapies. The Introduction says brief guided parent-delivered CBT, which uses a self-help book, had similar outcomes to more intensive traditional CBT; the Discussion likewise describes outcomes as similar to more intensive child-focused CBT. The paper does not establish the broader comparison for computerized therapy. (LLM, conf=0.85)

      Checked by a reasoning model — may be wrong.

      Experimental — accuracy not yet measured
    • cites [100] Lillevoll, 2014, Uptake and adherence of a self-directed internet-based mental health intervention with tailored e-mail reminders in senior high schools in Norway, BMC Psychiatry source

      The Background (page unavailable) says therapist-supported internet-based CBT has larger effect sizes than fully automated, unguided interventions. That supports a narrower comparison, but it does not establish the cited claim that self-help interventions are generally less effective than face-to-face therapies. (LLM, conf=0.78)

      Experimental — accuracy not yet measured
    • cites [101] Bennett, 2019, Practitioner review: Unguided and guided self-help interventions for common mental health disorders in children and adolescents: a systematic review and meta-analysis, J Child Psychol Psychiatry Allied Discip source
  • May combine two claims.

    Premisecitation

    Duration of quarantine, fear of infection, boredom, frustration, lack of necessary supplies, lack of information, financial loss, and stigma appear to increase the risk of negative psychological outcomes.

    “Duration of quarantine, fear of infection, boredom, frustration, lack of necessary supplies, lack of information, financial loss, and stigma appear to increase the risk of negative psychological outcomes.1”
    Quote in the paperSubstantial claim1 of 1 sources checked
    • cites [1] Brooks, 2020, The psychological impact of quarantine and how to reduce it: rapid review of the evidence, Lancet source
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Premisecitation

    A large survey of young adult students in China reported that around one in four are experiencing at least mild anxiety symptoms.

    “Furthermore, a large survey of young adult students in China has reported that around one in four are experiencing at least mild anxiety symptoms.84”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [84] Cao, 2020, The psychological impact of the COVID-19 epidemic on college students in China, Psychiatry Res source
  • May combine two claims.

    Findingcitation

    Duration of peer loneliness, rather than intensity of peer loneliness, was associated with depression 8 years later (from age 5 to age 13 years); family-related loneliness was not independently associated with subsequent depression.

    “Duration of peer loneliness rather than intensity of peer loneliness was associated with depression 8 years later (ie, from age 5 to age 13 years); in contrast, family-related loneliness was not independently associated with subsequent depression.73”
    Quote in the paperNot a substantial claim1 of 1 sources checked
    • cites [73] Qualter, 2010, Childhood loneliness as a predictor of adolescent depressive symptoms: an 8-year longitudinal study, Eur Child Adolesc Psychiatry source
  • May combine two claims.

    Interpretationcitation

    There may be sex differences, with some research indicating loneliness was more strongly associated with elevated depression symptoms in girls and with elevated social anxiety in boys.

    “There may also be sex differences, with some research indicating that loneliness was more strongly associated with elevated depression symptoms in girls and with elevated social anxiety in boys.70 , 71”
    Quote in the paperNot a substantial claim1 of 2 sources checked
    • cites [70] Liu, 2020, Gender differences in the influence of social isolation and loneliness on depressive symptoms in college students: a longitudinal study, Soc Psychiatry Psychiatr Epidemiol source
    • cites [71] Mak, 2018, The role of family for youth friendships: examining a social anxiety mechanism, J Youth Adolesc source

      The Results and Discussion (page unavailable) report that loneliness predicted increased social anxiety for boys but not girls. They do not report that loneliness was more strongly associated with depressive symptoms in girls; the reported gender difference involving internalizing symptoms instead runs from those symptoms to later loneliness and is stronger in boys. (LLM, conf=0.88)

      Experimental — accuracy not yet measured
  • May combine two claims.

    Premisecitation

    Mobile applications for mental health have been found to be generally acceptable to children and adolescents, but there is a lack of convincing evidence of effectiveness on intended mental health outcomes, and few mobile health apps have been thoroughly tested.

