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Cited by 209Neural and Behavioral Psychology StudiesCognitive Abilities and TestingNeurobiology of Language and Bilingualism

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Common and unique components of inhibition and working memory: An fMRI, within-subjects investigation

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McNab, Fiona, Leroux, Gaëlle, Strand, Fredrik, Thorell, Lisa, Bergman, Sissela, Klingberg, Torkel·2008·Neuropsychologia
DOI 10.1016/j.neuropsychologia.2008.04.023
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Abstract

Behavioural findings indicate that the core executive functions of inhibition and working memory are closely linked, and neuroimaging studies indicate overlap between their neural correlates. There has not, however, been a comprehensive study, including several inhibition tasks and several working memory tasks, performed by the same subjects. In the present study, 11 healthy adult subjects completed separate blocks of 3 inhibition tasks (a stop task, a go/no-go task and a flanker task), and 2 working memory tasks (one spatial and one verbal). Activation common to all 5 tasks was identified in the right inferior frontal gyrus, and, at a lower threshold, also the right middle frontal gyrus and right parietal regions (BA 40 and BA 7). Left inferior frontal regions of interest (ROIs) showed a significant conjunction between all tasks except the flanker task. The present study could not pinpoint the specific function of each common region, but the parietal region identified here has previously been consistently related to working memory storage and the right inferior frontal gyrus has been associated with inhibition in both lesion and imaging studies. These results support the notion that inhibitory and working memory tasks involve common neural components, which may provide a neural basis for the interrelationship between the two systems.

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Metadata

Authors
McNab, F., Leroux, G., Strand, F., Thorell, L., Bergman, S., & Klingberg, T.
Affiliations
  • Karolinska Institutet (SE)
  • Uppsala University (SE)
Corresponding author
Klingberg, Torkel
ORCID
Venue
Neuropsychologia
Publisher
Elsevier BV
Published
2008-09
Volume
46
Issue
11
Pages
2668-2682
ISSN
0028-3932 (ISSN-L)
DOI
10.1016/j.neuropsychologia.2008.04.023
OpenAlex
W2122215233
Cited by
209
References
16
Citations by year
2026: 3 · 2025: 7 · 2024: 6 · 2023: 11 · 2022: 8 · 2021: 8 · 2020: 11 · 2019: 16 · 2018: 9 · 2017: 11 · 2016: 15 · 2015: 17 · 2014: 17 · 2013: 18 · 2012: 14
FWCI
6.56
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuropsychologia (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • UCL Discovery (University College London) (submittedVersion)
Funders
Knut och Alice Wallenbergs Stiftelse
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
Keywords
inhibition, working memory, executive function, stop-signal task, go/no-go task, flanker task, spatial working memory, verbal working memory, right inferior frontal gyrus, right parietal cortex
MeSH terms
Adult, Brain, Brain Mapping, Choice Behavior, Female, Humans, Image Processing, Computer-Assisted, Inhibition, Psychological, Magnetic Resonance Imaging, Male, Memory, Short-Term, Neuropsychological Tests, Oxygen, Verbal Behavior

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