Perceived social support moderates the link between threat-related amygdala reactivity and trait anxiety
Open accessAbstract
Several lines of research have illustrated that negative environments can precipitate psychopathology, particularly in the context of relatively increased biological risk, while social resources can buffer the effects of these environments. However, little research has examined how social resources might buffer proximal biological risk for psychopathology or the neurobiological pathways through which such buffering may be mediated. Here we report that the expression of trait anxiety as a function of threat-related amygdala reactivity is moderated by perceived social support, a resource for coping with adversity. A significant positive correlation between amygdala reactivity and trait anxiety was evident in individuals reporting below average levels of support but not in those reporting average or above average levels. These results were consistent across multiple measures of trait anxiety and were specific to anxiety in that they did not extend to measures of broad negative or positive affect. Our findings illuminate a biological pathway, namely moderation of amygdala-related anxiety, through which social support may confer resilience to psychopathology. Moreover, our results indicate that links between neural reactivity and behavior are not static but rather may be contingent on social resources.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Fewer studies have demonstrated relations between perceived social support and anxiety, but observed effects parallel findings with depression.
“Fewer studies have demonstrated these relations with anxiety as well, but the observed effects parallel the findings with depression.16–20”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433 · see citing works
Stress, social support, and the buffering hypothesis
Cohen, S., & Wills, T. A. (1985) · Psychological Bulletin · doi:10.1037/0033-2909.98.2.310 · Cited by 18,093 · cited 2× · see citing works
“…neighbors, community members) that are available in times of need and can provide resources such as emotional support (someone to communicate with), companionship (someone to spend time and share activities with), and instrumental aid (financial and material resources; Cohen & Wills, 1985).”
BackgroundMethodOrdinary magic: Resilience processes in development.
Masten, A. S. (2001) · American Psychologist · doi:10.1037/0003-066x.56.3.227 · Cited by 8,497 · cited 2× · see citing works
“Partly in response to the work emphasizing the harmful psychological effects of negative environments, resiliency research has explored factors that may buffer against negative environments and biological risk leading to positive outcomes even in unfavorable environments (Cohen & Hoberman, 1983; Masten, 2001; Masten &…”
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · cited 3× · see citing works
“…of stressful or adverse circumstances in precipitating psychopathology, particularly in relation to individual differences in personality, brain function, and genetic predisposition (Caspi, Hariri, Holmes, Uher, & Moffitt, 2010; Caspi et al., 2003; Costello et al., 2002; Monroe & Simons, 1991).”
BackgroundA psychobiological model of temperament and character
Cloninger, C. R. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820240059008 · Cited by 5,458 · see citing works
Preacher, K. J., Curran, P. J., & Bauer, D. J. (2006) · Journal of Educational and Behavioral Statistics · doi:10.3102/10769986031004437 · Cited by 5,044 · cited 1× · see citing works
“By using interaction methods described above (Preacher et al., 2006), we were able to determine at what values of social support the relationship between left dorsal amygdala reactivity and the latent construct of anxiety became significant.”
MethodRole of genotype in the cycle of violence in maltreated children
Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton, R. (2002) · Science · doi:10.1126/science.1072290 · Cited by 4,842 · cited 2× · see citing works
“, genetic polymorphisms) do not uniformly affect behavior in the form of increased risk for psychopathology (Caspi et al., 2002; Caspi et al., 2003), the current study emphasizes that similarly meaningful interactions may occur at the level of more proximate biology (i.”
BackgroundEkman, P. (1976) · Medical Entomology and Zoology · Cited by 4,345 · see citing works
Masten, A. S., & Coatsworth, J. D. (1998) · American Psychologist · doi:10.1037//0003-066x.53.2.205 · Cited by 3,334 · see citing works
Hammen, C. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143938 · Cited by 2,979 · cited 2× · see citing works
“In general, epidemiological studies have reported increased risk for psychopathology, particularly mood and anxiety disorders, in individuals having encountered a variety of adverse or stressful situations including childhood maltreatment, violent crime, divorce, unemployment, and medical illness (Hammen, 2005; Kendle…”
BackgroundPositive Events and Social Supports as Buffers of Life Change Stress <sup>1</sup>
Cohen, S., & Hoberman, H. M. (1983) · Journal of Applied Social Psychology · doi:10.1111/j.1559-1816.1983.tb02325.x · Cited by 2,675 · see citing works
Causal Relationship Between Stressful Life Events and the Onset of Major Depression
Kendler, K. S., Karkowski, L. M., & Prescott, C. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.6.837 · Cited by 2,486 · cited 1× · see citing works
“Phone: 011-412-624-4332.”
Masten, A. S., & Coatsworth, J. D. (1998) · American Psychologist · doi:10.1037/0003-066x.53.2.205 · Cited by 2,438 · cited 1× · see citing works
“…psychological effects of negative environments, resiliency research has explored factors that may buffer against negative environments and biological risk leading to positive outcomes even in unfavorable environments (Cohen & Hoberman, 1983; Masten, 2001; Masten & Coatsworth, 1998; Rutter, 2006).”
BackgroundMcCrae, R. R., & Costa, P. T. (2010) · Medical Entomology and Zoology · Cited by 2,345 · see citing works
The temperament and character inventory (TCI) : a guide to its development and use
Cloninger, C. R. (1994) · Medical Entomology and Zoology · Cited by 2,319 · see citing works
Monroe, S. M., & Simons, A. D. (1991) · Psychological Bulletin · doi:10.1037/0033-2909.110.3.406 · Cited by 2,143 · cited 2× · see citing works
“…of stressful or adverse circumstances in precipitating psychopathology, particularly in relation to individual differences in personality, brain function, and genetic predisposition (Caspi, Hariri, Holmes, Uher, & Moffitt, 2010; Caspi et al., 2003; Costello et al., 2002; Monroe & Simons, 1991).”
