Cited by 93Stress Responses and CortisolNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 268 of the 268 references it cites were found in a registry or an index.

Evidence for the role of corticotropin-releasing factor in major depressive disorder

Open access

Waters, R. Parrish, Rivalan, Marion, Bangasser, D.A., Deussing, J.M., Ising, M., Wood, S.K., Holsboer, F., Summers, Cliff H.·2015·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2015.07.011PMC PMC4828243

Open this paper in CoChat — free account

Abstract

Major depressive disorder (MDD) is a devastating disease affecting over 300 million people worldwide, and costing an estimated 380 billion Euros in lost productivity and health care in the European Union alone. Although a wealth of research has been directed toward understanding and treating MDD, still no therapy has proved to be consistently and reliably effective in interrupting the symptoms of this disease. Recent clinical and preclinical studies, using genetic screening and transgenic rodents, respectively, suggest a major role of the CRF1 gene, and the central expression of CRF1 receptor protein in determining an individual's risk of developing MDD. This gene is widely expressed in brain tissue, and regulates an organism's immediate and long-term responses to social and environmental stressors, which are primary contributors to MDD. This review presents the current state of knowledge on CRF physiology, and how it may influence the occurrence of symptoms associated with MDD. Additionally, this review presents findings from multiple laboratories that were presented as part of a symposium on this topic at the annual 2014 meeting of the International Behavioral Neuroscience Society (IBNS). The ideas and data presented in this review demonstrate the great progress that has been made over the past few decades in our understanding of MDD, and provide a pathway forward toward developing novel treatments and detection methods for this disorder.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neubiorev.2015.07.011

Cites

268 of 268 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Diagnostic and Statistical Manual of Mental Disorders
(2012) · Springer eBooks · doi:10.1007/springerreference_121117 · Cited by 20,772
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
An Analysis of Coping in a Middle-Aged Community Sample
Folkman, S., & Lazarus, R. S. (1980) · Journal of Health and Social Behavior · doi:10.2307/2136617 · Cited by 6,361
Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429 · cited 1×
“…is linked with depression through its effects on structural and ultra-structural brain integrity as well as the modulation of neurotransmission, and evidence supports a role for CRF in each of these processes (Anacker, 2014; de Kloet et al., 2005; Duman, 2014; Mahar et al., 2014; McEwen, 2007).”
Background
Stress and the brain: from adaptation to disease
de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621
Self-citation
Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-Endorphin
Vale, W., Spiess, J., Rivier, C., & Rivier, J. (1981) · Science · doi:10.1126/science.6267699 · Cited by 3,965
Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin
Vale, W., Spiess, J., RIVIER, C. L., & Rivier, J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198205000-00013 · Cited by 3,904
The Neuroendocrinology of Stress: A Never Ending Story
Lightman, S. L. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01711.x · Cited by 3,588
Neurobiology of Depression
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217
Stress and Depression
Hammen, C. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143938 · Cited by 2,979
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889
Coping styles in animals: current status in behavior and stress-physiology
Koolhaas, J. M., Korte, S. M., De Boer, S. F., Van Der Vegt, B. J., Van Reenen, C. G., Hopster, H., De Jong, I. C., Ruis, M. A. W., & Blokhuis, H. J. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00026-3 · Cited by 2,875 · cited 1×
“These diverse coping strategies are related to divergent physiological responses to stress, as passive behaviors are characterized by higher HPA axis reactivity and active behaviors are associated with enhanced sympathetic activity (Koolhaas et al., 1999).”
Background
Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · cited 2×
“Subjecting rodents to chronic social stress produces defeat, social avoidance, and susceptibility to depression-like behaviors in some subjects, but not others (Arendt et al., 2014; de Kloet et al., 2005; Krishnan et al., 2007; Krishnan and Nestler, 2010, 2011).”
Background
Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis
Herman, J. P., & Cullinan, W. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10069-2 · Cited by 2,270
Sex and depression in the National Comorbidity Survey, I: lifetime prevalence, chronicity and recurrence
Kessler, R. (1993) · Journal of Affective Disorders · doi:10.1016/0165-0327(93)90026-g · Cited by 2,207 · cited 3×
“While this is observed in both sexes, the study also confirmed the higher occurrence of depression in women (100% higher than men), and this is reflected in the higher burden of the disease that is observed in women (Kessler, 2003; Kessler et al., 1993; Collins et al., 2011; Marcus et al., 2014).”
BackgroundResult
The Corticosteroid Receptor Hypothesis of Depression
Holsboer, F. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00159-7 · Cited by 2,181
Self-citation
Grand challenges in global mental health
Collins, P. Y., Patel, V., Joestl, S. S., March, D., Insel, T. R., Daar, A. S., Bordin, I. A., Costello, E. J., Durkin, M., Fairburn, C., et al. (2011) · Nature · doi:10.1038/475027a · Cited by 2,043
Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders
Sapolsky, R. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.925 · Cited by 2,016
Epidemiology of women and depression
Kessler, R. (2003) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00426-3 · Cited by 2,006
Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study
Swanson, L. W., Sawchenko, P. E., Rivier, J., & Vale, W. W. (2008) · Neuroendocrinology · doi:10.1159/000123454 · Cited by 1,953
A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex
Taniguchi, H., He, M., Wu, P., Kim, S., Paik, R., Sugino, K., Kvitsani, D., Fu, Y., Lu, J., Lin, Y., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.026 · Cited by 1,828
Transduction of Receptor Signals by ß-Arrestins
Lefkowitz, R. J., & Shenoy, S. K. (2005) · Science · doi:10.1126/science.1109237 · Cited by 1,729
Explaining the gender difference in depressive symptoms.
Nolen-Hoeksema, S., Larson, J., & Grayson, C. (1999) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.77.5.1061 · Cited by 1,543 · cited 1×
“If these sex differences occur in humans, they may explain the sex bias in the rates of depression, as well as the prevalence of certain hyperarousal symptoms in depressed women (Nolen-Hoeksema et al., 1999; Plante et al., 2012).”
Background
Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients
Nemeroff, C. B., Widerlöv, E., Bissette, G., Walléus, H., Karlsson, I., Eklund, K., Kilts, C. D., Loosen, P. T., & Vale, W. (1984) · Science · doi:10.1126/science.6334362 · Cited by 1,485
β-Arrestins and Cell Signaling
DeWire, S. M., Ahn, S., Lefkowitz, R. J., & Shenoy, S. K. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.022405.154749 · Cited by 1,397
Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses?
