Cited by 151Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesSubstance Abuse Treatment and Outcomes

Neural responses to acute cocaine administration in the human brain detected by fMRI

Kufahl, Peter R., Li, Zhu, Risinger, Robert C., Rainey, Charles J., Wu, Gaohong, Bloom, Alan S., Li, Shi-Jiang·2005·NeuroImage

Abstract

An improved functional MRI (fMRI) method for the reduction of susceptibility artifacts has been utilized to measure blood oxygen level-dependent (BOLD) responses to acute cocaine administration in the human brain of cocaine users. Intravenous administration of cocaine (20 mg/70 kg) activated mesolimbic and mesocortical dopaminergic projection regions and showed temporal positive or negative BOLD responses. These results obtained from human cocaine users supported the involvement of the dopaminergic pathway in cocaine addiction from animal models. In addition, the cocaine administration also induced activations in the hierarchical brain networks in the anterior prefrontal cortex (aPFC) of the Brodmann area 10 (BA10) and orbitofrontal cortex (OFC). It is suggested that the dopaminergic pathways and the hierarchical brain networks may participate in mediating cocaine reward processes, associative learning, motivation, and memory in cocaine addiction in the human brain.

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Crossref · 10.1016/j.neuroimage.2005.06.039

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  • Drugs of abuse such as cocaine stimulate dopamine pathways in similar brain regions.

    “Likewise, drugs of abuse such as cocaine stimulate DA pathways in similar brain regions (Kufahl et al., 2005).”

    From The maternal brain and its plasticity in humans (2016) · cites this paper as Kufahl et al., 2005

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Authors
Kufahl, P. R., Li, Z., Risinger, R. C., Rainey, C. J., Wu, G., Bloom, A. S., & Li, S.-J.
Affiliations
Medical College of Wisconsin (US)
Corresponding author
Li, Shi-Jiang
ORCID
Li, Zhu
Venue
NeuroImage
Publisher
Elsevier BV
Published
2005-12
Volume
28
Issue
4
Pages
904-914
ISSN
1053-8119 (ISSN-L)
OpenAlex
W2118569540
Cited by
151
References
66
Citations by year
2025: 1 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 8 · 2017: 5 · 2016: 9 · 2015: 5 · 2014: 14 · 2013: 11 · 2012: 11
FWCI
3.27
Type
journal article
Language
en
Open access
closed
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Drug Abuse (DA10214, R01DA010214)
  • National Center for Research Resources (RR00058, M01RR000058)
  • NIH Clinical Center
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords
cocaine, acute cocaine administration, BOLD signal, mesolimbic dopamine system, mesocortical dopamine pathway, anterior prefrontal cortex, orbitofrontal cortex, cocaine dependence, cocaine reward, associative learning, motivation, memory
MeSH terms
Adult, Algorithms, Behavior, Blood Pressure, Brain, Brain Mapping, Cerebral Cortex, Cocaine, Dopamine, Female, Heart Rate, Humans, Image Processing, Computer-Assisted, Infusions, Intravenous, Limbic System, Male, Oxygen, Echo-Planar Imaging, Cocaine-Related Disorders

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