BackgroundDomains and Facets: Hierarchical Personality Assessment Using the Revised NEO Personality Inventory
Costa, P. T., & McCrae, R. R. (1995) · Journal of Personality Assessment · doi:10.1207/s15327752jpa6401_2 · Cited by 2,080 · see citing works
Public health significance of neuroticism
Lahey, B. B. (2009) · American Psychologist · doi:10.1037/a0015309 · Cited by 1,901 · cited 2× · see citing works
“…study we asked if perceived social support, a resource for coping with adversity, moderates the link between amygdala reactivity to threat-related cues and the expression of trait anxiety, a well-established personality risk factor for psychopathology (Kendler, Kuhn, & Prescott, 2004; Lahey, 2009).”
BackgroundPsychological Stress and Susceptibility to the Common Cold
Cohen, S., Tyrrell, D. A. J., & Smith, A. P. (1991) · New England Journal of Medicine · doi:10.1056/nejm199108293250903 · Cited by 1,712 · see citing works
Implications of resilience concepts for scientific understanding
RUTTER, M. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1376.002 · Cited by 1,648 · cited 2× · see citing works
“Partly in response to the work emphasizing the harmful psychological effects of negative environments, resiliency research has explored factors that may buffer against negative environments and biological risk leading to positive outcomes even in unfavorable environments (Cohen & Hoberman, 1983; Masten, 2001; Masten &…”
BackgroundNeurocircuitry of Mood Disorders
Price, J. L., & Drevets, W. C. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.104 · Cited by 1,606 · see citing works
Caspi, A., Hariri, A. R., Holmes, A., Uher, R., & Moffitt, T. E. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09101452 · Cited by 1,346 · see citing works
Siegle, G. J., Steinhauer, S. R., Thase, M. E., Stenger, V. A., & Carter, C. S. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01314-8 · Cited by 859 · see citing works
Increased Amygdala and Insula Activation During Emotion Processing in Anxiety-Prone Subjects
Stein, M. B., Simmons, A. N., Feinstein, J. S., & Paulus, M. P. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.2.318 · Cited by 851 · cited 2× · see citing works
“Specifically, the commonly observed positive correlation between threat-related amygdala reactivity and anxiety (Dickie & Armony, 2008; Etkin et al., 2004; Fakra et al., 2009; Haas et al., 2007; Hariri, 2009; Killgore & Yurgelun-Todd, 2005; Most et al., 2006; Ray et al., 2005; Stein et al., 2007) was absent in individ…”
BackgroundKendler, K. S., Kuhn, J., & Prescott, C. A. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.4.631 · Cited by 799 · see citing works
Etkin, A., Klemenhagen, K. C., Dudman, J. T., Rogan, M. T., Hen, R., Kandel, E. R., & Joy Hirsch, C. (2004) · Neuron · doi:10.1016/j.neuron.2004.12.006 · Cited by 679 · cited 3× · see citing works
“…between trait anxiety and amygdala reactivity is particularly robust and seen across many different studies and approaches (Dickie & Armony, 2008; Etkin et al., 2004; Fakra et al., 2009; Haas, Omura, Constable, & Canli, 2007; Hariri, 2009; Killgore & Yurgelun-Todd, 2005; Most, Chun, Johnson, &…”
BackgroundSocial support as a contingency in psychological well-being
Turner, R. J. (1981) · Journal of Health and Social Behavior · doi:10.2307/2136677 · Cited by 633 · cited 2× · see citing works
“Social support has been shown to buffer the relationship between negative life events and depressive symptomatology (Cohen & Hoberman, 1983; Cohen, McGowan, Fooskas, & Rose, 1984), and has been associated broadly with well-being and health, both directly and as a buffer against stressful circumstances (Turner, 1981).”
BackgroundPhan, K. L., Fitzgerald, D. A., Nathan, P. J., & Tancer, M. E. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.012 · Cited by 539 · see citing works
Development and natural history of mood disorders
Costello, E. J., Pine, D. S., Hammen, C., March, J. S., Plotsky, P. M., Weissman, M. M., Biederman, J., Goldsmith, H. H., Kaufman, J., Lewinsohn, P. M., et al. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01372-0 · Cited by 430 · cited 2× · see citing works
“…of stressful or adverse circumstances in precipitating psychopathology, particularly in relation to individual differences in personality, brain function, and genetic predisposition (Caspi, Hariri, Holmes, Uher, & Moffitt, 2010; Caspi et al., 2003; Costello et al., 2002; Monroe & Simons, 1991).”
BackgroundHuman Bed Nucleus of the Stria Terminalis Indexes Hypervigilant Threat Monitoring
Somerville, L. H., Whalen, P. J., & Kelley, W. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.04.002 · Cited by 351 · see citing works
Monk, C. S., Klein, R. G., Telzer, E. H., Schroth, E. A., Mannuzza, S., Moulton, J. L., Guardino, M., Masten, C. L., McClure-Tone, E. B., Fromm, S., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06111917 · Cited by 335 · cited 2× · see citing works
“depression (Monk et al., 2008; Siegle, Steinhauer, Thase, Stenger, & Carter, 2002), and therefore represents a well researched biological risk factor for negative psychological outcomes.”
BackgroundIndividual differences in trait rumination and the neural systems supporting cognitive reappraisal
RAY, R. D., OCHSNER, K. N., COOPER, J. C., ROBERTSON, E. R., GABRIELI, J. D. E., & GROSS, J. J. (2005) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.5.2.156 · Cited by 316 · cited 4× · see citing works
“Specifically, the commonly observed positive correlation between threat-related amygdala reactivity and anxiety (Dickie & Armony, 2008; Etkin et al., 2004; Fakra et al., 2009; Haas et al., 2007; Hariri, 2009; Killgore & Yurgelun-Todd, 2005; Most et al., 2006; Ray et al., 2005; Stein et al., 2007) was absent in individ…”
BackgroundInfluentialThe neurobiology of individual differences in complex behavioral traits
Hariri, A. R. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135335 · Cited by 273 · cited 6× · see citing works
“N IH -PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript et al., 2007; Hariri, 2009; Killgore & Yurgelun-Todd, 2005; Most et al., 2006; Ray et al., 2005; Stein et al., 2007) was absent in individuals reporting average or above average levels of social support.”