Dunn, A. J., & Berridge, C. W. (1990) · Brain Research Reviews · doi:10.1016/0165-0173(90)90012-d · Cited by 1,352
Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states
Gold, P. W., & Chrousos, G. P. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001032 · Cited by 1,274
CRF and CRF receptors: role in stress responsivity and other behaviors
Bale, T. L., & Vale, W. W. (2004) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121410 · Cited by 1,270
Coping, stress, and social resources among adults with unipolar depression.
Billings, A. G., & Moos, R. H. (1984) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.46.4.877 · Cited by 1,157
Depression: A Global Public Health Concern
Marcus, M., Yasamy, M. T., van Ommeren, M., Chisholm, D., & Saxena, S. (2012) · PsycEXTRA Dataset · doi:10.1037/e517532013-004 · Cited by 997
The stress system in the human brain in depression and neurodegeneration
Swaab, D. F., Bao, A.-M., & Lucassen, P. J. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.03.003 · Cited by 984
Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression
Chalmers, D., Lovenberg, T. W., & Souza, E. D. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06340.1995 · Cited by 925
Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor
Lewis, K., Li, C., Perrin, M. H., Blount, A., Kunitake, K., Donaldson, C., Vaughan, J., Reyes, T. M., Gulyas, J., Fischer, W., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121165198 · Cited by 925
Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1
Timpl, P., Spanagel, R., Sillaber, I., Kresse, A., Reul, J. M. H. M., Stalla, G. K., Blanquet, V., Steckler, T., Holsboer, F., & Wurst, W. (1998) · Nature Genetics · doi:10.1038/520 · Cited by 919
Self-citation
Corticotropin Releasing Factor Receptor 1–Deficient Mice Display Decreased Anxiety, Impaired Stress Response, and Aberrant Neuroendocrine Development
Smith, G. W., Aubry, J.-M., Dellu, F., Contarino, A., Bilezikjian, L. M., Gold, L. H., Chen, R., Marchuk, Y., Hauser, C., Bentley, C. A., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80491-2 · Cited by 892
Urocortin II: A Member of the Corticotropin-Releasing Factor (CRF) Neuropeptide Family that Is Selectively Bound by Type 2 CRF Receptors
Reyes, T. M., Lewis, K., Perrin, M. H., Kunitake, K. S., Vaughan, J., Arias, C. A., Hogenesch, J. B., Gulyas, J., Rivier, J., Vale, W. W., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051626398 · Cited by 887
Neuropeptide Transmission in Brain Circuits
van den Pol, A. N. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.014 · Cited by 810
Coping, stress, and social resources among adults with unipolar depression.
Billings, A. G., & Moos, R. H. (1984) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.46.4.877 · Cited by 793
Corticotropin releasing factor produces behavioural activation in rats
Sutton, R., Koob, G., le Moal, M., Rivier, J., & Vale, W. (1982) · Nature · doi:10.1038/297331a0 · Cited by 744
Sex differences in stress-related psychiatric disorders: neurobiological perspectives
Bangasser, D. A., & Valentino, R. J. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.03.008 · Cited by 737
Self-citation
Regulation of Receptor Trafficking by GRKs and Arrestins
Moore, C. A. C., Milano, S. K., & Benovic, J. (2006) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.022405.154712 · Cited by 709
Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects
Mahar, I., Bambico, F. R., Mechawar, N., & Nobrega, J. N. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.009 · Cited by 694
Monoamine neurocircuitry in depression and strategies for new treatments
Hamon, M., & Blier, P. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.04.009 · Cited by 674
Linking Molecules to Mood: New Insight Into the Biology of Depression
Krishnan, V., & Nestler, E. J. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.10030434 · Cited by 666
Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor
Hsu, S. Y., & Hsueh, A. J. W. (2001) · Nature Medicine · doi:10.1038/87936 · Cited by 651
Corticotropin-Releasing Factor: Actions on the Sympathetic Nervous System and Metabolism*
Brown, M. R., Fisher, L. A., Spiess, J., RIVIER, C. L., Rivier, J., & Vale, W. (1982) · Endocrinology · doi:10.1210/endo-111-3-928 · Cited by 651
Cautionary Statement for Forensic Use of DSM-5
(2014) · Diagnostic and Statistical Manual of Mental Disorders, 5th Edition · doi:10.1176/appi.books.9780890425596.744053 · Cited by 624
Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part III: Bipolar Disorder
Segurado, R., Detera‐Wadleigh, S. D., Levinson, D. F., Lewis, C. M., Gill, M., Nürnberger, J. I., Craddock, N. J., DePaulo, J. R., Baron, M., Gershon, E. S., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/376547 · Cited by 569
Anhedonia and motivational deficits in rats: Impact of chronic social stress
Rygula, R., Abumaria, N., Flügge, G., Fuchs, E., Rüther, E., & Havemann-Reinecke, U. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.03.009 · Cited by 554
The CRF peptide family and their receptors: yet more partners discovered
Dautzenberg, F. M., & Hauger, R. L. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)01946-6 · Cited by 534
Intraventricular corticotropin-releasing factor enhances behavioral effects of novelty
Britton, D. R., Koob, G. F., Rivier, J., & Vale, M. L. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90416-7 · Cited by 534
Animal Models of Depression: Molecular Perspectives
Krishnan, V., & Nestler, E. J. (2011) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2010_108 · Cited by 528
Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need
Muglia, L., Jacobson, L., Dikkes, P., & Majzoub, J. A. (1995) · Nature · doi:10.1038/373427a0 · Cited by 524
Distribution of corticotropin-releasing factor receptor mRNA expression in the rat brain and pituitary.