    “Although mobile applications for mental health have been found to be generally acceptable to children and adolescents, there is a lack of convincing evidence of effectiveness on intended mental health outcomes98 and few mobile health apps have been thoroughly tested.97”
    Quote in the paperNot a substantial claim2 of 2 sources checked
    • cites [98] Grist, 2017, Mental health mobile apps for preadolescents and adolescents: a systematic review, J Med Internet Res source
    • cites [97] Grist, 2019, Technology delivered interventions for depression and anxiety in children and adolescents: a systematic review and meta-analysis, Clin Child Fam Psychol Rev source

      Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.

      Experimental — accuracy not yet measured
  • May combine two claims.

    Premisecitation

    Reviews have tended to conclude that effects are better if there is some therapist input and if parents are involved, especially for younger children.

    “Importantly, reviews have tended to conclude that effects are better if there is some therapist input97 , 101 and if parents are involved especially for younger children.96 , 97”
    Quote in the paperSubstantial claim3 of 3 sources checked
    • cites [97] Grist, 2019, Technology delivered interventions for depression and anxiety in children and adolescents: a systematic review and meta-analysis, Clin Child Fam Psychol Rev source

      The Results sections on Therapist Support and Parental Involvement report larger effect sizes for therapist-supported and parent-supported interventions, respectively. But the Discussion (Comparison with Previous Work; page not supplied) says evidence for children under 12 is limited and calls for further research on the level of parental support that may benefit them. It does not establish that parental involvement is especially beneficial for younger children. (LLM, conf=0.88)

      Experimental — accuracy not yet measured
    • cites [101] Bennett, 2019, Practitioner review: Unguided and guided self-help interventions for common mental health disorders in children and adolescents: a systematic review and meta-analysis, J Child Psychol Psychiatry Allied Discip source

      The Meta-analysis section reports larger effects for guided than unguided self-help, although the difference was not significant when restricted to low-risk-of-bias studies. The Discussion suggests parental involvement may matter, particularly for younger children, but says the review could not test whether it was associated with effect size. No page numbers are available in our copy. (LLM, conf=0.88)

      Experimental — accuracy not yet measured
    • cites [96] Pennant, 2015, Computerised therapies for anxiety and depression in children and young people: a systematic review and meta-analysis, Behav Res Ther source

      In “Moderators of effectiveness” (page unavailable), the review says therapist input may be important and parental input may be valuable for children. But its therapist-input subgroup analysis found no significant difference, and it says evidence for computerised parent-focused treatments is limited. The cited review therefore does not establish that either form of input produces better effects. (LLM, conf=0.88)

      Experimental — accuracy not yet measured
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingown data

    Two included studies evaluated interventions.

    “Two studies evaluated interventions.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingown data

    Social isolation and loneliness increased the risk of depression, and possibly anxiety, at the time loneliness was measured and between 0.25 and 9 years later.

    “Social isolation and loneliness increased the risk of depression, and possibly anxiety at the time at which loneliness was measured and between 0.25 and 9 years later.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    Among the 63 studies, 61 were observational, 18 were longitudinal, and 43 were cross-sectional studies assessing self-reported loneliness in healthy children and adolescents.

    “In all, 61 studies were observational, 18 were longitudinal, and 43 were cross-sectional studies assessing self-reported loneliness in healthy children and adolescents.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingown data

    One included study was a retrospective investigation conducted after a pandemic.

    “One of these studies was a retrospective investigation after a pandemic.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingown data

    The search located 4,531 articles, of which 83 articles representing 80 studies met the inclusion criteria.

    “We located 4,531 articles (Figure 1 ), of which 83 articles (80 studies) met the inclusion criteria.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingown data

    Of the included articles, 63 studies examined how social isolation and loneliness affect mental health in previously healthy children and adolescents, with 51,576 participants and a mean age of 15.3 years.

    “Of these, 63 studies reported on the impact of social isolation and loneliness on the mental health of previously healthy children and adolescents (n = 51,576; mean age 15.3 years).”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingown data

    Of the included articles, 18 articles representing 17 studies reported on loneliness in individuals with various health conditions, including mental health problems in 12 studies, physical health problems in one study, and neurodevelopmental conditions in 4 studies.