BackgroundInfluentialHariri, A. R., Gorka, A. X., Hyde, L. W., Kimak, M. A., Halder, I., Ducci, F., Ferrell, R. E., Goldman, D. A., & Manuck, S. B. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.10.047 · Cited by 250 · cited 2× · see citing works
“…paradigm which elicits robust bilateral amygdala reactivity to threat-related cues (Bigos et al., 2008; Brown et al., 2005; Fakra et al., 2009; Fisher et al., 2009; Fisher, Meltzer, Ziolko, Price, & Hariri, 2006; Hariri et al., 2009; Manuck, Brown, Forbes, & Hariri, 2007; Manuck et al., 2010).”
BackgroundMethodHaas, B. W., Omura, K., Constable, R. T., & Canli, T. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.2.249 · Cited by 242 · see citing works
A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity
Brown, S. M., Peet, E., Manuck, S. B., Williamson, D. E., Dahl, R. E., Ferrell, R. E., & Hariri, A. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001716 · Cited by 241 · see citing works
Acute 5-HT Reuptake Blockade Potentiates Human Amygdala Reactivity
Bigos, K. L., Pollock, B. G., Aizenstein, H. J., Fisher, P. M., Bies, R. R., & Hariri, A. R. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.52 · Cited by 164 · cited 1× · see citing works
“…We used a well-characterized and widely used fMRI challenge paradigm which elicits robust bilateral amygdala reactivity to threat-related cues (Bigos et al., 2008; Brown et al., 2005; Fakra et al., 2009; Fisher et al., 2009; Fisher, Meltzer, Ziolko, Price, & Hariri, 2006; Hariri et al., 2009;…”
MethodEffects of HTR1A C(−1019)G on Amygdala Reactivity and Trait Anxiety
Fakra, E., Hyde, L. W., Gorka, A., Fisher, P. M., Muñoz, K. E., Kimak, M., Halder, I., Ferrell, R. E., Manuck, S. B., & Hariri, A. R. (2009) · Archives of General Psychiatry · doi:10.1001/archpsyc.66.1.33 · Cited by 159 · cited 8× · see citing works
“The link between trait anxiety and amygdala reactivity is particularly robust and seen across many different studies and approaches (Dickie & Armony, 2008; Etkin et al., 2004; Fakra et al., 2009; Haas, Omura, Constable, & Canli, 2007; Hariri, 2009; Killgore & Yurgelun-Todd, 2005; Most, Chun, Johnson, & Kiehl, 2006; Ra…”
BackgroundMethodInfluentialCohen, L. H., McGowan, J., Fooskas, S., & Rose, S. C. (1984) · American Journal of Community Psychology · doi:10.1007/bf00897213 · Cited by 156 · cited 3× · see citing works
“Although some literature indicates that perceptions of these resources are more important than objective measures, particularly in the context of buffering risk for negative outcomes (Cohen et al., 1984), it would have been helpful to have had additional objective measures of social support such as reports from other…”
BackgroundInfluentialCapacity for 5-HT1A–mediated autoregulation predicts amygdala reactivity
Fisher, P. M., Meltzer, C. C., Ziolko, S. K., Price, J. C., Moses-Kolko, E. L., Berga, S. L., & Hariri, A. R. (2006) · Nature Neuroscience · doi:10.1038/nn1780 · Cited by 156 · see citing works
Self-citationAttentional modulation of the amygdala varies with personality
Most, S. B., Chun, M. M., Johnson, M. R., & Kiehl, K. A. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.12.031 · Cited by 135 · see citing works
Social anxiety predicts amygdala activation in adolescents viewing fearful faces
Killgore, W. D. S., & Yurgelun-Todd, D. A. (2005) · Neuroreport · doi:10.1097/01.wnr.0000180143.99267.bd · Cited by 135 · see citing works
Fisher, P. M., Meltzer, C. C., Price, J. C., Coleman, R. L., Ziolko, S. K., Becker, C., Moses-Kolko, E. L., Berga, S. L., & Hariri, A. R. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp022 · Cited by 125 · cited 2× · see citing works
“…paradigm which elicits robust bilateral amygdala reactivity to threat-related cues (Bigos et al., 2008; Brown et al., 2005; Fakra et al., 2009; Fisher et al., 2009; Fisher, Meltzer, Ziolko, Price, & Hariri, 2006; Hariri et al., 2009; Manuck, Brown, Forbes, & Hariri, 2007; Manuck et al., 2010).”
BackgroundMethodManuck, S. B., Marsland, A. L., Flory, J. D., Gorka, A. X., Ferrell, R. E., & Hariri, A. R. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.04.013 · Cited by 114 · cited 6× · see citing works
“…paradigm which elicits robust bilateral amygdala reactivity to threat-related cues (Bigos et al., 2008; Brown et al., 2005; Fakra et al., 2009; Fisher et al., 2009; Fisher, Meltzer, Ziolko, Price, & Hariri, 2006; Hariri et al., 2009; Manuck, Brown, Forbes, & Hariri, 2007; Manuck et al., 2010).”
BackgroundResultInfluentialTemporal stability of individual differences in amygdala reactivity
MANUCK, S. B., BROWN, S. M., FORBES, E. E., & HARIRI, A. R. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07040609 · Cited by 111 · see citing works
Amygdala responses to unattended fearful faces: Interaction between sex and trait anxiety
Dickie, E. W., & Armony, J. L. (2008) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.08.002 · Cited by 101 · see citing works
Regional Response Differences Across the Human Amygdaloid Complex during Social Conditioning
Davis, F. C., Johnstone, T., Mazzulla, E. C., Oler, J. A., & Whalen, P. J. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp126 · Cited by 101 · see citing works
There Is No "Right Answer": Comment on McDowell.
Cohen, I. L. (1984) · American Psychologist · doi:10.1037/0003-066x.39.5.567b · Cited by 53 · see citing works
Unbiased ROI selection in neuroimaging studies of individual differences
Viviani, R. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.10.085 · Cited by 30 · cited 1× · see citing works
“Hence, we avoided any possibility of correlations that are artificially inflated due to extraction and correlation techniques that capitalize on the same data twice (Viviani, 2010).”