Potter, E., Sutton, S., Donaldson, C., Chen, R., Perrin, M., Lewis, K., Sawchenko, P. E., & Vale, W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8777 · Cited by 514
Social defeat as a stressor in humans
Björkqvist, K. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00490-5 · Cited by 502
Stress Hormone Regulation: Biological Role and Translation into Therapy
Holsboer, F., & Ising, M. (2010) · Annual Review of Psychology · doi:10.1146/annurev.psych.093008.100321 · Cited by 473
Self-citation
Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior
Stenzel‐Poore, M. P., Heinrichs, S. C., Rivest, S., Koob, G. F., & Vale, W. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-05-02579.1994 · Cited by 468
Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress
Müller, M. B., Zimmermann, S., Sillaber, I., Hagemeyer, T. P., Deussing, J. M., Timpl, P., Kormann, M., Droste, S. K., Kühn, R., Reul, J. M. H. M., et al. (2003) · Nature Neuroscience · doi:10.1038/nn1123 · Cited by 458
Self-citation
CRF2 alpha and CRF2 beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues
Lovenberg, T. W., Chalmers, D. T., Liu, C., & Souza, E. B. D. (1995) · Endocrinology · doi:10.1210/endo.136.9.7544278 · Cited by 457
Regulation of G Protein-Coupled Receptor Kinases and Arrestins During Receptor Desensitization
Kohout, T. A., & Lefkowitz, R. J. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.1.9 · Cited by 449
Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice
Elliott, E., Ezra-Nevo, G., Regev, L., Neufeld-Cohen, A., & Chen, A. (2010) · Nature Neuroscience · doi:10.1038/nn.2642 · Cited by 436
Corticotropin Releasing Factor Receptors and Their Ligand Family
Perrin, M. H., & Vale, W. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08687.x · Cited by 431
Corticotropin-releasing factor immunoreactivity is widely distributed within the central nervous system of the rat: an immunohistochemical study
Cummings, S., Elde, R., Ells, J., & Lindall, A. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-07-01355.1983 · Cited by 414
Sex differences in corticotropin-releasing factor receptor signaling and trafficking: potential role in female vulnerability to stress-related psychopathology
Bangasser, D. A., Curtis, A., Reyes, B. A. S., Bethea, T. T., Parastatidis, I., Ischiropoulos, H., Van Bockstaele, E. J., & Valentino, R. J. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.66 · Cited by 401
Self-citation
Dysregulation in the Suicide Brain: mRNA Expression of Corticotropin-Releasing Hormone Receptors and GABAAReceptor Subunits in Frontal Cortical Brain Region
Merali, Z., Du, L., Hrdina, P., Palkovits, M., Faludi, G., Poulter, M. O., & Anisman, H. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4734-03.2004 · Cited by 400
A new test for aggression in rats without aversive stimulation: Differential effects of d-amphetamine and cocaine
Miczek, K. A. (1979) · Psychopharmacology · doi:10.1007/bf00426664 · Cited by 398
Bed Nucleus of the Stria Terminalis Subregions Differentially Regulate Hypothalamic–Pituitary–Adrenal Axis Activity: Implications for the Integration of Limbic Inputs
Choi, D. C., Furay, A. R., Evanson, N. K., Ostrander, M. M., Ulrich-Lai, Y. M., & Herman, J. P. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4301-06.2007 · Cited by 392
Agonist‐selective mechanisms of GPCR desensitization
Kelly, E., Bailey, C. P., & Henderson, G. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707604 · Cited by 388
The current state of the neurogenic theory of depression and anxiety
Miller, B. R., & Hen, R. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.08.012 · Cited by 386
The Neurobiology of Depression
Nemeroff, C. B. (1998) · Scientific American · doi:10.1038/scientificamerican0698-42 · Cited by 381
The Flinders Sensitive Line rat: A selectively bred putative animal model of depression
Overstreet, D. H., Friedman, E. M., Mathé, A. A., & Yadid, G. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.015 · Cited by 380
The CRF system, stress, depression and anxiety—insights from human genetic studies
Binder, E. B., & Nemeroff, C. B. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.141 · Cited by 379
Cloning and characterization of human urocortin.
Donaldson, C. J., Sutton, S. W., Perrin, M. H., CORRIGAN, A. Z., Lewis, K. A., Rivier, J., Vaughan, J. M., & Vale, W. (1996) · Endocrinology · doi:10.1210/endo.137.5.8612563 · Cited by 371
Life events and affective disorders
Paykel, E. S. (2003) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.108.s418.13.x · Cited by 368
Urocortin Expression in Rat Brain: Evidence Against a Pervasive Relationship of Urocortin-Containing Projections With Targets Bearing Type 2 CRF Receptors
Bittencourt, J. C., Vaughan, J. M., Arias, C., Rissman, R. A., Vale, W., & Sawchenko, P. E. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19991220)415:3 · Cited by 367
International Union of Pharmacology. XXXVI. Current Status of the Nomenclature for Receptors for Corticotropin-Releasing Factor and Their Ligands
Hauger, R. L., Grigoriadis, D. E., Dallman, M. F., Plotsky, P. M., Vale, W., & Dautzenberg, F. M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.1.3 · Cited by 365
Studies on the cellular architecture of the bed nuclei of the stria terminalis in the rat: I. cytoarchitecture
Ju, G., & Swanson, L. W. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902800409 · Cited by 359
The Molecular Mechanisms Underlying the Regulation of the Biological Activity of Corticotropin-Releasing Hormone Receptors: Implications for Physiology and Pathophysiology
Hillhouse, E. W., & Grammatopoulos, D. K. (2006) · Endocrine Reviews · doi:10.1210/er.2005-0034 · Cited by 358
Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins
Potter, E., Behan, D. P., Fischer, W. H., Linton, E. A., Lowry, P. J., & Vale, W. (1991) · Nature · doi:10.1038/349423a0 · Cited by 357
Untitled work
(1997) · PubMed · Cited by 350
Stressful Life Events and Depression Symptoms: The Effect of Childhood Emotional Abuse on Stress Reactivity
Shapero, B. G., Black, S. K., Liu, R. T., Klugman, J., Bender, R. E., Abramson, L. Y., & Alloy, L. B. (2013) · Journal of Clinical Psychology · doi:10.1002/jclp.22011 · Cited by 349
Corticotropin Releasing Factor (CRF) Receptor Signaling in the Central Nervous System: New Molecular Targets
Hauger, R., Risbrough, V. B., Brauns, O., & Dautzenberg, F. M. (2006) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152706777950684 · Cited by 344
Do Centrally Administered Neuropeptides Access Cognate Receptors?: An Analysis in the Central Corticotropin-Releasing Factor System
Bittencourt, J. C., & Sawchenko, P. E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-03-01142.2000 · Cited by 339
Distribution and efferent projections of corticotropin-releasing factor-like immunoreactivity in the rat amygdaloid complex
Sakanaka, M., Shibasaki, T., & Lederis, K. (1986) · Brain Research · doi:10.1016/0006-8993(86)91332-6 · Cited by 337