    “Of these, 18 articles (17 studies) reported on the impact of loneliness in individuals with a variety of health conditions, including mental health problems (12 studies), physical health problems (one study) and neurodevelopmental conditions (4 studies).”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingnone given

    In the one study examining mental health problems after enforced isolation and quarantine in previous pandemics, children who had experienced enforced isolation or quarantine were five times more likely to require mental health service input and experienced higher levels of posttraumatic stress.

    “Furthermore, in the one study that examined mental health problems after enforced isolation and quarantine in previous pandemics, children who had experienced enforced isolation or quarantine were five times more likely to require mental health service input and experienced higher levels of posttraumatic stress.”
    Quote in the paperNot a substantial claim
  • The quote only partly states this claim.

    Findingcitation

    On the PTSD Checklist Civilian Version, 28% of children who had experienced isolation/quarantine scored above the cut-off for PTSD, compared to 5.8% of those who had not.

    “On the PTSD Checklist Civilian Version, 28% of children who had experienced isolation/quarantine scored about the cut-off for PTSD, compared to 5.8% of those who had not experienced isolation/quarantine.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingcitation

    One study found a small association between panic and loneliness (r = 0.13).

    “One study found a small association between panic and loneliness (r = 0.13).75 , 76”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [75] Vanhalst, 2013, The development of loneliness from mid- to late adolescence: trajectory classes, personality traits, and psychosocial functioning, J Adolesc source
    • cites [76] Vanhalst, 2012, The interplay of loneliness and depressive symptoms across adolescence: exploring the role of personality traits, J Youth Adolesc source
  • May combine two claims.

    Findingcitation

    The most frequently reported diagnoses in the retrospective study were acute stress disorder (16.7%), adjustment disorder (16.7%), grief (16.7%), and PTSD (6.2%).

    “The most frequently reported diagnoses were acute stress disorder (16.7%), adjustment disorder (16.7%), grief (16.7%), and posttraumatic stress disorder (PTSD) (6.2%).”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingcitation

    The retrospective study included 398 parents of exposed children from the United States, Canada, and Mexico; 20.9% of children experienced social isolation and 3.8% had been quarantined.

    “This retrospective study included 398 parents of exposed children from the United States, Canada, and Mexico, of whom 20.9% experienced social isolation and a further 3.8% had been quarantined.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingreasoning

    Neither intervention specifically addressed mental health problems that had developed in the context of loneliness, so the review could not answer its second question about which interventions are effective for individuals who developed mental health problems as a result of social isolation or loneliness.

    “Neither intervention specifically addressed mental health problems that had developed in the context of loneliness; therefore, we are unable to answer our second review question, which was what interventions are effective for individuals who have developed mental health problems as a result of social isolation or loneliness.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Findingcitation

    Another large study of adolescents (n = 541) found a significant association between loneliness and subsequent depression, but this did not hold in a cross-lagged model, suggesting a possible bidirectional relationship.

    “There were mixed findings in another large study of adolescents (n = 541), which found a significant association between loneliness and subsequent depression, although this did not hold in a cross-lagged model,69 suggesting a possible bidirectional relationship between the variables.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [69] Lasgaard, 2011, Loneliness, depressive symptomatology, and suicide ideation in adolescence: cross-sectional and longitudinal analyses, J Abnorm Child Psychol source
  • May combine two claims.

    Findingcitation

    Positive associations were reported between social isolation/loneliness and suicidal ideation, self-harm, and eating disorder risk behavior.

    “Positive associations were also reported between social isolation/loneliness and suicidal ideation,20 , 21 , 34 self-harm,34 and eating disorder risk behavior.34”
    Quote in the paperSubstantial claim0 of 3 sources checked
    • cites [20] Brage, 1993, Correlates of loneliness among midwestern adolescents, Adolescence
    • cites [21] Brage, 1995, Psychological correlates of adolescent depression, J Child Adolesc Psychiatr Nurs source
    • cites [34] Lasgaard, 2011, Different sources of loneliness are associated with different forms of psychopathology in adolescence, J Res Personal source
  • May combine two claims.