Method
Flagged first, then by citations
Cited by
Sorted by citations
Individual Differences in Environmental Sensitivity
Pluess, M. (2015) · Child Development Perspectives · doi:10.1111/cdep.12120 · Cited by 556 · see citing works
What is a representative brain? Neuroscience meets population science
Falk, E. B., Hyde, L. W., Mitchell, C., Faul, J., Gonzalez, R., Heitzeg, M. M., Keating, D. P., Langa, K. M., Martz, M. E., Maslowsky, J., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310134110 · Cited by 265 · see citing works
Multilocus Genetic Profile for Dopamine Signaling Predicts Ventral Striatum Reactivity
Nikolova, Y. S., Ferrell, R. E., Manuck, S. B., & Hariri, A. R. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.82 · Cited by 267 · see citing works
Dour, H. J., Wiley, J. F., Roy-Byrne, P., Stein, M. B., Sullivan, G., Sherbourne, C. D., Bystritsky, A., Rose, R. D., & Craske, M. G. (2014) · Depression and Anxiety · doi:10.1002/da.22216 · Cited by 243 · see citing works
Servaas, M. N., van der Velde, J., Costafreda, S. G., Horton, P., Ormel, J., Riese, H., & Aleman, A. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.05.005 · Cited by 200 · see citing works
The neural signatures of distinct psychopathic traits
Carré, J. M., Hyde, L. W., Neumann, C. S., Viding, E. M., & Hariri, A. R. (2012) · Social Neuroscience · doi:10.1080/17470919.2012.703623 · Cited by 194 · see citing works
“We have successfully used this more conservative and rigorous analytic strategy in recent studies (Carré et al., in press; Hyde et al., 2011).”
Cumulative stress in childhood is associated with blunted reward-related brain activity in adulthood
Hanson, J. L., Albert, D., Iselin, A.-M. R., Carré, J. M., Dodge, K. A., & Hariri, A. R. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv124 · Cited by 185 · see citing works
White, M. G., Bogdan, R., Fisher, P. M., Muñoz, K. E., Williamson, D. E., & Hariri, A. R. (2012) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2012.00837.x · Cited by 180 · see citing works
“We have used this more conservative and rigorous analytic strategy in recent studies (Carré et al. 2010; Hyde et al. 2011).”
MethodBogdan, R., Williamson, D. E., & Hariri, A. R. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11060855 · Cited by 165 · see citing works
Swartz, J. R., Williamson, D. E., & Hariri, A. R. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14020195 · Cited by 144 · see citing works
Understanding Resilience and Preventing and Treating PTSD
Horn, S. R. G.-V., & Feder, A. (2018) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000194 · Cited by 150 · see citing works
The social brain: Neurobiological basis of affiliative behaviours and psychological well-being
Walker, S. C., & McGlone, F. P. (2013) · Neuropeptides · doi:10.1016/j.npep.2013.10.008 · Cited by 138 · see citing works
“A range of studies have demonstrated that the presence of a significant-other during an acutely stressful intervention can reduce physiological and neural responses to stress (Coan et al., 2006, 2013; Hyde et al., 2011; Connor et al., 2012; Eisenberger et al., 2007).”
BackgroundImpact of Sleep Quality on Amygdala Reactivity, Negative Affect, and Perceived Stress
Prather, A. A., Bogdan, R., & Hariri, A. R. (2013) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31828ef15b · Cited by 135 · see citing works
The Cambridge Handbook of Personality Psychology
(2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822 · Cited by 140 · see citing works
Characteristics associated with low resilience in patients with depression and/or anxiety disorders
Min, J., Jung, Y., Kim, D., Yim, H., Kim, J.-J., Kim, T., Lee, C., Lee, C., & Chae, J. (2012) · Quality of Life Research · doi:10.1007/s11136-012-0153-3 · Cited by 136 · see citing works
Ventral striatum reactivity to reward and recent life stress interact to predict positive affect
Nikolova, Y. S., Bogdan, R., Brigidi, B. D., & Hariri, A. R. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.03.014 · Cited by 130 · see citing works
Self-citationIn Search of Neural Endophenotypes of Postpartum Psychopathology and Disrupted Maternal Caregiving
Moses‐Kolko, E. L., Horner, M. S., Phillips, M. L., Hipwell, A. E., & Swain, J. E. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12183 · Cited by 129 · see citing works
Attachment-security priming attenuates amygdala activation to social and linguistic threat
Norman, L. J., Lawrence, N., Iles, A. T., Benattayallah, A., & Karl, A. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu127 · Cited by 116 · see citing works
Structural brain correlates of loneliness among older adults
Düzel, S., Drewelies, J., Gerstorf, D., Demuth, I., Steinhagen-Thiessen, E., Lindenberger, U., & Kühn, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-49888-2 · Cited by 111 · see citing works
McNaughton, N., DeYoung, C. G., & Corr, P. J. (2016) · Neuroimaging Personality, Social Cognition, and Character · doi:10.1016/b978-0-12-800935-2.00002-6 · Cited by 123 · see citing works
Understanding risk for psychopathology through imaging gene–environment interactions
Hyde, L. W., Bogdan, R., & Hariri, A. R. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.07.001 · Cited by 102 · see citing works
Hyde, L. W., Byrd, A. L., Votruba‐Drzal, E., Hariri, A. R., & Manuck, S. B. (2014) · Journal of Abnormal Psychology · doi:10.1037/a0035467 · Cited by 104 · see citing works
“Consistent with past studies (e.g., Hyde et al., 2011) gender was controlled for in all regressions given its main effect on amygdala reactivity in this sample (see Table 1).”
Hyde, L. W., Shaw, D. S., & Hariri, A. R. (2013) · Developmental Review · doi:10.1016/j.dr.2013.06.001 · Cited by 99 · see citing works
Carré, J. M., Fisher, P. M., Manuck, S. B., & Hariri, A. R. (2010) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsq101 · Cited by 96 · see citing works
“Also, the importance of contextual factors was recently highlighted in a study in which social support moderated the association between threat-related amygdala reactivity and trait anxiety (Hyde et al., 2011).”