CSF corticotropin-releasing factor-like immunoreactivity in depression and schizophrenia
Bánki, C. M., Bissette, G., Arató, M., O'Connor, L., & Nemeroff, C. B. (1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.7.873 · Cited by 336
Corticotropin releasing factor‐like immunoreactivity in the rat brain as revealed by a modified cobalt‐glucose oxidase‐diaminobenzidine method
Sakanaka, M., Shibasaki, T., & Lederis, K. P. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902600209 · Cited by 335
Bed nucleus of the stria terminalis: Cytoarchitecture, immunohistochemistry, and projection to the parabrachial nucleus in the rat
Moga, M. M., Saper, C. B., & Gray, T. S. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902830302 · Cited by 333
Selective participation of the bed nucleus of the stria terminalis and CRF in sustained anxiety-like versus phasic fear-like responses
Walker, D. L., Miles, L. A., & Davis, M. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.06.022 · Cited by 331
Glutamatergic and Dopaminergic Neurons Mediate Anxiogenic and Anxiolytic Effects of CRHR1
Refojo, D., Schweizer, M., Kühne, C., Ehrenberg, S., Thoeringer, C. K., Vogl, A. M., Dedic, N., Schumacher, M., von Wolff, G., Avrabos, C., et al. (2011) · Science · doi:10.1126/science.1202107 · Cited by 321
Self-citation
Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive
Lemos, J. C., Wanat, M. J., Smith, J. S., Reyes, B. A. S., Hollon, N. G., Bockstaele, E. J. V., Chavkin, C., & Phillips, P. E. M. (2012) · Nature · doi:10.1038/nature11436 · Cited by 319
Effects of Corticotropin-Releasing Factor on Neuronal Activity in the Serotonergic Dorsal Raphe Nucleus
Kirby, L., Rice, K., & Valentino, R. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00093-7 · Cited by 318
In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation
WEBSTER, E. L., Lewis, D. B., Torpy, D. J., Zachman, E. K., Rice, K. C., & Chrousos, G. P. (1996) · Endocrinology · doi:10.1210/endo.137.12.8940412 · Cited by 311
Long-term impairment of autonomic circadian rhythms after brief intermittent social stress
Tornatzky, W., & Miczek, K. A. (1993) · Physiology & Behavior · doi:10.1016/0031-9384(93)90278-n · Cited by 306
The Endocrinology of Melancholic and Atypical Depression: Relation to Neurocircuitry and Somatic Consequences
Gold, P. W., & Chrousos, G. P. (1999) · Proceedings of the Association of American Physicians · doi:10.1046/j.1525-1381.1999.09423.x · Cited by 300
Corticotropin-releasing factor potentiates acoustic startle in rats: Blockade by chlordiazepoxide
Swerdlow, N. R., Geyer, M. A., Vale, W. W., & Koob, G. F. (1986) · Psychopharmacology · doi:10.1007/bf00652231 · Cited by 299
Interaction between stress and the BDNFVal66Met polymorphism in depression: a systematic review and meta-analysis
Hosang, G. M., Shiles, C., Tansey, K. E., McGuffin, P., & Uher, R. (2014) · BMC Medicine · doi:10.1186/1741-7015-12-7 · Cited by 292
The central distribution of a corticotropin-releasing factor (CRF)-binding protein predicts multiple sites and modes of interaction with CRF.
Potter, E., Behan, D. P., Linton, E. A., Lowry, P. J., Sawchenko, P. E., & Vale, W. W. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.9.4192 · Cited by 285
Association of fluoxetine treatment with reductions in CSF concentrations of corticotropin-releasing hormone and arginine vasopressin in patients with major depression
(1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.4.656 · Cited by 278
The distribution of corticotropin releasing factor-like immunoreactive neurons in rat brain
Olschowka, J. A., O’Donohue, T. L., Mueller, G. P., & Jacobowitz, D. M. (1982) · Peptides · doi:10.1016/0196-9781(82)90071-7 · Cited by 277
Variant Brain-Derived Neurotrophic Factor Val66Met Polymorphism Alters Vulnerability to Stress and Response to Antidepressants
Yu, H., Wang, D.-D., Wang, Y., Liu, T., Lee, F. S., & Chen, Z.-Y. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5048-11.2012 · Cited by 275
The combined dexamethasone/CRH test as a potential surrogate marker in depression
Ising, M., Kunzel, H. E., Binder, E. B., Nickel, T., Modell, S., & Holsboer, F. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.03.014 · Cited by 275
Self-citation
A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22
Kelsoe, J. R., Spence, M. A., Loetscher, E., Foguet, M., Sadovnick, A. D., Remick, R. A., Flodman, P. L., Khristich, J. V., Mroczkowski‐Parker, Z., Brown, J. L., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.585 · Cited by 275
Social defeat stress induces a depression-like phenotype in adolescent male c57BL/6 mice
Iñiguez, S. D., Riggs, L. M., Nieto, S. J., Dayrit, G., Zamora, N. N., Shawhan, K. L., Cruz, B., & Warren, B. L. (2014) · Stress · doi:10.3109/10253890.2014.910650 · Cited by 269
CORTICOTROPIN-RELEASING FACTOR (CRF): CENTRAL EFFECTS ON MEAN ARTERIAL PRESSURE AND HEART RATE IN RATS.
Fisher, L. A., JRIVIER, E., RIVIER, C. L., Spiess, J., Vale, W., & Brown, M. R. (1982) · Endocrinology · doi:10.1210/endo-110-6-2222 · Cited by 260
Neuropeptide Concentrations in the Cerebrospinal Fluid of Depressed Patients Treated with Electroconvulsive Therapy
Nemeroff, C. B., Bissette, G., Akil, H., & Fink, M. (1991) · The British Journal of Psychiatry · doi:10.1192/bjp.158.1.59 · Cited by 251
Individual Differences in Reactivity to Social Stress Predict Susceptibility and Resilience to a Depressive Phenotype: Role of Corticotropin-Releasing Factor
Wood, S. K., Walker, H. E., Valentino, R. J., & Bhatnagar, S. (2010) · Endocrinology · doi:10.1210/en.2009-1026 · Cited by 251
Self-citation
Combined Analysis from Eleven Linkage Studies of Bipolar Disorder Provides Strong Evidence of Susceptibility Loci on Chromosomes 6q and 8q
McQueen, M. B., Devlin, B., Faraone, S. V., Nimgaonkar, V. L., Sklar, P., Smoller, J. W., Abou Jamra, R., Albus, M., Bacanu, S.-A., Baron, M., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/491603 · Cited by 245
Corticotropin Releasing Factor (CRF) Binding Protein: A Novel Regulator of CRF and Related Peptides
Behan, D. P., Souza, E. B. D., Lowry, P. J., Potter, E., Sawchenko, P. E., & Vale, W. W. (1995) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1995.1013 · Cited by 243
Stress-induced behaviors require the corticotropin-releasing hormone (CRH) receptor, but not CRH
Weninger, S. C., Dunn, A. J., Muglia, L. J., Dikkes, P., Miczek, K. A., Swiergiel, A. H., Berridge, C. W., & Majzoub, J. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.8283 · Cited by 240
Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression
Pezawas, L., Meyer‐Lindenberg, A., Goldman, A. L., Verchinski, B. A., Chen, G., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.32 · Cited by 240
Effects of Corticotropin-Releasing Factor on Brain Serotonergic Activity
Price, M. L., Curtis, A., Kirby, L., Valentino, R., & Lucki, I. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00197-8 · Cited by 240
Medical Students’ Experience of and Reaction to Stress: The Role of Depression and Anxiety
