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Abnormal functional connectivity of default mode sub-networks in autism spectrum disorder patients
Open accessAbstract
Autism spectrum disorders (ASDs) are characterized by deficits in social and communication processes. Recent data suggest that altered functional connectivity (FC), i.e. synchronous brain activity, might contribute to these deficits. Of specific interest is the FC integrity of the default mode network (DMN), a network active during passive resting states and cognitive processes related to social deficits seen in ASD, e.g. Theory of Mind. We investigated the role of altered FC of default mode sub-networks (DM-SNs) in 16 patients with high-functioning ASD compared to 16 matched healthy controls of short resting fMRI scans using independent component analysis (ICA). ICA is a multivariate data-driven approach that identifies temporally coherent networks, providing a natural measure of FC. Results show that compared to controls, patients showed decreased FC between the precuneus and medial prefrontal cortex/anterior cingulate cortex, DMN core areas, and other DM-SNs areas. FC magnitude in these regions inversely correlated with the severity of patients' social and communication deficits as measured by the Autism Diagnostic Observational Schedule and the Social Responsiveness Scale. Importantly, supplemental analyses suggest that these results were independent of treatment status. These results support the hypothesis that DM-SNs under-connectivity contributes to the core deficits seen in ASD. Moreover, these data provide further support for the use of data-driven analysis with resting-state data for illuminating neural systems that differ between groups. This approach seems especially well suited for populations where compliance with and performance of active tasks might be a challenge, as it requires minimal cooperation.
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In the citing paper
“evidence for differences in connectivity between distant brain regions in children with ASD (Abrams et al., 2013; Assaf et al., 2010; Maximo et al., 2014; Plitt et al., 2015) would also suggest a propensity towards multisensory deficits”
From Behavioral, Perceptual, and Neural Alterations in Sensory and Multisensory Function in Autism Spectrum Disorder (2015) · cites this paper as Assaf et al., 2010
In the citing paper
“the magnitude of connection strength between DMN nodes is inversely correlated with the severity of social and communication difficulties (Assaf et al., 2010)”
From Behavioral, Perceptual, and Neural Alterations in Sensory and Multisensory Function in Autism Spectrum Disorder (2015) · cites this paper as Assaf et al., 2010
In the citing paper
“In fact, several recent imaging studies on resting-state functional connectivity and DTI confirm disruptive neural activation dynamics in ASD within the vmPFC–VS–amygdala circuitry [78-81].”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [78]
In the citing paper
“Activation in the DMN during this phase of the game is posited to occur due to mentalizing processes (e.g., trying to infer the opponent's strategy) as well as future planning (e.g., what chip to play next) and is measured by the show>no-show contrast [Assaf et al., 2010[Assaf et al., , 2009b]].”
From Specific default mode subnetworks support mentalizing as revealed through opposing network recruitment by social and semantic FMRI tasks: Mentalizing and Default-Mode Subnetworks (2015) · cites this paper as Assaf et al., 2010
In the citing paper
“This contrasts with earlier studies of resting state fMRI using low-order sICA (<= 30 components) where the DMN (excluding the temporal poles) was typically encompassed by only two to three ICNs [Assaf et al., 2010;Calhoun et al., 2008], or in some cases, by only a single ICN [Franco et al., 2009;Meindl et al., 2010;Patel et al., 2013].”
From Specific default mode subnetworks support mentalizing as revealed through opposing network recruitment by social and semantic FMRI tasks: Mentalizing and Default-Mode Subnetworks (2015) · cites this paper as Assaf et al., 2010
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Metadata
- Authors
- Assaf, M., Jagannathan, K., Calhoun, V. D., Miller, L., Stevens, M. C., Sahl, R., O'Boyle, J. G., Schultz, R. T., & Pearlson, G. D.
- Affiliations
- Hartford Hospital (US)
- Children's Hospital of Philadelphia (US)
- Corresponding author
- Assaf, Michal
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 53
- Issue
- 1
- Pages
- 247-256
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC3058935
- OpenAlex
- W2063167566
- Cited by
- 680
- References
- 71
- Citations by year
- 2026: 28 · 2025: 37 · 2024: 33 · 2023: 28 · 2022: 39 · 2021: 52 · 2020: 52 · 2019: 60 · 2018: 53 · 2017: 39 · 2016: 41 · 2015: 47 · 2014: 47 · 2013: 46 · 2012: 43
- FWCI
- 23.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Autism Speaks
- National Institute of Biomedical Imaging and Bioengineering (R01EB000840, R01EB020407, R01EB006841)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, default mode network, functional connectivity, resting-state fMRI, independent component analysis, precuneus, medial prefrontal cortex, anterior cingulate cortex, theory of mind, high-functioning autism
- MeSH terms
- Adolescent, Brain, Child, Child Development Disorders, Pervasive, Female, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Nerve Net, Neural Pathways, Sensitivity and Specificity, Reproducibility of Results, Young Adult
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