BackgroundHur, J., Stockbridge, M. D., Fox, A. S., & Shackman, A. J. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2019.03.012 · Cited by 91 · see citing works
Neural Mechanisms Underlying 5-HTTLPR-Related Sensitivity to Acute Stress
Drabant, E. M., Ramel, W., Edge, M. D., Hyde, L. W., Kuo, J. R., Goldin, P. R., Hariri, A. R., & Gross, J. J. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10111699 · Cited by 90 · see citing works
Temperament and brain networks of attention
Posner, M. I., & Rothbart, M. K. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0254 · Cited by 87 · see citing works
Bogdan, R., Hyde, L. W., & Hariri, A. R. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.35 · Cited by 82 · see citing works
Investigating patterns of neural response associated with childhood abuse v. childhood neglect
Puetz, V. B., Viding, E. M., Gerin, M. I., Pingault, J., Sethi, A., Knodt, A. R., Radtke, S. R., Brigidi, B. D., Hariri, A. R., & McCrory, E. J. P. (2019) · Psychological Medicine · doi:10.1017/s003329171900134x · Cited by 70 · see citing works
“This approach is justified based on previous imaging research indicating that individual difference factors map onto specific regions of the amygdala (Etkin et al., 2004; Manuck et al., 2010; Hyde et al., 2011; Carré et al., 2012).”
MethodSleep quality and neural circuit function supporting emotion regulation
Minkel, J. D., McNealy, K., Gianaros, P. J., Drabant, E. M., Gross, J. J., Manuck, S. B., & Hariri, A. R. (2012) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-2-22 · Cited by 67 · see citing works
“We have used this more conservative and rigorous analytic strategy in recent studies [25,26].”
MethodWhat lies beneath the face of aggression?
Carré, J. M., Murphy, K. R., & Hariri, A. R. (2011) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr096 · Cited by 61 · see citing works
Social support, stress and the aging brain
Sherman, S. M., Cheng, Y., Fingerman, K. L., & Schnyer, D. M. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv071 · Cited by 61 · see citing works
“of social support on brain function (Eisenberger et al., 2007; Hyde et al., 2011; Bickart et al., 2012) to our knowledge only two previous studies examined the relationship between social support and brain structure in humans (Bickart et al.”
BackgroundSilverman, M. H., Wilson, S., Ramsay, I. S., Hunt, R. H., Thomas, K. M., Krueger, R. F., & Iacono, W. G. (2019) · Development and Psychopathology · doi:10.1017/s0954579419000610 · Cited by 59 · see citing works
“…activation and trait neuroticism (Brück et al., 2011; Chan et al., 2009; Cunningham et al., 2011; Haas et al., 2007; Harenski et al., 2009), a number have also reported nonsignificant results (Cremers et al., 2010; Drabant et al., 2009; Haas et al., 2008; Hyde et al., 2011; Thomas et al., 2011).”
ResultThe Epidemiology and Etiology of Adolescent Substance Use in Developmental Perspective
Schulenberg, J. E., Patrick, M. E., Maslowsky, J., & Maggs, J. L. (2014) · Springer eBooks · doi:10.1007/978-1-4614-9608-3_30 · Cited by 53 · see citing works
Genetic Moderation of Stress Effects on Corticolimbic Circuitry
Bogdan, R., Pagliaccio, D., Baranger, D. A. A., & Hariri, A. R. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.216 · Cited by 48 · see citing works
“To understand mechanisms, it will be important for well-powered iGxE to assess moderated mediation models and for collaboration across iGxE researchers and non-human animal models, while also assessing signatures of epigenetic regulation (Bogdan et al, 2013a; Hyde et al, 2011a).”
BackgroundMethodInfluentialHarnish, R. J., Bridges, K. R., Gump, J. T., & Carson, A. E. (2018) · International Journal of Mental Health and Addiction · doi:10.1007/s11469-018-9883-y · Cited by 48 · see citing works
“For example, social support has been found to reduce depression (Kendler et al. 2005) and anxiety (Hyde et al. 2011) in times of stress.”
BackgroundWang, S., & Zhang, D. (2020) · Computers in Human Behavior · doi:10.1016/j.chb.2020.106247 · Cited by 49 · see citing works
An oxytocin receptor polymorphism predicts amygdala reactivity and antisocial behavior in men
Waller, R. E., Corral-Frías, N. S., Vannucci, B., Bogdan, R., Knodt, A. R., Hariri, A. R., & Hyde, L. W. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw042 · Cited by 45 · see citing works
“Moreover, the use of genetics, an intermediate neural phenotype and self-reported social behavior in a single model allowed us to examine a full pathway from gene to brain to behavior—a mediated pathway that has been explicitly tested in very few previous studies (Hyde et al., 2011).”
BackgroundMethodThe Role of the Amygdala in Anxiety Disorders
Gina, L., Andrew, M., Jamie, L. A., & Michael, J. (2012) · InTech eBooks · doi:10.5772/50323 · Cited by 45 · see citing works
Hyde, L. W. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000188 · Cited by 45 · see citing works
A Robotic Companion for Psychological Well-being
Jeong, S., Aymerich-Franch, L., Alghowinem, S., Picard, R. W., Breazeal, C., & Park, H. W. (2023) · ACM/IEEE International Conference on Human-Robot Interaction (HRI) · doi:10.1145/3568162.3578625 · Cited by 43 · see citing works
Rapamycin blocks the antidepressant effect of ketamine in task-dependent manner
Holubová, K., Kletečková, L., Škurlová, M., Říčný, J., Stuchlı́k, A., & Valeš, K. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4256-3 · Cited by 41 · see citing works
Dupasquier, J. R., Kelly, A. C., Moscovitch, D., & Vidovic, V. (2017) · Mindfulness · doi:10.1007/s12671-017-0792-0
“Distress disclosure also predicts perceived social support, which plays an important role in protecting the individual from psychosocial stress (Heinrichs et al. 2003; Hyde et al. 2011; Kahn and Hessling 2001).”