    Findingcitation

    The associations between loneliness/social isolation and depressive symptoms were stronger in older participants and in female participants.

    “The associations were stronger in older participants35 and in female participants.47”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [35] Lau, 1999, Facets of loneliness and depression among Chinese children and adolescents, J Soc Psychol source
    • cites [47] Singhvi, 2011, Psychological correlates of loneliness among adolescents, Indian J Psychol Sci

      Not checked in the free run.

  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingown data

    Fewer studies (N = 23) examined symptoms of anxiety.

    “Fewer studies (N = 23) examined symptoms of anxiety.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).

    Findingnone given

    More studies have examined the relationship between loneliness and depression than between loneliness and anxiety.

    “More studies have examined the relationship between loneliness and depression than between loneliness and anxiety.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Findingnone given

    There is little evidence pertaining to interventions.

    “There is little evidence pertaining to interventions.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Findingnone given

    In the included studies, social isolation was not enforced upon participants, nor was it almost ubiquitous across their peer groups and communities.

    “Social isolation was not enforced upon the participants, nor was social isolation almost ubiquitous across their peer groups and across the communities in which they lived.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductcitation

    A truncated quality assessment was conducted by one author using criteria adapted from the National Institutes of Health.

    “A truncated quality assessment was conducted by one author (SR) using criteria adapted from the National Institutes of Health (NIH)14 (Table 1 ).”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [14] National Institutes of Health. Study Assessment Tools. 2018. Available at: https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools. Accessed May 22, 2020.

      Not checked in the free run.

  • May combine two claims.

    Interpretationreasoning

    Children and adolescents are probably more likely to experience high rates of depression and most likely anxiety during and after enforced isolation ends.

    “Children and adolescents are probably more likely to experience high rates of depression and most likely anxiety during and after enforced isolation ends.”
    Quote in the paperSubstantial claim
    • Rests on an assumption: COVID-19 disease containment measures have caused widespread social isolation.
    • Rests on an assumption: Children and adolescents are in a prolonged state of physical separation from peers, teachers, extended family, and community networks.
    • Rests on an assumption: Evidence about non-enforced social isolation and loneliness can inform the likely mental health outcome for children and adolescents subjected to enforced social isolation.
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductnone given

    A random 20% of extracted data was double-entered to ensure accuracy.

    “A random 20% of the data was double-entered to ensure accuracy.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductown data

    The review checked 20% of all study eligibility results to ensure adherence to the eligibility criteria.

    “We checked 20% of all study eligibility results (both included and excluded) to ensure adherence to the eligibility criteria.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Study design and conductown data

    The included studies had a high risk of bias, although longitudinal studies had better methodological quality.

    “Studies had a high risk of bias, although longitudinal studies were of better methodological quality.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Interpretationreasoning

    The current social distancing measures enforced on children because of COVID-19 could lead to an increase in mental health problems, as well as possible posttraumatic stress.

    “This suggests that the current social distancing measures enforced on children because of COVID-19 could lead to an increase in mental health problems, as well as possible posttraumatic stress.”
    Quote in the paperSubstantial claim
    • Rests on an assumption: Current social distancing measures are enforced on children because of COVID-19.
  • May combine two claims.

    Study design and conductreasoning

    Longitudinal studies typically assessed and controlled for confounds and could assess the most plausible direction of causality between loneliness/social isolation and mental health.

    “Importantly, they typically assessed and controlled for confounds and could assess the most plausible direction of causality between loneliness/social isolation and mental health.”
    Quote in the paperNot a substantial claim
  • May combine two claims.

    Premisecitation

    Early results from the UK Co-SPACE online survey of more than 1,500 parents suggest high levels of COVID-19-related worries and fears, with younger children aged 4-10 years significantly more worried than older children and adolescents aged 11-16 years.