Saravanan, C., & Wilks, R. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/737382 · Cited by 237
4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1 S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1, 3-thiazol-2-amine Hydrochloride (SSR125543A), a Potent and Selective Corticotrophin-Releasing Factor1 Receptor Antagonist. II. Characterization in Rodent Models of Stress-Related Disorders
Griebel, G., Simiand, J., Steinberg, R., Jung, M., Gully, D., Roger, P., Geslin, M., Scatton, B., Maffrand, J., & Soubrié, P. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.301.1.333 · Cited by 237
The Role of Corticotropin‐Releasing Factor in Behavioural Responses to Stress
Koob, G. F., Heinrichs, S. C., Pich, E. M., Menzaghi, F., Baldwin, H. A., Miczek, K. A., & Britton, K. T. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514368.ch14 · Cited by 232
Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 11Published on the World Wide Web on 27 November 1998.1
Contarino, A., Dellu-Hagedorn, F., Koob, G. F., Smith, G. W., Lee, K., Vale, W., & Gold, L. H. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01158-5 · Cited by 228
Repeated social defeat-induced depression-like behavioral and biological alterations in rats: involvement of cholecystokinin
Becker, C., Zeau, B., Rivat, C., Blugeot, A., Hamon, M., & Benoliel, J. J. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002097 · Cited by 225
Sexually Dimorphic Responses of the Brain Norepinephrine System to Stress and Corticotropin-Releasing Factor
Curtis, A. L., Bethea, T., & Valentino, R. J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300875 · Cited by 222
Corticotropin releasing factor (CRF) receptor antagonist blocks activating and ‘anxiogenic’ actions of CRF in the rat
Britton, K. T., Lee, G., Vale, W., Rivier, J., & Koob, G. F. (1986) · Brain Research · doi:10.1016/0006-8993(86)90539-1 · Cited by 217
Role of CRF Receptor Signaling in Stress Vulnerability, Anxiety, and Depression
Hauger, R. L., Risbrough, V., Oakley, R. H., Olivares‐Reyes, J. A., & Dautzenberg, F. M. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05011.x · Cited by 217
NEUROBIOLOGY OF STRESS, DEPRESSION, AND RAPID ACTING ANTIDEPRESSANTS: REMODELING SYNAPTIC CONNECTIONS: Review: Remodeling Synaptic Connections
Duman, R. S. (2014) · Depression and Anxiety · doi:10.1002/da.22227 · Cited by 213
A Neurochemically Distinct Dorsal Raphe-Limbic Circuit with a Potential Role in Affective Disorders
Commons, K. G., Connolley, K. R., & Valentino, R. J. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300045 · Cited by 211
Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway
Walsh, J. J., Friedman, A. K., Sun, H., Heller, E. A., Ku, S. M., Juarez, B., Burnham, V. L., Mazei-Robison, M. S., Ferguson, D., Golden, S. A., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3591 · Cited by 210
Circuitry Underlying Regulation of the Serotonergic System by Swim Stress
Roche, M., Commons, K. G., Peoples, A., & Valentino, R. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-03-00970.2003 · Cited by 207
Anxiogenic and aversive effects of corticotropin-releasing factor (CRF) in the bed nucleus of the stria terminalis in the rat: role of CRF receptor subtypes
Sahuque, L. L., Kullberg, E. F., Mcgeehan, A. J., Kinder, J. R., Hicks, M. P., Blanton, M. G., Janak, P. H., & Olive, M. F. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0362-y · Cited by 207
Stress and trauma: BDNF control of dendritic-spine formation and regression
Bennett, M. R., & Lagopoulos, J. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.10.005 · Cited by 199
Changes in Hypothalamic‐Pituitary‐Adrenal Function, Body Temperature, Body Weight and Food Intake with Repeated Social Stress Exposure in Rats
Bhatnagar, S., Vining, C., Iyer, V., & Kinni, V. (2005) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2005.01375.x · Cited by 197
Neuropeptide receptor ligands as drugs for psychiatric diseases: the end of the beginning?
Griebel, G., & Holsboer, F. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3702 · Cited by 194
Self-citation
Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment
Papiol, S., Arias, B., Gastó, C., Gutiérrez, B., Catalán, R., & Fañanás, L. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.02.017 · Cited by 188
Corticotropin-releasing factor administration elicits a stress-like activation of cerebral catecholaminergic systems
Dunn, A. J., & Berridge, C. W. (1987) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(87)90195-x · Cited by 187
STRESS EXPOSURE ACROSS THE LIFE SPAN CUMULATIVELY INCREASES DEPRESSION RISK AND IS MODERATED BY NEUROTICISM
Vinkers, C. H., Joëls, M., Milaneschi, Y., Kahn, R. S., Penninx, B. W. J. H., & Boks, M. P. (2014) · Depression and Anxiety · doi:10.1002/da.22262 · Cited by 185
β-Arrestin Binding to the β2-Adrenergic Receptor Requires Both Receptor Phosphorylation and Receptor Activation
Krasel, C., Bünemann, M., Lorenz, K., & Lohse, M. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413078200 · Cited by 178
Corticotropin Releasing Hormone Type 2 Receptors in the Dorsal Raphe Nucleus Mediate the Behavioral Consequences of Uncontrollable Stress
Hammack, S. E., Schmid, M. J., LoPresti, M. L., Der‐Avakian, A., Pelleymounter, M. A., Foster, A. C., Watkins, L. R., & Maier, S. F. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-03-01019.2003 · Cited by 176
Corticotropin-releasing hormone-binding protein: biochemistry and function from fishes to mammals
Af, S., Valverde, R., & Denver, R. J. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1750089 · Cited by 174
Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans
Licinio, J., O'Kirwan, F., Irizarry, K. J. L., Merriman, B., Thakur, S., Jepson, R., Lake, S. L., Tantisira, K. G., Weiss, S. T., & Wong, M. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001587 · Cited by 173
Increased Depression-Like Behaviors in Corticotropin-Releasing Factor Receptor-2-Deficient Mice: Sexually Dichotomous Responses
Bale, T. L., & Vale, W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05295.2003 · Cited by 169
The Corticotropin-Releasing Hormone Gene and Behavioral Inhibition in Children at Risk for Panic Disorder
Smoller, J. W., Yamaki, L. H., Fagerness, J. A., Biederman, J., Racette, S., Laird, N. M., Kagan, J., Snidman, N. C., Faraone, S. V., Hirshfeld‐Becker, D. R., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.02.018 · Cited by 168
Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling
Wang, X., Chen, Y., Wolf, M., Wagner, K. V., Liebl, C., Scharf, S. H., Harbich, D., Mayer, B., Wurst, W., Holsboer, F., et al. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.020 · Cited by 164
Self-citation
Forebrain CRF1Modulates Early-Life Stress-Programmed Cognitive Deficits
Wang, X., Rammes, G., Kraev, I., Wolf, M., Liebl, C., Scharf, S. H., Rice, C. J., Wurst, W., Holsboer, F., Deussing, J. M., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2259-11.2011 · Cited by 163