BackgroundPidgeon, A. M., McGrath, S., Magya, H. B., Stapleton, P., & Lo, B. C. Y. (2014) · Open Journal of Social Sciences · doi:10.4236/jss.2014.211004 · Cited by 39 · see citing works
Lahey, B. B., McNealy, K., Knodt, A. R., Zald, D. H., Sporns, O., Manuck, S. B., Flory, J. D., Applegate, B. E., Rathouz, P. J., & Hariri, A. R. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.02.002 · Cited by 35 · see citing works
“…of any current DSM-IV Axis I mental disorder, as determined by clinical interview using the electronic MINI (Sheehan et al., 1998), was not an exclusion as the DNS seeks to establish broad variability in multiple behavioral phenotypes related to psychopathology (e.g., trait anxiety, impulsivity).”
MethodThe association between perceived social support and amygdala structure
Sato, W., Kochiyama, T., Kubota, Y., Uono, S., Sawada, R., Yoshimura, S., & Toichi, M. (2016) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2016.03.036 · Cited by 34 · see citing works
“A previous functional MRI study (Hyde et al., 2011) has also suggested amygdala involvement in perceived social support.”
BackgroundStevens, J. S., van Rooij, S. J. H., Stenson, A. F., Ely, T. D., Powers, A. D., Clifford, A., Kim, Y. J., Hinrichs, R. C., Tottenham, N., & Jovanović, T. (2021) · Development and Psychopathology · doi:10.1017/s0954579421001085 · Cited by 34 · see citing works
“Adult social support may have similar buffering effects, as amygdala reactivity is associated with anxiety symptoms in adults with low social support but this effect is absent in adults with high social support (Hyde et al., 2011).”
BackgroundSwartz, J. R., & Monk, C. S. (2013) · Current topics in behavioral neurosciences · doi:10.1007/7854_2013_242 · Cited by 41 · see citing works
“Hariri and Weinberger (2003) and Hyde et al. (2011a), among others, have suggested that neural function can be used as a mediator to examine the influence of genes and gene–environment interactions.”
BackgroundFuller‐Thomson, E., Jayanthikumar, J., & Agbeyaka, S. (2016) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13010 · Cited by 34 · see citing works
“In terms of social support and anxiety, it appears that social support is a protective factor against the development and expression of anxiety.(71,72) Thus, complete lack of support, as measured by lack of a confidant, is very strongly associated with GAD.”
BackgroundWarnell, K. R., Pecukonis, M., & Redcay, E. (2017) · Development and Psychopathology · doi:10.1017/s0954579417001626 · Cited by 33 · see citing works
“…hyperactivity and altered patterns of amygdala functional connectivity (e.g., Bishop, Duncan, & Lawrence, 2004; Etkin et al., 2004; Hahn et al., 2011; Hyde, Gorka, Manuck, & Hariri, 2011; Kim, Gee, Loucks, Davis, & Whalen, 2011; Sehlmeyer et al., 2011; Sripada, Wang, Sripada, & Liberzon, 2012).”
Ben‐Eliyahu, A., & Zeidner, M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.041 · Cited by 33 · see citing works
Guo, S., Fu, H., & Guo, K. (2024) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2024.1362816 · Cited by 32 · see citing works
“A robust social support system acts as a buffer against the impact of negative life events (23) and aids in maintaining mental health, recovery capacity, and reducing loneliness as well as the risk for depression (24), ultimately enhancing subjective well-being.”
BackgroundCao, Q., & Zhou, Y. (2019) · Journal of Ethnicity in Substance Abuse · doi:10.1080/15332640.2019.1657545 · Cited by 31 · see citing works
Li, Q., Liu, L., Gu, Z., Li, M., Liu, C., & Wu, H. L. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-04792-y · Cited by 30 · see citing works
“Based on the literature review, we found that variables such as perceived social support (PSS) and sense of coherence (SOC) were key research topics in this field [22, 28].”
BackgroundSynchronous activation within the default mode network correlates with perceived social support
Che, X., Zhang, Q., Zhao, J., Wei, D., Li, B., Guo, Y., Qiu, J., & Liu, Y. (2014) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2014.07.035 · Cited by 31 · see citing works
Personal Growth and Well-Being in the Time of COVID: An Exploratory Mixed-Methods Analysis
Kim, J. J., Munroe, M., Feng, Z., Morris, S., Al-Refae, M., Antonacci, R., & Ferrari, M. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.648060 · Cited by 34 · see citing works
“, 1984; Hayes and Ross, 1986; Hsieh and Waite, 2019; Park and Adler, 2003), and social support (Turner, 1981; Thoits, 1985; Portero and Oliva, 2007; Hyde et al., 2011) are known to be predictive of well-being.”
BackgroundDeYoung, C. G., & Blain, S. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.026 · Cited by 31 · see citing works
An honest reckoning with the amygdala and mental illness
Fox, A. S., & Shackman, A. (2024) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20240941 · Cited by 27 · see citing works
A multilevel approach to social support as a determinant of mental health during COVID‐19
Schulder, T., Rudenstine, S., Bhatt, K. J., McNeal, K., Ettman, C. K., & Galea, S. (2022) · Journal of Community Psychology · doi:10.1002/jcop.22832 · Cited by 27 · see citing works
“…(Ikiz & Cakar, 2010; Moreira et al., 2003; Roohafza et al., 2014; Schwarzer & Knoll, 2007; Uchino, 2004) and there is a well‐documented relationship between individual‐level social support and mental health (Hyde et al., 2011; Moreira et al., 2003; Robinaugh et al., 2011; Rueger et al., 2016).”
BackgroundScheuplein, M., & van Harmelen, A. (2022) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2022.101310 · Cited by 29 · see citing works
Nikolova, Y. S., Singhi, E. K., Drabant, E. M., & Hariri, A. R. (2013) · Genes Brain & Behavior · doi:10.1111/gbb.12035 · Cited by 26 · see citing works
“We have successfully used this conservative strategy in previous reports (Carre et al. 2012; Hyde et al. 2011; Nikolova et al. 2011, 2012).”