    “In the United Kingdom, early results from the Co-SPACE (COVID-19 Supporting Parents, Adolescents and Children in Epidemics) online survey of more than 1,500 parents suggest high levels of COVID-19−related worries and fears, with younger children (aged 4−10 years) significantly more worried than older children and adolescents (aged 11−16 years).85 , 86”
    Quote in the paperNot a substantial claim0 of 2 sources checked
    • cites [85]

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

    • cites [86] Weale

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • May combine two claims.

    Interpretationreasoning

    Young people's propensity to experience loneliness may make them particularly vulnerable to loneliness in the COVID-19 context, which may further exacerbate the mental health impacts of disease containment measures.

    “This propensity to experience loneliness may make young people particularly vulnerable to loneliness in the COVID-19 context, which, based on our findings, may further exacerbate the mental health impacts of the disease containment measures.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Study design and conductreasoning

    The studies were mainly observational and did not consistently control for potential confounders.

    “Furthermore, the studies were mainly observational and did not consistently control for potential confounders.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Study design and conductreasoning

    Most studies were cross-sectional, so the direction of the association cannot be inferred.

    “Most studies were cross-sectional, and therefore the direction of the association cannot be inferred.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Study design and conductown data

    Few studies used independent measures of mental health or social isolation/loneliness, increasing the risk of bias.

    “Few studies used independent (ie, not self-report) measures of mental health or social isolation/loneliness, thereby increasing the risk of bias.”
    Quote in the paperSubstantial claim
  • May combine two claims.

    Study design and conductnone given

    The postpandemic study has limitations: the sample was self-selecting, and the demographics of the children and time elapsed since the experience were not reported.

    “However, the postpandemic study has several limitations in that the sample was self-selecting, and the demographics of the children and the time elapsed since the experience were not reported.”
    Quote in the paperNot a substantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.

    Interpretationcitation

    Because loneliness involves social comparison, the shared experience of social isolation imposed by disease containment measures may mitigate the negative effects.

    “As loneliness involves social comparison,91 it is possible that the shared experience of social isolation imposed by disease containment measures may mitigate the negative effects.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [91] Wiseman, 2008, On failed intersubjectivity: recollections of loneliness experiences in offspring of Holocaust survivors, Am J Orthopsychiatry source
  • May combine two claims.

    Interpretationcitation

    The results are consistent with one study investigating mental health problems in children after pandemics, improving confidence in the results.

    “The results are also consistent with one study investigating mental health problems in children60 after pandemics, improving our confidence in the results.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [60] Sprang, 2013, Posttraumatic stress disorder in parents and youth after health-related disasters, Disaster Med Public Health Prep source
  • May combine two claims.

    Study design and conductcitation

    In line with Cochrane rapid review guidance, gray literature and trial registry databases were not searched, hand-search strategies were not used, and only English-language publications were included, meaning some relevant studies may have been missed.

    “In line with Cochrane rapid review guidance,10 gray literature, and trial registry databases were not searched, hand-search strategies were not used, and only English-language publications were included, meaning that some relevant studies may have been missed.”
    Quote in the paperNot a substantial claim0 of 1 sources checked
    • cites [10] Garritty

      Couldn’t be matched to a paper in Crossref, so it can’t be checked.

  • May combine two claims.

    Study design and conductreasoning

    The results were consistent across all study methodology for depression, but less so for anxiety, suggesting that these results are reliable.

    “The results were consistent across all study methodology for depression (but less so for anxiety), suggesting that these results are reliable.”
    Quote in the paperSubstantial claim
  • Probably not a substantial claim: may not pass S3 (load-bearing).

    Study design and conductnone given

    During the rapid data extraction phase, there was no scope to contact authors to request missing information.

    “During the rapid data extraction phase, there was no scope to contact authors to request any missing information.”
    Quote in the paperNot a substantial claim
46 of 46
  • The paper relies on this without support.

    COVID-19 disease containment measures have caused widespread social isolation.

    “Disease containment of COVID-19 has necessitated widespread social isolation.”
  • The paper relies on this without support.

    Children and adolescents are in a prolonged state of physical separation from peers, teachers, extended family, and community networks.