Self-citation
Increased corticotropin-releasing hormone immunoreactivity in monoamine-containing pontine nuclei of depressed suicide men
Austin, M. C., Janosky, J. E., & Murphy, H. A. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001250 · Cited by 162
The Role of CRF in Behavioral Aspects of Stress
Heinrichs, S. C., Menzaghi, F., Pich, E. M., Britton, K. T., & Koob, G. F. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44673.x · Cited by 160
Corticotropin-Releasing Hormone, Arginine Vasopressin, Gastrin-Releasing Peptide, and Neuromedin B Alterations in Stress-Relevant Brain Regions of Suicides and Control Subjects
Merali, Z., Kent, P., Du, L., Hrdina, P. D., Palkovits, M., Faludi, G., Poulter, M. O., Bédard, T., & Anisman, H. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.008 · Cited by 160
Sex Differences in Molecular and Cellular Substrates of Stress
Bangasser, D. A., & Valentino, R. J. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9824-4 · Cited by 160
Self-citation
CSF corticotropin-releasing hormone and somatostatin in major depression: response to antidepressant treatment and relapse
Banki, C. M., Karmacsi, L., Bissette, G., & Nemeroff, C. B. (1992) · European Neuropsychopharmacology · doi:10.1016/0924-977x(92)90019-5 · Cited by 149
Association of corticotropin-releasing hormone receptor1 gene SNP and haplotype with major depression
Liu, Z., Zhu, F., Wang, G., Xiao, Z., Wang, H., Tang, J., Wang, X., Qiu, D.-S., Liu, W., Cao, Z., et al. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.06.016 · Cited by 149
Stress and VTA synapses: implications for addiction and depression
Polter, A. M., & Kauer, J. A. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12490 · Cited by 147
Corticotropin-Releasing Factor in the Norepinephrine Nucleus, Locus Coeruleus, Facilitates Behavioral Flexibility
Snyder, K., Wang, W., Han, R., McFadden, K., & Valentino, R. J. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.218 · Cited by 144
Activating and ‘anxiogenic’ effects of corticotropin releasing factor are not inhibited by blockade of the pituitary-adrenal system with dexamethasone
Britton, K. T., Lee, G., Dana, R. C., Risch, S. C., & Koob, G. F. (1986) · Life Sciences · doi:10.1016/0024-3205(86)90189-x · Cited by 144
Chronic overexpression of corticotropin-releasing factor from the central amygdala produces HPA axis hyperactivity and behavioral anxiety associated with gene-expression changes in the hippocampus and paraventricular nucleus of the hypothalamus
Flandreau, E. I., Ressler, K. J., Owens, M. J., & Nemeroff, C. B. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.04.014 · Cited by 143
Rat cerebral cortex corticotropin‐releasing hormone receptors: evidence for receptor coupling to multiple G‐proteins
Grammatopoulos, D. K., Randeva, H. S., Levine, M. A., Kanellopoulou, K. A., & Hillhouse, E. W. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00067.x · Cited by 143
High-Affinity CRF1 Receptor Antagonist NBI-34041: Preclinical and Clinical Data Suggest Safety and Efficacy in Attenuating Elevated Stress Response
Ising, M., Zimmermann, U. S., Kunzel, H. E., Uhr, M., Foster, A. C., Learned, S. M., Holsboer, F., & Grigoriadis, D. E. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301328 · Cited by 143
Self-citation
Novel and Transient Populations of Corticotropin-Releasing Hormone-Expressing Neurons in Developing Hippocampus Suggest Unique Functional Roles: A Quantitative Spatiotemporal Analysis
Chen, Y., Bender, R. A., Frotscher, M., & Baram, T. Z. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07171.2001 · Cited by 140
Polymorphisms in CRHR1 and the serotonin transporter loci: Gene × Gene × Environment interactions on depressive symptoms
Ressler, K. J., Bradley, B., Mercer, K. B., Deveau, T. C., Smith, A. K., Gillespie, C. F., Nemeroff, C. B., Cubells, J. F., & Binder, E. B. (2010) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31052 · Cited by 140 · cited 4×
“Additionally, CRF1 SNPs interacting with the serotonin transporter (5-HTT) SNPs and child abuse, also predict adult depression (Ressler et al., 2010).”
BackgroundInfluential
Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibition
Smoller, J. W., Rosenbaum, J. F., Biederman, J., Kennedy, J. C., Dai, D., Racette, S., Laird, N. M., Kagan, J., Snidman, N. C., Hirshfeld‐Becker, D. R., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00598-5 · Cited by 140
Stress-Induced Redistribution of Corticotropin-Releasing Factor Receptor Subtypes in the Dorsal Raphe Nucleus
Waselus, M., Nazzaro, C., Valentino, R. J., & Bockstaele, E. J. V. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.02.014 · Cited by 139
Monoamine Theories of Depression: Historical Impact on Biomedical Research
Mulinari, S. (2012) · Journal of the History of the Neurosciences · doi:10.1080/0964704x.2011.623917 · Cited by 137
Sleep and endocrinology
Steiger, A. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01175.x · Cited by 137
Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior
Lu, A., Steiner, M. A., Whittle, N., Vogl, A. M., Walser, S. M., Ableitner, M., Refojo, D., Ekker, M., Rubenstein, J. L. R., Stalla, G. K., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.51 · Cited by 136
Self-citation
Elevated Concentrations of CRF in the Locus Coeruleus of Depressed Subjects
Bissette, G., Klimek, V., Pan, J., Stockmeier, C., & Ordway, G. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300191 · Cited by 136
Long‐Lasting Deficient Dexamethasone Suppression of Hypothalamic‐Pituitary‐Adrenocortical Activation Following Peripheral CRF Challenge in Socially Defeated Rats
Buwalda, de Boer, S. F., Schmidt, Felszeghy, Nyakas, Sgoifo, A., der Vegt, V., Tilders, Bohus, & Koolhaas (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00350.x · Cited by 135
Stress-Induced Intracellular Trafficking of Corticotropin-Releasing Factor Receptors in Rat Locus Coeruleus Neurons
Reyes, B. A. S., Valentino, R. J., & Bockstaele, E. J. V. (2007) · Endocrinology · doi:10.1210/en.2007-0705 · Cited by 134
Inflammatory Factors Mediate Vulnerability to a Social Stress-Induced Depressive-like Phenotype in Passive Coping Rats
Wood, S. K., Wood, C. S., Lombard, C. M., Lee, C. S., Zhang, X.-Y., Finnell, J. E., & Valentino, R. J. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.10.026 · Cited by 129
Self-citation
Urocortin Messenger Ribonucleic Acid: Tissue Distribution in the Rat and Regulation in Thymus by Lipopolysaccharide and Glucocorticoids
Kageyama, K., BRADBURY, M. J., Zhao, L., Blount, A. L., & Vale, W. (1999) · Endocrinology · doi:10.1210/endo.140.12.7223 · Cited by 128
A review of selected candidate endophenotypes for depression
Goldstein, B. L., & Klein, D. N. (2014) · Clinical Psychology Review · doi:10.1016/j.cpr.2014.06.003 · Cited by 128
Long-lasting consequences of a social conflict in rats: Behavior during the interaction predicts subsequent changes in daily rhythms of heart rate, temperature, and activity.