MethodCulture, inequality, and health: evidence from the MIDUS and MIDJA comparison
Ryff, C. D., Miyamoto, Y., Boylan, J. M., Coe, C. L., Karasawa, M., Kawakami, N., Kan, C., Love, G. D., Levine, C. S., Markus, H. R., et al. (2015) · Culture and Brain · doi:10.1007/s40167-015-0025-0 · Cited by 26 · see citing works
“These patterns were evident after adjusting for demographic factors, medication use, and a number of disease conditions.”
Amygdala activation during unconscious visual processing of food
Sato, W., Kochiyama, T., Minemoto, K., Sawada, R., & Fushiki, T. (2019) · Scientific Reports · doi:10.1038/s41598-019-43733-2 · Cited by 26 · see citing works
The mere physical presence of another person reduces human autonomic responses to aversive sounds
Qi, Y., Herrmann, M. J., Bell, L., Fackler, A., Han, S., Deckert, J., & Hein, G. (2020) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2019.2241 · Cited by 26 · see citing works
Liu, K., Yang, X., & Xin, M. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18073347 · Cited by 25 · see citing works
“On the other hand, according to the buffer model, individual health-related behaviors are affected by the situation, and social support plays the role of adjustment and buffer in this process [20].”
BackgroundFörster, K., Danzer, L., Redlich, R., Opel, N., Grotegerd, D., Leehr, E. J., Dohm, K., Enneking, V., Meinert, S. L., Goltermann, J., et al. (2021) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.200162 · Cited by 24 · see citing works
Pedersen, W. S., Balderston, N. L., Miskovich, T. A., Belleau, E. L., Helmstetter, F. J., & Larson, C. L. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw178 · Cited by 24 · see citing works
“…study found that the correlation between trait anxiety and amygdala reactivity only exists for participants who are low in perceived social support (Hyde et al., 2011), and a study using an adolescent sample found that amygdala reactivity to facial expressions only correlated with social…”
ResultReisenzein, R., Hildebrandt, A., & Weber, H. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.009 · Cited by 26 · see citing works
Thinking about negative life events as a mediator between depression and fading affect bias
Marsh, C., Hammond, M. D., & Crawford, M. T. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211147 · Cited by 22 · see citing works
Association between Neuroticism and Emotional Face Processing
Klamer, S., Schwarz, L., Krüger, O., Koch, K., Erb, M., Scheffler, K., & Ethofer, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-17706-2 · Cited by 23 · see citing works
Xiao, M., Chen, X., Yi, H., Luo, Y., Yan, Q., Feng, T., He, Q., Lei, X., Qiu, J., & Chen, H. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100418 · Cited by 22 · see citing works
“According to the stress-buffering hypothesis (Cohen and McKay, 2020; Cohen and Wills, 1985), social support moderates the relationship between NA or stress and the physiological reaction (Giesbrecht et al., 2013; Puterman et al., 2014), such as the amygdala action (Hyde et al., 2011).”
Swartz, J. R., Knodt, A. R., Radtke, S. R., & Hariri, A. R. (2017) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.12.019 · Cited by 21 · see citing works
Zhong, G., Shu, Y., Zhou, Y., Li, H., Zhou, J., & Yang, L. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06615-8 · Cited by 29 · see citing works
“According to the buffering theory of social support, when individuals face stress or emotional distress, support from social relationships can effectively alleviate negative emotions [42].”
Cultural neuroscience: new directions as the field matures
Hyde, L. W., Tompson, S., Creswell, J. D., & Falk, E. B. (2015) · Culture and Brain · doi:10.1007/s40167-014-0024-6 · Cited by 21 · see citing works
“…and Sasaki 2012, 2014; Kitayama et al. 2014) and the moderating effect of culture on many brain-behavior links (Chiao et al. 2010; Han et al. 2013; Hyde et al. 2011), an emerging emphasis in cultural neuroscience will be merging brain–culture and gene–culture interactions into broader integrative…”
BackgroundInfluentialRabelo, D. F., & Neri, A. L. (2015) · Revista Brasileira de Geriatria e Gerontologia · doi:10.1590/1809-9823.2015.14120 · Cited by 22 · see citing works
Pedersen, W. S., Muftuler, L. T., & Larson, C. L. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.05.009 · Cited by 20 · see citing works
“…study found that the correlation between trait anxiety and amygdala reactivity only exists for participants who are low in perceived social support (Hyde et al., 2011), and a study using an adolescent sample found that amygdala reactivity to facial expressions only correlated with social…”
Pagni, B. A., Hill, E., Walsh, M. J. M., Delaney, S., Ogbeama, D., Monahan, L., Cook, J. R., Guerithault, N., Dixon, M. V., Ballard, L., et al. (2023) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.220159 · Cited by 20 · see citing works
“31,32”
Lewis, G. J., Bates, T. C., Posthuma, D., & Polderman, T. J. C. (2013) · Journal of Personality · doi:10.1111/jopy.12064 · Cited by 20 · see citing works
Neural Effects of the Social Environment
A, L. K. M., Hooker, C. I., & Aleman, A. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt233 · Cited by 20 · see citing works
Corr, R., Glier, S., Bizzell, J., Pelletier‐Baldelli, A., Campbell, A., Killian-Farrell, C., & Belger, A. (2021) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsab129 · Cited by 18 · see citing works
Parental control and adolescents’ bullying victimization: the moderating role of teacher support
Ren, P., Yang, L., Chen, C., & Luo, F. (2022) · Current Psychology · doi:10.1007/s12144-022-03864-8 · Cited by 18 · see citing works
“When adolescents are in stressful or unfavorable situations (e.g., under high parental psychological control), teacher support might satisfy adolescents’ security needs to counteract pos - sible negative impacts (Hyde et al., 2011).”