    “Children and adolescents are experiencing a prolonged state of physical isolation from their peers, teachers, extended families, and community networks.”
  • The paper relies on this without support.

    The current COVID-19 context involves an uncertain but dangerous threat to health.

    “The studies were also not in the context of an uncertain but dangerous threat to health.”
  • The paper relies on this without support.

    Current social distancing measures are enforced on children because of COVID-19.

    “the current social distancing measures enforced on children because of COVID-19”
  • The paper relies on this without support.

    Evidence about non-enforced social isolation and loneliness can inform the likely mental health outcome for children and adolescents subjected to enforced social isolation.

    “However, we used all available evidence on social isolation and loneliness to inform the likely outcome for healthy children and adolescents subjected to social isolation.”
5 of 5

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Experts predict a surge in young people seeking clinical care for behavioral health concerns during the peri- and post-pandemic periods.

    “Experts predict a surging number of young people-seeking clinical care for various behavioral health concerns during the peri- and post-pandemic period (Fegert et al., 2020; Golberstein et al., 2020; Loades et al., 2020; Marques de Miranda et al., 2020; Sanderson et al., 2020; Simon et al., 2020; Abbott, 2021).”

    From Intolerance of Uncertainty and Health-Related Anxiety in Youth amid the COVID-19 Pandemic: Understanding and Weathering the Continuing Storm (2022) · cites this paper as Loades et al., 2020

    The paper's discussion of policy and practice says COVID-19 containment-related loneliness could lead to subsequent mental health problems in young people. Its Results section also reports that, after earlier infectious-disease outbreaks, some children affected by containment measures needed mental health services. Neither passage predicts a surge in young people seeking clinical care during or after COVID-19. (LLM, conf=0.83)

    Experimental — accuracy not yet measured
  • Loneliness and social isolation arising from disease containment measures in previous outbreaks (SARS and MERS) were associated with significant increases in risk of mental illness in adolescents and poor mental health up to nine years later.

    “Existing research shows that the loneliness and social isolation arising from disease containment measures in previous outbreaks (e.g., severe acute respiratory syndrome [SARS] and Middle East respiratory syndrome) were associated with significant increases in risk of mental illness in adolescents and poor mental health up to nine years later (Brooks et al., 2020; Cénat et al., 2020; Loades et al.”

    From Adolescents' longitudinal trajectories of mental health and loneliness: The impact of COVID‐19 school closures (2022) · cites this paper as Loades et al., 2020

    The Results section, “Impact of Social Isolation in an Infectious Disease Context” (page unavailable), reports worse postpandemic mental-health outcomes among children isolated or quarantined during outbreaks that included SARS, but does not identify MERS. The Discussion (page unavailable) separately reports an association between loneliness and mental-health problems up to nine years later across studies of young people; it does not establish that nine-year outcome specifically for outbreak-related containment measures or adolescents. (LLM, conf=0.88)

    Experimental — accuracy not yet measured
  • In the context of disease containment measures, any associated loneliness and social isolation significantly increases risk of mental illness in adolescents.

    “In the context of disease containment measures, any associated loneliness and social isolation significantly increases risk of mental illness in adolescents (see Loades et al., 2020).”

    From Adolescents' longitudinal trajectories of mental health and loneliness: The impact of COVID‐19 school closures (2022) · cites this paper as Loades et al., 2020

    The Discussion reports a clear association between loneliness and later mental health problems in children and adolescents, and the Policy and Practice section says loneliness arising from COVID-19 containment measures could be associated with subsequent problems. The claim overstates that evidence as a definite increase in risk: the Discussion cautions that the studies of social isolation did not mirror isolation imposed by current containment measures, limiting extrapolation to that context. (LLM, conf=0.87)

    Experimental — accuracy not yet measured
  • Findings support the assumption that pre-pandemic loneliness increased the risk of poor mental health outcomes, but not vice versa.

    “Findings support the assumption that pre-pandemic loneliness increased the risk of poor mental health outcomes, but not vice versa (Houghton et al., 2022; Loades et al., 2020).”