Meerlo, P., Sgoifo, A., de Boer, S. F., & Koolhaas, J. M. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.6.1283 · Cited by 127
A Novel Spliced Variant of the Type 1 Corticotropin-Releasing Hormone Receptor with a Deletion in the Seventh Transmembrane Domain Present in the Human Pregnant Term Myometrium and Fetal Membranes
Grammatopoulos, D. K., Dai, Y., Randeva, H. S., Levine, M. A., Karteris, E., Easton, A. J., & Hillhouse, E. W. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.12.0391 · Cited by 125
Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls
Hiroi, N., Wong, M. L., Licinio, J., Park, C., Young, M., Gold, P. W., Chrousos, G. P., & Bornstein, S. R. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000908 · Cited by 124
The CRHR1 gene: a marker for suicidality in depressed males exposed to low stress
Wasserman, D., Sokolowski, M., Rozanov, V. A., & Wasserman, J. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00310.x · Cited by 124
Evidence for a putative bipolar disorder locus on 2p13–16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21–24, 13q32, 14q21 and 17q11–12
Liu, J., Juo, S. H., DeWan, A. T., Grunn, A., Tong, X., Brito, M., Park, N., Loth, J. E., Kanyas, K., Lerer, B., et al. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001254 · Cited by 123
Anxiolytic- and antidepressant-like profile of a new CRF1 receptor antagonist, R278995/CRA0450
Chaki, S., Nakazato, A., Kennis, L. E. J., Nakamura, M., Mackie, C. E., Sugiura, M., Vinken, P., ASHTON, D. S., Langlois, X., & Steckler, T. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.11.032 · Cited by 123
Treatment with the CRH1-receptor-antagonist R121919 improves sleep-EEG in patients with depression
Held, K., Kunzel, H. E., Ising, M., Schmid, D. A., Zobel, A. W., Murck, H., Holsboer, F., & Steiger, A. (2003) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(03)00076-1 · Cited by 123
Self-citation
Corticotropin‐releasing Factor Receptors: Distribution and Regulation in Brain, Pituitary, and Peripheral Tissues
Aguilera, G., MILLAN, M. A., Hauger, R. L., & Catt, K. J. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb24950.x · Cited by 119
A corticotropin-releasing factor antagonist reverses the stress-induced changes of exploratory behavior in mice
Berridge, C. W., & Dunn, A. J. (1987) · Hormones and Behavior · doi:10.1016/0018-506x(87)90023-7 · Cited by 119
CORTICOTROPIN-RELEASING FACTOR INCREASES GABA SYNAPTIC ACTIVITY AND INDUCES INWARD CURRENT IN 5-HYDROXYTRYPTAMINE DORSAL RAPHE NEURONS
Kirby, L., Freeman-Daniels, E., Lemos, J. C., Nunan, J., Lamy, C., Akanwa, A. C., & Beck, S. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2887-08.2008 · Cited by 118
Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder
Keck, M. E., Kern, N., Erhardt, A., Unschuld, P. G., Ising, M., Salyakina, D., Müller, M. B., Knorr, C. C., Lieb, R., Hohoff, C., et al. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30750 · Cited by 117
Self-citation
Peptides that fine-tune the serotonin system
Valentino, R. J., & Commons, K. G. (2004) · Neuropeptides · doi:10.1016/j.npep.2004.09.005 · Cited by 111
Conditional corticotropin-releasing hormone overexpression in the mouse forebrain enhances rapid eye movement sleep
Kimura, M., Müller-Preuss, P., Lu, A., Wiesner, E., Flachskamm, C., Wurst, W., Holsboer, F., & Deussing, J. M. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.46 · Cited by 111
Self-citation
Prolonged and site-specific over-expression of corticotropin-releasing factor reveals differential roles for extended amygdala nuclei in emotional regulation
Regev, L., Neufeld-Cohen, A., Tsoory, M., Kuperman, Y., Getselter, D., Gil, S., & Chen, A. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.64 · Cited by 110
Sex-specific association between the 5-HTT gene-linked polymorphic region and basal cortisol secretion
Wüst, S., Kumsta, R., Treutlein, J., Frank, J., Entringer, S., Schulze, T. G., & Rietschel, M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.01.011 · Cited by 110
Sex differences in stress-related receptors: ″micro″ differences with ″macro″ implications for mood and anxiety disorders
Bangasser, D. A. (2013) · Biology of Sex Differences · doi:10.1186/2042-6410-4-2 · Cited by 110
Self-citation
Immunocytochemical localization of CRF in the ovine hypothalamus
Paull, W. K., Schöler, J., Arimura, A., Meyers, C. A., Chang, J. K., Chang, D.-M., & Shimizu, M. (1982) · Peptides · doi:10.1016/0196-9781(82)90049-3 · Cited by 109
Early‐life stress‐induced anxiety‐related behavior in adult mice partially requires forebrain corticotropin‐releasing hormone receptor 1
Wang, X., Labermaier, C., Holsboer, F., Wurst, W., Deussing, J. M., Müller, M. B., & Schmidt, M. V. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08148.x · Cited by 108
Self-citation
Distribution of corticotropin-releasing factor receptors in primate brain.