BackgroundA complexidade emocional dos relacionamentos intergeracionais e a saúde mental dos idosos
Rabelo, D. F., & Neri, A. L. (2014) · Pensando familias · Cited by 18 · see citing works
Robinson, M. D., & Sedikides, C. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.031 · Cited by 17 · see citing works
The Five-Factor Model of Personality: Consensus and Controversy
McCrae, R. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.013 · Cited by 18 · see citing works
Grisanzio, K. A., Flournoy, J. C., Mair, P., & Somerville, L. H. (2022) · Emotion · doi:10.1037/emo0001079 · Cited by 15 · see citing works
The association among neighborhood mutual support, well-being, and social work
Yang, H., Zhang, W., Wu, Y., Yao, Y.-D., & Su, M. (2022) · Journal of Social Work · doi:10.1177/14680173221093511 · Cited by 16 · see citing works
“First, regarding the formation of social support, frequent and effective neighborhood mutual support facilitates the formation of supportive social relations, which positively affects mental health (Hyde et al., 2011).”
BackgroundWang, J., Wang, X., Li, P., Zhang, M., Wu, H.-Y., Li, D.-L., Fang, M., & Chi, X. (2022) · Current Psychology · doi:10.1007/s12144-022-03783-8 · Cited by 14 · see citing works
“…effect on both physical and mental health (House et al., 1988); the buffering model of social support suggests that good social support can buffer the negative effects of stressful events (Aneshensel & Stone, 1982), which can improve physical and mental health indi - rectly (Hyde et al., 2011).”
BackgroundZhu, L., Zheng, D., Li, R., Shen, C.-J., Cai, R., Lyu, C., Tang, B., Sun, H. X., Wang, X., Ding, Y., et al. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01081-2 · Cited by 14 · see citing works
“The amygdala is crucial for regulating emotions [1–5] and plays a pivotal role in the pathophysiology of various mental diseases, such as depression [6, 7], social fear [8], and anxiety [9, 10].”
BackgroundAvaliação das Relações Familiares por Idosos com Diferentes Condições Sociodemograficas e de Saúde
Rabelo, D. F., & Neri, A. L. (2016) · Psico-USF · doi:10.1590/1413-82712016210318 · Cited by 14 · see citing works
Wang, B., Zhong, X., Fu, H., Hu, R., He, M., & Zhang, G. (2022) · Scientific Reports · doi:10.1038/s41598-022-25126-0 · Cited by 13 · see citing works
Wang, L., Yu, J., Diao, X., Zhang, Y., Miao, Y., & He, W. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1400267 · Cited by 13 · see citing works
Vidal, C., Silverman, J. R., Petrillo, E. K., & Lilly, F. R. W. (2019) · The Social Science Journal · doi:10.1016/j.soscij.2019.08.008 · Cited by 13 · see citing works
Magal, N., Hendler, T., & Admon, R. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100361 · Cited by 13 · see citing works
“…brain regions, particularly the hippocampus, amygdala, and anterior cingulate cortex (ACC) (Allen and DeYoung, 2016; Brown et al., 2020; Canli, 2008; Chan et al., 2009; Cunningham et al., 2011; Haas et al., 2007; Hyde et al., 2011; Ormel et al., 2013; Schuyler et al., 2014; Servaas et al., 2013).”
BackgroundDeng, K., Jin, W., Jiang, K., Li, Z., Im, H., Chen, S., Du, H., Guan, S., Ge, W. H., Wei, C., et al. (2023) · Behavioral and Brain Functions · doi:10.1186/s12993-023-00223-w · Cited by 13 · see citing works
“The reactivity of the amygdala to negative stimuli has been shown to predict improvements in major depression [11], depressive symptoms 2 years later [48], trait anxiety [32], cannabis use 5 years later [80], psychological vulnerability to future life stress [84], and psychological well-being [90].”
BackgroundThe future of neuroscience in developmental psychopathology
Hyde, L. W., Bezek, J. L., & Michael, C. (2024) · Development and Psychopathology · doi:10.1017/s0954579424000233 · Cited by 14 · see citing works
Qi, Y., Bruch, D., Krop, P., Herrmann, M. J., Latoschik, M. E., Deckert, J., & Hein, G. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01761-5 · Cited by 14 · see citing works
“, stronger social buffering effects [9, 12, 13].”
Prediction Along a Developmental Perspective in Psychiatry: How Far Might We Go?
Nees, F., Deserno, L., Holz, N. E., Romanos, M., & Banaschewski, T. (2021) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2021.670404 · Cited by 12 · see citing works
Social support and fear-inhibition: an examination of underlying neural mechanisms
Hornstein, E. A., Leschak, C. J., Parrish, M. H., Haltom, K. E. B., Fanselow, M. S., Craske, M. G., & Eisenberger, N. I. (2024) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsae002 · Cited by 11 · see citing works
“…a buffering effect of social support on anxiety in the left amygdala; while greater left amygdala activity is related to greater levels of anxiety in those with lower levels of social support, for those with high levels of social support, this relationship is non-significant (Hyde et al. , 2011).”
BackgroundEvolutionary Personality Psychology
Lewis, D. M. G., Al-Shawaf, L., & Buss, D. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822.022 · Cited by 11 · see citing works
The School: A Setting for Evidence-Based Prevention Interventions and Policies
Sloboda, Z., & Ringwalt, C. L. (2019) · Advances in prevention science · doi:10.1007/978-3-030-00627-3_9 · Cited by 10 · see citing works
- Authors
- Hyde, L. W., Gorka, A., Manuck, S. B., & Hariri, A. R.
- Affiliations
- University of Pittsburgh (US)
- Duke University (US)
- Corresponding author
- Hyde, Luke W.
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 49
- Issue
- 4
- Pages
- 651-656
- ISSN
- 0028-3932 (ISSN-L)
- PMC
- PMC3026865
- OpenAlex
- W2062947524
- Cited by
- 188
- References
- 49
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 9 · 2023: 10 · 2022: 10 · 2021: 15 · 2020: 42 · 2019: 13 · 2018: 3 · 2017: 8 · 2016: 10 · 2015: 9 · 2014: 14 · 2013: 12 · 2012: 13
- FWCI
- 12.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropsychologia (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (HL040962, HL065137, MH072837)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- perceived social support, amygdala reactivity, trait anxiety, moderation, resilience, psychopathology, biological risk, social buffering, neural reactivity
- MeSH terms
- Adaptation, Psychological, Adult, Aggression, Amygdala, Anxiety, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Reference Values, Social Support, Temperament
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
