Co-occurring anxiety influences patterns of brain activity in depression

Engels, A. S.; Heller, W.; Spielberg, J. M.; Warren, S. L.; Sutton, B. P.; Banich, M. T.; Miller, G. A.

doi:10.3758/cabn.10.1.141

Cited by 133Neural and Behavioral Psychology StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesTreatment of Major Depression

Co-occurring anxiety influences patterns of brain activity in depression

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Engels, A. S., Heller, W., Spielberg, J. M., Warren, S. L., Sutton, B. P., Banich, M. T., Miller, G. A.·2010·Cognitive, Affective, & Behavioral Neuroscience

DOI 10.3758/cabn.10.1.141PMC PMC4403735

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Abstract

Brain activation associated with anhedonic depression and co-occurring anxious arousal and anxious apprehension was measured by fMRI during performance of an emotion word Stroop task. Consistent with EEG findings, depression was associated with rightward frontal lateralization in the dorsolateral prefrontal cortex (DLPFC), but only when anxious arousal was elevated and anxious apprehension was low. Activity in the right inferior frontal gyrus (IFG) was also reduced for depression under the same conditions. In contrast, depression was associated with more activity in the anterior cingulate cortex (dorsal ACC and rostral ACC) and the bilateral amygdala. Results imply that depression, particularly when accompanied by anxious arousal, may result in a failure to implement top-down processing by appropriate brain regions (left DLPFC, right IFG) due to increased activation in regions associated with responding to emotionally salient information (right DLPFC, amygdala).

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Individuals with depression commonly show abnormal brain activity in regions thought to implement executive function.
“For example, individuals with depression commonly exhibit abnormal brain activity in brain regions purported to implement EF (Engels et al. 2010; Herrington et al. 2010; Warren et al. 2013).”
From Executive Function Deficits in Daily Life Prospectively Predict Increases in Depressive Symptoms (2014) · cites this paper as Engels et al. 2010

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Bear DM 1986 Hemispheric asymmetries in emotional function: A reflection of lateral specialization in cortical-limbic connections Doane BK Livingston KE The Limbic System: Functional Organization and Clinical Disorders 29 42 New York Raven Press

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Authors: Engels, A. S., Heller, W., Spielberg, J. M., Warren, S. L., Sutton, B. P., Banich, M. T., & Miller, G. A.
Affiliations: Pennsylvania State University (US)
University of Illinois Urbana-Champaign (US)
University of Colorado Boulder (US)
Corresponding author: Engels, A. S.
ORCID: Heller, W.
Spielberg, J. M.
Warren, S. L.
Sutton, B. P.
Banich, M. T.
Venue: Cognitive, Affective, & Behavioral Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2010-03-01
Volume: 10
Issue: 1
Pages: 141-156
ISSN: 1530-7026 (ISSN-L)
1531-135X
DOI: 10.3758/cabn.10.1.141
PMC: PMC4403735
OpenAlex: W2013128451
Cited by: 133
References: 83
Citations by year: 2026: 5 · 2025: 7 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 8 · 2020: 11 · 2019: 8 · 2018: 9 · 2017: 6 · 2016: 13 · 2015: 6 · 2014: 14 · 2013: 8 · 2012: 9
FWCI: 6.38
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Cognitive Affective & Behavioral Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01 MH-61358, P50MH079485, T32MH019554, T32 MH-19554, R01MH061358)
National Institute on Drug Abuse (R21DA014111, R21 DA 14111)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: anhedonic depression, anxious arousal, anxious apprehension, dorsolateral prefrontal cortex, inferior frontal gyrus, anterior cingulate cortex, amygdala, top-down processing
MeSH terms: Adolescent, Anxiety, Association, Brain, Brain Mapping, Depression, Emotions, Female, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Oxygen, Pattern Recognition, Visual, Surveys and Questionnaires, Reaction Time, Time Factors, Vocabulary, Multivariate Analysis, Young Adult

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