    From Adolescent Loneliness and Negative Affect during the COVID-19 Pandemic: The Role of Extraversion and Neuroticism (2023) · cites this paper as Loades et al., 2020

    The Results section reports that loneliness was associated with later depression in 12 of 15 longitudinal studies, supporting the claim's forward association, though not establishing causation. It also says one study suggested a possible bidirectional relationship, so the claim that the reverse does not occur is not supported. Page numbers were not available in our copy. (LLM, conf=0.86)

    Experimental — accuracy not yet measured
  • Isolation through confinement and quarantine in the context of COVID-19 has been associated with negative psychological outcomes including stress, depression and post-traumatic stress disorders.

    “Isolation through confinement and quarantine in the context of COVID-19 have been associated with negative psychological outcomes including stress, depression and post-traumatic stress disorders (21, 22).”

    From Social Isolation, Loneliness and Health: A Descriptive Study of the Experiences of Migrant Mothers With Young Children (0–5 Years Old) at La Maison Bleue (2022) · cites this paper as [22]

    The Results section, “Impact of Social Isolation in an Infectious Disease Context” (page not provided), reports acute stress disorder and PTSD among children exposed to isolation or quarantine during earlier infectious-disease outbreaks. The Discussion links loneliness with depression, but cautions that those findings cannot be directly extrapolated to COVID-19 confinement; the review does not establish the claimed set of outcomes for COVID-19 quarantine. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

Cites

Flagged first, then by citations

14 of the 107 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. Perlman, 1981, Toward a social psychology of loneliness, Pers Relat, 3, 31
  2. Oxford ARC Study. Achieving resilience during COVID-19 weekly report 2. 2020. Available at: http://mentalhealthresearchmatters.org.uk/achieving-resilience-during-covid-19-psycho-social-risk-protective-factors-amidst-a-pandemic-in-adolescents/. Accessed May 22, 2020.
  3. Singhvi, 2011, Psychological correlates of loneliness among adolescents, Indian J Psychol Sci, 2, 8

Cited by

Sorted by citations

Authors
Loades, M. E., Chatburn, E., Higson-Sweeney, N., Reynolds, S., Shafran, R., Brigden, A., Linney, C., McManus, M. N., Borwick, C., & Crawley, E.
Affiliations
  • University of Bath (GB)
  • University of Reading (GB)
  • University College London (GB)
  • University of Bristol (GB)
  • University of Edinburgh (GB)
Corresponding author
Loades, Maria Elizabeth
Venue
Journal of the American Academy of Child & Adolescent Psychiatry
Publisher
Elsevier BV
Published
2020-11
Volume
59
Issue
11
Pages
1218-1239.e3
ISSN
0890-8567 (ISSN-L)
OpenAlex
W3032994313
Cited by
2,906
References
107
Citations by year
2026: 227 · 2025: 291 · 2024: 398 · 2023: 568 · 2022: 716 · 2021: 603 · 2020: 99 · 2018: 1 · 2013: 1
FWCI
39.27
Type
journal article
Language
en
Open access
Locations
  • Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Pure (University of Bath) (publishedVersion, cc-by-nc-nd)
  • CentAUR (University of Reading) (submittedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Bristol Research (University of Bristol) (submittedVersion, cc-by-nc-nd)
  • UEA Digital Repository (University of East Anglia) (submittedVersion)
Funders
  • National Institute for Health Research (DRF-2017-10-169, DRF-2016-09-021)
  • Great Ormond Street Hospital Charity
  • University College London
Topics
  • Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Keywords
social isolation, loneliness, COVID-19 pandemic, child mental health, adolescent mental health, depression, anxiety, lockdown measures, early intervention
MeSH terms
COVID-19, Adolescent, Child, Humans, Loneliness, Mental Health, Pneumonia, Viral, Social Isolation, Coronavirus Infections, Pandemics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Claims read by deepseek-v4.1-flash under definition version 3 (extract-v3) on 2026-09-28.

Classified by jev-1.13-20260917 (gold-guideline-v0.2) on 2026-09-28.

Cited sources are checked by gpt-6-sol.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

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