Millan, M. A., Jacobowitz, D. M., Hauger, R. L., Catt, K. J., & Aguilera, G. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.6.1921 · Cited by 107
The Anteroventral Bed Nucleus of the Stria Terminalis Differentially Regulates Hypothalamic-Pituitary-Adrenocortical Axis Responses to Acute and Chronic Stress
Choi, D. C., Evanson, N. K., Furay, A. R., Ulrich‐Lai, Y. M., Ostrander, M. M., & Herman, J. P. (2007) · Endocrinology · doi:10.1210/en.2007-0883 · Cited by 106
Genome‐wide linkage analyses of extended Utah pedigrees identifies loci that influence recurrent, early‐onset major depression and anxiety disorders
Camp, N. J., Lowry, M. R., Richards, R. L., Plenk, A. M., Carter, C., Hensel, C. H., Abkevich, V., Skolnick, M. H., Shattuck, D., Rowe, K. G., et al. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30177 · Cited by 106
Increased vulnerability of the brain norepinephrine system of females to corticotropin-releasing factor overexpression
Bangasser, D. A., Reyes, B. A. S., Piel, D., Garachh, V., Zhang, X.-Y., Plona, Z., Bockstaele, E. J. V., Beck, S. G., & Valentino, R. J. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.24 · Cited by 106
Self-citation
Widespread tissue distribution and diverse functions of corticotropin-releasing factor and related peptides
Boorse, G. C., & Denver, R. J. (2006) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2005.11.014 · Cited by 104
Enriched environment treatment reverses depression-like behavior and restores reduced hippocampal neurogenesis and protein levels of brain-derived neurotrophic factor in mice lacking its expression through promoter IV
Jha, S., Dong, B. E., & Sakata, K. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.33 · Cited by 102
Corticotropin-releasing factor elicits naloxone sensitive stress-like alterations in exploratory behavior in mice
Berridge, C. W., & Dunn, A. J. (1986) · Regulatory Peptides · doi:10.1016/0167-0115(86)90196-5 · Cited by 98
Corticotropin-releasing factor, vasopressin and receptor systems in depression and anxiety
Keck, M. E. (2006) · Amino Acids · doi:10.1007/s00726-006-0333-y · Cited by 95
Transient Early-Life Forebrain Corticotropin-Releasing Hormone Elevation Causes Long-Lasting Anxiogenic and Despair-Like Changes in Mice
Kolber, B. J., Boyle, M. P., Wieczorek, L., Kelley, C. L., Onwuzurike, C., Nettles, S. A., Vogt, S. K., & Muglia, L. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4470-09.2010 · Cited by 95
Species and sex differences in brain distribution of corticotropin‐releasing factor receptor subtypes 1 and 2 in monogamous and promiscuous vole species
Lim, M. M., Nair, H. P., & Young, L. J. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20532 · Cited by 95 · cited 14×
“The CRF2 receptors are located in brain as the CRF2(a) isoform (Lovenberg et al., 1995), in a variety of subcortical areas including amygdala, BNST, raphé nuclei, hypothalamus, and pituitary.”
BackgroundInfluential
Life stress and family history for depression: The moderating role of past depressive episodes
Monroe, S. M., Slavich, G. M., & Gotlib, I. H. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.11.005 · Cited by 93
Site-Specific Genetic Manipulation of Amygdala Corticotropin-Releasing Factor Reveals Its Imperative Role in Mediating Behavioral Response to Challenge
Regev, L., Tsoory, M., Gil, S., & Chen, A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.036 · Cited by 93
The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats
Jutkiewicz, E. M., Wood, S. K., Houshyar, H., Hsin, L., Rice, K. C., & Woods, J. H. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2164-z · Cited by 92
Self-citation
Urocortin 2-Deficient Mice Exhibit Gender-Specific Alterations in Circadian Hypothalamus–Pituitary–Adrenal Axis and Depressive-Like Behavior
Chen, A., Zorrilla, E. P., Smith, S., Rousso, D. L., Levy, C. L., Vaughan, J. M., Donaldson, C., Roberts, A. L., Lee, K., & Vale, W. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3955-05.2006 · Cited by 91
Overexpression of corticotropin‐releasing hormone in transgenic mice and chronic stress‐like autonomic and physiological alterations
Dirks, A., Groenink, L., Bouwknecht, J. A., Hijzen, T. H., van der Gugten, J., Ronken, E., Verbeek, J. S., Veening, J. G., Dederen, P. J. W. C., Kőrösi, A., et al. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02245.x · Cited by 91
Agonist‐induced internalization of corticotropin‐releasing factor receptors in noradrenergic neurons of the rat locus coeruleus
Reyes, B. A. S., Fox, K. M., Valentino, R. J., & Bockstaele, E. J. V. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04820.x · Cited by 90
Localization of urocortin messenger RNA in rat brain and pituitary.
Wong, M., Alshekhlee, A., Bongiorno, P. B., Esposito, A., Khatri, P., Sternberg, E. M., Pw, G., & Licinio, J. (1996) · PubMed · Cited by 90

Sorted by citations

Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model
Price, R. B., & Duman, R. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0615-x · Cited by 739
Sex differences in stress regulation of arousal and cognition
Bangasser, D. A., Eck, S. R., Telenson, A. M., & Salvatore, M. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.09.025 · Cited by 133
Self-citation
Hypothalamic-pituitary-adrenal (HPA) axis functioning as predictor of antidepressant response - meta-analysis
Fischer, S., Macare, C., & Cleare, A. J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.10.012 · Cited by 70

See all 93

Authors: Waters, R. P., Rivalan, M., Bangasser, D. A., Deussing, J. M., Ising, M., Wood, S. K., Holsboer, F., & Summers, C. H.
Affiliations: University of Mary Washington (US)
Charité – Universitätsmedizin Berlin (DE)
Temple University (US)
Max Planck Institute of Psychiatry (DE)
University of South Carolina (US)
HolsboerMaschmeyer NeuroChemie (Germany) (DE)
University of South Dakota (US)
Corresponding author: Waters, R. Parrish
Rivalan, Marion
Summers, Cliff H.
ORCID: Waters, R. Parrish
Rivalan, Marion
Bangasser, D.A.
Deussing, J.M.
Ising, M.
Wood, S.K.
Summers, Cliff H.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2015-11
Volume: 58
Pages: 63-78
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2015.07.011
PMC: PMC4828243
OpenAlex: W1133363097
Cited by: 93
References: 268
Citations by year: 2026: 8 · 2025: 5 · 2024: 9 · 2023: 9 · 2022: 3 · 2021: 6 · 2020: 7 · 2019: 9 · 2018: 15 · 2017: 14 · 2016: 8
FWCI: 0.98
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Funders: National Institute of Mental Health (R15MH104485)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: major depressive disorder, corticotropin-releasing factor, CRF1 receptor, genetic risk, stress response, transgenic rodent models, depression treatment, depression detection
MeSH terms: CRF Receptor, Type 1, Corticotropin-Releasing Hormone, Major Depressive Disorder, Humans, Receptors, Corticotropin-Releasing Hormone

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Evidence for the role of corticotropin-releasing factor in major depressive disorder

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks